Description of Related Technology Histamine is a well-known modulator of neuronal activity. At least four types of histamine receptors have been reported in the literature, typically referred to as histamine-1, histamine-2, histamine-3, and histamine-4. The class of histamine receptor known as histamine-3 receptors is believed to play a role in neurotransmission in the central nervous system.

The histamine-3 (H3) receptor was first characterized pharmacologically on histaminergic nerve terminals (Nature, 302: 832-837 (1983) ), where it regulates the release of neurotransmitters in both the central nervous system and peripheral organs, particularly the lungs, cardiovascular system and gastrointestinal tract. H3 receptors are thought to be disposed presynaptically on histaminergic nerve endings, and also on neurons possessing other activity, such as adrenergic, cholinergic, serotoninergic, and dopaminergic activity. The existence of H3 receptors has been confirmed by the development of selective H3 receptor agonists and antagonists ( (Nature, 327: 117-123 (1987); Leurs and Timmerman, ed. "The History of H3 Receptor: a Target for New Drugs,"Elsevier (1998) ).

The activity at the H3 receptors can be modified or regulated by the administration of H3 receptor ligands. The ligands can demonstrate antagonist, agonist or partial agonist activity. For example, H3 receptors have been linked to conditions and disorders related to memory and cognition processes, neurological

processes, cardiovascular function, and regulation of blood sugar, among other systemic activities. Although various classes of compounds demonstrating H3 receptor-modulating activity exist, it would be beneficial to provide additional compounds demonstrating activity at the H3 receptors that can be incorporated into pharmaceutical compositions useful for therapeutic methods.

SUMMARY OF THE INVENTION The invention is directed to substituted amines and, more particularly, bicyclic-substituted amines. Accordingly, one aspect of the invention relates to compounds of formula (I) : or a pharmaceutical acceptable salt, ester, amide, or prodrug thereof, wherein: Y, and Y'are each independently selected from the group consisting of CH, CF, and N; X, X', Z, and Z'are each independently C or N; one of Ri and R2 is selected from the group consisting of halogen, cyano, and LZR6 ; the other of Ri and R2 is selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, cycloalkyl, halogen, cyano, and thioalkoxy, provided that R2 is absent when Z'is N; R3 is absent when X'is N or R3 is selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, cyano, and thioalkoxy ; R3a is absent when Z is N or R3a is selected from the group consisting of hydrogen, methyl, alkoxy, halogen, and cyano; R3b is absent when X is N or R3b is selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, hydroxy, cyano, and thioalkoxy ; R4 and R5 are each independently selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl and (NRARB) alkyl, or R4 and R5 taken together with the nitrogen atom to which each is attached form a non-aromatic ring of the formula :

R6 is selected from the group consisting of aryl, heteroaryl, heterocycle, and cycloalkyl ; R7, R8, Rg, and Rio at each occurrence are each independently selected from the group consisting of hydrogen, hydroxyalkyl, fluoroalkyl, and alkyl ; or one of the pair R7 and R8 or the pair Rg and Rio is taken together to form a C3-C6 ring, wherein 0,1, or 2 heteroatoms selected from O, N, or S replace a carbon atom in the ring; R11, R12, R13, and Ri4 are each independently selected from the group consisting of hydrogen, hydroxy, hydroxyalkyl, alkyl, and fluoro ; Q is selected from the group consisting of a bond, O, S, and NRie ; L is- [C (R16) (r17)]n- or -[C(R16)(R17)]pO-; L2 is a bond or L2 is selected from the group consisting of-O-,-C (=O)-, -S-, -[C(R18)(R19)]q-, -O-[C(R18)(R19)]q-, -NH- and -N(alkyl)-; R15 is selected from the group consisting of hydrogen, alkyl, acyl, amido, and formyl ; Ra6 and R17 at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkoxy, and fluoro ; Rieand Rie at each occurrence are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, alkoxy, and fluoro ; Rx and Ry at each occurrence are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, alkoxy, alkylamino, dialkylamino, and

fluoro, or one of Rx or Ry represents a covalent bond when taken together with Rx or Ry on an adjacent carbon atom such that a double bond is represented between the adjacent carbon atoms; m is an integer from 1 to 5; n is an integer from 1 to 6; p is an integer from 2 to 6; and q is an integer from 1 to 4; wherein 0,1, or 2 of X, X', Y, Y', Z, and Z'can be nitrogen; provided that R3 is absent when X'is N; R3a is absent when Z is N ; R2 is absent when Z'is N; and R3b is absent when X is N.

Another aspect of the invention relates to pharmaceutical compositions comprising compounds of the invention. Such compositions can be administered in accordance with a method of the invention, typically as part of a therapeutic regimen for treatment or prevention of conditions and disorders related to H3 receptor activity.

Yet another aspect of the invention relates to a method of selectively modulating H3 receptor activity. The method is useful for treating and/or preventing conditions and disorders related to H3 receptor modulation in mammals. More particularly, the method is useful for conditions and disorders related to memory and cognition processes, neurological processes, cardiovascular function, and body weight.

Processes for making compounds of the invention also are contemplated.

The compounds, compositions comprising the compounds, methods for making the compounds, and methods for treating or preventing conditions and disorders by administering the compounds are further described herein.

DETAILED DESCRIPTION OF THE INVENTION Definition of Terms Certain terms as used in the specification are intended to refer to the following definitions, as detailed below.

The term"acyl"as used herein, means an alkyl group, as defined herein, appended to the parent molecular moiety through a carbonyl group, as defined

herein. Representative examples of acyl include, but are not limited to, acetyl, 1- oxopropyl, 2, 2-dimethyl-1-oxopropyl, 1-oxobutyl, and 1-oxopentyl.

The term"acyloxy"as used herein, means an acyl group, as defined herein, appended to the parent molecular moiety through an oxygen atom.

Representative examples of acyloxy include, but are not limited to, acetyloxy, propionyloxy, and isobutyryloxy.

The term"alkenyl"as used herein, means a straight or branched chain hydrocarbon containing from 2 to 10 carbons and containing at least one carbon- carbon double bond formed by the removal of two hydrogens. Representative examples of alkenyl include, but are not limited to, ethenyl, 2-propenyl, 2-methyl- 2-propenyl, 3-butenyl, 4-pentenyl, 5-hexenyl, 2-heptenyl, 2-methyl-1-heptenyl, and 3-decenyl.

The term"alkoxy"as used herein, means an alkyl group, as defined herein, appended to the parent molecular moiety through an oxygen atom.

Representative examples of alkoxy include, but are not limited to, methoxy, ethoxy, propoxy, 2-propoxy, butoxy, tert-butoxy, pentyloxy, and hexyloxy.

The term"alkoxyalkoxy"as used herein, means an alkoxy group, as defined herein, appended to the parent molecular moiety through another alkoxy group, as defined herein. Representative examples of alkoxyalkoxy include, but are not limited to, tert-butoxymethoxy, 2-ethoxyethoxy, 2-methoxyethoxy, and methoxymethoxy.

The term"alkoxyalkyl"as used herein, means an alkoxy group, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of alkoxyalkyl include, but are not limited to, tert-butoxymethyl, 2-ethoxyethyl, 2-methoxyethyl, and methoxymethyl.

The term"alkoxycarbonyl"as used herein, means an alkoxy group, as defined herein, appended to the parent molecular moiety through a carbonyl group, as defined herein. Representative examples of alkoxycarbonyl include, but are not limited to, methoxycarbonyl, ethoxycarbonyl, and tert-butoxycarbonyl.

The term"alkoxyimino"as used herein, means an alkoxy group, as defined herein, appended to the parent molecular moiety through an imino group, as defined herein. Representative examples of alkoxyimino include, but are not limited to, ethoxy (imino) methyl and methoxy (imino) methyl.

The term"alkoxysulfonyl"as used herein, means an alkoxy group, as defined herein, appended to the parent molecular moiety through a sulfonyl group, as defined herein. Representative examples of alkoxysulfonyl include, but are not limited to, methoxysulfonyl, ethoxysulfonyl, and propoxysulfonyl.

The term"alkyl"as used herein, means a straight or branched chain hydrocarbon containing from 1 to 10 carbon atoms. Representative examples of alkyl include, but are not limited to, methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec- butyl, iso-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, n-hexyl, 3-methylhexyl, 2, 2-dimethylpentyl, 2, 3-dimethylpentyl, n-heptyl, n-octyl, n-nonyl, and n-decyl.

The term"alkylamino"as used herein, means an alkyl group, as defined herein, appended to the parent molecular moiety through a NH group.

Representative examples of alkylamino include, but are not limited to, methylamino, ethylamino, isopropylamino, and butylamino.

The term"alkylcarbonyl"as used herein, means an alkyl group, as defined herein, appended to the parent molecular moiety through a carbonyl group, as defined herein. Representative examples of alkylcarbonyl include, but are not limited to, methylcarbonyl, ethylcarbonyl, isopropylcarbonyl, n-propylcarbonyl, and the like.

The term"alkylsulfonyl"as used herein, means an alkyl group, as defined herein, appended to the parent molecular moiety through a sulfonyl group, as defined herein. Representative examples of alkylsulfonyl include, but are not limited to, methylsulfonyl and ethylsulfonyl.

The term"alkynyl"as used herein, means a straight or branched chain hydrocarbon group containing from 2 to 10 carbon atoms and containing at least one carbon-carbon triple bond. Representative examples of alkynyl include, but are not limited, to acetylenyl, 1-propynyl, 2-propynyl, 3-butynyl, 2-pentynyl, and 1- butynyl.

The term"amido"as used herein, means an amino, alkylamino, or dialkylamino group appended to the parent molecular moiety through a carbonyl group, as defined herein. Representative examples of amido include, but are not limited to, aminocarbonyl, methylaminocarbonyl, dimethylaminocarbonyl, and ethylmethylaminocarbonyl.

The term"amino"as used herein, means a-NH2 group.

The term"aryl"as used herein, means a monocyclic aromatic ring system.

Representative examples of aryl include, but are not limited to, phenyl.

The aryl groups of this invention are substituted with 0,1, 2,3, 4, or 5 substituents independently selected from acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylsulfonyl, alkynyl, amido, carboxy, cyano, cycloalkylcarbonyl, formyl, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, nitro, t thioalkoxy, NRARB, and (NRARB) sulfonyl.

The term"arylalkoxy"as used herein, means an aryl group, as defined herein, appended to the parent molecular moiety through an alkoxy group, as defined herein. Representative examples of arylalkoxy include, but are not limited to, 2-phenylethoxy, 3-naphth-2-ylpropoxy, and 5-phenylpentyloxy.

The term"arylalkoxycarbonyl"as used herein, means an arylalkoxy group, as defined herein, appended to the parent molecular moiety through a carbonyl group, as defined herein. Representative examples of arylalkoxycarbonyl include, but are not limited to, benzyloxycarbonyl.

The term"arylalkyl"as used herein, means an aryl group, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of arylalkyl include, but are not limited to, benzyl, 2-phenylethyl and 3-phenylpropyl.

The term"carbonyl"as used herein, means a-C (=O)- group.

The term"carboxy"as used herein, means a-CO2H group, which may be protected as an ester group-C02-alkyl.

The term"cyano"as used herein, means a-CN group.

The term"cycloalkenyl"as used herein, means a cyclic hydrocarbon containing from 3 to 8 carbons and containing at least one carbon-carbon double bond formed by the removal of two hydrogens. Representative examples of cycloalkenyl include, but are not limited to, 2-cyclohexen-1-yl, 3-cyclohexen-1-yl, 2, 4-cyclohexadien-1-yl and 3-cyclopenten-1-yl.

The term"cycloalkyl"as used herein, means a saturated cyclic hydrocarbon group containing from 3 to 8 carbons. Examples of cycloalkyl include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl.

The cycoalkyl groups of the invention are substituted with 0, 1,-2, 3, or 4 substituents selected from acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkyl, alkynyl, amido, carboxy, cyano, ethylenedioxy, formyl, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, methylenedioxy, thioalkoxy, and-NRARB.

The term"cycloalkylalkyl"as used herein, means a cycloalkyl group, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of cycloalkylalkyl include, but are not limited to, cyclopropylmethyl, 2-cyclobutylethyl, cyclopentylmethyl, cyclohexylmethyl, and 4-cycloheptylbutyl.

The term"cycloalkylcarbonyl"as used herein, means a cycloalkyl group, as defined herein, appended to the parent molecular moiety through a carbonyl group, as defined herein. Representative examples of cycloalkylcarbonyl include, but are not limited to, cyclopropylcarbonyl, cyclopentylcarbonyl, cyclohexylcarbonyl, and cycloheptylcarbonyl.

The term"dialkylamino"as used herein, means two independent alkyl groups, as defined herein, appended to the parent molecular moiety through a nitrogen atom. Representative examples of dialkylamino include, but are not limited to, dimethylamino, diethylamino, ethylmethylamino, butylmethylamino.

The term"ethylenedioxy"as used herein, means a-O (CH2) 20- group wherein the oxygen atoms of the ethylenedioxy group are attached to the parent molecular moiety through one carbon atom forming a five-membered ring or the oxygen atoms of the ethylenedioxy group are attached to the parent molecular moiety through two adjacent carbon atoms forming a six-membered ring.

The term"fluoro"as used herein means-F.

The term"fluoroalkyl"as used herein, means at least one fluoro group, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein. Representative example of fluoroalkyl include, but are not limited to, fluoromethyl, difluoromethyl, trifluoromethyl, pentafluoroethyl, and 2,2, 2- trifluoroethyl.

The term"formyl"as used herein, means a-C (O) H group.

The term"halo"or"halogen"as used herein, means-Cl,-Br,-I or-F.

The term"haloalkoxy"as used herein, means at least one halogen, as defined herein, appended to the parent molecular moiety through an alkoxy group, as defined herein. Representative examples of haloalkoxy include, but are not limited to, chloromethoxy, 2-fluoroethoxy, trifluoromethoxy, and pentafluoroethoxy.

The term"haloalkyl"as used herein, means at least one halogen, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of haloalkyl include, but are not limited to, chloromethyl, 2-fluoroethyl, trifluoromethyl, pentafluoroethyl, and 2- chloro-3-fluoropentyl.

The term"heteroaryl,"as used herein, refers to an aromatic five-or six- membered ring wherein 1,2, 3, or 4 heteroatoms are independently selected from nitrogen, oxygen, or sulfur, or a tautomer thereof. Examples of such rings include, but are not limited to, a ring wherein one carbon is replaced with an O or S atom; one, two, or three N atoms arranged in a suitable manner to provide an aromatic ring, or a ring wherein two carbon atoms in the ring are replaced with one O or S atom and one N atom. The heteroaryl groups are connected to the parent molecular moiety through a carbon or nitrogen atom. Representative examples of heteroaryl include, but are not limited to, furyl, imidazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl, pyridazinonyl, pyridinyl, pyridinonyl, pyrimidinyl, pyrrolyl, tetrazolyl, thiadiazolyl, thiazolyl, thienyl or thiophenyl, triazinyl, and triazolyl. Specific heteroaryl groups include, but are not limited to, 2H-pyridazin-3-one-2-yl.

The heteroaryl groups of the invention are substituted with 0,1, 2,3, or 4 substituents independently selected from acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylsulfonyl, alkynyl, amido, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, nitro, thioalkoxy,-NRARB, (NRARB) carbonyl, and (NRARB) sulfonyl.

The term"heterocycle,"as used herein, refers to a three-, four-, five-, six-, seven-, or eight-membered ring containing one, two, or three heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur.

Rings containing at least four members can be saturated or unsaturated. For example, the four-and five-membered ring has zero or one double bond. The

six-membered ring has zero, one, or two double bonds. The seven-and eight- membered rings have zero, one, two, or three double bonds. The heterocycle groups of the invention can be attached to the parent molecular moiety through a carbon atom or a nitrogen atom. Representative examples of nitrogen-containing heterocycles include, but are not limited to, azepanyl, azetidinyl, aziridinyl, azocanyl, morpholinyl, piperazinyl, piperidinyl, pyrrolidinyl, pyrrolinyl, dihydrothiazolyl, and thiomorpholinyl. Representative examples of non-nitrogen '\ containing heterocycles include, but are not limited to, tetrahydrofuryl and tetrahydropyranyl.

The heterocycles of the invention are substituted with 0,1, 2,3, or 4 substituents independently selected from acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylsulfonyl, alkynyl, amido, arylalkyl, arylalkoxycarbonyl, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, nitro, oxo, thioalkoxy,-NRARB, and (NRARB) sulfonyl.

The term"hydroxy"as used herein means a-OH group.

The term"hydroxyalkyl"as used herein, means at least one hydroxy group, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of hydroxyalkyl include, but are not limited to, hydroxymethyl, 2-hydroxyethyl, 2-methyl-2-hydroxyethyl, 3- hydroxypropyl, 2, 3-dihydroxypentyl, and 2-ethyl-4-hydroxyheptyl.

The term"hydroxy-protecting group"means a substituent which protects hydroxyl groups against undesirable reactions during synthetic procedures.

Examples of hydroxy-protecting groups include, but are not limited to, methoxymethyl, benzyloxymethyl, 2-methoxyethoxymethyl, 2- (trimethylsilyl) ethoxymethyl, benzyl, triphenylmethyl, 2,2, 2-trichloroethyl, t-butyl, trimethylsilyl, t-butyldimethylsilyl, t-butyldiphenylsilyl, methylene acetal, acetonide benzylidene acetal, cyclic ortho esters, methoxymethylene, cyclic carbonates, and cyclic boronates. Hydroxy-protecting groups are appended onto hydroxy groups by reaction of the compound that contains the hydroxy group with a base, such as triethylamine, and a reagent selected from an alkyl halide, alkyl trifilate, trialkylsilyl halide, trialkylsilyl triflate, aryidialkylsilyltriflate, or an alkylchloroformate, CH212, or a dihaloboronate ester, for example with methyliodide, benzyl iodide,

triethylsilyltriflate, acetyl chloride, benzylchloride, or dimethylcarbonate. A protecting group also may be appended onto a hydroxy group by reaction of the compound that contains the hydroxy group with acid and an alkyl acetal.

The term"imino"as defined herein means a-C (=NH)- group.

The term"mercapto"as used herein, means a-SH group.

The term"methylenedioxy"as used herein, means a-OCH20-group wherein the oxygen atoms of the methylenedioxy are attached to the parent molecular moiety through two adjacent carbon atoms.

The term"-NRARB"as used herein, means two groups, RA and RB, which are appended to the parent molecular moiety through a nitrogen atom. RA and RB are independently selected from hydrogen, alkyl, acyl and formyl. Representative examples of-NRARB include, but are not limited to, amino, dimethylamino, methylamino, acetylamino, and acetylmethylamino.

The term" (NRARB) alkyl" as used herein, means an-NRARB group, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of (NRARB) alkyl include, but are not limited to, 2-(methylamino) ethyl, 2-(dimethylamino) ethyl, 2-(amino) ethyl, 2- (ethylmethylamino) ethyl, and the like.

The term" (NRARB) carbonyl" as used herein, means an alkyl group, as defined herein, appended to the parent molecular moiety through a carbonyl group, as defined herein. Representative examples of alkylcarbonyl include, but are not limited to, methylcarbonyl, ethylcarbonyl, isopropylcarbonyl, n- propylcarbonyl, and the like.

The term"(NRARB) sulfonyl"as used herein, means a-NRARB group, as defined herein, appended to the parent molecular moiety through a sulfonyl group, as defined herein. Representative examples of (NRARB) sulfonyl include, but are not limited to, aminosulfonyl, (methylamino) sulfonyl, (dimethylamino) sulfonyl and (ethylmethylamino) sulfonyl.

The term"nitro"as used herein means a-N02 group.

The term"nitrogen protecting group"as used herein, means those groups intended to protect a nitrogen atom against undesirable reactions during synthetic procedures. Nitrogen protecting groups comprise carbamates, amides, N-benzyl derivatives, and imine derivatives. Preferred nitrogen protecting groups are

acetyl, benzoyl, benzyl, benzyloxycarbonyl (Cbz), formyl, phenylsulfonyl, pivaloyl, tert-butoxycarbonyl (Boc), tert-butylacetyl, trifluoroacetyl, and triphenylmethyl (trityl). Nitrogen-protecting groups are appended onto primary or secondary amino groups by reacting the compound that contains the amine group with base, such as triethylamine, and a reagent selected from an alkyl halide, an alkyl trifilate, a dialkyl anhydride, for example as represented by (alkyl-0) 2C=O, a diaryl anhydride, for example as represented by (aryl-0) 2C=O, an acyl halide, an ' alkylchlòroformate, or an alkylsulfonylhalide, an arylsulfonylhalide, or halo- CON (alkyl) 2, for example acetylchloride, benzoylchloride, benzylbromide, <BR> <BR> <BR> <BR> benzyloxycarbonylchloride, formylfluoride, phenylsulfonylchloride, pivaloylchloride, (tert-butyl-Ó-C=0) 20, trifluoroacetic anhydride, and triphenylmethylchloride.

The term"hydroxy protecting group"or"O-protecting group"or"oxygen protecting group"means a substituent which protects hydroxy groups against undesirable reactions during synthetic procedures. Examples of hydroxy protecting groups include, but are not limited to, substituted methyl ethers, for example, methoxymethyl, benzyloxymethyl, 2-methoxyethoxymethyl, 2- (trimethylsilyl) ethoxymethyl, benzyl, and triphenylmethyl ; tetrahydropyranyl ethers; substituted ethyl ethers, for example, 2,2, 2-trichloroethyl and t-butyl ; silyl ethers, for example, trimethylsilyl, tert-butyldimethylsilyl and tert-butyldiphenylsilyl ; cyclic acetals and ketals, for example, methylene acetal, acetonide, and benzylidene acetal ; cyclic ortho esters, for example, methoxymethylene ; cyclic carbonates; and cyclic boronates.

The term"oxo"as used herein means (=0).

The term"sulfonyl"as used herein means a-S (0) 2-group.

The term"thioalkoxy"as used herein means an alkyl group, as defined herein, appended to the parent molecular moiety through a sulfur atom.

Representative examples of thioalkoxy include, but are no limited to, methylthio, ethylthio, and propylthio.

As used herein, the term"antagonist"encompasses and describes compounds that prevent receptor activation by an H3 receptor agonist alone, such as histamine, and also encompasses compounds known as"inverse agonists".

Inverse agonists are compounds that not only prevent receptor activation by an H3 receptor agonist, such as histamine, but also inhibit intrinsic H3 receptor activity.

Compounds of the Invention Compounds of the invention can have the general formula (I) as described above.

As previously described, Y, and Y'each can be CH, CF, or N, and X, X', Z, and Z'each can be independently selected from C or N.

R, can be halogen, cyano, or L2R6, wherein L2 is selected from the group consisting of a bond,-O-,-C (=O)-,-S-,-[C (Rr8) (R : s)] q-, as defined herein,-0- [C (Ri8) (Rt9)] q-, as defined herein, -NH-, and-N (alkyl)-, and R6 is selected from the group consisting of aryl, heteroaryl, heterocycle, and cycloalkyl.

Typically, the substituent for R, is selected from bromo, cyano, or L2R6.

Specific examples of groups for R, wherein the substituent is halogen or cyano include, but are not limited to, bromo and cyano.

Preferably L2 is selected from a bond,-O-,-C (=O)-,-S-, or-[C (Rr8) (Rro)] q- Specific groups for L2 include, but are not limited to, -CH (OH)-,-C (=O)-, and where L2 is a bond.

L2 as a bond is most preferred. Preferred groups for R6 are aryl, heteroaryl, and cycloalkyl. The aryl, heteroaryl, and heterocyclic groups can be unsubstituted or substituted, for example as described in the Definition of Terms.

Examples of aryl groups for R6 can include, but are not limited to, phenyl.

The phenyl groups can be substituted with at least 0,1, or 2 substituents.

Preferred substituents for aryl are cyano, halogen,-NRARB, alkoxy, hydroxyalkyl, alkylcarbonyl, alkoxycarbonyl, cycloalkylcarbonyl, thioalkoxy, alkylsulfonyl, and haloalkyl. The more preferred substituent is cyano. Specific examples include, but are not limited to, 4-chlorophenyl, 3-cyanophenyl, 4-cyanophenyl, 3,5- difluorophenyl, 4- (dimethylamino) phenyl, 4-ethoxyphenyl, 3-fluorophenyl, 4- fluorophenyl, 3-hydroxymethylphenyl, 4- (1-hydroxy-1-methylethyl) phenyl, 3- (methylcarbonyl) phenyl, 4- (methylcarbonyl) phenyl, 4- (methylsulfanyl) phenyl, 4- (methylsulfonyl) phenyl, 4-methoxyphenyl, 4- (cyclopropylcarbonyl) phenyl, 4- (methoxycarbonyl) phenyl, and 4- (trifluoromethyl) phenyl.

One particular embodiment is a compound of formula (I) wherein Ri is LzRe, L2 is a bond and R6 is aryl wherein the aryl is phenyl substituted with 0,1, or 2 substituents selected from the group consisting of cyano, halogen,-NRARB,

alkoxy, hydroxyalkyl, alkylcarbonyl, alkoxycarbonyl, cycloalkylcarbonyl, alkylsulfonyl, haloalkyl, and thioalkoxy.

Specific heteroaryl groups for R6 can include, but are not limited to, furyl, <BR> <BR> <BR> <BR> imidazolyl, isothiazolyl, isoxazolyl, oxadiazolyl, oxazolyl, pyrazinyl, pyrazolyl,<BR> <BR> <BR> <BR> <BR> <BR> pyridazinyl, pyridazinonyl, pyridinonyl, pyridinyl, pyrimidinyl, pyrrolyl, tetrazolyl, thiadiazolyl, thiazolyl, thienyl, triazinyl, and triazolyl. Specific heteroaryl groups for the invention include, but are not limited to, for example, furan-3-yl, pyrazin-2-yl, <BR> <BR> t<BR> <BR> <BR> pyrazol-3-yl, pyrazol-4-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrimidin-2-yl, pyrimidin-5-yl, pyrrol-2-yl, 1, 3-thiazol-2-yl, 1, 3-thiazol-5-yl, thiophen-3-yl, and thiophen-2-yl. Also included as heteroaryl groups of the invention are 2H- pyridazin-3-one, particularly 2H-pyridazin-3-one-2-yl, and 1 H-pyridin-2-one, particularly 1 H-pyridin-2-one-1-yl. A preferred heteroaryl group is 2H-pyridazin-3- one-2-yl : The heteroaryl groups can be substituted with at least 0,1, 2, or 3 substituents. Preferred substituents for the heteroaryl groups are-NRARB, halogen, alkyl, cyano, alkoxyimino, alkoxycarbonyl, (NRARB) carbonyl, alkylcarbonyl, haloalkyl, and alkoxy. Specific examples of substituted heteroaryl groups for the invention include, but are not limited to, 2-aminopyrimidin-5-yl, 3- <BR> <BR> <BR> <BR> bromoisoxazol-5-yl, 3-chloropyridin-4-yl, 6-chloropyridin-3-yl, 5-cyanopyridin-3-yl, 3-cyano-2, 6-dimethylpyridin-3-yl, 2, 6-dichloropyridin-3-yl, 2, 6-dimethylpyridin-3-yl, 1, 3-dimethylpyrazol-4-yl, 1, 5-dimethylpyrazol-4-yl, 3, 5-dimethylpyrazol-4-yl, 5- cyanothien-2-yl, 2-cyanopyrimidin-5-yl, 2, 5-dimethylfur-3-yl, 3, 5-dimethylthien-2-yl,.

5-(ethoxyiminomethyl) thien-2-yl, 6-fluoropyridin-3-yl, 2, 6-difluoropyridin-3-yl, 4- (ethoxycarbonyl)-3-methylisoxazol-5-yl, 3, 5-dimethylisoxazol-4-yl, 3- (ethoxycarbonyl) isoxazol-5-yl, 3-methylpyrazin-2-yl, 6-fluoropyridin-3-yl, 6- methylpyridin-3-yl, 2, 6-dimethyl-5-(aminocarbonyl) pyridin-3-yl, 2, 6-dimethyl-5- (methylcarbonyl) pyridin-3-yl, 4-hydroxy-2- (trifluoromethyl) pyridin-3-yl, 6- (methylcarbonyl) pyridin-2-yl, 2, 4-dimethoxypyrimidin-5-yl, 6-methoxypyridin-3-yl, 5-methoxypyridin-3-yl, 2, 4-dimethylthiazol-5-yl, 2, 4-dimethyloxazol-5-yl, 6- chloropyridazin-3-yl, 6-methoxypyridazin-3-yl, 6-methylpyridazinonyl, 4- methylpyridinonyl, and 1-(tert-butoxycarbonyl) pyrrol-2-yl.

A particular embodiment is a compound of formula (I) wherein Ri is L2R6, L2 is a bond, and R6 is selected from the group consisting of furyl, isoxazolyl,

oxazolyl, pyrazinyl, pyrazolyl, pyridinyl, pyridinonyl, pyridazinyl, pyridazinonyl, pyrimidinyl, pyrrolyl, thiazolyl, and thienyl, substituted with 0,1, 2, or 3 substituents selected from the group consisting of-NRARB, halogen, alkyl, cyano, alkoxyimino, alkoxycarbonyl, (NRARB) carbonyl, alkylcarbonyl, haloalkyl, and alkoxy.

Heterocycle groups for R6 can include, but are not limited to, azepanyl, azetidinyl, aziridinyl, azocanyl, dihydrothiazolyl, morpholinyl, piperazinyl, piperidinyl, pyrrolidinyl, pyrrolinyl, thiomorpholinyl, and tetrahydropyridinyl, as well as non-nitrogen containing heterocycles, for example, tetrahydrofuryl and tetrahydropyranyl. Heterocycles can be substituted with 0,1, or 2 substituents as described in the Definition of Terms. Specific examples of heterocycles for the invention include, but are not limited to, morpholin-4-yl, thiomorpholin-4-yl, and 4, 5-dihydrothiazol-2-yl. Preferred heterocycles are dihydrothiazolyl, morpholinyl, piperidinyl, pyrrolidinyl, thiomorpholinyl, and tetrahydropyranyl.

Specific cycloalkyl groups for R6 can include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl.

R2 in a compound of formula (I) is absent when Z'is N. R2 also can be independently selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, cycloalkyl, halogen, cyano, and thioalkoxy when Z'is C. Preferred groups for R2 are hydrogen, alkyl, and cycloalkyl. Alternatively, R2 can be halogen, cyano, or L2R6, as defined for Ri.) In compounds wherein R2 is a group of the formula L2R6, R1 can be selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, cycloalkyl, halogen, cyano, and thioalkoxy.

R3 in a compound of formula (I) is absent when X'is N. In addition, R3 can be independently selected from the group consisting of hydrogen, alkyl, alkoxy, cycloalkyl, halogen, cyano, and thioalkoxy when X'is C. Preferred groups for R3 are hydrogen, alkyl, and cycloalkyl.

R3a in a compound of formula (I) is absent when Z is N. In addition, R3a can be independently selected from the group consisting of hydrogen, methyl, alkoxy, halogen, and cyano when Z is C. Preferred groups for R3a are hydrogen and methyl.

R3b in a compound of formula (I) is absent when X is N. In addition, R3b can be independently selected from the group consisting of hydrogen, alkyl,

alkoxy, halogen, hydroxy, cyano, and thioalkoxy when X is C. Preferred groups for R3b are hydrogen and hydroxy.

R4 and R5 in a compound of formula (I) are each independently selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, and (NRARB) alkyl. Preferred compounds of formula (I), wherein R4 and R5 are independently selected are those wherein R4 and R5 are each independently selected from methyl, ethyl, and propyl, particularly isopropyl.

'\ R4 and Rs also can be taken together with the nitrogen atom to which each is attached form a non-aromatic ring of the formula: wherein R7, R8, Rg, Rio, R11, R12, R13, R14, Rx, Ry, and m are as described herein.

In one embodiment, R4 and Rs taken together with the nitrogen atom to which each is attached form a 4-to 8-membered non-aromatic ring represented by formula (a).

R7, R8, Rg, and Rio each can be independently selected from the group consisting of hydrogen, hydroxyalkyl, fluoroalkyl, and alkyl. Alternatively, each pair of R7 and R8 or Rg and Rio taken together can form a C3-C6 ring, including the carbon atom to which each is attached. The C3-C6 ring can include 0,1, or 2 heteroatoms selected from 0, N, or S to replace a carbon atom in the ring.

Examples of C3-C6 rings can include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, pyrrolidinyl, oxirane, and the like.

Rx and Ry each can be independently selected from hydrogen, hydroxy, alkyl, alkoxy, alkylamino, dialkylamino, and fluoro. Also, one of Rx and Ry can represent a bond when taken with Rx or Ry on an adjacent carbon atom, such that a double bond is represented between the adjacent carbon atoms.

The value represented by m can be selected from 1 to 5, inclusive.

Preferred values for m are 2 and 3.

Compounds of formula (I) also are those wherein R4 and R5 are taken together with the nitrogen atom to which each is attached to form a non-aromatic ring of formula (b), wherein R7, R8, Rg, and Rio are as previously defined for a ring of formula (a) ; Rll, R12, R13, and R14 are each independently selected from the group consisting of hydrogen, hydroxy, hydroxyalkyl, alkyl, and fluoro ; and Q is a bond or'Q is selected from the group consisting of 0, S, and NR1s, wherein Rosis selected from the group consisting of hydrogen, alkyl, acyl, amido, and formyl.

Preferably, R7, R8, Rg, and Rio are each independently selected from hydrogen, methyl, ethyl, fluoromethyl, and hydroxymethyl. Ril, R12, R13, and R14 preferably each are hydrogen. Alternatively, it is preferred that Ril and Riz are hydrogen, R13 and R14 are each independently selected from hydrogen or alkyl, and R7, R8, Rg, and Rio are as previously defined.

Compounds wherein R4 and R5 taken together with the nitrogen atom to which each is attached to form a 4-to 8-membered non-aromatic ring of formula (a) can include, but are not limited to, those wherein the 4-to 8-membered non- aromatic ring is selected from azetidinyl, azepanyl, azepinyl, pyrrolidinyl, pyrrolinyl, piperidinyl, piperazinyl, and tetrahydropyridinyl. The ring can be substituted with 0,1, or 2 substituents as previously described for heterocycle groups in the Definition of Terms. Preferred substituents are selected from the group consisting of alkyl, halogen, hydroxyalkyl, fluoroalkyl, and-NRARB.

Groups for R4 and R5 also can be taken together with the nitrogen atom to which each is attached to form a 4-to 8-membered non-aromatic ring of formula (a) or formula (b), wherein the ring is substituted with at least one substituent selected from hydroxy, alkyl, halogen, fluoroalkyl, or hydroxyalkyl.

More specific groups for R4 and Rs include, for example, those wherein R4 and Rs are taken together with the nitrogen atom to which each is attached to form a 4-to 8-membered non-aromatic ring selected from morpholinyl and thiomorpholinyl, and unsubstituted or substituted pyrrolidinyl, for example, methylpyrrolidinyl, ethylpyrrolidinyl, dimethylaminopyrrolidinyl, isopropylpyrrolidinyl, isobutylpyrrolidinyl, hydroxymethylpyrrolidinyl, and

fluoromethylpyrrolidinyl. Pyrrolidinyl, and particularly methylpyrrolidinyl, for example 2-methylpyrrolidinyl, are preferred.

In one embodiment, groups for R4 and R5 are taken together with the nitrogen atom to which each is attached to form a non-aromatic ring of formula (a) or formula (b) and at least one of the substituents R7, Rs, Rg, and Rio is selected from hydroxyalkyl, fluoroalkyl, or alkyl. In this embodiment, at least one of R7, R8, R9, and Rio can be selected from methyl, ethyl, fluoromethyl, or hydroxymethyl, and the'like. In such embodiment, it is particularly preferred that one substituent represented by R7, R8, Rg, and Raois alkyl, and particularly methyl, and the other three substituents are hydrogen.

One specific embodiment relates to compounds having the formula (I) wherein R4 and Rs taken together with the nitrogen atom to which each is attached form a non-aromatic ring of formula (b) and Q is NR15. In such embodiment, Ris preferably is selected from hydrogen, alkyl, amido, or formyl.

The moiety represented by L can be -[C(R16)(R17)]n- or -[C(R16)(R17)]pO-, wherein Rie and R17 are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, and fluoro, and n is an integer selected from 1 to 6, inclusive, and p is an integer selected from 2 to 6, inclusive. Rie and R17 preferably are hydrogen. The preferred value of n is 2 or 3. The preferred value for p is 2.

L2 can be a bond or selected from-O-,-C (=O)-,-S-,- [C (Ri8) (R19)] q~,-NH-, -N (alkyl)-, wherein R18 and R1g are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, alkoxy, and fluoro, and q is an integer selected from 1 to 4, inclusive. The alkyl group of-N (alkyl)- preferably contains from 1 to 6 carbons. Compounds of the invention can have the formula (I) wherein L2 is- [C (Ri8) (Ri9)] q-, Ris and Rig are hydrogen, and q is 1,2, 3 or 4. The preferred value for q is 1.

Preferred compounds of formula (I) are those wherein Ri is a group L2R6, wherein L2 is a bond and R6 is heteroaryl or heterocycle ; R2, R3, R3a, and R3b are hydrogen; L is-[C (R16) (R17)] n-; n is 2; Rig and R17 are hydrogen at each occurrence; R4 and R5 are taken together to form a methylpyrrolidinyl ring of formula (a), wherein one of R7, R8, Rg, and R10 is methyl and the remaining three

substituents are hydrogen; Y and Y'are CH; X, X', Z, and Z'are C. A preferred heteroaryl group is pyridazinonyl and, more particularly, 2H-pyridazin-3-one-2-yl.

With respect to the ring system, 0, 1, or 2 atoms represented by X, X', Y, Y', Z, and Z'can be nitrogen.

Compounds of the invention can have the formula (I) wherein Y and Y'are CH; X, X', Z, and Z'are C; and R2, R3, R3a, and R3b are hydrogen.

Alternatively, compounds of the invention have formula (I) wherein Y and Y' @ are CH ;'X, X', and Z are C; R3, R3a, and R3b are hydrogen; Z'is N; and R2 is absent.

Compounds of the invention also can have the formula (I) wherein Y and Y' are CH; X', Z', and Z are C; R2, R3, and R3a are hydrogen; X is N; and R3b is absent.

The invention also includes compounds having the formula (I) wherein Y and Y'are CH; X, X', and Z'are C; R2, R3, and R3b are hydrogen; Z is N; and R3a is absent.

In another embodiment, compounds of the invention can have formula (I) wherein Y is CH; X, X', Z, and Z'are C; R2, R3, R3a, and R3b are hydrogen; and Y' is N.

In yet another embodiment, compounds of the invention have formula (I) wherein Y and Y'are CH; X and Z'are C; R2 and R3b are hydrogen; X'is N; Z is N; and R3 and R3a are absent.

Yet another embodiment relates to compounds of the invention having the. formula (I) wherein X, X', Z, and Z'are C; R2, R3, R3a, and R3b are hydrogen; Y is N; and Y'is N.

Still yet another embodiment relates to compounds of the invention having the formula (I) wherein Y'is CH; X, X', and Z are C ; R3, R3a, and R3b are hydrogen; Y is N; Z'is N; and R2 is absent.

Another embodiment relates to compounds of the invention having the formula (I) wherein Y'is CH; X, Z, and Z'are C; R2, R3a, and R3b are hydrogen; Y is N; X'is N; and R3 is absent.

Still yet another embodiment relates to compounds of the invention having the formula (I) wherein Y'is CH; X, X', and Z'are C; R2, R3, and R3b are hydrogen; Y is N; Z is N; and R3a is absent.

Still yet another embodiment relates to compounds of the invention having the formula (I) wherein Y is CH; X, X', and Z are C; R3, Rusa, and R3b are hydrogen; Y'is N; Z'is N; and R2 is absent.

Still yet another embodiment relates to compounds of the invention having the formula (I) wherein Y and Y'are CH; Z'and Z are C; R2 and R3a are hydrogen; X'is N; X is N; and R3 and R3b are absent.

Compounds of the invention also can have the formula (1) wherein Y'is CH; X, X', Z and Z'are C; R2, R3, R3a, and R3b are hydrogen; and Y is N.

In yet another embodiment, compounds of the invention have formula (I) wherein Y and Y'are CH; X'and Z'are C; R2 and R3 are hydrogen; X is N; Z is N; and R3a and R3b are absent.

Still yet another embodiment relates to compounds of the invention having the formula (I) wherein Y is CH; X, Z', and Z are C; R2, R3a, and R3b are hydrogen; Y'is N; X'is N; and R3 is absent.

When substituents represented by R2, R3, Rusa, and R3b are present, Z', X', Z, and X respectively, represent a carbon atom to allow for the substituents represented by R2, R3, R3a, and R3b. Specific examples of compounds of the invention include, but are not limited to: 4-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl] ethyl}-2-naphthyl) benzonitrile ; (2R)-1- [2- (6-bromo-2-naphthyl) ethyl]-2-methylpyrrolidine ; 1- [3- (6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-2-naphthyl) phenyl] ethanone ; 2- [3- (6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-2-naphthyl) phenyl]-2- propanol ; 6-{2-[(2R)-2-methyl-1-pyrrolidinyl] ethyl}-2-naphthonitrile ; 4-(6-{[(2R)-2-methyl-1-pyrrolidinyl] methyl}-2-naphthyl) benzonitrile ; 3-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl] ethyl}-2-naphthyl) benzonitrile ; 4-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-naphthyl) pyridine; 3-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl] ethyl}-2-naphthyl) pyridine; (3-fluorophenyl) (6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-2- naphthyl) methanol ; 3, 5-dimethyl-4- (6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-2- naphthyl) isoxazole ; 4-(6-{2-[(2S)-2-(hyd roxymethyl)-1-pyrrolid inyl] ethyl}-2-naphthyl) benzonitrile ;

4- (6- {2- [ (3R)-3-hydroxy-1-pyrrolidinyl] ethyl}-2-naphthyl) benzonitrile ; 4- {6- [2- (2-isobutyl-1-pyrrolidinyl) ethyl]-2-naphthyl} benzonitrile ; 4- {6- [2- (2-isopropyl-1-pyrrolidinyl) ethyl]-2-naphthyl} benzonitrile ; 4- (6- {2- [ (3R)-3- (dimethylamino)-l-pyrrolidinyl] ethyl}-2-naphthyl) benzonitrile ; 4- {6- [2- (diethylamino) ethyl]-2-naphthyl} benzonitrile ; 4-{6-[2-(dimethylamino)ethyl]-2-naphthyl}benzonitrile ; 4-(6-{2-[ethyl(isopropyl)amino]ethyl}-2-naphthyl)benzonitril e ; 4-(6-{2-[tert-butyl (methyl) amino] ethyl}-2-naphthyl) benzonitrile ; 4-(6-{2-[(2S)-2-methyl-1-pyrrolidinyl]ethyl}-2-naphthyl)benz onitrile ; 4-(6-{2-[(2R)-2-methyl-1-piperidinyl]ethyl}-2-naphthyl)benzo nitrile ; 4- {6- [2- (2, 5-dihydro-1 H-pyrrol-1-yl) ethyl]-2-naphthyl} benzonitrile ; 4- (6- {2- [methyl (propyl) amino] ethyl}-2-naphthyl)benzonitrile ; 4- (6-{2-[(2-hydroxyethyl)(methyl) amino] ethyl}-2-naphthyl) benzonitrile ; 5-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-maphthyl)pyri midine ; 4- (6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-naphthyl)morpho line ; 2-(642-[(2R)-2-methyl-1-pyrrolidinyl] ethyl}-2-naphthyl)-1, 3-thiazole ; 4-(6-{2-[(2S)-2-(fluoromethyl)-1-pyrrolidinyl]ethyl}-2-napht hyl)benzonitrile ; (3-fluorophenyl) (6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-2- naphthyl) methanone; 2-(6-{2-[(2R)-2-methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthale n-2-yl)-2H- pyridazin-3-one ; 2-methoxy-5-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-nap hthyl)pyridine ; 4- (6- {2- [ (2R)-2- (hydroxymethyl)-l-pyrrolidinyl] ethyl)-2-naphthyl) benzonitrile ; 4-{6-[2-(2-methyl-1-pyrrolidinyl)ethyl]-2-naphthyl}benzonitr ile ; 4- {6- [2- (1-pyrrolidinyl) ethyl]-2-naphthyl} benzonitrile ; 4-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-naphthyl)thio morpholine ; 1-{2-[(6-bromo-2-naphthyl) oxy] ethyl} pyrrolidine ; 3- {6- [2- (1-pyrrolidinyl) ethoxy]-2-naphthyl} benzonitrile ; 3-{6-[2-(1-pyrrolidinyl)ethoxy]-2-naphthyl}pyridine ; 3-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethoxy}-2-naphthyl)ben zonitrile ; 3-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethoxy}-2-naphthyl)pyr idine ; 4-(2-{2-[(2R)-2-methyl-1-pyrrolidiny !] ethyl}-6-qu inolinyl) benzonitrile ; 6-(4-fluorophenyl)-2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl} quinoline ;

3-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl] ethyl}-6-quinolinyl) benzonitrile ; 1- [3- (2- {2- [ (2R)-2-methyl-1-pyrrolid inyl] ethyl}-6-q u i nol i nyl) phenyl] etha none ; 6-(4-methoxyphenyl)-2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl }quinoline ; 2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-6-[4- (trifluoromethyl) phenyl] quinoline ; 2- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-6- [4- (methylsulfonyl) phenyl] quinoline ; 6-(3,5-difluorophenyl)-2-{2-[(2R)-2-methyl-1-pyrrolidinyl]et hyl}quinoline ; (3-fluorophenyl) (2-{2-[(2R)-2-methyl-1-pyrrolid inyl] ethyl}-6- quinolinyl) methanone; 2-{2-[(2R)-2-methyl-1\-pyrrolidinyl] ethyl}-6-(3-pyrid inyl) q uinoline ; 4-(3-{2-[(2R)-2-methyl-1-pyrrolidinyl] ethyl}-7-isoq uinolinyl) benzonitrile ; 3-(3-{2-[(2R)-2-methyl-1-pyrrolidinyl] ethyl}-7-isoq uinolinyl) benzonitrile ; 6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-(3-pyridinyl)qui noline ; 6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-(4-pyridinyl)qui noline ; 6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-(2-pyridinyl)qui noline ; 6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-(1,3-thiazol-2-y l)quinoline ; 2-(2, 4-dimethyl-1, 3-thiazol-5-yl)-6-{2-[(2R)-2-methyl-1- pyrrolidinyl] ethyl} quinoline ; 6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-(2-pyrazinyl)qui noline ; 1-[6-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-quinolinyl )-2- pyridinyl] ethanone; 4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-6-quinoxalinyl) benzonitrile ; 4-(3-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-6-quinoxalinyl) benzonitrile ; 7-(2,6-difluoro-3-pyridinyl)-3-{2-[(2R)-2-methyl-1- pyrrolidinyl] ethyl} isoquinoline ; 3-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-7-(3-pyridinyl)iso quinoline ; 3-(benzyloxy)-2-methyl-6-{2-[(2R)-2-methyl-1-pyrrolidinyl]et hyl}quinoline ; 2-cyclopropyl-6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}quino line ; 4-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl] ethyl}-2-quinolinyl) benzonitrile ; 2, 6-dimethyl-5-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2- quinolinyl) nicotinonitrile ; 2-(3-methyl-2-pyrazinyl)-6-{2-{(2R)-2-methyl-1-pyrrolidinyl[ ethyl}quinoline ;

ethyl 5-(6-{2-[(2R)-2-methyl-1-pyrrolid inyl] ethyl}-2-quinolinyl)-3- isoxazolecarboxylate ; 5- (6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl)-2-quinolinyl)-2- thiophenecarbonitrile ; ethyl 5-(6-{2-[(2R)-2-methyl-1-pyrrolid inyl] ethyl}-2-quinolinyl)-2- thiophenecarboximidoate; 2-(2, 4-dimethyl-1, 3-oxazol-5-yl)-6-{2-[(2R)-2-methyl-1- pyrrolidihyl] ethyl} quinoline ; ethyl 3-methyl-5- (6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-2-quinolinyl)-4- isoxazolecarboxylate ; 4-(7-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-3-isoquinolinyl )benzonitrile ; 6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-(4-methoxyphenyl )quinoxaline ; 7-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-(4-methoxyphenyl )quinoxaline ; 6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-phenylquinoxalin e ; 7-{2-[(2R)-2-methyl-1-pyrrolidinyl] ethyl}-2-phenylquinoxaline ; 6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-2- (3-pyridinyl) quinazoline ; 6-methyl-2-{6-[2-((2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-naph thalen-2-yl}-2H- pyridazin-3-one; 5-{6-[2-((2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2- yl}-pyrimidine-2- carbonitrile ; 1- {6- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl}-1 H-pyridin-2- one; 5-{6-[2-(2(R)-methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl }-nicotinonitrile ; 4-methyl-1-{6-[2-(2(R)-methyl-pyrrolidin-1-yl)-ethyl]-naphth alen-2-yl}-1H- pyridin-2-one; 2- {6- [2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl)-pyraz ine ; 2- {6- [2- ( (2R)-2-methyl-2, 5-dihydro-pyrrol-1-yl)-ethyl]-naphthalen-2-yl}-2H- pyridazin-3-one; 4-(6-{2-[(2-d imethylamino-ethyl)-methyl-amino]-ethyl}-naphthalen-2-yl)- benzonitrile ; 4-{6-[2-(4-methyl-piperazin-1-yl)-ethyl]-naphthalen-2-yl}-be nzonitrile ; 2- (2, 5-dimethyl-furan-3-yl)-6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}- quinoline ;

6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-2- (4-methylsulfanyl-phenyl)- quinoline ; 2-(6-methyl-pyridin-3-yl)-6-{2-[(2R)-2-methyl-1-pyrrolidinyl ]ethyl}-quinoline ; 2- (1, 3-dimethyl-1 H-pyrazol-4-yl)-6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}- quinoline ; 6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-2-thiophen-3-yl-quinoline ; 6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-2-pyrimidin-5-yl-quinoline ; Z (2, 6-dimethyl-pyridin-3-yl)-6-{2-[(2R)-2-methyl-1-pyrrolidinyl] ethyl}- quinoline ; 1- 6-d 6-dimethyl-5- (6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl} =quinolin-2-yl)- pyridin-3-yl]-ethanone. ; 6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-2- (2H-pyrazol-3-yl)-quinoline ; 2-(3-bromo-isoxazol-5-yl)-6-{2-[(2R)-2-methyl-1-pyrrolidinyl ]ethyl}-quinoline ; 2-(6-chloro-pyridin-3-yl)-6-{2-[(2R)-2-methyl-1-pyrrolidinyl ]ethyl}-quinoline ; 2- (3, 5-dimethyl-thiophen-2-yl)-6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}- quinoline ; 6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-thiophen-2-yl-qu inoline ; 2-furan-3-yl-6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-quino line ; 2-(4,5-dihydro-thiazol-2-yl)-6-{2-[(2R)-2-methyl-1-pyrrolidi nyl]ethyl}- quinoline ; 1- [4- (6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-quinolin-2-yi)-phenyl]- ethanone; 3- (6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-quinolin-2-yl)-2-trifluoromethyl- pyridin-4-ol ; 2-(3,5-dimethyl-1H-pyrazol-4-yl)-6-{2-[(2R)-2-methyl-1-pyrro lidinyl]ethyl}- quinoline ; 6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-2- (1 H-pyrazol-4-yl)-quinoline ; 2, 6-dimethyl-5- (6- {2- [ (2R)-2-methyl-1-pyrrolidinyl] ethyl}-quinolin-2-yl)- nicotinamide; 2- [2- (2R-methyl-pyrrolidin-1-yl)-ethyl]-6-pyridin-4-yl-quinoline ; 6-(6-methoxy-pyridin-3-yl)-2-[2(R)-(2-methyl-pyrrolidin-1-yl )-ethyl]-quinoline ; 6- (2, 6-difluoro-pyridin-3-yl)-2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]- quinoline ;

6-(6-chloro-pyridin-3-yl)-2-[2-(2(R)-methyl-pyrrolidin-1-yl) -ethyl]-quinoline ; 6- (2, 6-dichloro-pyridin-3-yl)-2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]- quinoline ; 2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]-6-pyrazin-2-yl-quinoline ; 2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]-6-pyrimidin-5-yl-quinolin e ; 6- (2, 4-dimethoxy-pyrimidin-5-yl)-2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]- quinoline ; dimethyl-(4-{2-[2-(2(R)-methyl-pyrrolidin-1-yl)-ethyl]-quino lin-6-yl}-phenyl)- amine; 1- (4- {2- [2- (2 (R)-methyl-pyrrolidin-1-yi)-ethyl]-quinolin-6-yl)-phenyl)- ethanone; 6- (4-chloro-phenyl)-2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]-q uinoline ; 6- (2, 6-dimethyl-pyridin-3-yl)-2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]- quinoline ; 6- (5-methoxy-pyridin-3-yl)-2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]-quinoline ; 6-(3,5-dimethyl-isoxazol-4-yl)-2-[2-(2(R)-methyl-pyrrolidin- 1-yl)-ethyl]- quinoline ; 4-{2-[2-(2(R)-methyl-pyrrolidin-1-yl)-ethyl]-quinolin-6-yl}- benzoic acid methyl ester; 2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]-6- (4-methylsulfanyl-phenyl)- quinoline ; 6- (6-fluoro-pyridin-3-yl)-2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]-quinoline ; 5- {2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]-quinolin-6-yi)-nicotinoni trile ; 2, 4-dimethoxy-5- {6-[2-((2R)-methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl}- pyrimidine; 2, 6-difluoro-3- {6- [2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl}- pyridine; cyclopropyl-(4-{6-[2-((2R)2-methyl-pyrrolidin-1-yl)-ethyl]-n aphthalen-2-yl}- phenyl)-methanone ; 3-methoxy-6-{6-[2-((2R) 2-methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl}- pyridazine; 4-{6-[2-(2-methyl-piperidin-1-yl)-ethyl]-naphthalen-2-yl}-be nzonitrile ; 4- {6- [2- ( (2R)-2-ethyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl)-benzon itrile ;

2-{6-[2-((2S)-2-methyl-pyrrolid in-1-yl)-ethyl]-naphthalen-2-yl}-2H-pyridazin- 3-one; 2- [6- ( (2R)-2-piperidin-1-yl-ethyl)-naphthalen-2-yl]-2H-pyridazin-3 -one ; 2- {6- [2- (tert-butyl-methyl-amino)-ethyl]-naphthalen-2-yl}-2H-pyridaz in-3- one ; 2- [6- (2-diethylamino-ethyl)-naphthalen-2-yl]-2H-pyridazin-3-one ; 2-[6-(2-morpholin-4-yl-ethyl)-naphthalen-2-yl]-2H-pyridazin- 3-one ; 2-{6-[2-(ethyl-methyl-amino)-ethyl]-naphthalen-2-yl}-2H-pyri dazin-3-one ; 2-{6-[2-((2S)-2-fluoromethyl-pyrrolidin-1-yl)-ethyl]-naphtha len-2-yl}-2H- pyridazin-3-one; 2- {6- [2- (2-hydroxymethyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl}-2H - pyridazin-3-one; 2-{6-[2-((R)-2-ethyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl }-2H-pyridazin-3- one; 2- [6- (2-azetidin-1-yl-ethyl)-naphthalen-2-yl]-2H-pyridazin-3-one ; 2-{6-[2-((2S)-2-fluoromethyl-azetidin-1-yl)-ethyl]-naphthale n-2-yl}-2H- pyridazin-3-one; 2-{6-[2-((2S)-2-hydroxymethyl-azetidin-1-yl)-ethyl]-naphthal en-2-yl}-2H- pyridazin-3-one; 2- {6- [2- ( (2R, 5R) -2, 5-dimethyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl}-2H- pyridazin-3-one; 2- {6- [2- ( (2R, 6S) -2, 6-dimethyl-piperidin-1-yl)-ethyl]-naphthalen-2-yl}-2H- pyridazin-3-one; 2- {6- [2- ( (R)-3-hydroxy-piperidin-1-yl)-ethyl]-naphthalen-2-yl}-2H-pyr idazin- 3-one; 2-{6-[2-((R)-2-methyl-piperidin-1-yl)-ethyl]-naphthalen-2-yl }-2H-pyridazin-3- one; 2, 6-dimethyl-3- {6- [2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl}- pyridine; 5-{6-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-y l}-thiazole ; 2-{6-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-y l}-pyrimidine ; 3-chloro-6- {6- [2- ( (R)-2-methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl}- pyridazine;

5-{6-[2-((R)-2-methyl-pyrrolid in-1-yl)-ethyl]-naphthalen-2-yl}-pyrimid in-2- ylamine ; 27-methyl-5-{6-[2-((2R)2-methyl-pyrrolidin-1-yl)-ethyl]-naph thalen-2-yl}- pyridine; 3-bromo-7- (2-pyrrolidin-1-yl-ethyl)- [1, 5] naphthyridine; 3-bromo-7- [2- (2R-2-methyl-pyrrolidin-1-yl)-ethyl]- [1, 5] naphthyridine; 3-bromo-7-(2-piperidin-1-yl-ethyl)-[1,5]naphthyridine; 3-(2,6-dimethyl-pyridin-3-yl)-7-[2-(2R-2-methyl-pyrrolidin-1 -yl)-ethyl]- [1,5] naphthyridine; 3-(2, 4-dimethoxy-pyrimidin-5-yl)-7-[2-(2R-2-methyl-pyrrolidin-1-y l)-ethyl]- [1,5] naphthyridine; 3- (2, 6-dimethyl-pyridin-3-yl)-7- (2-pyrrolidin-1-yl-ethyl)- [1, 5] naphthyridine ; 3- (2, 4-dimethoxy-pyrimidin-5-yl)-7- (2-pyrrolidin-1-yl-ethyl)- [1,5] naphthyridine; 3- (2, 6-dimethyl-pyridin-3-yl)-7- (2-piperidin-1-yl-ethyl)- [1, 5] naphthyridine; 3- (2, 4-dimethoxy-pyrimidin-5-yl)-7- (2-piperidin-1-yl-ethyl)- [1,5] naphthyridine; 3- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]-7-pyridin-4-yl-isoquinoli ne ; 7-(6-methoxy-pyridin-3-yl)-3-[2-(2 (R)-methyl-pyrrolid in-1-yl)-ethyl]- isoquinoline ; 3- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]-7-pyrimidin-5-yl-isoquino line ; 7-(6-fluoro-pyridin-3-yl)-3-[2-(2 (R)-methyl-pyrrolidin-1-yl)-ethyl]-isoq uinoline, 5- {3- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]-isoquinolin-7-yl}-nicotin onitrile ; 7- (3-chloro-pyridin-4-yl)-3- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyl]- isoquinoline ; 7-bromo-3- [2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-cinnolin-4-ol ; 4- {3- [2- (2-methyl-pyrrolidin-1-yl)-ethyl]-cinnolin-7-yl}-benzonitril e ; 7-bromo-4-chloro-3- [2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-cinnoline ; 4-{4-hydroxy-3-[2-((2 R)-2-methyl-pyrrolidin-1-yl)-ethyl]-cinnolin-7-yl}- benzonitrile ; 4- {4-isopropoxy-3- [2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-cinnolin-7-yl}- benzonitrile ; 4- {3- [2- (4-methyl-piperazin-1-yl)-ethyl]-cinnolin-7-yl}-benzonitrile ;

4- [3- (2-piperidin-1-yl-ethyl)-cinnolin-7-yl]-benzonitrile ; 4- [3- (2-pyrrolidin-1-yl-ethyl)-cinnolin-7-yl]-benzonitrile ; 4-{3-[2-((2R)-2-methyl-pyrrolid in-1-yl)-ethyl]-cinnolin-7-yl}-benzonitrile ; 4-{3-[2-((2R)-2-hydroxymethyl-pyrrolidin-1-yl)-ethyl]-cinnol in-7-yl}- benzonitrile ; 4- [3- (2-morpholin-4-yl-ethyl)-cinnolin-7-yl]-benzonitrile ; 4- {3- [2- (4-methyl-piperidin-1-yl)-ethyl]-cinnolin-7-yl}-benzonitrile ; 4- {3-[2-(ethyl-methyl-amino)-ethyl]-cinnolin-7-yl}-benzonitril e ; 7-(2,6-dimethyl-pyridin-3-yl)-3-[2-((2R)-2-methyl-pyrrolidin -1-yl)-ethyl]- cinnoline ; 7-(2, 4-d imethoxy-pyrimid in-5-yl)-3-[2-((2R)-2-methyl-pyrrolidin-1-yl)-ethyl]- cinnoline ; 7- (6-methoxy-pyridin-3-yl)-3- [2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyl]- cinnoline ; 3- {3- [2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-cinnolin-7-yl}-benzoni trile ; 5-{3-[2-((2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-cinnolin-7-yl }-n icotinonitrile ; 7- (4-fluoro-phenyl)-3- [2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-cinnoline ; 2-{3-[2-((2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-cinnolin-7-yl }-pyrrole-1- carboxylic acid ter-butyl ester; (3-{3-[2-((2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-cinnolin-7-y l}-phenyl)- methanol ; 7-(3,5-difluoro-phenyl)-3-[2-((2R)-2-methyl-pyrrolidin-1-yl) -ethyl]-cinnoline ; 3- [2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-7-thiophen-3-yl-cinnol ine ; 7-(4-chloro-phenyl)-3-[2-((2R)-2-methyl-pyrrolidin-1-yl)-eth yl]-cinnoline ; 7-(4-ethoxy-phenyl)-3-[2-((2R)-2-methyl-pyrrolidin-1-yl)-eth yl]-cinnoline ; 3- [2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-7- (lH-pyrrol-2-yl)-cinnoline ; and 2-(1,5-dimethyl-1H-pyrazol-4-yl)-6-{2-[(2R)-2-methyl-1-pyrro lidinyl]ethyl}- quinoline ; or a pharmaceutically acceptable salt thereof.

A preferred compound is 2-(6-{2-[(2R)-2-methyl-1-pyrrolidin-1-yl]-ethyl}-2- naphthalen-2-yl)-2H-pyridazin-3-one, which also can be named 2- (6- {2- [ (2R)-2- methyl-1-pyrrolidinyl] ethyl}-2-naphthyl)-3 (2H)-pyridazinone.

Compounds of the invention may exist as stereoisomers wherein, asymmetric or chiral centers are present. These stereoisomers are"R"or"S"

depending on the configuration of substituents around the chiral carbon atom.

The terms"R"and"S"used herein are configurations as defined in IUPAC 1974 Recommendations for Section E, Fundamental Stereochemistry, Pure Appl.

Chem. , 1976,45 : 13-30. The invention contemplates various stereoisomers and mixtures thereof and these are specifically included within the scope of this invention. Stereoisomers include enantiomers and diastereomers, and mixtures of enantiomers or diastereomers. Individual stereoisomers of compounds of the invention may be prepared synthetically from commercially available starting materials which contain asymmetric or chiral centers or by preparation of racemic mixtures followed by resolution well-known to those of ordinary skill in the art.

These methods of resolution are exemplified. by (1) attachment of a mixture of enantiomers to a chiral auxiliary, separation of the resulting mixture of diastereomers by recrystallization or chromatography and optional liberation of the optically pure product from the auxiliary as described in Furniss, Hannaford, Smith, and Tatchell,"Vogel's Textbook of Practical Organic Chemistry", 5th edition (1989), Longman Scientific & Technical, Essex CM20 2JE, England, or (2) direct separation of the mixture of optical enantiomers on chiral chromatographic columns or (3) fractional recrystallization methods.

Methods for Preparing Compounds of the Invention The compounds of the invention can be better understood in connection with the following synthetic schemes and methods which illustrate a means by which the compounds can be prepared.

Abbreviations which have been used in the descriptions of the schemes and the examples that follow are : Ac for acetyl ; atm for atmosphere (s); BINAP for 2,2'-bis (diphenylphosphino)-1, 1'-binaphthyl ; Boc for butyloxycarbonyl ; Bu for butyl ; DCM for dichloromethane ; DMAP for 4- (N, N-dimethylamino) pyridine; DMF for N, N-dimethylformamide ; DMSO for dimethylsulfoxide ; Et for ethyl ; EtOH for ethanol ; EtOAc for ethyl acetate; HPLC for high pressure liquid chromatography; IPA for isopropyl alcohol ; IPAC or IPAc for isopropyl acetate; LDA for lithium diisopropylamide ; NBS for N-bromosuccinimide; NIS for N-iodosuccinimide ; Me for methyl ; MeOH for methanol ; Ms for methanesulfonyl ; MTBE for tert-butyl

methyl ether; Pd for palladium ; tBu for ter-butyl ; TEA for triethylamine ; TFA for trifluoroacetic acid; THF for tetrahydrofuran; and Ts for p-MePhS (0) 2-.

The compounds of this invention can be prepared by a variety of synthetic procedures. Representative procedures are shown in, but are not limited to, Schemes 1-24.

Scheme 1 R3 R3 Z, X YvBr 1, LDA/ether/-78°C O Z-X Br l [1, AX Y ; ZsR2 2. Ethyl Chloroformate EtO<X Y ; R X Y Rz Y Et0 X Y Rz (1) (2) R3 R3 X'Y Br ZIX'Y Br LiBH4 Zl t 8 TsCI/DMAP/TEA I t Z o----, A x Y R2 : cy 2 HO X Y Rz Ts0 X Y Rz (3) (4) 3 X'Y Br (OH) 2BR6 R, 3 HNR R , 7 Z- s (4) ( ;. Z () I -. Z'. R5R4N X Y Rz Pd, base 2CO3/CH3CN (6) 40-80 OC () 1-48 hrs (8) 60°C R3 O 1. n-BuLi/THF/-78°C 0 'I ;. Z'. 2 N Re (io) OMe (9) R IR3 lR3 Z. X Y\Br Z'Xw LzRs ^ I ,-' : Z' R R N_ v X Y'ZR 5 a z R5R4N X Y Rz (6) (6) (11)

Compounds of formula (8) and (10), wherein X, X', Y, Y', Z, Z', R2, R3, R4, and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 1. Bromides of formula (1), purchased or prepared using methodolgy known to those of ordinary skill in the art, can be treated with lithium diisopropylamine and a chloroformate such as, but not limited to, ethyl chloroformate to provide esters of formula (2). Esters of formula (2) can be

treated with a reducing agent such as, but not limited to, lithium borohydride to provide alcohols of formula (3). Alcohols of formula (3) can be treated with a base such as, but not limited to, triethylamine and a sulfonate such as, but not limited to, methanesulfonyl chloride or p-toluensulfonyl chloride or triflic anhydride to provide sulfonates of formula (4). Sulfonates of formula (4) can be treated with an optional base such as, but not limited to, potassium carbonate or sodium carbonate and an amine of formula (5) with or without heat to provide amines of formula (6).

The Suzuki reaction can be used to produce compounds of formula (I), wherein R, is an aryl, heteroaryl, heterocyclic, or cycloalkyl ring. In such a Suzuki reaction, compounds of formula (I) wherein Ri is a triflate or halogen are reacted with boronic acids of formula (7), a metal catalyst such as, but not limited to, palladium diacetate or Pd (PPh3) 4, optionally with a Pd ligand added such as (dicyclohexylphosphinyl) biphenyl or trifurylphosphine, and a base such as, but not limited to, aqueous 0.2 M K3PO4 to provide products of formula (I) wherein Ri is an aryl, heteroaryl, heterocyclic or cycloalkyl ring. Boronic acid esters of formula (7a) can be used in place of boronic acids. Boronic acids can be esterified to the corresponding boronic acid esters with alcohols such as methanol or with diols such as pinacol. Likewise, amines of formula (6) can be subjected to the Suzuki reaction to provide amines of formula (8).

There are many aryl, heteroaryl, and heterocyclic boronic acids and boronic acid esters that are available commercially or that can be prepared as described in the scientific literature of synthetic organic chemistry. The preparation of boronic acid and boronic acid ester reagents suitable for incorporating into the synthetic methods for preparing compounds of formula (I) are more specifically described in Reference Example 2 herein.

Alternatively, using the Stille coupling, compounds of formula (8) may be prepared from compounds of formula (6) by treatment with aryl, heteroaryl, and heterocyclic stannanes (Me3SnR6, Bu3SnR6), a palladium source such as tris (dibenzylidineacetone) dipalladium (CAS # 52409-22-0) or palladium diacetate, and a ligand such as tri (2-fury) phosphine (CAS # 5518-52-5) or triphenyl arsine in a solvent, for example in DMF at 25-150 °C. While many organotin reagents for the Stille coupling are commercially available or described in the literature, new

organotin reagents can be prepared from arylhalides, aryltriflates, heteroarylhalides, heteroaryltriflates by reaction with distannanes like (Me3Sn) 2 (hexamethyl distannane) in the presence of a palladium source like Pd (Ph3P) 4.

Such methods are described, for instance, in Krische, et. al., Helvetica Chimica Acta 81 (11): 1909-1920 (1998), and in Benaglia, et al., Tetrahedron Letters 38: 4737-4740 (1997). These reagents can be reacted with (6) to give (8) as described under Suzuki conditions, or for example under the conditions reported by Littke, Schwartz, and Fu, Journal of the American Chemical Society 124: 6343- 6348 (2002).

Compounds of formula (8) wherein the R6 group is a nitrogen-containing heteroaryl or heterocyclic ring linked to the bicyclic core group through a nitrogen may be prepared by heating compounds of formula (6) with the H-R6 (R6 = heteroaryl or heterocyclic group) with a base such as, but not limited to, sodium t- butoxide or cesium carbonate, in the presence of a metal catalyst such as, but not limited to copper metal or Cul, palladium diacetate, and also optionally with a ligand such as, but not limited to, BINAP, tri-tertbutylphosphine in solvents such as dioxane, toluene and pyridine. References that describe these methodologies may be found in the following references: J. Hartwig et al., Angew. Chem. Int. Ed.

37: 2046-2067 (1998); J. P. Wolfe et al., Acc. Chem. Res. , 13: 805-818 (1998); M.

Sugahara et al., Chem. Pharm. Bull., 45: 719-721 (1997); J. P. Wolfe et al., J. Org. Chem. , 65: 1158-1174, (2000); F. Y. Kwong et al., Org. Lett. , 4: 581-584, (2002); A. Klapars et al., J. Amer. Chem. Soc. , 123: 7727-7729 (2001); B. H. Yang et al., J. Organomet. Chem., 576: 125-146 (1999); and A. Kiyomori et al., Tet.

Lett., 40: 2657-2640 (1999). Additional references may also be found in Hartwig, J. Org. Chem. , 64 (15): 5575-5580 (1999), where compounds of structure (6) can be transformed to compounds of structure (8) or (11) by reaction with amines, anilines, amides with tris-tert-butyl phosphine and a palladium source such as Pd (OAc) 2. Compounds of structure (6) can be transformed to heterocyclic or heteroaryl compounds of structure (8) where the R6 moiety is, for instance, a N- pyridazinone by heating with 3 (2-pyridazinone (or an optionally functionalized heterocycle that contains an acidic NH group in the heterocycle, such as pyridin-2- one) with copper powder and base as described in WO 0024719, p. 127, Example 62.

Compounds of formula (6) can also be treated with an organolithium reagent such as, but not limited to, n-butyllithium, methyllithium, or tert-butyllithium and an amide of formula (9) to provide compounds of formula (10).

Compounds of formula (11), wherein L2 is-NH-or-N (alkyl)- and R6 is as defined for a compound of formula (I) can be prepared by heating compounds of formula (6) with a compound of formula H2N-R6 or HN (alkyl)-R6 with a base such as, but not limited to sodium t-butoxide or cesium carbonate in the presence of a metal catalyst such as, but not limited to copper metal or Cul, palladium diacetate, and also optionally with a ligand such as, but not limited to, BINAP, tri- tertbutylphosphine in solvents such as dioxane, toluene, pyridine. References that describe these methodologies may be found in the following references: J.

Hartwig, et al., Angew. Chem. Int. Ed. , 37: 2046-2067 (1998); J. P. Wolfe et al., Acc. Chem. Res. , 13: 805-818 (1998); J. P. Wolfe et al., J. Org. Chem. , 65: 1158- 1174 (2000); F. Y. Kwong et al., Org. Lett., 4: 581-584, (2002); and B. H. Yang et al., J. Organomet. Chem. , 576: 125-146 (1999).

Compounds of formula (11), wherein L2 is oxygen and R6 is defined in formula (I) can be prepared by heating compounds of formula (6) with a compound of formula HOR6 using a base such as but not limited to sodium hydride in a solvent such as toluene or N, N-dimethylformamide in the presence of a metal containing catalyst such as Cul or palladium diacetate. References that describe these methodologies may be found in the following references: J.

Hartwig et al., Angew. Chem. Int. Ed. , 37: 2046-2067 (1998); J. -F. Marcoux et al., J. Am. Chem. Soc. , 119: 10539-10540 (1997); A. Aranyos et al., J. Amer. Chem.

Soc. , 121: 4369-4378 (1999); M. Palucki et al., J. Amer. Chem. Soc. , 119: 3395- 3396 (1997); and T. Yamamoto et al., Can. J. Chem. , 61: 86-91 (1983). Additional methodologies useful for the synthesis of compounds of formula (11), wherein the L2 is oxygen and R6 is defined in formula (1) can be found in the following references: A. Aranyos et al., J. Amer. Chem. Soc. , 121: 4369-4378 (1999) ; and E. Baston et al., Synth. Commun. , 28: 2725-2730 (1998).

Compounds of formula (11), wherein L2 is sulfur and R6 is as defined for a compound of formula (I) can be prepared by heating compounds of formula (6) with a compound of formula HSR6 using a base with or without a metal catalyst such as Cul or palladium diacetate in the presence of a base in a solvent such as

dimethylformamide or toluene. References that describe these methodologies may be found in the following references: G. Y. Li et al., J. Org. Chem. , 66: 8677- 8681 (2001); G. Y. Li et al., Angew. Chem. Int. Ed., 40: 1513-1516 (2001); U.

Schopfer et al., Tetrahedron, 57: 3069-3074 (2001); and C. Palomo et al., Tet.

Lett., 41 : 1283-1286 (2000). Additional methodologies useful for the synthesis of compounds of formula (11), wherein the L2 is oxygen and R6 is defined in formula (1) can be found in the following reference A. Toshimitsu et al., Het. Chem., 12: 392-397 (2001).

Compounds of formula (11), wherein L2 is-[C (R18) (R19)] q and R6, Ris and Rrs are as defined for a compound of formula (I) and q = 1, can be prepared from compounds of formula (10). Compounds of formula (10) can be manipulated by reactions well known to those skilled in the art of organic chemistry such as the Grignard reaction, catalytic hydrogenation, metal hydride reaction, alkylation of alcohols, fluorination with (diethylamino) sulfur trifluoride, fluorination with [bis (2- methoxyethyl) amino] sulfur trifluoride to provide compounds of formula (11), wherein L2 iS-[C (R18) (R19)] q and R6, Ris and Rig are defined in for a compound of formula (I) and q = 1.

Compounds of formula (11), wherein L2 is-[C (R18) (Ras)] q and R6, Ria, Rig and q are as defined for a compound of formula (I) can be prepared by cross- coupling reactions known to those skilled in the art Examples of these reactions are the Kumada, Suzuki, Heck, Stille, Suzuki-Miyaaura, Tamao-Kamuda and Sonogashira reaction. Suitable reagents, for example, alkyl Grignard reagents, boronic acids or ester, tin intermediates, alkenes and alkynes can be coupled with compounds of formulas (6) in the presence of a metal catalyst such as palladium, nickel, silver or indium, to prepare compounds of formula (11) wherein L2 is a substituted or unsubstituted alkyl, alkenyl or alkynyl chain. Compounds of formula (11) wherein L2 is an alkenyl or alkynyl chain can be reduced to compounds of formula (11) wherein L2 is an alkyl by methods known to those skilled in the art such as catalytic hydrogenation. References that describe these methodologies may be found in the following references: G. A. Molander et al., Tetrahedron, 58: 1465-1470 (2002); W. Dohle et. al., Org. Lett., 3: 2871-2873 (2001); G. Zou et al, Tet. Lett., 42: 7213-7216 (2001); A. J. Suzuki, Organomet. Chem., 576 : 147- 168 (1999); A. F. Littke, J. Amer. Chem. Soc. , 122: 4020-4028 (2000); N. Miyaura

et al., Chem. Rev. , 95: 2457-2483 (1995); H. Horie et al., J. Mater. Chem., 11 : 1063-1071 (2001) ; C. Dai et al., J. Amer. Chem. Soc. , 123: 2719-2724 (2001) ; F. Diederich et al., Metal-catalyzed Cross-Coupling Reactions, Wiley-VCH ; Weinheim, 1998; A. Mohanakrishnan et al., Syn. Lett., 7: 1097-1099 (1999); B. H.

Lipshutz et al., Org. Lett., 3: 1869-1872 (2001); B. H. Lipshutz et al., Tet. Lett., 40: 197-200 (1999); and J. Tsuji, Palladium Reagents and Catalysts-lnnovations in Organic Synthesis, John Wiley & Sons: New York, 1995.

, Scheme 2

Ft3 R 3 X, Br LAH X'Y Br SOC ZIX'Y Br Z' X Y R2 X Y RZ X Y R2 O (13) R=alkyl (14) (15) R3, R3 () H02C Z Z H02C", AX 11yZ', (16) (17) R3 R3 R3 R3 ZIX'Y Br Scheme 1 X'Y R6 ;. Z,. ;. Z,. TBDMSO Y ; R2 TBDMSO X Y"R (18) (19) R3 HNR4R5 R3 (19) 1. deprotect ; Z oXYt 6 (5) oX tW 2. TsCI, base : c i :, TsO4X Y R2 R5R4N X Y R2 (20) (8)

Alternatively, compounds of formula (8), wherein X, X', Y, Y', Z, Z', R2, R3, R4, and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 2. Esters of formula (13) can be treated with a reducing agent such as, but not limited to, lithium aluminum hydride to provide alcohols of formula (14). Alcohols of formula (14) can be treated with thionyl chloride to provide chlorides of formula (15). Chlorides of formula (15) can be treated with sodium cyanide or potassium cyanide to provide the nitrile which can

be treated with aqueous acid to provide acids of formula (16). Acids of formula (16) can be treated with a reducing agent such as, but not limited to, diborane or borane THF complex to provide alcohols of formula (17). Alcohols of formula (17) can be treated with a hydroxy-protecting reagent such as, but not limited to, tert- butyldimethylsilyl chloride. The protected compounds of formula (18) can be processed as described in Scheme 1 to provide compounds of formula (19).

Compounds of formula (19) can be deprotected using methods known to those of ' ordinary skill in the art and then treated with a sulfonyl chloride such as, but not limited to, methanesulfonyl chloride or p-toluensulfonyl chloride to provide sulfonates of formula (20). Sulfonates of formula (20) can be treated with an amine of formula (5) to provide compounds of formula (8).

Scheme 3 R3 ? 3 Z, X% Y\Z Br R3 Rl3 O X Y R HO X Y'ruz R2 2 (23) (24) , R3 lR3 4 5R5R4N Z'X Yv Br'R5R4N X'Y R6 (24) O X Y'R2 ° X Y ; R2 JJJ, O X Y'ZR2 O X Y'ZR2 (5) (25) (26) Compounds of formula (26), wherein X, X', Y, Y', Z,-Z', R2, R3, R4, and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 3. Hydroxy compounds of formula (23), purchased or prepared using methods known to those of ordinary skill in the art, can be treated with 1, 2-dibromoethane to provide bromides of formula (24). Bromides of formula (24) can be treated with amines of formula (5) to provide compounds of formula (25). Compounds of formula (25) can be processed as described in Scheme 1 to provide compounds of formula (26).

Scheme 4 0 0 Br Br Là ' : Z'. Y ; R2 BrCH2CO2Et EtO 4< (Br (28) (29) HO I YBr/I YBr 1. t-BuNH2BH3, Z. acid. Z' (29)'2. NaOH HO Y'R2 RO Y' R2 (30) ° (31) R=alkyl o Y Br NH40H NX qzz /I NH40H : Z' : Z' (31) HO Y'R2 HO \ Y'R2 (32) (33) Scheme 1 Y R and N Scheme 2 1 1l Z' (33) R5R4Nwy ; sR2 (34)

Compounds of formula (34), wherein Y, Y', Z', R2, R4, and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 4. Indanones of formula (28) can be treated with a base such as, but not limited to, lithium diisopropylamide and ethyl bromoacetate to provide esters of formula (29). Esters of formula (29) can be treated with tert-butylamineborane and then an aqueous basic solution such as, but not limited to, sodium hydroxide : in water to provide hydroxyacids of formula (30). Hydroxyacids of formula (30) can be treated with a strong acid such as, but not limited to, concentrated sulfuric acid with heat in a solvent such as methanol to provide esters of formula (31).

Esters of formula (31) can be treated with a reducing agent such as, but not limited to, lithium aluminum hydride to provide alcohols of formula (32). Alcohols of formula (32) can be treated with ozone followed by dimethylsulfide and ammonium hydroxide to provide isoquinolines of formula (33). Isoquinolines of formula (33) can be processed as described in Schemes 1 and 2 to provide compounds of formula (34).

Scheme 5 NO HNR4R5 NO 2 (5) I 2 Br KZC03, DMF RsRaN (37) H 1. H2, Pd/C N 2. t-BuCOCI (37) R5R4N w (38) O n-BuLi, TMEDA (38) DMF deprotect NH2 NU 54 0) (39) O R3 R2'-A L2 1 6 I s (40) (41) RsRaN//R2 KOEt (42) L2, R 3 Ru (/2 R'-Rs Z N R I//i Rs BEt R5R4N +RLz R6 (44)

Compounds of formula (42), wherein R2, R3, R4, R5 and R6 are as defined in formula (I) and L2 is-[C (R18) (R19)] q-or a bond can be prepared as described in Scheme 5. 1- (2-Bromoethyl)-4-nitrobenzene can be treated with amines of formula (5) to provide amines of formula (37). Amines of formula (37) can be treated with palladium on carbon under a hydrogen atmosphere to provide anilines which can then be treated with a nitrogen protecting reagent such as, but not limited to, trimethylacetyl chloride to provide protected anilines of formula (38).

Protected anilines of formula (38) can be treated with an organolithium reagent such as, but not limited to, n-butyllithium, sec-butyllithium, or tert-butyllithium and N, N-dimethylformamide to provide aldehydes of formula (39). The aniline of aldehydes of formula (39) can be deprotected using methods well know to those skilled in the art such as, but not limited to, heating in aqueous hydrochloric acid

to provide aldehydes of formula (40). Aldehydes of formula (40) can be treated with ketones of formula (41) and a base such as, but not limited to, potassium ethoxide to provide compounds of formula (42).

Compounds of formula (44), wherein Ri, R3, R4, R5 and R6 are as defined in formula (I) and L2 is -[C(R18)(R19)]q- or a bond can be prepared as described in Scheme 5. Aldehydes of formula (40) can be treated with ketones of formula (43) and a base such as, but not limited to, potassium ethoxide to provide compounds of formula (44).

Compounds of formula (41) and (43) can be purchased commercially or synthesized from procedures which are known to those skilled in the art.

Scheme 6

reducing N-0-- 1"0 agent HO, : : = SOC12_ 0 Cl 0 N 0 NaCN I acid CI//----NC// 0 N reducing < MsCI argent Ho//'-'HO // NHNR. R, T"Y N 0-,, HNR4R5 N oll 'VSL' (5) BBr3 Ms0 -5 a-' (47) N OH N"IZz OTf (OH) 2BR,, // R5R4N// R5R4N (48) (49) I Nw Rs R5R4N vJ (50) Compounds of formula (50), wherein R4 and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 6. Ethyl 7-methoxy-2-methyl-3-quinolinecarboxylate can be prepared using the procedures.

described in Synthetic Comm., 17 (14) : 1647-1653 (1987). Ethyl 7-methoxy-2- methyl-3-quinolinecarboxylate can be treated with a reducing agent, such as, but not limited to, lithium aluminum hydride or sodium borohydride, to provide (7- methoxy-2-methyl-3-quinolinyl) methanol. (7-Methoxy-2-methyl-3- quinolinyl) methanol can be treated with a chlorinating reagent, such as, but not limited to, thionyl chloride to provide 3- (chloromethyl)-7-methoxy-2- methylquinoline. 3- (Chloromethyl)-7-methoxy-2-methylquinoline can be treated . with sodium cyanide or potassium cyanide to provide (7-methoxy-2-methyl-3- quinolinyl) acetonitrile. (7-Methoxy-2-methyl-3-quinolinyl) acetonitrile can be treated with acid, such as, but not limited to, glacial acetic acid and concentrated sulfuric acid, in water and 1,4-dioxane with heat to provide (7-methoxy-2-methyl-3- quinolinyl) acetic acid. (7-Methoxy-2-methyl-3-quinolinyl) acetic acid can be treated with a reducing agent, such as, but not limited to, B2H6, borane-THF complex, or borane-pyridine complex, to provide 2- (7-methoxy-2-methyl-3-quinolinyl) ethanol.

2- (7-Methoxy-2-methyl-3-quinolinyl) ethanol can be treated with methanesulfonyl chloride and a base, such as, but not limited to, triethylamine or diisopropylamine to provide 2- (7-methoxy-2-methyl-3-quinolinyl) ethyl methanesulfonate. 2- (7- Methoxy-2-methyl-3-quinolinyl) ethyl methanesulfonate can be treated with an amine of formula (5) to provide amines of formula (47). Amines of formula (47) can be treated with BBr3 to provide hydroxy compounds of formula (48). Hydroxy compounds of formula (48) can be treated with trifluoromethanesulfonic anhydride or trifluoromethanesulfonyl chloride to provide triflates of formula (49). Triflates of formula (49) can be treated with boronic acids of formula (7) as described in Scheme 1 to provide compounds of formula (50).

Scheme 7 N B r N Br , (Et) 4N+CI- ! g NBracid Br N Pd (Ph3P) 2CI2 N + O Sn (nBu) 3 N Br N Br I", Z (OH) 2BR6 (52) . Y. R5R4N 4 N (53)

1,5-Naphthyridines of formula (53), wherein R4 and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 7.3, 7-Dibromo- [1, 5] naphthyridine, prepared as described by W. W. Paudler, J.

Org. Chem. , 33: 1384 (1968), can be treated with (2-ethoxyvinyl) tributylstannane, a halide source, such as, but not limited to, tetraethylammonium chloride, and a palladium source, such as, but not limited to, dichlorobis (triphenylphosphine) palladium (II) in a solvent, such as, but not limited to, N, N-dimethylformamide with heat (about 50 °C to about 150 °C) to provide 3- bromo-7- [2-ethoxyvinyl]-1, 5-naphthyridine. 3-Bromo-7- [2-ethoxyvinyl]-1, 5- naphthyridine can be treated with an acid, such as, but not limited to, formic acid at about 0 °C to about 60 °C in a solvent, such as, but not limited to, 1,2- dichloroethane to provide (7-bromo-1, 5-naphthyridin-3-yl) acetaldehyde.

Alternatively, 3-bromo-7- [2-ethoxyvinyl]-1, 5-naphthyridine in a solvent, such as, but not limited to, tetrahydrofuran can be treated with an aqueous acid, such as, but not limited to, hydrochloric acid at about 0 °C to about 60 °C to provide (7- bromo-1, 5-naphthyridin-3-yl) acetaldehyde. (7-Bromo-1,5-naphthyridin-3- yl) acetaldehyde can be treated with an amine of formula (5) under reductive amination conditions, such as, but not limited to, sodium triacetoxyborohydride and an acid, such as, but not limited to, acetic acid in a solvent, such as, but not limited to, 1, 2-dichloroethane at about 0 °C to about 50 °C to povide amines of formula (52). Amines of formula (52) can be treated with boronic acids of formula

(7), a palladium source, such as, but not limited to, tris (dibenzylideneacetone) dipalladium (0), a ligand, such as, but not limited to, tri (tert-butyl) phosphine, and a base, such as, but not limited to, potassium fluoride in a solvent, such as, but not limited to, tetrahydrofuran at about 20 °C to about 80 OC to provide 1,5-naphthyridines of formula (53).

Scheme 8 t OMs ZNR4R5 HNR4R5 + (5)// // (55) Pd (Ph3P) 2C12 H2N Br H2N I Br RaRs Cul, base (55) R5R4N (56) I// (55) R5R4N (56) Br (OH) () s. N (rus aqueous N. 56 a () NaN02 RsRaN OH RaN W i OH (58) N-, NAR6 N, N AR6 ( (58) > R5R4N X R5R4N <J (60) OTf zu Cinnolines of formula (60), wherein R4 and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 8. Amines of formula (5) can be treated with 3-butynyl methanesulfonate at room temperature with stirring for about 1 hour and then heated at about 50 °C for about 24 hours. The mixture is allowed to cool to room temperature, and filtered.

The filtrate is diluted with acetonitrile to provide a 0.1 M solution of alkynes of formula (55) for use in subsequent steps. 5-Bromo-2-iodophenylamine, prepared as described by Sakamoto in Chem. Pharm. Bull., 35: 1823 (1987), can be treated with alkynes of formula (55), a source of palladium (II), such as, but not limited to, Pd (Ph3P) 2CI2, Cul, and a base, such as, but not limited to, triethylamine in an organic solvent, such as, but not limited to, DMF at about 50 °C to about 80 °C to provide alkynes of formula (56). Alkynes of formula (56) can be treated with

aqueous acid, such as but not limited to aqueous HCI in the presence of sodium nitrite at about 0 °C to about 100 °C to provide hydroxy cinnolines of formula (57).

Hydroxy cinnolines of formula (57) can be treated with boronic acids of formula (7) as described in Scheme 1 to provide hydroxy cinnolines of formula (58). Hydroxy cinnolines of formula (58) can be treated with N- phenylbis (trifluoromethanesulfonimide) and a base, such as, but not limited to, diisopropylethylamine in an organic solvent, such as, but not limited to, 1,2- dichloròèthane at about 25 °C to about 40 °C to provide triflates of formula (59).

Triflates of formula (59) can be treated with a catalytic palladium source, such as, but not limited to, palladium (II) acetate and a hydrogen donor, such as, but not limited to, formic acid at about 25 °C to about 50 °C to provide cinnolines of formula (60).

Scheme 9 N'N Cl (CF3S02) 20 N'-N ci HO I/\ Tuf0 N N CI TfO) (Et) 4N+CI- Tao N. N\. CI 3P) 2C [2 \i0/O \ Sn (nBu) 3 N. N\ CI (OH) 2BRs N. N\ Rs Scheme 7 I () I -' RsR4N//-'R5R4N// (62) (60) Cinnolines of formula (60), wherein R4 and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, also can be prepared as described in Scheme 9.7- Chloro-3-cinnolinol, prepared as described by H. E. Baumgarten, J. Het. Chem., 6: 333 (1969), can be treated with trifluoromethanesulfonyl chloride or trifluoromethanesulfonic anhydride and a base, such as, but not limited to, triethylamine or pyridine in a solvent, such as, but not limited to, dichloromethane at about 0 °C or room temperature to provide 7-chloro-3-cinnolinyl trifluoromethanesulfonate. 7-Chloro-3-cinnolinyl trifluoromethanesulfonate can be treated with (2-ethoxyvinyl) tributylstannane, a halide source, such as, but not

limited to, tetraethylammonium chloride, and a palladium source, such as, but not limited to, dichlorobis (triphenylphosphine) palladium (II) in a solvent, such as, but not limited to, N, N-dimethylformamide at about 50 °C to about 150 °C to provide 7-chloro-3- (2-ethoxyvinyl) cinnoline. 7-Chloro-3- (2-ethoxyvinyl) cinnoline can be processed as described in Scheme 7 to provide amines of formula (62). Amines of formula (62) can be treated with boronic acids of formula (7), a palladium source, such as, but not limited to, dichloro (di-tert-butylphosphinous acid) palladium (II) dimer) or tris (dibenzylideneacetone) dipalladium (0), tri (tert- butyl) phosphine, and a base, such as, but not limited to, cesium fluoride, in a solvent, such as, but not limited to, 1,4-dioxane at about 30 °C to about 120 °C to provide cinnolines of formula (60).

Scheme 10 , <OTf (OH) 2BR6, R6 N (7) C, IN Ci N C) N (64) (Et) 4N+Cl- R6 0-B O Pd (Ph3P) 2CI2 O \, /N ; N + (65) , +R6 HNR4R5 eR6 acid 5 /N : N RSR4N I/N : N (66) (67) Cinnolines of formula (67), wherein R4 and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 10.7- Chloro-3-cinnolinyl trifluoromethanesulfonate, prepared as described in Scheme 9, can be treated with boronic acids of formula (7), a palladium source, such as, but not limited to, tris (dibenzylideneacetone) dipalladium (0), tricyclohexylphosphine (or triphenylphosphine or tri (tert-butyl) phosphine), and a base, such as, but not limited to, potassium fluoride, in a solvent, such as, but not limited to, tetrahydrofuran at about 20 °C to about 80 °C to provide chlorides of formula (64). Chlorides of formula (64) can be treated with 2- (2-ethoxy-vinyl)- 4,4, 5, 5-tetramethyl- [1, 3,2] dioxaborolane, prepared as described by C. M. Vogels

in Chem. Commun. (2000) 1,51, a palladium source, such as, but not limited to, tris (dibenzylideneacetone) dipalladium (0), tri (tert-butyl) phosphine or, in place of both, dichloro (di-tert-butylphosphinous acid) palladium (II) dimer and a base such as cesium fluoride, in a solvent, such as, but not limited to, 1,4-dioxane at about 30 °C to about 120 °C to provide ethers of formula (65). Ethers of formula (65) can be processed as described in Scheme 7 to provide cinnolines of formula (67).

\ Scheme 11 Quinolines of formula (73), wherein R4 and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 11. 2- (3- Nitrophenyl) ethanol, CAS 100-27-6, can be treated with methanesulfonyl chloride (or toluenesulfonyl chloride), and a base, such as, but not limited to, triethylamine in a solvent, such as, but not limited to, methylene chloride to provide 2- (3- nitrophenyl) ethyl methanesulfonate. 2- (3-Nitrophenyl) ethyl methanesulfonate can be treated with amines of formula (5) and a base, such as, but not limited to, potassium carbonate in a solvent, such as, but not limited to, acetonitrile to provide amines of formula (70). Amines of formula (70) can be treated with hydrogen with a palladium source, such as but not limited to palladium on carbon in a solvent, such as, but not limited to, methanol, ethanol, or ethyl acetate to provide anilines of formula (71). Anilines of formula (71) can be treated with 2,2, 3- tribromopropanal as described in S. W. Tinsley, J. Amer. Chem. Soc. 77: 4175- 4176 (1955), to provide quinolines of formula (72). Quinolines of formula (72) can be treated with boronic acids of formula (7) and treated as described in Scheme 1 to provide quinolines of formula (73).

Scheme 12 Br RsM9X Rs 1. LDA, THF,-87 °C OHC R6 (75) I 2. DMF N Cl-Br 4N Br4N PhOXO (76) (77) 3-butyn-1-ol OHC Rs NH3 N Rs Pd (Ph3P) 2CI2 ethanol 8Cul, Et3N, DMF/<N 80 °C N (78)- (79) N R6 N Rs Scheme 1 RsRaN (80)

Naphthyridines of formula (80), wherein R4 and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 12. 3-Bromo-1- (phenoxycarbonyl) pyridinium chloride can be treated with Grignard reagents of formula (75) as described in D. Comins et al., J. Het. Chem.

1239-1243 (1983) to provide compounds of formula (76). Compounds of formula (76) can be treated with a base, such as, but not limited to, lithium diisopropylamide and N, N-dimethylformamide, as described in Numata et al, Synthesis, 1999,306-311, to provide compounds of formula (77). Compounds of formula (77) can be treated with 3-butyn-1-ol, Cul, a base, such as, but not limited to, triethylamine, and palladium source, such as, but not limited to, Pd (PPh3) 2CI2 in a solvent, such as but not limited to N, N-dimethylformamide to provide alkynes of formula (78). Alkynes of formula (78) can be treated with ammonia at about 80 °C in a solvent, such as, but not limited to, ethanol to provide naphthyridines of formula (79). Naphthyridines of formula (79) can be processed as described in Scheme 1 to provide naphthyridines of formula (80).

Scheme 13 OHC N Br NIS, OHC N Br OHC N Br WI H2SO4, HOAc v + ul + I/ I I (82) (83) 3-butyn-1-ol N N Br Pd (Ph3P) 2CI2 N N Br tBuNH2 Cul, Et, N, DMF (83) HO ; (84) (85) N'. R6 Scheme 1 (85) RaRsN 4 5 (86)

Naphthyridines of formula (86), wherein R4 and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 13. 6-Bromo-2-pyridinecarbaldehyde can be treated with N-iodosuccinimide in sulfuric acid and acetic acid to provide 6-bromo-3-iodo-2-pyridinecarbaldehyde and 6-bromo-5-iodo-2-pyridinecarbaldehyde. 6-Bromo-3-iodo-2- pyridinecarbaldehyde can be treated with tert-butylamine in a solvent, such as, but not limited to, THF to provide imine (84). Imine (84) can be treated with 3-butyn- 1-0l ; Cul, a base, such as, but not limited to, triethylamine or diisopropylamine, and a palladium source, such as, but not limited to, Pd (PPh3) 2Cl2 in a solvent, such as but not limited to N, N-dimethylformamide to provide alcohols of formula (85). Alcohols of formula (85) can be processed as described in Scheme 1 to provide naphthyridines of formula (86).

Scheme 14 N Br-R R (88) w I N Ber N (84) (89) R6 Scheme 1 R6 0 nBuLi R4R5N N ion Naphthyridines of formula (91), wherein R4 and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme

14. Imines of formula (84), prepared as described in Scheme 13, can be treated with alkynes of formula (88), Cul, a base, such as, but not limited to, triethylamine or diisopropylamine, and a palladium source, such as, but not limited to, Pd (PPh3) 2CI2 in a solvent, such as but not limited to N, N-dimethylformamide to provide naphthyridines of formula (89). Naphthyridines of formula (89) can be treated with an alkyllithium reagent, such as, but not limited to, methyllithium, n- butyllithium, sec-butyllithium, or t-butyllithium, and ethylene oxide in a solvent, such as ; but not limited to, THF or diethyl ether to provide alcohols of formula (90).

Alcohols of formula (90) can be treated as described in Scheme 1 to provide naphthyridines of formula (91).

Scheme 15 NBS reducing I -4zCO2Me H2S04, ACOH CO2Me agent ¢$f OH Br Br I I oxidizing Pd (Ph3P) 2CI2 agent t-BuNH2 N Cul, Et3N, DMF - Rs Br Br (88) < O n-BuLi R6 Br N + HO' N (93) (94) w Rs Scheme 1 / N --- RaRsN (95) Isoquinolines of formula (95), wherein R4 and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 15.

Methyl 2-iodobenzoate can be treated with N-bromosuccinimide in acetic acid and sufuric acid to provide methyl 5-bromo-2-iodobenzoate. Methyl 5-bromo-2- iodobenzoate can be treated with a reducing agent, such as, but not limited to, sodium borohydride or lithium aluminum hydride in a solvent, such as, but not limited to, THF, ethanol, or a mixture thereof, to provide (5-bromo-2-

iodophenyl) methanol. (5-Bromo-2-iodophenyl) methanol can be treated with an oxidizing agent, such as, but not limited to, pyridinium chlorochromate, pyridinium dichromate, MnOz, a peracid such as meta-chloroperoxybenzoic acid, or Swern conditions (DMSO/CI (CO) 2CI/TEA) to provide 5-bromo-2-iodobenzaldehyde. 5- Bromo-2-iodobenzaldehyde can be treated with tert-butylamine in a solvent, such as, but not limited to, THF to provide N- [ (5-bromo-2-iodophenyl) methylene]-N- (tert-butyl) amine. N- [ (5-Bromo-2-iodophenyl) methylene]-N- (tert-butyl) amine can be treated with alkynes of formula (88), Cul, a base, such as, but not limited to, triethylamine or diisopropylamine, and a palladium source, such as, but not limited to, Pd (PPh3) 2CI2 in a solvent, such as but not limited to N, N-dimethylformamide to provide isoquinolines of formula (93). Isoquinolines of formula (93) can be treated with an alkyllithium reagent, such as, but not limited to, methyllithium, n- butyllithium, sec-butyllithium, or t-butyllithium, and ethylene oxide in a solvent, such as, but not limited to, THF or diethyl ether to provide alcohols of formula (94).

Alcohols of formula (94) can be treated as described in Scheme 1 to provide isoquinolines of formula (95).

Scheme 16 NBS I reducing CO2Me H2SO4, AcOH C02Me agent OH Br Br I I oxidizing Pd (Ph3P) 2CI2 agent t-BuNH2 N Cul, Et3N, DMF // - CH2CH20H Br Br Br IN Scheme 1 R and Scheme2 ! ! ! RsR4N Isoquinolines of formula (34a) are a subgenus of compounds (34), wherein X, Y', and Z'are all carbon atoms, for instance CH, and R4 and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, and the compounds of the subgenus (34a) can be prepared as described in Scheme 16. Methyl 2-iodobenzoate can be treated with N-bromosuccinimide in acetic acid and sufuric acid to provde

methyl 5-bromo-2-iodobenzoate. Methyl 5-bromo-2-iodobenzoate can be treated with a reducing agent, such as, but not limited to, sodium borohydride or lithium aluminum hydride in a solvent, such as, but not limited to, THF, ethanol, or a mixture thereof, to provide (5-bromo-2-iodophenyl) methanol. (5-Bromo-2- iodophenyl) methanol can be treated with an oxidizing agent, such as, but not limited to, pyridinium chlorochromate, pyridinium dichromate, Mn02, a peracid such as meta-chloroperoxybenzoic acid, or Swern conditions (DMSO/Cl(CO)2Cl/TEA) to provide 5-bromo-2-iodobenzaldehyde. 5-Bromo-2- iodobenzaldehyde can be treated with tert-butylamine in a solvent, such as, but not limited to, THF to provide N- [ (5-bromo-2-iodophenyl) methylene]-N- (tert- butyl) amine. N- [ (5-Bromo-2-iodophenyl) methylene]-N- (tert-butyl) amine can be treated with the alkyne but-3-yn-1-ol, Cul, a base, such as, but not limited to, triethylamine or diisopropylamine, and a palladium source, such as, but not limited to, Pd (PPh3) 2CI2 in a solvent, such as, but not limited to, N, N-dimethylformamide to provide an isoquinoline. The 2-hydroxyethylisoquinoline can be treated as described in Scheme 1 to provide isoquinolines of formula (34a).

Scheme 17 N02 1. H2, Pd/C Y. HN03, Au20 tu 2, NH NH 2. Ac2O H2SO4 s a RRN v v RRN v (37) 5 4 s a NOZ (100) (101) \ O 1. BoczO, DMAP (101) 0 0 0 0 2. 2-diethylaminodiethylaminey (103) y 3. H2, Pd/C NH-NH S RSR4N NHZ RsRaN I N R (102) (104) Hw N Rs. acid N R6 : r 6 AgN03 RsRaN H s a (106) acid (105) acid

Quinoxalines of formula (105), wherein R4 and R5 are as defined in formula (I) and R6 is aryl, heteroaryl, heterocycle, or cycloalkyl, can be prepared as described in Scheme 17. Amines of formula (37), prepared as described in Scheme 5, can be treated with palladium on carbon under a hydrogen atmosphere to provide anilines that can then be treated with acetic anhydride in a solvent such as a mixture of sulfuric acid and water to provide acetamides of formula (100). Acetamides of formula (100) can be nitrated using conditions well known to those skilled in the art such as, but not limited to, nitric acid in sulfuric acid in the presence of acetic anhydride to provide acetamides of formula (101).

Acetamides of formula (101) can be converted to Boc protected nitroanilines using a procedure described in Grehen, L, et. al, Acta Chem. Scand. Ser. B. 41,1, 18- 23, in which the acetamide is reacted with di-tert-butyidicarbonate in the presence of aminopyridine followed by treatment with 2-diethylaminodiethylamine to provide a Boc protected nitroaniline which can be treated with palladium on carbon under a hydrogen atmosphere to provide anilines of formula (102).

Anilines of formula (102) can be reacted with an acetyl bromide of formula (103) to provide amines of formula (104). Amines of formula (104) can be treated with an acid such as trifluoroacetic acid with heating to provide quinoxalines of formula (105). Treatment of amines of formula (104) may result in the formation of dihydroquinoxalines of formula (106). Dihydroquinoxalines of formula (106) may be oxidized with an oxidant such as silver nitrate to provide quinoxalines of formula (105).

't Scheme 18 c BrR Y 0 N 0 R5R4N"aNH2 R5R4N,-, N-R s a z s a H II R R NV v _N (102) (110) H R5R4N N (111) H triflic AgN03 I N O anhydride N OS. CF3 AgN03 02 s a R5R4N N (112) (113) (OH) 2BR6 N R6 (7). RSR4N N (105) An alternate route to quinoxalines of formula (105), wherein R4 and R5 are as defined in formula (1) and R6 is aryl or heteroaryl, is described in Scheme 18.

Anilines of formula (102), prepared as described in Scheme 17, can be reacted with a bromoacetate to provide anilines of formula (110). Anilines of formula (110) can be treated with an acid such as, but not limited to, trifluoroacetic acid with heating to provide dihydroquinoxalinones of formula (111).

Dihydroquinoxalinones of formula (111) can be oxidized using an oxidizing agent such as, but not limited to, silver nitrate to provide quinoxalinones of formula (112). Quinoxalinones of formula (112) can be treated with triflic anhydride in the presence of a base such as 2, 6-lutidine in a solvent such as dichloromethane to

provide triflates of formula (113). Triflates of formula (113) can be treated with boronic acids of formula (7) as described in Scheme 1 to provide quinoxalines of formula (105).

Scheme 19

Quinazolines of formula (123), wherein R4 and R5 are as defined in formula (I) and R6 is aryl, heteroaryl, heterocycle, or cycloalkyl, can be prepared as described in Scheme 19. Anilines of formula (40), prepared as described in Scheme 5, can be treated with acid chlorides of formula (121) in the presence of a base such as pyridine in a solvent such as dichloromethane to provide amides of formula (122). Amides of formula (122) can be treated with a source of ammonia, such as aqueous ammonium hydroxide, and heated to provide quinazolines of formula (123).

Scheme 20 H NH2 urea N f' O RSRaN RsRaN (40) (130) triflic N N QSoCF3 (130) anhydride 02 (131) (OH) 2BR6 ~ NR6 (131) (7) N --f R5RaN (123) Quinazolines of formula (123), wherein R4 and R5 are as defined in formula (I) and R6 is aryl or heteroaryl can also be prepared as described in Scheme 20.

Anilines of formula (40), prepared as described in Scheme 5, can be teated with urea and heated as described in Troeger, et. al.. Prakt. Chem. 117,1927, 181, to provide quinazolinones of formula (130). Quinazolinones of formula (130) can be treated with triflic anhydride in the presence of a base such as 2, 6-lutidine in a solvent such as dichloromethane to provide triflates of general strucure (131).

Triflates of formula (131) can be treated with boronic acids of general structure (7) as described in Scheme 1 to provide quinoxalines of formula (123).

Scheme 21

N Y Br OHC NyrZR 02N ly H2 H2N Y 0 (140) , _ HzN/yR PbC HzN/yR CH3CN z THF z N YYBr YR, z (141) N Y Br N Y Br N yr R2 HNR4Rs R5R4N N YrZ'sR (140) (5) + (142) Y R5R4N N Y Br Z Jazz N yr. Rz N,,. Z', R (141) (143) Ny ly R6 N Y Br R5R N N YR2 R5R4N'-NY R 5 a z Scheme 1 + (144) (142) R5R4N N Y Br ly v. R"NY-R, il* (143)

Compounds of formula (144) and (145), wherein Y, Y', Z', R2, R4, and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 21. Nitrobenzenes of formula (138) can be treated with a reducing agent such as, but not limited to, platinum on carbon under a hydrogen atmosphere to provide diaminobenzenes of formula (139). Diaminobenzenes of formula (139) can be treated with 2-oxopropanal to provide a mixture of bromides

of formula (140) and (141). Bromides of formula (140) and (141) can be treated with formaldehyde and amines of formula (5) to provide a mixture of aminobromides of formula (142) and (143). Aminobromides of formula (142) and (143) can be processed as described in Scheme 1 to provide compounds of formula (144) and (145). Scheme 22 02N Yq, Br 1) NaNO2 02N Yq, Br S Cl H2NYq, Br y y SnC12 HZN Y R2 2) aq KI I Y R2 I Y R2 (147) (148) (149) (147) "' (148) (149) OH Pd (Ph3P) 2Cl2 H2N Y Br (149) + A4 Cul, base yi R2 HO HO (150) N Br N Y Br 6M HCI \ .. Z1 POCI3 \ (150) HO Y'RZ--r CI Y'R2 6M HCI +y ; Z'sR 3 » Cl X y ; sR2 OH (151) Cl (152) (OH) 2BR6, N Y R6 R4R5NH (7) (5) Nr' \ . Z'- PdCl2 (PPh3) 2 CI Y R2 R4R5Nw Y ; ZR Na2CO3 (153) (154) Compounds of formula (154), wherein Y, Y', Z', R2, R4, and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 22. Compounds of formula (147), purchased or prepared using known methods in the art, can be treated with NaN02 and acid, such as, but not limited to, concentrated sulfuric acid followed by treatment with KI to provide iodo compounds of formula (148). lodo compounds of formula (148) can be treated with SnCl2 and an acid such as, but not limited, concentrated HCI to provide compounds of formula (149). Compounds of formula (149) can be treated with but-3-yn-1-ol, copper (I) iodide, base such as, but not limited to triethylamine, and a metal catalyst such as but not limited to PdCI2 (PPh3) 2 to provide alkynes of formula (150). Alkynes of formula (150) can be treated with NaN02 and an acid such as, but not limited to, 6M HCI to provide compounds of formula (151).

Compounds of formula (151) can be treated with POC13 to provide chlorides of formula (152). Chlorides of formula (152) can be treated with boronic acids of formula (7) as described in Scheme 1 to provide compounds of formula (153).

Compounds of formula (153) can be treated with amines of formula (5) to provide compounds of formula (154).

Scheme 23 H2N Y Br NR4Rs Pd (Ph3P) 2CI2 H2N Y Br + Cul, base/Y ;-Z'R2 I Y R2 (149) (55) RSRaN (157) (OH) 2BR6 NaN02 N"I''--r (7) 1 (157) R5R4N y R2 PdC12 (PPh3) 2 OH (158) Na2CO3 OH (159) alkyl halide N, N Y'Rs base XY ; R2 (159)--- R5R4N Y'R2 (160) Oalkyl N. N Rs POCI3 .. Z'. (159)--- RSR4N Y'RZ (161) Cl Compounds of formula (159-161), wherein Y, Y', Z', R2, R4, and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, can be prepared as described in Scheme 23. Compounds of formula (149), can be treated with amines of formula (55), copper (I) iodide, a base such as, but not limited to triethylamine, and a metal catalyst such as, but not limited to, PdCl2 (PPh3) 2 to provide alkynes of formula (157). Alkynes of formula (157) can be treated with NaN02 and an acid such as, but not limited to, 6 M HCI to provide compounds of formula (158).

Compounds of formula (158) can be treated with boronic acids of formula (7) as described in Scheme 1 to provide compounds of formula (159). Compounds of formula (159) can be treated with an alkyl halide such as, but not limited to, iodomethane or iodoethane and a base such as, but not limited to, triethylamine to provide compounds of formula (160). Compounds of formula (159) can be treated with phosphorus oxychloride to provide chlorides of formula (161), phosphorus oxybromide may also be used to generate the corresponding bromides.

Scheme 24 NN Y Br N N Y Br \ ,- O-protecting group HO Y,. Z", R2 HO y R2 OH (151) OPG (163) OH (151) 't. MsCI N'IN Br R4R5NH N Br base I, (5) N, N I Y'Br (163)-Ms0 \ I Y'ZR2 \ ;. \1Z'' R4R5N v Y RZ OPG (164) OPG (165) (OH) 2BRó, N Y R6 (7) N, 1) deprotect N"I 165 (165) PdC12 (PPh I Z, 2) POC13-R4R5N y R2 Na2CO3 OPG (166) Cl (161) NYRe Ns, N yRs y 4 5 2 Oalkyl (160) y (161) alkylSH N"N R6 R4R5N y R2 Salkyl (167) N. N Rs (161) N R R N \ I Y'ZR 4 5 2 CN CN (168) N N y R6 161) atkygBr) ! ! RaRsN I _Y R2 alkyl a ! kyt (169)

An alternative method for preparing compounds of formula (160-161) and methods for preparation of compounds of formula (167-169), wherein Y, Y', Z', R2, R4, and R5 are as defined in formula (I) and R6 is aryl or heteroaryl, is described in

Scheme 24. Compounds of general formula (151), can be treated with a reagent for protecting a hydroxy group known to those of skill in the art such as, but not limited to, tert-butyldimethylsilyl chloride or benzyl bromide, and a base such as, but not limited to, sodium bicarbonate or imidazole to provide compounds of formula (163) wherein PG is the hydroxy protecting group. Compounds of formula (163) can be treated with methanesulfonyl chloride (or toluenesulfonyl chloride) and a base such as, but not limited to, diisopropylamine or triethylamine to provide 't sulfonats of formula (164). Sulfonates of formula (164) can be treated with amines of formula (5) to provide compounds of formula (165). Compounds of formula (165) can be treated with boronic acids of formula (7) as described in Scheme 1 to provide compounds of formula (166). The hydroxy protecting group of compounds of formula (166) can be removed using methods known to those in the art such as, but not limited to, treatment with fluoride ion, acid, or hydrogenation in the presence of a metal catalyst (H2 and Pd/C) followed by treatment with phosphorus oxychloride to provide chlorides of formula (161), phosphorus oxybromide may also be used to generate the corresponding bromides. Chlorides of formula (161) can be treated with nucleophiles such as, but not limited to, alkoxide, alkyl mercaptans, alkyl grignards, or sodium cyanide to provide compounds of formula (167-169).

The invention also relates to preparing a compound of formula (I) or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein Ri is L2R6 wherein L2 is a bond and R6 is 3 (2H)-pyridazinon-2-yl ; R2, R3, R3a, and R3b are hydrogen; L is-[C (R16) (Ra7)] n-; n is 2; Rie and R17 at each occurrence are hydrogen ; R4 and R5 are taken together to form a methylpyrrolidinyl ring of formula (a), wherein one of R7, R8, Rg, and Rio is methyl and the remaining three substituents are hydrogen; Y and Y'are CH; and X, X', Z, and Z'are C. The process comprises the steps of : (a) providing a compound (11) :

(b) reducing the compound (II) with BH3-THF to provide a compound (III) : (c) treating the compound of formula (III) with 3 (2H)-pyridazinone, copper powder, and base to provide a compound (IV) : (d) activating the hydroxy group of compound (IV) ; and reacting the resulting compound with methylpyrrolidine to provide a compound of formula (I).

Compound (II), 6-bromo-naphthalen-2-yl-acetic acid [CAS 3271-06-5] can be prepared by various known methods, for example, Jones et al., J. Amer.

Chem. Soc. , 70: 2843-2848 (1948). Compound (II) can be reduced by treatment with borane-THF, preferably using from about three to four equivalents while maintaining the reaction below 0 °C. Compound (III) can be reacted with 3 (2H)- pyridazinone by the method described in WO 0024719, Example 62, using about one equivalent of copper powder and about three equivalents of base. The preferred base is K2CO3. Compound (IV) can be activated by treatment with methanesulfonyl chloride or toluensulfonyl chloride, preferably in the presence of a base, for example triethylamine. The resulting compound can be reacted with

an amine, for example methylpyrrolidine and, more particularly, 2- methylpyrrolidine, to provide a compound within the scope of formula (I).

The compounds and intermediates of the invention may be isolated and purified by methods well-known to those skilled in the art of organic synthesis.

Examples of conventional methods for isolating and purifying compounds can include, but are not limited to, chromatography on solid supports such as silica gel, alumina, or silica derivatized with alkylsilane groups, by recrystallization at high or low temperature with an optional pretreatment with activated carbon, thin- layer chromatography, distillation at various pressures, sublimation under vacuum, and trituration, as described for instance in"Vogel's Textbook of Practical Organic Chemistry", 5th edition (1989), by Furniss, Hannaford, Smith, and Tatchell, pub.

Longman Scientific & Technical, Essex CM20 2JE, England.

The compounds of the invention have at least one basic nitrogen whereby the compound can be treated with an acid to form a desired salt. For example, a compound may be reacted with an acid at or above room temperature to provide the desired salt, which is deposited, and collected by filtration after cooling.

Examples of acids suitable for the reaction include, but are not limited to tartaric acid, lactic acid, succinic acid, as well as mandelic, atrolactic, methanesulfonic, ethanesulfonic, toluenesulfonic, naphthalenesulfonic, carbonic, fumaric, gluconic, acetic, propionic, salicylic, hydrochloric, hydrobromic, phosphoric, sulfuric, citric, or hydroxybutyric acid, camphorsulfonic, malic, phenylacetic, aspartic, glutamic, and the like.

Compositions of the Invention The invention also provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of formula (I) in combination with a pharmaceutical acceptable carrier. The compositions comprise compounds of the invention formulated together with one or more non-toxic pharmaceutical acceptable carriers. The pharmaceutical compositions can be formulated for oral administration in solid or liquid form, for parenteral injection or for rectal administration.

The term"pharmaceutically acceptable carrier, "as used herein, means a non-toxic, inert solid, semi-solid or liquid filler, diluent, encapsulating material or

formulation auxiliary of any type. Some examples of materials which can serve as pharmaceutical acceptable carriers are sugars such as lactose, glucose and sucrose; starches such as corn starch and potato starch; cellulose and its derivatives such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; powdered tragacanth; malt ; gelatin ; talc ; cocoa butter and suppository waxes; oils such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil ; glycols ; such a propylene glycol ; esters such as ethyl '\ oleate and ethyl laurate ; agar; buffering agents such as magnesium hydroxide and aluminum hydroxide ; alginic acid; pyrogen-free water; isotonic saline ; Ringer's solution ; ethyl alcohol, and phosphate buffer solutions, as well as other non-toxic compatible lubricants such as sodium lauryl sulfate and magnesium stearate, as well as coloring agents, releasing agents, coating agents, sweetening, flavoring and perfuming agents, preservatives and antioxidants can also be present in the composition, according to the judgment of one skilled in the art of formulations.

The pharmaceutical compositions of this invention can be administered to huma'ns and other mammals orally, rectally, parenterally, intracisternally, intravaginally, intraperitoneally, topically (as by powders, ointments or drops), bucally or as an oral or nasal spray. The term"parenterally,"as used herein, refers to modes of administration which include intravenous, intramuscular, intraperitoneal, intrasternal, subcutaneous, intraarticular injection and infusion.

Pharmaceutical compositions for parenteral injection comprise pharmaceutically acceptable sterile aqueous or nonaqueous solutions, dispersions, suspensions or emulsions and sterile powders for reconstitution into sterile injectable solutions or dispersions. Examples of suitable aqueous and nonaqueous carriers, diluents, solvents or vehicles include water, ethanol, polyols (propylene glycol, polyethylene glycol, glycerol, and the like, and suitable mixtures thereof), vegetable oils (such as olive oil) and injectable organic esters such as ethyl oleate, or suitable mixtures thereof. Suitable fluidity of the composition may be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersions, and by the use of surfactants.

These compositions may also contain adjuvants such as preservative agents, wetting agents, emulsifying agents, and dispersing agents. Prevention of

the action of microorganisms may be ensured by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, sorbic acid, and the like. It may also be desirable to include isotonic agents, for example, sugars, sodium chloride and the like. Prolonged absorption of the injectable pharmaceutical form may be brought about by the use of agents delaying absorption, for example, aluminum monostearate and gelatin.

In some cases, in order to prolong the effect of a drug, it is often desirable to slow the absorption of the drug from subcutaneous or intramuscular injection.

This may be accomplished by the use of a liquid suspension of crystalline or amorphous material with poor water solubility. The rate of absorption of the drug then depends upon its rate of dissolution which, in turn, may depend upon crystal size and crystalline form. Alternatively, delayed absorption of a parenterally administered drug form is accomplished by dissolving or suspending the drug in an oil vehicle.

Suspensions, in addition to the active compounds, may contain suspending agents, for example, ethoxylated isostearyl alcohols, polyoxyethylene sorbitol and sorbitan esters, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar-agar, tragacanth, and mixtures thereof.

If desired, and for more effective distribution, the compounds of the invention can be incorporated into slow-release or targeted-delivery systems such as polymer matrices, liposomes, and microspheres. They may be sterilized, for example, by filtration through a bacteria-retaining filter or by incorporation of sterilizing agents in the form of sterile solid compositions, which may be dissolved in sterile water or some other sterile injectable medium immediately before use.

Injectable depot forms are made by forming microencapsulated matrices of the drug in biodegradable polymers such as polylactide-polyglycolide. Depending upon the ratio of drug to polymer and the nature of the particular polymer employed, the rate of drug release can be controlled. Examples of other biodegradable polymers include poly (orthoesters) and poly (anhydrides) Depot injectable formulations also are prepared by entrapping the drug in liposomes or microemulsions which are compatible with body tissues.

The injectable formulations can be sterilized, for example, by filtration through a bacterial-retaining filter or by incorporating sterilizing agents in the form

of sterile solid compositions which can be dissolved or dispersed in sterile water or other sterile injectable medium just prior to use.

Injectable preparations, for example, sterile injectable aqueous or oleaginous suspensions may be formulated according to the known art using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation may also be a sterile injectable solution, suspension or emulsion in a nontoxic, parenterally acceptable diluent or solvent such as a \ solution in 1, 3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution, U. S. P. and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil can be employed including synthetic mono-or diglycerides. In addition, fatty acids such as oleic acid are used in the preparation of injectables.

Solid dosage forms for oral administration include capsules, tablets, pills, powders, and granules. In such solid dosage forms, one or more compounds of the invention is mixed with at least one inert pharmaceutically acceptable carrier such as sodium citrate or dicalcium phosphate and/or a) fillers or extenders such as starches, lactose, sucrose, glucose, mannitol, and salicylic acid; b) binders such as carboxymethylcellulose, alginates, gelatin, polyvinylpyrrolidinone, sucrose, and acacia; c) humectants such as glycerol ; d) disintegrating agents such as agar-agar, calcium carbonate, potato or tapioca starch, alginic acid, certain silicates, and sodium carbonate; e) solution retarding agents such as paraffin ; f) absorption accelerators such as quaternary ammonium compounds; g) wetting agents such as cetyl alcohol and glycerol monostearate; h) absorbents such as kaolin and bentonite clay ; and i) lubricants such as talc, calcium stearate, magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate, and mixtures thereof. In the case of capsules, tablets and pills, the dosage form may also comprise buffering agents.

Solid compositions of a similar type may also be employed as fillers in soft and hard-filled gelatin capsules using lactose or milk sugar as well as high molecular weight polyethylene glycols.

The solid dosage forms of tablets, dragees, capsules, pills, and granules can be prepared with coatings and shells such as enteric coatings and other

coatings well known in the pharmaceutical formulating art. They may optionally contain pacifying agents and can also be of a composition that they release the active ingredient (s) only, or preferentially, in a certain part of the intestinal tract in a delayed manner. Examples of materials which can be useful for delaying release of the active agent can include polymeric substances and waxes.

Compositions for rectal or vaginal administration are preferably suppositories which can be prepared by mixing the compounds of this invention with suitable non-irritating carriers such as cocoa butter, polyethylene glycol or a suppository wax which are solid at ambient temperature but liquid at body temperature and therefore melt in the rectum or vaginal cavity and release the active compound.

Liquid dosage forms for oral administration include pharmaceutical acceptable emulsions, microemulsions, solutions, suspensions, syrups and elixirs.

In addition to the active compounds, the liquid dosage forms may contain inert diluents commonly used in the art such as, for example, water or other solvents, solubilizing agents and emulsifiers such as ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3- butylen glycol, dimethylformamide, oils (in particular, cottonseed, groundnut, corn, germ, olive, castor, and sesame oils), glycerol, tetrahydrofurfuryl alcohol, polyethylene glycols and fatty acid esters of sorbitan, and mixtures thereof : Besides inert diluents, the oral compositions can also include adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring, and perfuming agents.

Dosage forms for topical or transdermal administration of a compound of this invention include ointments, pastes, creams, lotions, gels, powders, solutions, sprays, inhalants or patches. A desired compound of the invention is admixed under sterile conditions with a pharmaceutical acceptable carrier and any needed preservatives or buffers as may be required. Ophthalmic formulation, ear drops, eye ointments, powders and solutions are also contemplated as being within the scope of this invention.

The ointments, pastes, creams and gels may contain, in addition to an active compound of this invention, animal and vegetable fats, oils, waxes,

paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicic acid, talc and zinc oxide, or mixtures thereof.

Powders and sprays can contain, in addition to the compounds of this invention, lactose, talc, silicic acid, aluminum hydroxide, calcium silicates and polyamide powder, or mixtures of these substances. Sprays can additionally contain customary propellants such as chlorofluorohydrocarbons.

Compounds of the invention may also be administered in the form of 't liposoms. As is known in the art, liposomes are generally derived from phospholipids or other lipid substances. Liposomes are formed by mono-or multi- lamella hydrated liquid crystals that are dispersed in an aqueous medium. Any non-toxic, physiologically acceptable and metabolizable lipid capable of forming liposomes may be used. The present compositions in liposome form may contain, in addition to the compounds of the invention, stabilizers, preservatives, and the like. The preferred lipids are the natural and synthetic phospholipids and phosphatidylcholines (lecithins) used separately or together.

Methods to form liposomes are known in the art. See, for example, Prescott, Ed. , Methods in Cell Biology, Volume XIV, Academic Press, New York, N. Y. , (1976), p 33 et seq.

Dosage forms for topical administration of a compound of this invention include powders, sprays, ointments and inhalants. The active compound is mixed under sterile conditions with a pharmaceutically acceptable carrier and any needed preservatives, buffers or propellants, which can be required. Opthalmic formulations, eye ointments, powders and solutions are contemplated as being within the scope of this invention. Aqueous liquid compositions comprising compounds of the invention also are contemplated.

The compounds of the invention can be used in the form of pharmaceutical acceptable salts, esters, or amides derived from inorganic or organic acids. The term"pharmaceutically acceptable salts, esters and amides," as used herein, refer to carboxylate salts, amino acid addition salts, zwitterions, esters and amides of compounds of formula (I) which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response, and the like,

are commensurate with a reasonable benefit/risk ratio, and are effective for their intended use.

The term"pharmaceutically acceptable salt"refers to those salts which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response, and the like, and are commensurate with a reasonable benefit/risk ratio.

Pharmaceutical acceptable salts are well-known in the art. The salts can be t prepared in situ during the final isolation and purification of the compounds of the invention or separately by reacting a free base function with a suitable organic acid.

Representative acid addition salts include, but are not limited to acetate, adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulfate, butyrate, camphorate, camphorsulfonate, digluconate, glycerophosphate, hemisulfate, heptanoate, hexanoate, fumarate, hydrochloride, hydrobromide, hydroiodide, 2-hydroxyethansulfonate (isethionate), lactate, maleat, methanesulfonate, nicotinate, 2-naphthalenesulfonate, oxalate, pamoate, pectinate, persulfate, 3-phenylpropionate, picrate, pivalate, propionate, succinate, tartrate, thiocyanate, phosphate, glutamate, bicarbonate, p-toluenesulfonate and undecanoate. Preferred salts of the compounds of the invention are the tartrate and hydrochloride salts.

Also, the basic nitrogen-containing groups can be quaternized with such agents as lower alkyl halides such as methyl, ethyl, propyl, and butyl chlorides, bromides and iodides; dialkyl sulfates such as dimethyl, diethyl, dibutyl and diamyl sulfates ; long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides; arylalkyl halides such as benzyl and phenethyl bromides and others. Water or oil-soluble or dispersible products are thereby obtained.

Examples of acids which can be employed to form pharmaceutically acceptable acid addition salts include such inorganic acids as hydrochloric acid, hydrobromic acid, sulphuric acid and phosphoric acid and such organic acids as oxalic acid, maleic acid, succinic acid, and citric acid.

Basic addition salts can be prepared in situ during the final isolation and purification of compounds of this invention by reacting a carboxylic acid-containing moiety with a suitable base such as the hydroxide, carbonate or bicarbonate of a

pharmaceutically acceptable metal cation or with ammonia or an organic primary, secondary or tertiary amine. Pharmaceutically acceptable salts include, but are not limited to, cations based on alkali metals or alkaline earth metals such as lithium, sodium, potassium, calcium, magnesium, and aluminum salts, and the like, and nontoxic quaternary ammonia and amine cations including ammonium, tetramethylammonium, tetraethylammonium, methylamine, dimethylamine, trimethylamine, triethylamine, diethylamine, ethylamine and the such as. Other representative organic amines useful for the formation of base addition salts include ethylenediamine, ethanolamine, diethanolamine, piperidine, and piperazine.

The term"pharmaceutically acceptable ester, "as used herein, refers to esters of compounds of the invention which hydrolyze in vivo and include those that break down readily in the human body to leave the parent compound or a salt thereof. Examples of pharmaceutical acceptable, non-toxic esters of the invention include Ci-to-Ce alkyl esters and Cs-to-C7 cycloalkyl esters, although Cr- to-C4 alkyl esters are preferred. Esters of the compounds of formula (I) may be prepared according to conventional methods. For example, such esters may be appended onto hydroxy groups by reaction of the compound that contains the hydroxy group with acid and an alkylcarboxylic acid such as acetic acid, or with acid and an arylcarboxylic acid such as benzoic acid. In the case of compounds containing carboxylic acid groups, the pharmaceutically acceptable esters are prepared from compounds containing the carboxylic acid groups by reaction of the : compound with base such as triethylamine and an alkyl halide, alkyl trifilate, for example with methyliodide, benzyl iodide, cyclopentyl iodide. They also may be prepared by reaction of the compound with an acid such as hydrochloric acid and an alkylcarboxylic acid such as acetic acid, or with acid and an arylcarboxylic acid such as benzoic acid.

The term"pharmaceutically acceptable amide, "as used herein, refers to non-toxic amides of the invention derived from ammonia, primary d-to-Ce alkyl amines and secondary d-to-Ce dialkyl amines. In the case of secondary amines, the amine may also be in the form of a 5-or 6-membered heterocycle containing one nitrogen atom. Amides derived from ammonia, Cl-tO-C3 alkyl primary amides and Cl-tO-C2 dialkyl secondary amides are preferred. Amides of the compounds

of formula (I) may be prepared according to conventional methods.

Pharmaceutical acceptable amides are prepared from compounds containing primary or secondary amine groups by reaction of the compound that contains the amino group with an alkyl anhydride, aryl anhydride, acyl halide, or aryl halide. In the case of compounds containing carboxylic acid groups, the pharmaceutical acceptable esters are prepared from compounds containing the carboxylic acid groups by reaction of the compound with base such as triethylamine, a 't dehydrating agent such as dicyclohexyl carbodiimide or carbonyl diimidazole, and an alkyl amine, dialkylamine, for example with methylamine, diethylamine, piperidine. They also may be prepared by reaction of the compound with an acid such as sulfuric acid and an alkylcarboxylic acid such as acetic acid, or with acid and an arylcarboxylic acid such as benzoic acid under dehydrating conditions as with molecular sieves added. The composition can contain a compound of the invention in the form of a pharmaceutical acceptable prodrug.

The term"pharmaceutically acceptable prodrug"or"prodrug, "as used herein, represents those prodrugs of the compounds of the invention which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response, and the like, commensurate with a reasonable benefit/risk ratio, and effective for their intended use. Prodrugs of the invention may be rapidly transformed in vivo to a parent compound of formula (I), for example, by hydrolysis in blood. A thorough discussion is provided in T. Higuchi and V. Stella, Pro-drugs as Novel Delivery Systems, V. 14 of the A. C. S. Symposium Series, and in Edward B. Roche, ed., Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press (1987), hereby incorporated by reference.

The invention contemplates pharmaceutically active compounds either chemically synthesized or formed by in vivo biotransformation to compounds of formula (I).

Methods of the Invention Compounds and compositions of the invention are useful for modulating the effects of histamine-3 receptors. In particular, the compounds and

compositions of the invention can be used for treating and preventing disorders modulated by the histamine-3 receptors. Typically, such disorders can be ameliorated by selectively modulating the histamine-3 receptors in a mammal, preferably by administering a compound or composition of the invention, either alone or in combination with another active agent as part of a therapeutic regimen.

The compounds of the invention, including but not limited to those specified in the examples, possess an affinity for the histamine-3 receptors. As histamine-3 receptor ligands, the compounds of the invention may be useful for the treatment and prevention of diseases or conditions such as acute myocardial infarction, Alzheimer's disease, asthma, attention-deficit hyperactivity disorder, bipolar disorder, cognitive dysfunction, cognitive deficits in psychiatric disorders, deficits of memory, deficits of learning, dementia, cutaneous carcinoma, drug abuse, diabetes, type 11 diabetes, depression, epilepsy, gastrointestinal disorders, inflammation, insulin resistance syndrome, jet lag, medullary thyroid carcinoma, melanoma, Meniere's disease, metabolic syndrome, mild cognitive impairment, migraine, mood and attention alteration, motion sickness, narcolepsy, neurogenic inflammation, obesity, obsessive compulsive disorder, pain, Parkinson's disease, polycystic ovary syndrome, schizophrenia, cognitive deficits of schizophrenia, seizures, septic shock, Syndrome X, Tourette's syndrome, vertigo, and sleep disorders.

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat septic shock and cardiovascular disorders, in particular, acute myocardial infarction may be demonstrated by Imamura et al., Circ. Res. , 78: 475-481 (1996); Imamura et. al., Circ. Res., 78 : 863- 869 (1996); R. Levi and N. C. E. Smith,"Histamine H3-receptors : A new frontier in myocardial ischemia", J. Pharm. Exp. Ther. , 292: 825-830 (2000); and Hatta, E. , K.

Yasuda and R. Levi, "Activation of histamine H3 receptors inhibits carrier-mediated norepinephrine release in a human model of protracted myocradial ischemia", J.

Pharm. Exp. Ther., 283: 494-500 (1997).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat sleep disorders, in particular, narcolepsy may be demonstrated by Lin et al., Brain Res. , 523: 325-330 (1990); Monti, et al., Neuropsychopharmacology 15: 31-35 (1996); Sakai, et al., Life Sci. , 48: 2397-2404

(1991); Mazurkiewicz-Kwilecki and Nsonwah, Can. J. Physio. Pharmacol., 67: 75- 78 (1989); P. Panula, et al., Neuroscience 44: 465-481 (1998); Wada, et al., Trends in Neuroscience 14: 415 (1991); and Monti, et al., Eur. J. Pharmacol.

205: 283 (1991).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat cognition and memory process disorders may be demonstrated by Mazurkiewicz-Kwilecki and Nsonwah, Can. J. Physio.

Pharmacol., 67: 75-78 (1989); P. Panula, et al., Neuroscience, 82: 993-997 (1997); Haas, et al., Behav. Brain Res. , 66: 41-44 (1995); De Almeida and Izquierdo, Arch.

Int. Pharmacodyn. , 283: 193-198 (1986); Kamei et al., Psychopharmacology, 102: 312-318 (1990); Kamei and Sakata, Jpn. J. Pharmacol., 57: 437-482 (1991) ; Schwartz et al., Psychopharmacology, The fourth Generation of Progress. Bloom and Kupfer (eds). Raven Press, New York, (1995) 397; and Wada, et al., Trends in Neurosci. , 14: 415 (1991).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat attention-deficit hyperactivity disorder (ADHD) may be demonstrated by Shaywitz et al., Psychopharmacology, 82: 73-77 (1984); Dumery and Blozovski, Exp. Brain Res., 67: 61-69 (1987); Tedford et al., J.

Pharmacol. Exp. Ther. , 275: 598-604 (1995); Tedford et al., Soc. Neurosci. Abstr., 22: 22 (1996); and Fox, et al., Behav. Brain Res. , 131: 151-161 (2002).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat seizures, in particular, epilepsy may be demonstrated by Yokoyama, et al., Eur. J. Pharmacol, 234 : 129 (1993); Yokoyama and linuma, CNS Drugs 5: 321 (1996); Onodera et al., Prog.

Neurobiol., 42: 685 (1994); R. Leurs, R. C. Vollinga and H. Timmerman,"The medicinal chemistry and therapeutic potential of ligands of the histamine H3 receptor", Progress in Drug Research 45: 170-165, (1995); Leurs and Timmerman, Prog. Drug Res. , 39: 127 (1992); The Histamine H3 Receptor, Leurs and Timmerman (eds), Elsevier Science, Amsterdam, The Netherlands (1998); H.

Yokoyama and K. linuma,"Histamine and Seizures: Implications for the treatment of epilepsy", CNS Drugs, 5 (5): 321-330 (1995); and K. Hurukami, H. Yokoyama, K.

Onodera, K. tinuma and T. Watanabe, "AQ-0145, A newly developed histamine H3

antagonist, decreased seizure susceptibility of electrically induced convulsions in mice", Meth. Find. Exp. Clin. Pharmacol., 17 (C): 70-73 (1995).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat motion sickness, Alzheimer's disease, and Parkinson's disease may be demonstrated by Onodera, et al., Prog.

Neurobiol., 42 : 685 (1994); Leurs and Timmerman, Prog. Drug Res., 39: 127 (1992); and The Histamine H3 Receptor, Leurs and Timmerman (eds), Elsevier Science, Amsterdam, The Netherlands (1998).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat narcolepsy, schizophrenia, depression, and dementia may be demonstrated by R. Leurs, R. C. Vollinga and H.

Timmerman, "The medicinal chemistry and therapeutic potential of ligands of the histamine H3 receptor", Progress in Drug Research 45: 170-165 (1995); The Histamine H3 Receptor, Leurs and Timmerman (eds), Elsevier Science, Amsterdam, The Netherlands (1998); and Perez-Garcia C, et. al., and Psychopharmacology (Berl) 142 (2): 215-20 (Feb, 1999).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat sleep disorders, cognitive dysfunction, mood and attention alteration, vertigo and motion sickness, and treatment of cognitive deficits in psychiatric disorders may be demonstrated by Schwartz, Physio. Review 71 : 1-51 (1991).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat mild cognitive impairment, deficits of memory, deficits of learning and dementia may be demonstrated by C. E. Tedford, in"The Histamine H3 Receptor: a target for new drugs", the Pharmacochemistry Library, vol. 30 (1998) edited by R. Leurs and H. Timmerman, Elsevier (New York). p. 269 and references also contained therein.

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat obesity may be demonstrated by Leurs, et al., Trends in Pharm. Sci. , 19: 177-183 (1998); E. Itoh, M. Fujimiay, and A. lnui, "Thioperamide, A histamine H3 receptor antagonist, powerfully suppresses peptide YY-induced food intake in rats,"Biol. Psych. , 45 (4): 475-481 (1999); S. I.

Yates, et al.,"Effects of a novel histamine H3 receptor antagonist, GT-2394, on

food intake and weight gain in Sprague-Dawley rats, "Abstracts, Society for Neuroscience, 102.10 : 219 (November, 2000); and C. Bjenning, et al., "Peripherally administered ciproxifan elevates hypothalamic histamine levels and potently reduces food intake in the Sprague Dawley rat, "Abstracts, International Sendai Histamine Symposium, Sendai, Japan, #P39 (November, 2000).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat inflammation and pain may be \ demonstrated by Philips, et al., Annual Reports in Medicinal Chemistry 33: 31-40 (1998).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat migraine may be demonstrated by R.

Leurs, R. C. Vollinga and H. Timmerman,"The medicinal chemistry and therapeutic potential of ligands of the histamine H3 receptor, "Progress in Drug Research 45: 170-165 (1995); Matsubara, et al., Eur. J. Pharmacol., 224: 145 (1992); and Rouleau, et al., J. Pharmacol. Exp. Ther. , 281: 1085 (1997).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat cancer, in particular, melanoma, cutaneous carcinoma and medullary thyroid carcinoma may be demonstrated by Polish Med. Sci. Mon. , 4 (5): 747 (1998); Adam Szelag,"Role of histamine H3- receptors in the proliferation of neoplastic cells in vitro, "Med. Sci. Monit., 4 (5): 747-755 (1998); and C. H. Fitzsimons, et al.,"Histamine receptors signalling in epidermal tumor cell lines with H-ras gene alterations, "Inflammation Res. , 47 (Suppl 1): S50-S51 (1998).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat vestibular dysfunctions, in particular, Meniere's disease may be demonstrated by R. Leurs, R. C. Vollinga and H.

Timmerman, "The medicinal chemistry and therapeutic potential of ligands of the histamine H3 receptor, "Progress in Drug Research 45: 170-165 (1995), and Pan, et al., Methods and Findings in Experimental and Chemical Pharmacology 21: 771-777 (1998).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat asthma may be demonstrated by A.

Delaunois A. , et al.,"Modulation of acetylcholine, capsaicin and substance P

effects by histamine H3 receptors in isolated perfused rabbit lungs,"European Journal of Pharmacology 277 (2-3): 243-250 (1995); and Dimitriadou, et al., "Functional relationship between mast cells and C-sensitive nerve fibres evidenced by histamine H3-receptor modulation in rat lung and spleen,"Clinical Science 87 (2): 151-163 (1994).

The ability of the compounds of the invention, including, but not limited to, those specified in the examples, to treat allergic rhinitis may be demonstrated by t McLeod, et al., Progress in Resp. Research 31: 133 (2001).

Compounds of the invention are particularly useful for treating and preventing a condition or disorder affecting the memory or cognition, for example Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, or the cognitive deficits of schizophrenia Actual dosage levels of active ingredients in the pharmaceutical compositions of this invention can be varied so as to obtain an amount of the active compound (s) which is effective to achieve the desired therapeutic response for a particular patient, compositions and mode of administration. The selected dosage level will depend upon the activity of the particular compound, the route of administration, the severity of the condition being treated and the condition and prior medical history of the patient being treated. However, it is within the skit) of the art to start doses of the compound at levels lower than required to achieve the desired therapeutic effect and to gradually increase the dosage until the desired effect is achieved.

When used in the above or other treatments, a therapeutical effective amount of one of the compounds of the invention can be employed in pure form or, where such forms exist, in pharmaceutical acceptable salt, ester, amide or prodrug form. Alternatively, the compound can be administered as a pharmaceutical composition containing the compound of interest in combination with one or more pharmaceutical acceptable carriers. The phrase "therapeutical effective amount"of the compound of the invention means a sufficient amount of the compound to treat disorders, at a reasonable benefit/risk ratio applicable to any medical treatment. It will be understood, however, that the total daily usage of the compounds and compositions of the invention will be decided by the attending physician within the scope of sound medical judgment.

The specific therapeutical effective dose level for any particular patient will depend upon a variety of factors including the disorder being treated and the severity of the disorder; activity of the specific compound employed ; the specific composition employed ; the age, body weight, general health, sex and diet of the patient; the time of administration, route of administration, and rate of excretion of the specific compound employed ; the duration of the treatment; drugs used in combination or coincidental with the specific compound employed ; and like factors well known in the medical arts. For example, it is well within the skill of the art to start doses of the compound at levels lower than required to achieve the desired therapeutic effect and to gradually increase the dosage until the desired effect is achieved.

The total daily dose of the compounds of this invention administered to a human or lower animal may range from about 0.003 to about 30 mg/kg/day. For purposes of oral administration, more preferable doses can be in the range of from about 0.01 to about 0.1 mg/kg/day. If desired, the effective daily dose can be divided into multiple doses for purposes of administration; consequently, single dose compositions may contain such amounts or submultiples thereof to make up the daily dose.

The compounds and processes of the invention will be better understood by reference to the following examples, which are intended as an illustration of and not a limitation upon the scope of the invention.

REFERENCE EXAMPLES Reference Example 1 Preparation of (2R)-2-methylpyrrolidine and (2S)-2-methylpyrrolidine (2R)-2-Methylpyrrolidine tartrate was prepared via resolution of 2-methylpyrrolidine with D-tartaric acid using procedures described by William Gaffield, et al. in Tetrahedron, 37: 1861-1869 (1981) or, alternatively, prepared from L-prolinol by methods described by Karrer and Ehrhardt in Helv. Chim. Acta, 34: 2202,2208 (1951). (2R)-2-methylpyrrolidine hydrobromide also is a suitable

source of (2R)-2-methylpyrrolidine, and was prepared using the procedure described by Nijhuis, Walter H. N. , et al., J. Org. Chem. , 54 (1) : 209-216,214 (1989).

Other procedures describing the synthesis of (2R)-2-methylpyrrolidine and salts thereof can be found in Andres, Jose M. , et al. Eur. J. Org. Chem. , 9: 1719-1726 (2000); and Elworthy, Todd R.; Meyers, A. I., Tetrahedron, 50 (20): 6089-6096 (1994).

(2S)-2-Methylpyrrolidine can be substituted for (2R)-2-methylpyrrolidine in the experimental procedures provided herein. The (2S)-2-methylpyrrolidine can be prepared by procedures described in Kim, Mahn-Joo, et al., Bioorg. Med. Chem. Lett. 6 (1) : 71-76 (1996).

Reference Example 2 Preparation of Boronic Acid and Ester Reagents There are many aryl, heteroaryl, and heterocyclic boronic acids and boronic acid esters that are available commercially or that can be prepared as described in the scientific literature of synthetic organic chemistry. Non-exhaustive examples of boronic acid and boronic acid ester reagents for the synthesis of compounds of formula (I) are provided in Table 1, below, and the following description.

Table 1 Examples of Boronic Acid and Boronic Acid Ester Reagents Boronic Acid or Boronic Acid Ester Commercial Source, Chemical Abstracts Number or Literature Reference 2-pyrimidinone-5-boronic acid Matrix Scientific, Columbia, SC, USA 1 H-pyrimidine-2, 4-dione-5-boranic Specs, Fleminglaan, the Netherlands acid pyridine-3-boronicacid 1692-25-7, Frontier Scientific, Inc., Logan, UT, USA 2, 4-dimethoxypyrimidine-5-boronic 89641-18-9, Frontier Scientific, Inc., Logan, acid UT, USA 2-methoxy-5-pyridine boronic acid Digital Specialty Chemicals, Dublin, NH pyrimidine-5-boronic acid S. Gronowitz, et al.,"On the synthesis of various thienyl-and selenienylpyrimidines," Chem. Scr. 26 (2) : 305-309 (1986). pyrimidine-5-boronic acid, pinacol Umemoto, et al., Angew. Chem. Int. Ed. ester 40 (14): 2620-2622 (2001).

Boronic acid esters of formula (7a): (ReO) (RfO) B-R6 (7a) may serve as synthetic replacements for boronic acids of formula (7) in the Schemes. The substituents represented by Re and Rf in compounds of formula (7a) may be alkyl, or alternatively Re and Rf can be taken together to form a ring, which may itself be substituted with alkyl or aryl groups. Examples of suitable compounds of formula (7a) include, but are not limited to (CH30) 2BPh and (4- cyanomethylphenyl) boronic acid, pinacol ester (CombiBlocks Inc., San Diego)).

Boronic acids of formula (7) and boronic acid esters of formula (7a) are commercially available or can be prepared by methods well known to those skilled in the art of synthetic organic chemistry. For instance, Takagi et al. (Tetrahedron Letters, 43: 5649-5651 (2002) ) prepared heteroaryl pinacolborane esters of formula (7a) using heteroaromatic compounds and reaction with bis (pinacolborane) in the presence of an iridium catalysis of IrCI [COD] 2- (4, 4'-di-t- butyl-2, 2'-bipyridine in octane. Other methods have been described wherein aryl halides and heteroaryl halides are transmetallated with alkyl lithiums or Grignard reagents, then treated with trialkylborate esters, then treated with acid to produce compounds of formulae (7) and (7a) (B. T. O'Neill, et al., Organic Letters, 2: 4201 (2000); M. D. Sindkhedkar, et al., Tetrahedron, 57: 2991 (2001); W. C. Black, et al., Journal of Medicinal Chemistry, 42: 1274 (1999); Letsinger; Dandegaonker, J.

Amer. Chem. Soc. , 81: 498-501 (1959); Carroll, F. Ivy, et al. J. Med. Chem. , 2229- 2237 (2001). Another method is the Miyaura reaction described in Ishiyama, Tatsuo; Ishida, Kousaku, Miyaura, Norio, Tetrahedron, 9813-9816 (2001) in which aryl and heteroaryl halides are reacted with bis (pinacolborane), KOAc, and Pd2dba3 and tris-cyclohexylphosphine or PdCl2dppf (Ishiyama, et al. Tetrahedron, 9813-9816 (2001) ). Another method for preparation of compounds of formula (7a) is the reaction described in O. Baudoin, et al., J. Org. Chem. , 65: 9268-9271 (2000), in which aryl and heteroaryl halides or triflates are reacted with a

dialkoxyborane such as pinacolborane, in the presence of Et3N and Pd (OAc) 2 in dioxane. Compounds of formula (7) and (7a) wherein R6 is a cycloalkyl ring can be prepared, for example, from cycloalkenes (for example, see H. C. Brown, et al., J. Amer. Chem. Soc. , 95: 2396-2397 (1973) and H. C. Brown, et al., J. Amer.

Chem. Soc., 98: 1798-1806 (1976) ) or cycloalkyl Grignard or cycloalkyl lithium intermediates (see, for example, Graf et al., Tetrahedron, 55: 8801-8814 (1999) and Michailow, et al., Izv. Akad. Nauk SSSR Ser. Khim, 76: 78 (1959)).

@ Reference Example 3 Preparation of Stannane-Type Reagents Many reagents such as Me3SnR6, Bu3SnR6, and R6ZnCl are suitable for reactions under Stille conditions in Scheme 1 and are commercially available.

However, where the reagents wherein R6 is heteroaryl, heterocyclic, or aryl are not commercially available, they may be prepared by methods available to one with skill in the art. Examples of such methods include lithium halogen-metal exchange of heteroaryl, heterocyclic or aryl halides, followed by treatment with Me3SnCl (Li, et al. J. Med. Chem. 1996,39, 1846), Bu3SnCl, ZnClz, or B (OCH3) 3 (O'Neill, et al. Org. Lett. 2000,2, 4201; Sindkhedkar, et al. Tet. 2001,57, 2991) and magnesium halogen-metal exchange with isopropylmagnesium chloride as described in Knochel, et al. J. Org. Chem. 2000,65, 4618-4634, followed by treatment with Me3SnCl, Bu3SnCl, or ZnCI2. Heteroaryl halides and triflates can be treated with trimethylstannyl sodium as described in A. O. Koren, et al. J. Med.- Chem. 1998,41, 3690, to give Me3SnR6. Heteroaryl halides and triflates can be treated wtih hexamethyidistannane as described in W. C. Black, et al. J. Med.

Chem. 1999,42, 1274., to give Me3SnR6.

EXAMPLES Example 1 4- (6-2-f (2R)-2-methyl-1-pyrrolidinyllethyl-2-naphthvl) benzonitrile Example 1A (6-bromo-2-naphthyl) methanol

To a stirred 1.0 M THF solution of lithium aluminum hydride (108 mL, 108 mmol) was added dropwise over 20 min a solution of methyl 6-bromo-2- naphthoate (18.9 g, 71.3 mmol) in THF (180 mL), while maintaining the reaction temperature below-5 °C. When the addition was complete, the reaction mixture was stirred at-10 °C for 1 hr, then quenched by the sequential dropwise addition of distilled water (4 mL), 2 N aqueous Na2CO3 (4 mL), and distilled water (12 mL).

After stirring for 15 min at room temperature, the reaction mixture was filtered.

'\ The fitter cake was washed with ethyl acetate (3 x 100 mL) and the combined filtrates were dried (MgS04) and filtered. This filtrate was concentrated under reduced pressure to give a white solid. Drying under vacuum overnight at 40 °C provided the product (16.84 g, 99% yield). M. p. 149.9-151. 6 °C.'H NMR (CDC13, 300 MHz) 6 7.99 (d, J=2 Hz, 1H), 7.79-7. 67 (m, 3H), 7.55 (dd, J=2,12 Hz, 1H), 7.52 (dd, J=2,12 Hz, 1 H), 4.85 (s, 2H). MS (DCI-NH3) [M] + at 236.

Example 1 B 2-bromo-6- (chloromethyl) naphthalene A stirred solution of the product from Example 1A (30.5 g, 129 mmol) in dioxane (320 mL) under a dry nitrogen atmosphere was chilled to-10 °C. Solid anhydrous Zinc12 (514 mg, 3.77 mmol, 0.03 equiv. ) was added in one lot, followed by the dropwise addition of thionyl chloride (19.3 mL, 264 mmol, 2.0 equiv. ). The reaction mixture was allowed to warm to room temperature then stirred an additional 2 hr. This reaction mixture was then concentrated under reduced pressure and the residue was partitioned between dichloromethane and saturated aqueous NaHC03 (500 mL). The organic layer was washed with brine (2 x 100 mL), dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure to give a white solid. Drying under vacuum overnight at 40 °C provided the product (32.6 g, 99% yield). M. p. 133.1-134. 1 °C.'H NMR (CD3, 300 MHz) 6 8.00 (d, J=2 Hz, 1 H), 7.81-7. 67 (m, 3H), 7.56 (dd, J=2,12 Hz, 1H), 7.54 (dd, J=2,12 Hz, 1H), 4.73 (s, 2H). MS (DCI-NH3) [M] + at 254. <BR> <BR> <BR> <P> Example 1C<BR> <BR> <BR> <BR> <BR> (6-bromo-2-naphthyl) acetonitrile

A mixture of the product from Example 1 B (32.2 g, 126 mmol) and NaCN (7.44 g, 152 mmol, 1.2 equiv. ) in acetonitrile (314 mL) and distilled water (32 mL) under a dry nitrogen atmosphere was stirred at reflux for 21 hr. The reaction mixture was cooled to room temperature then concentrated under reduced pressure. The residue was stirred with distilled water (314 mL) for 45 min. The resulting white solid was isolated by filtration and washed with distilled water (1500 mL). Drying under vacuum overnight at 40 °C provided the product (32.2 g, 97% yield). M. p. 119.6-120. 6 °C.'H NMR (CDC13, 300 MHz) 5 8.01 (d, J=2 Hz, 1H), 7.82-7. 68 (m, 3H), 7.60 (dd, J=2, 12 Hz, 1H), 7.41 (dd, J=2,12 Hz, 1H), 3.90 (s, 2H). MS (DCI-NH3) [M+NH4] + at 263, [M+NH4 NH3] + at 280.

Example 1 D (6-bromo-2-naphthyl) acetic acid A stirred mixture of the product from Example 1C (29.62 g, 120 mmol) in glacial acetic acid (300 mL) and distilled water (150 mL) under a dry nitrogen atmosphere was cooled to-15 °C. Concentrated sulfuric acid (120 mL, 4.32 mol, 36.0 equiv. ) was added dropwise over 20 min while maintaining the reaction temperature below 10 °C. The reaction mixture was then stirred at reflux for 2 hr.

After cooling to 35 °C, ice (500 g) was added to the mixture and stirring was continued for 45 min. The resulting white solid was isolated by filtration and washed with distilled water (1500 mL). Drying under vacuum overnight at 40 °C provided the product (29.57 g, 93% yield).'H NMR (CDC13, 300 MHz) 6 7.99 (d, J=2 Hz, 1H), 7.76-7. 64 (m, 3H), 7.54 (dd, J=2,12 Hz, 1H), 7.44 (dd, J=2, 12 Hz, 1 H), 3.81 (s, 2H). MS (DCI-NH3) [M+NH4] +at 282.

Example 1 E 2- (6-bromo-2-naphthyl) ethanol To a stirred,-15 °C solution of the product from Example 1 D (28.6 g, 108 mmol) in anhydrous THF (143 mL) under a dry nitrogen atmosphere was added dropwise over 15 min a 1.0 M solution of BH3-THF (409 mL, 409 mmol, 3.8 equiv. ) while maintaining the reaction temperature below 0 °C. When the addition was complete, the reaction mixture was stirred at-15 °C for 15 min, then allowed to warm to room temperature and stirred an additional 2 hr. The reaction mixture

was then cooled to-10 °C and quenched with distilled water (104 mL). After stirring for 15 min at room temperature, the reaction mixture was concentrated under reduced pressure. The residue was partitioned between dichloromethane (350 mL) and distilled water (200 mL) and the aqueous layer was extracted with dichloromethane (2 x 100 mL). The combined organic extracts were washed with distilled water (3 x 100 mL), dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure to give a white solid. Drying under vacuum overnight at 40 °C provided the product (26.1 g, 96% yield). M. p. 102.3-103. 1 °C.

'H NMR (CDC13, 300 MHz) 5 7.98 (d, J=2 Hz, 1H), 7.74-7. 63 (m, 3H), 7.53 (dd, J=2,12 Hz, 1H), 7.49 (dd, J=2,12 Hz, 1H), 4.00-3. 92 (m, 2H), 3.02 (t, J=6 Hz, 2H), 1.43-1. 35 (t br, J=6 Hz, 1 H). MS (DCI-NH3) [M+NH4] + at 268.

Example 1 F 4- [6- (2-hydroxyethyl)-2-naphthyllbenzonitrile A mixture of the product from Example 1 E (0.60 g, 2.39 mmol), 4- <BR> <BR> <BR> <BR> cyanophenylboronic acid (0.42 g, 2.87 mmol, 1.2 equiv. ), PdCI2 (PPh3) 2 (34 mg, 0.048 mmol, 0.020 equiv. ) and K3PO4 H20 (1.38g, 7.17 mmol, 3.0 equiv. ) in isopropanol (40 mL) and distilled water (15 mL) was stirred at 65 °C under a dry nitrogen atmosphere for 1.5 hr. The reaction mixture was cooled to room temperature then concentrated under reduced pressure. The residue was partitioned between ethyl acetate and brine. The aqueous layer was washed with ethyl acetate, and the combined organic extracts were washed with saturated aqueous NH4CI, dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (7: 3 hexane/ethyl acetate). Fractions containing product were combined and concentrated under reduced pressure to provide the product as an off-white solid (0.59 g, 90% yield).'H NMR (CD3, 300 MHz) 6 8.04 (d, J=2 Hz, 1H), 7.93-7. 68 (m, 8H), 7.44 (dd, J=2,12 Hz, 1H), 3.98 (t, J=6 Hz, 2H), 3.07 (t, J=6 Hz, 2H). MS (DCI-NH3) [M+NH4] + at 291, [M+NH4 NH3] + at 308.

Example 1G 2-r6-(4-cvanophenyl)-2-naphthvilethyl 4-methylbenzenesulfonate

A mixture of the product from Example 1 F (0.48 g, 1.76 mmol), p- toluenesulfonyl chloride (0.37 g, 1.93 mmol, 1.1 equiv. ), and pyridine (3.0 mL, 37.1 mmol, 21.1 equiv. ) in anhydrous dichloromethane (20 mL) was stirred at room temperature under a dry nitrogen atmosphere for 3 days. The reaction mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and 10% aqueous citric acid. The aqueous layer was washed with ethyl acetate, and the combined organic extracts were washed with ' saturated aqueous NaHCO3, dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (6: 4 dichloromethane/hexane). Fractions containing product were combined and concentrated under reduced pressure to provide the product as a white solid (0.30 g, 40% yield).'H NMR (CDC13, 300 MHz) 5 8.01 (d, J=2 Hz, 1 H), 7.86-7. 75 (m, 6H), 7.72-7. 56 (m, 4H), 7.29 (dd, J=2,12 Hz, 1H), 7.17 (d, J=9 Hz, 2H), 4.34 (t, J=6 Hz, 2H), 3.14 (t, J=6 Hz, 2H), 2.36 (s, 3H). MS (DCI-NH3) [M+NH4] + at 445.

Example 1 H 4-(6-82-r (2 R)-2-methyl-1-pyrrolidinyllethylT-2-naphthyl) benzonitrile A mixture of the product from Example 1G (0.30 g, 1.08 mmol), (2R) -2- methylpyrrolidine (0.30 g, 3.52 mmol, 5.0 equiv. ), and cesium carbonate (0.70 g, 2.1 mmol, 3.0 equiv. ) in anhydrous acetonitrile (5 mL) was stirred in a sealed tube at 50 °C under a dry nitrogen atmosphere for 2 days. The reaction mixture was cooled to room temperature then concentrated under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous Na2CO3.

The aqueous layer was washed with ethyl acetate, and the combined organic extracts were washed with brine, dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (95: 5 : trace dichloromethane/methanol/NH40H). Fractions containing product were combined and concentrated under reduced pressure to provide the product as an off-white solid (0.130 g, 54.4% yield). This solid was dissolved in methanol and stirred with one equivalent of L-tartaric acid. The solvent was removed under reduced pressure to give the tartrate salt of the product as a white solid. M. p. 157.4-158. 1 °C.'H NMR (tartrate, CD30D, 300

MHz) 6 8.20 (d, J=2 Hz, 1 H), 8.01-7. 93 (m, 4H), 7.88-7. 81 (m, 4H), 7.53 (dd, J=2, 12 Hz, 1H), 4.40 (s, 2H), 3.81-3. 63 (m, 2H), 3.63-3. 50 (m, 1H), 3.40-3. 20 (m, 4H), 2.40-2. 27 (m, 1H), 2.18-2. 04 (m, 2H), 1.85-1. 70 (m, 1H), 1.47 (d, J=6 Hz, 3H).

MS (DCI-NH3) [M+H] + at 341.

Example 2 <BR> <BR> <BR> (2R)-1-[2-(6-bromo-2-naphthvl) ethvil-2-methylpyrrolidine<BR> <BR> <BR> ! Example 2A 2-(6-bromo-2-naphthyl) ethyl trifluoromethanesulfonate To a stirred, 0 °C solution of the product from Example 1 E (1.08 g, 4.3 mmol) and pyridine (0.46 mL, 5.6 mmol, 1.3 equiv. ) in anhydrous dichloromethane (40 mL) was added dropwise trifluoromethane sulfonic acid anhydride (0.87 mL, 5.16 mmol, 1.2 equiv. ). The reaction mixture was stirred at 0 °C for 1 hr, then treated with ice water (20 mL). The organic layer was isolated, dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure to give an oil that was purified by elution through a plug of silica gel with 95: 5 hexane/ethyl acetate. Fractions containing product were combined and concentrated under reduced pressure to give the product as an off-white solid (1.34 g, 81 % yield).'H NMR (CDC13, 300 MHz) 5 8.00 (d, J=2 Hz, 1H), 7.77-7. 64 (m, 3H), 7.56 (dd, J=2, 12 Hz, 1 H), 7.35 (dd, J=2,12 Hz, 1 H), 4.73 (t, J=6 Hz, 2H), 3.28 (t, J=6 Hz, 2H).

MS (DCI-NH3) [M+NH4] + at 400, [M+NH4 NH3] + at 417.

Example 2B (2R) ~ 2-(6-bromo-2-naphthvl) ethvil-2-methylpyrrolidine A mixture of the product from Example 2A (1.34 g, 3.5 mmol), (2R) -2- methylpyrrolidine (0.90 g, 10.57 mmol, 3.0 equiv. ), and cesium carbonate (3.42 g, 10.49 mmol, 3.0 equiv. ) in acetonitrile (15 mL) was stirred at 50 °C in a sealed tube for 18 hr. The reaction mixture was cooled to room temperature then concentrated under reduced pressure. The residue was partitioned between ethyl acetate and distilled water. The organic layer was washed with brine, then dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure to give a beige solid that was dissolved in Et20. The resulting solution was filtered

free of any insoluble material, then treated'with HCI (g) to give a white precipitate that was collected by filtration. This hydrochloride salt was dissolved in a minimum of water and sodium hydroxide was added to bring the pH to 14. This basic aqueous mixture was extracted with Et20. The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure to provide the free base product as a white solid (0.90 g, 80.8% yield). M. p. (HCI salt) 247.3- 250.7 °C. 1H NMR (free base, CD30D, 300 MHz) 5 8.00 (d, J=2 Hz, 1H), 7.77- 7. 67 (m, 3H), 7.52 (dd, J=2,12 Hz, 1H), 7.42 (dd, J=2,12 Hz, 1H), 3.32-3. 23 (m, 1 H), 3. 18-3. 03 (m, 1H), 3.03-2. 87 (m, 2H), 2.48-2. 24 (m, 3H), 2.07-1. 94 (m, 1H), 1.86-1. 73 (m, 2H), 1.52-1. 38 (m, 1H), 1.15 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 318.

Example 3 1-r3- (6-f2-r (2R)-2-methyl-1-pyrrolidinyllethyl-2-naphthyl) phenvIlethanone Example 3A 1- {3-r6- (2-hydroxvethyl)-2-naphthyllphenyllethanone A mixture of the product from Example 1 E (0.78 g, 3.11 mmol), 3- acetylphenylboronic acid (0. 61 g, 3.72 mmol, 1.2 equiv.), PdCl2 (PPh2) 2 (0.044 g, 0.062 mmol, 0.02 equiv), and K3PO4 H20 (1.80 g, 9.35 mmol, 3 equiv) in isopropanol (40 mL) and distilled water (15 mL) was stirred at 65 °C under a dry nitrogen atmosphere for 1.5 hr. The reaction mixture was cooled to room temperature then concentrated under reduced pressure. The residue was partitioned between ethyl acetate and brine. The aqueous layer was washed with ethyl acetate, and the combined organic extracts were washed with saturated aqueous NH4CI, dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (7: 3 hexane/ethyl acetate). Fractions containing product were combined and concentrated under reduced pressure to provide the product as an off-white solid (0.57 g, 63% yield).'H NMR (CD30D, 300 MHz) 8 8.31 (s, 1 H), 8.05 (s, 1 H), 8.92- 8.98 (m, 4H), 8.72-8. 79 (m, 2H), 8. 54 (t, J=7Hz, 1 H), 7.4 (d, J=5.7 Hz, 1 H), 3.96 (t,

J=5.3 Hz, 2H), 3.04 (t, J=5.3 Hz, 2H), 2.67, (s, 3H), 2.48 (bs, 1 H). MS (DCI-NH3) [M+H] + at 291 [M+NH4] + at 308.

Example 3B 2-f6- (3-acetylphenl)-2-naphth ly lethyl methanesulfonate To a stirred, 0 °C solution of the product from Example 3A (0.44 g, 1.49 mmol) and Et3N (0.30 g, 2.98 mmol, 2.0 equiv), methanesulfonyl chloride (0.24 g, 2.09 mmol, 1.4 equiv) was added dropwise via a syringe. After 15 minutes the ice bath was removed and the reaction mixture was stirred at room temperature for 1.5 hours. The reaction mixture was concentrated under reduced pressure. The residue was partitioned between brine and CH2CI2. The aqueous layer was washed with CH2CI2. The combined organic extracts were dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure to provide the product as an off-white solid (0.547 g, 99.6% yield).'H NMR (CDC13, 300 MHz) 8 8.28 (s, 1H), 8.05 (s, 1 H), 7.87-7. 98 (m, 4H), 7.72-7. 79 (m, 2H), 7.55 (t, J=5.6 Hz, 1 H), 7.38 (d, J=5.6 Hz, 1 H), 4.48 (t, J=6 Hz, 2H), 3.22 (t, J=6 Hz, 2H), 2.86 (s, 3H), 2.66 (s, 3H). MS (DCI-NH3) [M+NH4] + at 386.

Example 3C 1-f3- (6- 2-r (2R)-2-methyl-1-pyrrolidinyllethvl-2-naphthyl) phenyllethanone A mixture of the product from Example 3B (0.55 g, 1.48 mmol), (2R) -2- methylpyrrolidine (0.26 g, 3.05 mmol, 3 equiv), and Cs2CO3 (1.16 g, 3.56 mmol, 2 equiv) in anhydrous acetonitrile (30 mL) was stirred in a sealed tube at 45 °C for 18 hrs. The reaction mixture was cooled to room temperature then concentrated under reduced pressure. The residue was partitioned between ethyl acetate and aqueous 2 N NaOH. The aqueous layer was washed with ethyl acetate. The combined organic layers were dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (95: 5 : trace dichloromethane/methanol/NH40H). Fractions containing product were combined and concentrated under reduced pressure to provide the product as an off-white solid (0.115 g, 22% yield). The solid was dissolved in ether and treated with HCI (g) to provide the HCI salt.'H NMR

(CD30D, 300 MHz) 8 8.31 (s, 1H), 8.10 (s, 1H), 7.99 (s, 1H), 7.96 (s, 1 H), 7.89 (s, 1H), 7.87 (d, J=13. 3 Hz, 1H), 7.75 (d, J=5.8 Hz, 1H), 7.71 (s, 1H), 7.58 (t, J=6.7 Hz, 1H), 7.39 (d, J=5.8 Hz, 1H), 3.2-3. 28 (m, 1H), 3.1-3. 2 (m, 1H), 2.9-3. 03 (m, 2H), 2.67 (s, 3H), 2.37-2. 47 (m, 2H), 2.26 (q, J=7Hz, 1 H), 1.94-2. 05 (m, 1 H), 1.74- 1.85 (m, 2H) 1.39-1. 52 (m, 1H), 1.17 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 358.

@ Example 4 2-r3-(6-82-[(2R)-2-methyl-1-pyrrolid inyllethylT-2-naphthyl) phenyll-2-propanol To a mixture of the product from Example 3C (0.68 g, 1.91 mmol) in anhydrous THF (10 mL), was added CH3MgCl (0. 91 g, 7.64 mmol, 4 equiv) dropwise via a syringe. The reaction mixture was stirred at room temperature for 18 hrs. The reaction was quenched by the addition of aqueous K2HP04 (25 mL).

The reaction mixture was concentrated under reduced pressure. The residue was partitioned between aqueous 2 N NaOH and ethyl acetate. The aqueous layer was washed with ethyl acetate, and the combined organic extracts were dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (90: 10: 0.1 dichloromethane/methanol/NH40H). Fractions containing product were combined and concentrated under reduced pressure to provide the product as an off-white solid (0.118 g, 17% yield). The solid was dissolved in ether and treated with HCI (g) to provide the HCI salt.'H NMR (CD30D, 300 MHz) 5 8.05 (s, 1H), 7.87-7. 9 (m, 3H), 7.42 (d, J=6Hz, 1 H), 7.0 (s, 1H), 7.7 (d, J=5.3 Hz, 1 H), 7.45-7. 49 (m, 1 H), 7.42 (s, 1 H), 7.4 (s, 1H), 3.2-3. 28 (m, 1H), 3.1-3. 2 (m, 1H), 2.9-3. 03 (m, 2H), 2.37- 2.47 (m, 2H), 2.26 (q, J=7Hz, 1 H), 1.94-2. 05 (m, 1 H), 1. 74-1. 85 (m, 2H) 1.39-1. 52 (m, 1H), 1.61 (s, 6H), 1.17 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 374.

Example 5 6-2-f (2R)-2-methyl-1-pyrrolidinyllethyl}-2-naphthonitrile A mixture of the product from Example 2B (100 mg, 0.314 mmol), zinc cyanide (22 mg, 0.188 mmol, 0.6 equiv. ), Pd2 (dba) 3 (14 mg, 0.016 mmol, 0.05 equiv. ), 1,1'-bis (diphenylphosphino) ferrocene (21 mg, 0.038 mmol, 0.12 equiv. ) in

DMF (5 mL) and distilled water (0.05 mL) was stirred under a dry nitrogen atmosphere at 120 °C for 24 hr. The reaction mixture was cooled to 80 °C and treated with 4: 1: 4 saturated aqueous NH4CI/NH40H/water, and stirred overnight while cooling to room temperature. The mixture was extracted with ethyl acetate.

The organic layer was washed first with 4: 1: 5 saturated aqueous NH4CI/NH40H/water, then with brine. The organic layer was dried (MgSO4), and filtered. The filtrate. was concentrated under reduced pressure and the residue was purified by column chromatography (97: 3 : trace dichloromethane/methanol/NH40H). Fractions containing product were combined and concentrated under reduced pressure and the residue was dissolved in Et20.

The solution was treated with HCI (g) and the mixture was concentrated under reduced pressure to provide the hydrochloride salt of the product as a white solid (51 mg, 43% yield). M. p. 187.4-188. 6 °C 1H NMR (CD30D, 300 MHz) o 8.38 (s br, 1 H), 8.03 (d, J=2 Hz, 1 H), 8.00 (d, J=2 Hz, 1 H), 7.94 (s br, 2H), 7.68 (dd, J=2, 12 Hz, 1 H), 7.63 (dd, J=2,12 Hz, 1H), 3.84-3. 67 (m, 2H), 3.63-3. 48 (m, 1H), 3.43- 3.19 (m, 4H), 2. 43-2. 29 (m, 1H), 2.24-2. 01 (m, 2H), 1.84-1. 68 (m, 1H), 1.48 (d, J=7 Hz, 3H). MS (DCI-NH3) [M+H] + at 265.

Example 6 4- (6-ff (2R)-2-methyl-1-pyrrolidinyllmethyl-2-naphthyl) benzonitrile Example 6A 4- [6- (hydroxymethyl)-2-naphthyllbenzonitrile A mixture of the product from Example 1A (0.119 g, 0.50 mmol), 4- cyanophenylboronic acid (0.088 g, 0.60 mmol, 1.2 equiv. ), PdCI2 (PPh3) 2 (7 mg, 0.001 mmol, 0.020 equiv. ) and K3PO4 H2O (288 mg, 1.5 mmol, 3.0 equiv. ) in isopropanol (10 mL) and distilled water (4 mL) was stirred at 50 °C under a dry nitrogen atmosphere for 1. 5 hr. The reaction mixture was cooled to room temperature then concentrated under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous NH4CI. The organic layer was dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (65: 35 hexane/ethyl acetate). Fractions containing product were combined and

concentrated under reduced pressure to provide the product as a white solid (95 mg, 73% yield). M. p. 174.1-175. 5 °C aH NMR (CDC13, 300 MHz) 6 8.06 (d, J=2 Hz, 1H), 7.97-7. 70 (m, 8H), 7.54 (dd, J=2,12 Hz, 1H), 4.90 (dbr, J=6 Hz, 2H), 1.78 (tbr, J=6 Hz, 1H). MS (DCI-NH3) [M+NH4] + at 277, [M+NH4 NH3] + at 294.

Example 6B <BR> <BR> <BR> 4-f6- (chloromethyl)-2-naphthyllbenzonitrile<BR> <BR> @ A mixture of the product from Example 6A (90 mg, 0.347 mmol), 0.5 M Zinc12 in THF (0.21 mL, 0.104 mmol, 0.3 equiv. ), and thionyl chloride (0.51 mL, 6.94 mmol, 20.0 equiv. ) in dioxane (40 mL) was stirred at room temperature under a dry nitrogen atmosphere for 3 hr. The reaction mixture was concentrated under reduced pressure and the residue was partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was dried (MgS04), and filtered.

The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (95: 5 hexane/ethyl acetate). Fractions containing product were combined and concentrated under reduced pressure to provide the product as a white solid (91 mg, 94.4% yield). M. p. 147.5-149. 2 °C aH NMR (CDC13, 300 MHz) 5 8.05 (d, J=2 Hz, 1H), 7.97-7. 90 (m, 2H), 7.89-7. 84 (m, 1H), 7.84-7. 71 (m, 5H), 7.57 (dd, J=2,12 Hz, 1H), 4.78 (s, 2H). MS (DCI-NH3) [M+NH4] + at 295, [M+NH4 NH3] + at 312.

Example 6C 4- (6-f [ (2R)-2-methyl-1-pyrrolidinyllmethyl-2-naphthyl) benzonitrile A mixture of the product from Example 6B (90 mg, 0.324 mmol), (2R) -2- methylpyrrolidine (138 mg, 1.62 mmol, 5.0 equiv. ), and cesium carbonate (317 mg, 0.972 mmol, 3.0 equiv. ) in acetonitrile (10 mL) in a seated tube was stirred at 45 °C for 3 hr then for 2 days at room temperature. The reaction mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and distilled water. The organic layer was dried (MgS04), and filtered.

The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (97: 3 : trace dichloromethane/methanol/NH40H). Fractions containing product were combined and concentrated under reduced pressure and the residue was dissolved in Et2O.

The solution was treated with HCI (g) and the precipitate was collected by filtration to provide the hydrochloride salt of the product as a white solid (51 mg, 43% yield). M. p. 212.6-213. 6 °C.'H NMR (CD30D, 300 MHz) 5 8.29 (d, J=2 Hz, 1H), 8.15-8. 06 (m, 3H), 7.98 (d, J=9 Hz, 2H), 7.93 (dd, J=2,12 Hz, 1H), 7.86 (d, J=9 Hz, 2H), 7.67 (dd, J=2,12 Hz, 1 H), 4.77 (, J=3 Hz, 1H), 4.37 (d, J=3 Hz, 1H), 3.75-3. 61 (m, 1 H), 3.46-3. 30 (m, 2H), 2.48-2. 35 (m, 1 H), 2.22-1. 92 (m, 2H), 1.86- 1.72(m, 1H), 1.47(d, J=7 Hz, 3H). MS(DCl-NH3)[M+H]+ at 327.

Example 7 3- (6-f 2-r (2R)-2-methyl-1-pyrrolidinyllethyl-2-naphthyl) benzonitrile Example 7A 3-96-(2-hydroxyethyl)-2-naphthyllbenzonitrile The title compound was prepared by the method of Example 3A, substituting 3-cyanophenylboronic acid in place of 3-acetylphenylboronic acid (0.21 g, 96% yield). 1H NMR (CDCl3, 300 MHz) # 8.03-7.97(m, 2H), 7.97-7.86 (m, 3H), 7.76-7.55(m, 4H), 7.43(dd, J=2, 12 Hz, 1H), 3.98(t, J=6 Hz, 2H), 3.07(t, J=6 Hz, 2H). MS (DCI-NH3) [M+NH4] + at 291, [M+NH4 NH3] + at 308.

Example 7B 2-f6- (3-cyanophenyl)-2-naphthyllethyl trifluoromethanesulfonate To a stirred, 0 °C solution of the product from Example 7A (0.21 g, 0.768 mmol) and pyridine (0.08 mL, 1.0 mmol, 1.3 equiv. ) in anhydrous dichloromethane (15 mL) was added dropwise trifluoromethane sulfonic acid anhydride (0.16 mL, 0.922 mmol, 1.2 equiv. ). The reaction mixture was stirred at 0 °C for 30 minutes, then treated with ice water (20 mL). The organic layer was isolated, dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure to give an oil that was purified by column chromatography (95: 5 to 70: 30 hexane/ethyl acetate). Fractions containing product were combined and concentrated under reduced pressure to give the product (60 mg, 19% yield).'H NMR (CD3, 300 MHz) 5 8.02-7. 87 (m, 5H), 7.76-7. 55 (m, 4H), 7.40 (dd, J=2,12 Hz, 1H), 4.80 (t, J=6 Hz, 2H), 3.32 (t, J=6 Hz, 2H). MS (DCI-NH3) [M+NH4] +at 423.

Example 7C 3- (6-12- [ (2R)-2-methyl-1-pyrrolidinyllethyll-2-naphthyl) benzonitrile The title compound was prepared by the method of Example 3C, substituting the product from Example 7B for the product from Example 3B (21 mg, 38% yield). M. p. 228. 5-231.6 °C. 1H NMR (CD30D, 300 MHz) # 8.23 (d, J=2 Hz, 1H), 8.20-8. 18 (m, 1H), 8.14-8. 09 (m, 1H), 8.04-7. 98 (m, 2H), 7.90-7. 85 (m, 2H), 7.70-7. 65 (m, 2H), 7.60 (t, J=7 Hz, 2H), 7.54 (dd, J=2,12 Hz, 1H), 3.81-3. 63 (m, 2H), 3. 60-3.48 (m, 1H), 3.40-3. 13 (m, 4H), 2.39-2. 24 (m, 1H), 2.18-2. 00 (m, 2H), 1.82-1. 67 (m, 1 H), 1.46 (d, J=7 Hz, 3H). MS (DCI-NH3) [M+H] + at 341.

Example 8 4-(6-82-r (2 R)-2-methyl-1-pyrrolid inyllethylT-2-naphthyl) pyridine A mixture of the product from Example 2B (50 mg, 0.157 mmol), 4- <BR> <BR> <BR> pyridinylboronic acid (48 mg, 0.393 mmol, 2.5 equiv. ), PdCI2 (PPh3) 2 (6 mg, 0.0085 mmol, 0.054 equiv. ) and K3PO4 H20 (181 mg, 0.943 mmol, 6.0 equiv. ) in isopropanol (5 mL) and distilled water (2 mL) was stirred at 60 °C under a dry nitrogen atmosphere for 1 hr. The reaction mixture was cooled to room temperature then concentrated under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was dried (MgSO4), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (95: 5 : trace dichloromethane/methanol/NH40H). Fractions containing product were combined and concentrated under reduced pressure to provide the product as an off-white solid that was dissolved in Et20 and treated with HCI (g). This mixture was concentrated under reduced pressure to provide the dihydrochloride salt of the product as an off-white, hygroscopic solid (21 mg, 34% yield NMR (CD30D, 300 MHz) 5 8.90 (d, J=6 Hz, 2H), 8.63 (d, J=2 Hz, 1 H), 8.56 (d, J=6 Hz, 2H), 8.15-8. 05 (m, 3H), 7.98-7. 95 (m, 1H), 7.64 (dd, J=2,12 Hz, 1H), 3.86-3. 69 (m, 2H), 3.65-3. 50 (m, 1H), 3.45-3. 19 (m, 4H), 2.44-2. 30 (m, 1H), 2.28-2. 01 (m, 2H), 1.85-1. 70 (m, 1 H), 1.50 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 317.

Example 9

3-(6-82-r (2R)-2-methyl-1-pyrrolidinyllethylT-2-naphthyl) PYrid ine The title compound was prepared by the method in Example 8, substituting 3-pyridinylboronic acid in place of 4-pyridinylboronic acid (16 mg, 26% yield).'H NMR (CD30D, 300 MHz) 5 9.35-9. 32 (m, 1H), 9.11-9. 06 (m, 1H), 8.89-8. 85 (m, 1 H), 8.41 (d, J=2 Hz, 1 H), 8.26-8. 20 (m, 1 H), 8.08 (t, J=9 Hz, 2H), 7.98-7. 93 (m, 2H), 7.62 (dd, J=2,12 Hz, 1H), 3.86-3. 69 (m, 2H), 3.65-3. 49 (m, 1H), 3.45-3. 22 (m, 4H), 2.43-2. 31 (m, 1H), 2.23-2. 01 (m, 2H), 1.86-1. 71 (m, 1H), 1.51 (d, J=7 Hz, 3H). MS (DCI-NH3) [M+H] at 317.

Example 10 (3-fluorophenyl) (6-{2-r (2 R)-2-methyl-1-pyrrolidinyllethylS2-naphthVl) methanol A 1.7 M solution of t-butyllithium in pentane (0.41 mL, 0.691 mmol, 2.2 equiv. ) was added dropwise to a stirred,-78 °C solution of the product from Example 2B (100 mg, 0.314 mmol) in anhydrous THF (3 mL). The reaction mixture was stirred at-78 °C for 20 min then 3-fluorobenzaldehyde (0.04 mL, 0.377 mmol, 1.2 equiv. ) was added dropwise to the reaction mixture. After stirring at-78 °C for 10 min, the reaction mixture was allowed to reach room temperature then partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was dried (MgSO4), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by preparative TLC (95: 5 : trace dichloromethane/methanol/NH40H). The band containing product was isolated and eluted with 95: 5 : trace dichloromethane/methanol/NH40H. The resulting solution was concentrated under reduced pressure to provide the free base product as a white solid (3.2 mg, 2.5% yield).'H NMR (CD30D, 300 MHz) 5 7.84- 7.72 (m, 3H), 7.66-7. 63 (m, 1H), 7.42-7. 26 (m, 3H), 7.22-7. 13 (m, 2H), 6.98-6. 91 (m, 1H), 5.91 (s, 1H), 3.32-3. 23 (m, 1H), 3.19-3. 09 (m, 2H), 2.51-2. 26 (m, 3H), 2.06-1. 94 (m, 1H), 1.85-1. 74 (m, 2H), 1.52-1. 38 (m, 1H), 1.15 (d, J=7 Hz, 3H).

MS (DCI-NH3) [M+H] + at 364.

Example 11 3, 5-dimethyl-4-(6-82-[(2R)-2-methyl-1-pyrrolidinyllethylT-2-na phthyl) isoxazole The title compound was prepared by the methods of Example 3A-3C, substituting 3, 5-dimethyl-4-isoxazolylboronic acid in place of 3-

acetylphenylboronic acid in Example 3A (38 mg, 12% yield).'H NMR (CD30D, 300 MHz) 5 7.95 (dd, J=2,12, 2H), 7.85 (dbr, J=12 Hz, 2H), 7.56-7. 45 (m, 2H), 3.84-3. 65 (m, 2H), 3.63-3. 47 (m, 1H), 3.43-3. 15 (m, 4H), 2.46 (s, 3H), 2.42-2. 26 (m, 1H), 2.30 (s, 3H), 2.21-2. 01 (m, 2H), 1.84-1. 68 (m, 1H), 1.48 (d, J=7 Hz, 3H).

MS (DCI-NH3) [M+H] + at 335.

Example 12 <BR> <BR> @<BR> <BR> 4-(6-82-r (2S)-2-(hydroxymethyl)-1-pyrrolidinyllethylT-2-naphthyl) benzonitrile The title compound was prepared by the method of Example 1 H, substituting (2S)-2-pyrrolidinylmethanol in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 5 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d. J=6Hz, 1H), 3.51-3. 64 (m, 2H), 3.2-3. 34 (m, 2H), 2.93-3. 1 (m, 2H), 2.69- 2.75 (m, 2H), 2.4 (q, J=6Hz, 1H), 1.9-2. 4 (m, 1 H), 1.95-2. 05 (m, 2H), 1.81-1. 91 (m, 1 H). MS (DCI-NH3) [M+H] + at 357.

Example 13 4-(6-{2-[(3R)-3-hydroxy-1-pyrrolidinyl]ethyl}-2-naphthyl)ben zonitrile The title compound was prepared by the method of Example 1 H, substituting (3R)-3-pyrrolidinol in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 58. 13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d.

J=6Hz, 1 H), 4. 34-4. 43 (m, 1 H), 2.82-3. 08 (m, 6H), 2.67-2. 78 (m, 1 H), 2.61 (d, J=5.7 Hz, 1 H), 2.11-2. 24 (m, 1 H), 1.71-2. 03 (m, 1 H). MS (DCI-NH3) [M+H] + at 343.

Example 14 4-f 6- [2- (2-isobutyl-1-pyrrolid inyl) ethyll-2-naphthyl} benzonitrile The title compound was prepared by the method of Example 1 H, substituting 2-isobutylpyrrolidine in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 6 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d.

J=6Hz, 1H), 3.31-3. 44 (m, 2H), 2.9-3. 11 (m, 2H), 2.4-2. 53 (m, 2H), 2.31 (q, J=5.7 Hz), 1.9-2. 12 (m, 2H), 1.4-1. 65 (m, 3H), 1.22-1. 36 (m, 1H),. 92 (d, J=5.6 Hz, 3H), . 87 (d, J=5.6 Hz, 3H). MS (DCI-NH3) [M+H] + at 383.

Example 15 4- (6- [2- (2-isopropvl-1-pyrrolidinyl) ethyll-2-naphthylbenzonitrile The title compound was prepared by the method of Example 1 H, substituting 2-isopropylpyrrolidine in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 6 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d.

J=6Hz, 1H), 3.11-3. 22 (m, 1H), 2.91-3. 1 (m, 2H), 2.46-2. 62 (m, 1H), 2.41-2. 45 (m, 2H), 1.8-1. 93 (m, 1 H), 1.68-1. 8 (m, 4H), 1.54-1. 63 (m 1 H),. 92 (d, J=5.6 Hz, 3H), . 79 (d, J=5. 6 Hz, 3H). MS (DCI-NH3) [M+H] + at 369.

Example 16 4-(6-{2-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]ethyl}-2-naph thyl)benzonitrile The title compound was prepared by the method of Example 1 H, substituting (3R)-N, N-dimethyl-3-pyrrolidinamine in place of (2R)-2- methylpyrrolidine. 1H NMR (CD30D, 300 MHz) 5 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d. J=6Hz, 1 H), 2.98-3. 08 (m, 4H), 2.83-2. 95 (m, 3H), 2.72-2. 76 (m, 1H) 2.5-2. 58 (m, 1H), 2.31 (s, 6H), 2.01-2. 13 (m, 1H), 1.75-1. 85 (m, 1 H). MS (DCI-NH3) [M+H] + at 370.

Example 17 4-46-r2- (diethylamino) ethyll-2-naphthyl} benzonitrile The title compound was prepared by the method of Example 1 H, substituting diethylamine in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 6 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d. J=6Hz, 1 H), 3.53 (t, J=3.3 Hz, 2H), 3.31 (q, J=3.6 Hz, 4H), 3.22 (t, J=3.3 Hz, 2H), 1.35 (t, J=3.6 Hz, 6H). MS (DCI-NH3) [M+H] + at 329.

Example 18 4-{6-[2-(dimethylamino)ethyl]-2-naphthyl}benzonitrile The title compound was prepared by the method of Example 1 H, substituting dimethylamine in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 5 8. 13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d. J=6Hz, 1 H), 3.49-3. 54 (t, J=3.3 Hz, 2H), 3.23-3. 28 (t, J=3.3 Hz, 2H), 2.97 (s, 6H). MS (DCI-NH3) [M+H] +at 301.

Example 19 4- (6-f 2-rethyl (isopropyl) aminolethyl}-2-naphthyl) benzonitrile The title compound was prepared by the method of Example 1 H, substituting isopropylethylamine in place of (2R)-2-methylpyrrolidine. IH NMR (CD30D, 300 MHz) 5 8.13 (s, 1H), 7. 87-7, 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d.

J=6Hz, 1H), 3.8-3. 87 (m, 1H), 3.1-3. 57 (m, 6H), 1.31-1. 45 (m, 9H). MS (DCI-NH3) [M+H] + at 343.

Example 20 4-(6-82-rtert-butyl (methvl) aminolethyl}-2-naphthyl) benzonitrile The title compound was prepared by the method of Example 1 H, substituting t-butylmethylamine in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 5 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d.

J=6Hz, 1H), 3.68-3. 75 (m, 1H), 3.3-3. 43 (m, 2H), 2.31-3. 28 (m, 1 H), 3.11-3. 19 (m, 1 H), 2.7 (s, 3H), 1.45 (s, 9H). MS (DCI-NH3) [M+H] + at 343.

Example 21 4-(6-82-[(2S)-2-methvl-1-pyrrolidinyllethylE-2-naphthyl) benzonitrile The title compound was prepared by the method of Example 1 H, substituting (2S)-2-methylpyrrolidine in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) # 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d.

J=6Hz, 1H), 3.34-3. 45 (m, 1H), 3.24-3. 35 (m, 1H), 2.97-3. 18 (m, 2H), 2.55-2. 78 (m, 3H), 2.02-2. 15 (m, 1H) 1.82-1. 94 (m, 2H), 1.48-1. 59 (m, 1H), 1.11 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 341.

Example 22 4-(6-{2-[(2R)-2-methyl-1-piperidinyl]ethyl}-2-naphthyl)benzo nitrile The title compound was prepared by the method of Example 1 H, substituting (2R)-2-methylpiperidine in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 5 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d.

J=6Hz, 1H), 2.86-3. 13 (m, 5H), 2.49-2. 55 (m, 2H), 1.67-1. 81 (m, 4H), 1.33-1. 46 (m, 2H), 1.08 (d, J=6Hz, 3H). MS (DCI-NH3) [M+H] + at 355.

Example 23 4-{6-[2-(2,5-dihydro-1H-pyrrol-1-yl)ethyl]-2-naphthyl}benzon itrile The title compound was prepared by the method of Example 1 H, substituting 2, 5-dihydro-1H-pyrrole in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 6 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d.

J=6Hz, 1 H), 5.83, (s, 2H), 3.57 (m, 4H), 2.99 (m, 4H). MS (DCI-NH3) [M+H] + at 325.

Example 24 4-(6-{2-[methyl(propyl)amino]ethyl}-2-naphthyl)benzonitrile The title compound was prepared by the method of Example 1 H, substituting propylmethylamine in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 5 8. 13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d.

J=6Hz, 1 H), 2.94-3. 03 (m, 2H), 2.74-2. 81 (m, 2H), 2.45-2. 53 (m, 2H), 2.38 (s, 3H), 1.51-1. 65 (m, 2H),. 91 (t, J=6.3 Hz, 3H). MS (DCI-NH3) [M+H] + at 329.

Example 25 4-(6-82-[(2-hydroxyethyl) (methvl) aminolethyl}-2-naphthyl) benzonitrile The title compound was prepared by the method of Example 1 H, substituting 2-(methylamino) ethanol in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 5 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d.

J=6Hz, 1 H), 3.67 (t, J=6 Hz, 2H), 2.96-3. 04 (m, 2H), 2.90-2. 98 (m, 2H), 2.66 (t, J=5.3 Hz, 2H), 2.42 (s, 3H). MS (DCI-NH3) [M+H] + at 331.

Example 26 5-(642-r (2R)-2-methyl-1-pyrrolidinyllethylT-2-naphthYl) pyrimidine Example 26A [2- (6-bromo-2-naphthyl) ethoxyl (tert-butyl) dimethylsilane A stirred solution of the product from Example 1 E (2.51 g, 10 mmol), imidazole (0.715 g, 10.5 mmol, 1.05 equiv), and DMAP (8 mg, 0.066 mmol,

0.0066 equiv.) in anhydrous dichloromethane (65 mL) was chilled at 0 °C under a dry nitrogen atmosphere. A solution of t-butyldimethylsilyl chloride in anhydrous dichloromethane (15 mL) was added slowly to the reaction mixture. When the addition was complete, the reaction mixture was allowed to warm to room temperature and stirred for 18 hr. An aqueous solution of citric acid (10%) was added to the reaction mixture. The organic layer was washed with brine then dried (MgSO4), and filtered. The filtrate was concentrated under reduced @ pressure and the residue was purified by column chromatography (100% hexane).

Fractions containing product were combined and concentrated under reduced pressure to provide the product as a white solid (3.25 g, 89% yield). 1H NMR (CD3, 300 MHz) 8 7.95 (d, J =2 Hz, 1 H), 7.68-7. 60 (m, 3H), 7.50 (dd, J=2,12 Hz, 1H), 7.37 (dd, J=2,12 Hz, 1H), 3.88 (t, J=6Hz, 2H), 2.96 (t, J=6 Hz, 2H), 1.46 (s, 9H), -0.04 (s, 6H). MS (DCI-NH3) [M+H] + at 365, [M+NH4] + at 382.

Example 26B <BR> <BR> <BR> <BR> ter-butyl (dimethyl) f2-r6- (4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolan-2-yl)-2-<BR> <BR> <BR> <BR> <BR> naphthyllethoxy} silane A solution of the product from Example 26A (920 mg, 2.518 mmol), <BR> <BR> <BR> Pd (OAc) 2, (28 mg, 0.126 mmol, 0.05 equiv. ), 2- (dicyclohexylphosphino) biphenyl (176 mg, 0.504 mmol, 0.2 equiv. ), and Et3N (1.4 mL, 10.07 mmol, 4 equiv. ) in dioxane (15 mL) was stirred under a dry nitrogen atmosphere at room temperature. Pinacolborane (1.1 mL, 7.553 mmol, 3 equiv. ) was added dropwise to the reaction mixture. When the addition was complete, the reaction was stirred at 80 °C for 1 hr. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. The residue was partitioned between saturated aqueous NH4CI and Et20. The organic layer was dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (98: 2 hexane/ethyl acetate). Fractions containing product were combined and concentrated under reduced pressure to give the product as a yellow solid (660 mg, 64% yield). NMR (CDCl3, 300 MHz) 8 8.32 (d, J = 2 Hz, 1 H), 7. 83- 7. 77 (m, 3H), 7.64-7. 62 (m, 1 H), 7.33 (dd, J = 2,12

Hz, 1H), 4.51 (t, 5.7 J = Hz, 2H), 3.22 (t, J = 5.7 Hz, 2H), 1.39, (s, 12H), 0.86 (s, 9H), 0.04 (s, 6H). MS (DCI-NH3) [M+NH4] + at 430.

Example 26C 5-r6-(2-81tert-butyl (dimethyl) silylloxyTethyl)-2-naphthvllpyrimidine A solution of the product from Example 26B (206 mg, 0.5 mmol), 5- bromopyrimidine (79.5 mg, 0.5 mmol), Pd (PPh3) 4 (28.9 mg, 0.025 mmol, 0.05 equiv.), and Na2C03 (106 mg, 1 mmol, 2 equiv. ) in toluene (10 mL) and distilled water (1. 5 mL) was stirred at reflux under a dry nitrogen atmosphere for 3 hr.

After cooling to room temperature, the mixture was concentrated under reduced pressure and the residue was partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (8: 2 hexane/ethyl acetate). Fractions containing product were combined and concentrated under reduced pressure to give the product as an off- white solid (57 mg, 31%). 1H NMR (CDCl3, 300 MHz) 6 9.23 (Sbr, 1H), 9.08 (Sbr, 2H), 8.02 (d, J=2Hz, 1H), 7.93 (dbr, J=7 Hz, 1H), 7.86 (dbr, J=7 Hz, 1 H), 7.72 (Sbr, 1H), 7.66 (dd, J=2,12 Hz, 1H), 7.44 (dd, J=2,12 Hz, 1H), 3.92 (t, J=6 Hz ; 2H), 3.01 (t, J=6 Hz, 2H), 0.88 (s, 9H), -0. 02 (s, 6H). MS (DCI-NH3) [M+H] + at 365.

Example 26D 2-f6- (5-pyrimidinyl)-2-naphthyllethanol A solution of the product from Example 26C (56 mg, 0.154 mmol) and TBAF-H20 (48 mg, 0.184 mmol, 1.2 equiv. ) in THF (3 mL) was stirred at room temperature under a dry nitrogen atmosphere for 30 min. The mixture was then partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was washed with brine then dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure to give the title compound as an off-white solid (32 mg, 83% yield) which was used in the next step without further purification.

Example 26E 2- [6- (5-pyrimidinyl)-2-naphthyllethvl methanesulfonate

The title compound was prepared by the method of Example 3B, substituting the product from Example 26D in place of the product from Example 3A to give an off-white solid.

Example 26F 5- (6-2- [ (2R)-2-methyl-1-pyrrolidinyllethyl-2-naphthyl) pyrimidine The title compound was prepared by the method of Example 3C substituting the product from Example 26E in place of the product from Example 3B (17 mg, 36% yield).'H NMR (CD30D, 300 MHz) 5 9.35 (Sbr, 2H), 9.28 (Sbr, 1H), 8.32 (d, J=2Hz, 1H), 8.09-8. 03 (m, 2H), 7.94-7. 88 (m, 2H), 7.60-7. 55 (m, 1H), 3.85-3. 69 (m, 2H), 3. 62-3. 50 (m, 1H), 3.44-3. 18 (m, 4H), 2. 43-2 : 30 (m, 1H), 2.27- 2.01 (m, 2H), 1.84-1. 70 (m, 1H), 1.50 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 318.

Example 27 4- (6-2- [ (2R)-2-methyl-1-pyrrolidinyllethyl}-2-naphthyl) morpholine A mixture of the product from Example 2B (318 mg, 1.0 mmol), morpholine <BR> <BR> <BR> <BR> (0.87 mL, 1.0 mmol), Pd2 (dba) 3 (18.3 mg, 0.02 mmol, 0.02 equiv. ), (t-Bu) 3P (3.6 mg, 0.016 mmol, 0.016 equiv. ), and sodium t-butoxide (144.2 mg, 1.5 mmol, 1.5 equiv. ) in toluene (2 mL) was stirred at room temperature under a dry nitrogen atmosphere for 66 hr. The reaction mixture was partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was then washed with brine, dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (97: 3 : trace dichloromethane/methanol/NH40H). Fractions containing product were combined and concentrated under reduced pressure to provide the product that was dissolved in Et20 and treated with HCI (g). This mixture was concentrated under reduced pressure to provide the dihydrochloride salt of the product as an off- white, hygroscopic solid (100 mg, 31% yield). 1H NMR (CD3OD, 300 MHz) # 8. 21 (d, J=6 Hz, 2H), 8.12-8. 00 (m, 2H), 7.95 (Sbr, 3H), 7.80 (dd, J=2,12 Hz, 1H), 7.64 (dd, J=2,12 Hz, 1H), 4.18-4. 13 (m, 4H), 3.94-3. 67 (m, 2H), 3.92-3. 87 (m, 4H), 3.63-3. 47 (m, 1H), 3.47-3. 21 (m, 4H), 2.42-2. 30 (m, 1 H), 2.23-2. 00 (m, 2H), 1.85- 1.70 (m, 1 H), 1.50 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 325.

Example 28 2- (6-f 2-r (2R)-2-methyl-1-pyrrolidinyllethyl}-2-naphthyl)-1, 3-thiazole Example 28A 2-[6-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-naphthyl]-1 ,3-thiazole The title compound was prepared by the method in Example 26C, substituting 2-bromothiazole in place of 5-bromopyrimidine (40 mg, 22% yield).

1 H NMR (CD13, 300 MHz) 5 8.44 (d, J=2 Hz, 1H), 8.07 (dd, J=2,12 Hz, 1H), 7.93 (d, J=3Hz, 1H), 7.19-7. 84 (m, 2H), 7.70-7. 68 (m, 1H), 7.42 (dd, J=2, 12, 1H), 7.38 (d, J=3 Hz, 1 H), 3.93 (t, J=6 Hz, 2H), 3.02 (t, J=6 Hz, 2H), 0.89 (s, 9H), 0.02 (s, 6H). MS (DCI-NH3) [M+H] + at 370.

Example 28B 2-[6-(1,3-thiazol-2-yl)-2-naphtyl]ethanol The title compound was prepared by the method in Example 26D, substituting the product from Example 28A in place of the product from Example 26C.

Example 28C 2- [6- (1, 3-thiazol-2-yl)-2-naphthyllethyl methanesulfonate The title compound was prepared by the method of Example 3B, substituting the product from Example 28B in place of the product from Example 3A to give an off-white solid.

Example 28D 2-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-naphthyl)-1,3 -thiazole The title compound was prepared by the method of Example 3C substituting the product from Example 28C in place of the product from Example 3B (hydrochloride salt, 4 mg, 14% yield NMR (CD30D, 300 MHz) 6 8.55 (d, J=2Hz, 1H), 8.12 (d, J=3 Hz, 1H), 8.10-8. 02 (m, 3H), 7.95-7. 92 (m, 1H), 7.89 (d, J=3 Hz, 1H), 7.61 (dd, J=2, 12 Hz, 1H), 3.84-3. 69 (m, 2H), 3.64-3. 49 (m, 1H),

3.43-3. 19 (m, 4H), 2.43-2. 30 (m, 1H), 2.23-2. 00 (m, 2H), 1.83-1. 69 (m, 1H), 1.50 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 323.

Example 29 4-(6-82-[(2S)-2-(fluoromethyl)-1-Pvrrolid inyllethyl}-2-naphthyl) benzon itrile The title compound was prepared by the method of Example 1 H, substituting (2S)-2- (fluoromethyl) pyrrolidine in place of (2R)-2-methylpyrrolidine.

H NMR (CD30D, 300 MHz) # 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d. J=6Hz, 1H), 4.44 (d, J=1.3 Hz, 1H), 4.28 (d, J=1.3 Hz, 1H), 3.18-3. 35 (m, 2H), 2.98-3. 06 (m, 2H), 2.84-2. 99 (m, 1 H), 2.69-2. 78 (M, 1 H), 2.41-2. 53 (m, 1 H), 1.92-2. 03 (m, 1 H), 1.75-1. 88 (m, 2H), 1.58-1. 7 (m, 1 H). MS (DCI-NH3) [M+H] + at 359.

Example 30 <BR> <BR> <BR> <BR> (3-fluorophenyl) (642-[(2R)-2-methyl-1-pyrrolid inyllethvlT-2-naphthel) methanone A mixture of the product from Example 10 (3.2 mg, 0.009 mmol) and manganese dioxide (5.4 mg, 0.062 mmol, 7 equiv. ) in anhydrous dichloromethane (1 mL) was stirred at room temperature for 3.5 hr. The reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. The residue was purified by preparative TLC (95: 5 : trace dichloromethane/methanol/NH40H). The band containing product was isolated and eluted with 95: 5 : trace dichloromethane/methanol/NH40H. The resulting solution was concentrated under reduced pressure to provide the free base product (0.91 mg, 28.5% yield). 1H NMR (CD30D, 300 MHz) 6 8.27 (d, J=2 Hz, 1 H), 8.02-7. 86 (m, 4H), 7.65-7. 51 (m, 4H), 7.46-7. 39 (m, 1 H), 3.56-3. 37 (m, 2H), 3.26-3. 07 (m, 2H), 3.02-2. 74 (m, 2H), 2.21-2. 10 (m, 1H), 2.02-1. 88 (m, 2H), 1.69- 1.52 (m, 2H), 1.30 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 362.

Example 31 <BR> <BR> <BR> <BR> 2- (6-f 2-r (2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl)-2-naphthalen-2-vl)-2 H-pvridazin-3- one Example 31A

(6-Bromo-naphthalen-2-yl)-methanol To a stirred 1.0 M solution of lithium aluminum hydride (108 mL, 108 mmol) was added dropwise over 20 min a solution of methyl 6-bromo-2-naphthoate (18.9 g, 71.3 mmol) in THF (180 mL), while maintaining the reaction temperature below - 5 °C. When the addition was complete, the reaction mixture was stirred at-10 °C for 1 hr, then quenched by the sequential dropwise addition of distilled water (4 mL), 2 N aqueous Na2CO3 (4 mL), and distilled water (12 mL). After stirring for 15 min at room temperature, the reaction mixture was filtered. The filter cake was washed with ethyl acetate (3 x 100 mL) and the combined filtrates were dried (MgS04) and filtered. This filtrate was concentrated under reduced pressure to give a white solid. Drying under vacuum overnight at 40 °C provided the product (16.84 g, 99% yield). M. p. 149.9-151. 6 °C.'H NMR (CD3, 300 MHz) 5 7.99 (d, J=2 Hz, 1H), 7.79-7. 67 (m, 3H), 7.55 (dd, J=2,12 Hz, 1H), 7.52 (dd, J=2,12 Hz, 1 H), 4.85 (s, 2H). MS (DCI-NH3) [M] +at 236.

Example 31 B 2-Bromo-6-chloromethyl-naphthalene A stirred solution of the product from Example 31A (30.5 g, 129 mmol) in dioxane (320 mL) under a dry nitrogen atmosphere was chilled to-10 °C. Solid anhydrous Zinc12 (514 mg, 3.77 mmol, 0.03 equiv. ) was added in one lot, followed by the dropwise addition of thionyl chloride (19.3 mL, 264 mmol, 2.0 equiv. ). The reaction mixture was allowed to warm to room temperature then stirred an additional 2 hr. This reaction mixture was then concentrated under reduced pressure and the residue was partitioned between dichloromethane and saturated aqueous NaHCO3 (500 mL). The organic layer was washed with brine (2 x 100 mL), dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure to give a white solid. Drying under vacuum overnight at 40 °C provided the product (32.6 g, 99% yield). M. p. 133.1-134. 1 °C.'H NMR (CD3, 300 MHz) 6 8.00 (d, J=2 Hz, 1H), 7.81-7. 67 (m, 3H), 7.56 (dd, J=2,12 Hz, 1H), 7.54 (dd, J=2, 12 Hz, 1 H), 4.73 (s, 2H). MS (DCI-NH3) [M] + at 254. <BR> <BR> <P> Example 31 C<BR> <BR> <BR> <BR> <BR> <BR> (6-Bromo-naphthalen-2-yl)-acetonitrile

A mixture of the product from Example 31 B (32.2 g, 126 mmol) and NaCN (7.44 g, 152 mmol, 1.2 equiv. ) in acetonitrile (314 mL) and distilled water (32 mL) under a dry nitrogen atmosphere was stirred at reflux for 21 hr. The reaction mixture was cooled to room temperature then concentrated under reduced pressure. The residue was stirred with distilled water (314 mL) for 45 min. The resulting white solid was isolated by filtration and washed with distilled water (1500 mL). Drying under vacuum overnight at 40 °C provided the product (32.2 g, 97% yield). M. p. 119.6-120. 6 °C.'H NMR (CDC13, 300 MHz) 5 8.01 (d, J=2 Hz, 1H), 7.82-7. 68 (m, 3H), 7.60 (dd, J=2,12 Hz, 1H), 7.41 (dd, J=2, 12 Hz, 1 H), 3.90 (s, 2H). MS (DCI-NH3) [M+NH4] + at 263, [M+NH4 NH3] + at 280.

Example 31 D (6-Bromo-naphthalen-2-yl)-acetic acid A stirred mixture of the product from Example 31 C (29.62 g, 120 mmol) in glacial acetic acid (300 mL) and distilled water (150 mL) under a dry nitrogen atmosphere was cooled to-15 °C. Concentrated sulfuric acid (120 mL, 4.32 mol, 36.0 equiv. ) was added dropwise over 20 min while maintaining the reaction temperature below 10 °C. The reaction mixture was then stirred at reflux for 2 hr.

After cooling to 35 °C, ice (500 g) was added to the mixture and stirring was continued for 45 min. The resulting white solid was isolated by filtration and washed with distilled water (1500 mL). Drying under vacuum overnight at 40 °C provided the product (29.57 g, 93% yield).'H NMR (CDC13, 300 MHz) 5 7.99 (d, J=2 Hz, 1H), 7.76-7. 64 (m, 3H), 7.54 (dd, J=2, 12 Hz, 1H), 7.44 (dd, J=2,12 Hz, 1H), 3.81 (s, 2H). MS (DCI-NH3) [M+NH4] + at 282. <BR> <BR> <BR> <BR> <BR> <BR> <P> Example 31 E<BR> <BR> <BR> <BR> <BR> <BR> 2-(6-Bromo-naphthalen-2-yl)-ethanol To a stirred,-15 °C solution of the product from Example 31 D (28.6 g, 108 mmol) in anhydrous THF (143 mL) under a dry nitrogen atmosphere was added dropwise over 15 min a 1.0 M solution of BH3-THF (409 mL, 409 mmol, 3.8 equiv. ) while maintaining the reaction temperature below 0 °C. When the addition was complete, the reaction mixture was stirred at-15 °C for 15 min, then allowed to warm to room temperature and stirred an additional 2 hr. The reaction mixture

was then cooled to-10 °C and quenched with distilled water (104 mL). After stirring for 15 min at room temperature, the reaction mixture was concentrated under reduced pressure. The residue was partitioned between dichloromethane (350 mL) and distilled water (200 mL) and the aqueous layer was extracted with dichloromethane (2 x 100 mL). The combined organic extracts were washed with distilled water (3 x 100 mL), dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure to give a white solid. Drying under vacuum overnight at 40 °C provided the product (26.1 g, 96% yield). M. p. 102.3-103. 1 °C. aH NMR (CDC13, 300 MHz) 5 7.98 (d, J=2 Hz, 1H), 7.74-7. 63 (m, 3H), 7.53 (dd, J=2, 12 Hz, 1H), 7.49 (dd, J=2,12 Hz, 1H), 4.00-3. 92 (m, 2H), 3.02 (t, J=6 Hz, 2H), 1.43-1. 35 (t br, J=6 Hz, 1 H). MS (DCI-NH3) [M+NH4] + at 268.

Example 31 F 2-[6-(2-Hydroxy-ethyl)-naphthalen-2-yll-2H-pyridazin-3-one A mixture of the product from Example 31 E (500 mg, 1.87 mmol), 2H- pyridazin-3-one (180 mg, 1.87 mmol), copper powder (120 mg, 1.87 mmol), and K2CO3 (775 mg, 5.61 mmol, 3 equiv. ) in pyridine (75 mL) was stirred at reflux under a dry nitrogen atmosphere for 20 hr. The reaction mixture was cooled to room temperature then concentrated under reduced pressure. Residual pyridine was removed by repeated evaporation with toluene. The residue was partitioned between ethyl acetate (350 mL) and saturated aqueous Na2CO3. The organic layer was washed twice with aqueous NH40H, dried (MgS04), filtered,, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (75: 25 ethyl acetate/hexane) to provide the title compound (270 mg, 54% yield NMR (CDC13, 300 MHz) 5 8.11 (d, J=2 Hz, 1H), 7.97-7. 93 (m, 1H), 7.88 (t, J=9 Hz, 2H), 7.75-7. 68 (m, 2H), 7.41 (dd, J=2,12 Hz, 1H), 7.31-7. 24 (m, 1H), 7.10 (dd, J=2,12 Hz, 1H), 3.97 (t, J=6 Hz, 2H), 3.06 (t, J=6 Hz, 2H). MS (DCI-NH3) [M+H] + at 267, [M+NH4] + at 284.

Example 31G Methanesulfonic acid 2-f6- (6-oxo-6H-pyridazin-1-yl)-naphthalen-2-vll-ethyl ester

Methanesulfonyl chloride (0.10 mL, 1.33 mmol, 1.3 equiv. ) was added dropwise via a syringe to a stirred, 0 °C solution of the product from Example 31 F (0.27 g, 1.01 mmol) and Et3N (0.28 mL, 2.02 mmol, 2.0 equiv. ). After one hour the ice bath was removed and the reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure. The residue was partitioned between EtOAc and saturated aqueous Na2CO3. The aqueous layer was extracted with EtOAc. The combined organic ' extracts were dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure then filtered through a pad of silica gel with EtOAc followed by a second removal of solvent to provide the title intermediate as an off-white solid (300 mg, 87% yield).'H NMR (CDC13, 300 MHz) 5 8.12 (d, J=2 Hz, 1 H), 7.97- 7.94 (m, 1H), 7.89 (t, J=9 Hz, 2H), 7.76-7. 71 (m, 2H), 7.41 (dd, J=2, 12 Hz, 1H), 7.31-7. 25 (m, 1H), 7.10 (dd, J=2, 12 Hz, 1H), 4.53 (t, J=6 Hz, 2H), 3.24 (t, J=6 Hz, 2H), 2.83 (s, 3H). MS (DCI-NH3) [M+H] + at 345, [M+NH4] + at 362.

Example 31 H <BR> <BR> <BR> 2-(642-[(2R)-2-Methyl-1-pyrrolidin-1-yll-ethylT-2-naphthalen -2-yl)-2H-pyridazin-3- one A mixture of the product from Example 31 G (0.30 g, 0.87 mmol) and (2R)- 2-methylpyrrolidine (0.37 g, 4.36 mmol, 5.0 equiv. ) in anhydrous acetonitrile (3.5 mL) was stirred in a sealed tube at room temperature for 66 hours. The reaction mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous Na2CO3. The aqueous layer was extracted with ethyl acetate, and the combined organic extracts were dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (97: 3 : trace dichloromethane/methanol/NH40H). Fractions containing product were combined and concentrated under reduced pressure to provide the free base product (220 mg, 75.7% yield). The free base was dissolved in Et20 and HCI gas was bubbled in until pH 2 was achieved. The resulting precipitate was crystallized from MeOH/Et2O to give the hydrochloride salt. M. p. 198.9-201. 5 °C.'H NMR (CD30D, 300 MHz) 6 8.12-8. 07 (m, 2H), 8.00-7. 88 (m, 3H), 7.68 (dd, J=2,12 Hz,

1H), 7.57-7. 49 (m, 2H), 7.13 (dd, J=2,12 Hz, 1H), 3.84-3. 64 (m, 2H), 3.64-3. 46 (m, 1H), 3.46-3. 13 (m, 4H), 2.43-2. 26 (m, 1H), 2.22-1. 99 (m, 2H), 1.85-1. 67 (m, 1 H), 1.48 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 334.

Example 32 2-methoxy-5-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-nap hthyl)pyridine The title compound was prepared by the method in Example 8, substituting 6-methòxy-3-pyridinylboronic acid in place of 4-pyridinylboronic acid (37 mg, 24% yield NMR (CD30D, 300 MHz) 5 8.50 (d, J=2 Hz, 1H), 8.10-8. 05 (m, 2H), 7.98-7. 92 (m, 2H), 7.85-7. 83 (m, 1H), 7.75 (dd, J=2,10 Hz, 1H), 7.50 (dd, J=2, 12 Hz, 1 H), 6.93 (d, J=9 Hz, 1H), 4.43 (s, 2H), 3.97 (s, 3H), 3.81-3. 47 (m, 3H), 3.42- 3.17 (m, 4H), 2.41-2. 28 (m, 1H), 2.26-2. 04 (m, 2H), 1.85-1. 71 (m, 1H), 1.47 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 347.

Example 33 4-(6-{2-[(2R)-2-(hydroxymethyl)-1-pyrrolidinyl]ethyl}-2-naph thyl)benzonitrile The title compound was prepared by the method of Example 1 H, substituting (2R)-2-pyrrolidinylmethanol in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) # 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d. J=6 Hz, 1H), 3.51-3. 64 (m, 2H), 3.2-3. 34 (m, 2H), 2.93-3. 1 (m, 2H), 2.69- 2.75 (m, 2H), 2.4 (q, J=6 Hz, 1 H), 1.9-2. 4 (m, 1 H), 1.95-2. 05 (m, 2H), 1.81-1. 91 (m, 1 H). MS (DCI-NH3) [M+H] + at 357.

Example 34 4-86-92-(2-methyl-1-pyrrolidinyl) ethvll-2-naphthylTbenzon itrile The title compound was prepared by the method of Example 1 H, substituting rac-2-methylpyrrolidine in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 5 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d.

J=6 Hz, 1H), 3.68-3. 83 (m, 2H), 3.51-3. 61 (m, 1H), 3.17-3. 42 (m, 4H), 2.3-2. 43 (m, 1H), 2.02-2. 12 (m, 2H), 1.68-1. 82 (m, 1H), 1.44 (d, J=6 Hz, 3H). MS (DCI- NH3) [M+H] +at 341.

Example 35

4-{6-[2-(1-pyrrolidinyl)ethyl]-2-naphthyl}benzonitrile The title compound was prepared by the method of Example 1 H, substituting pyrrolidine in place of (2R)-2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 5 8.13 (s, 1H), 7.87-7. 96 (m, 4H), 7.71-7. 85 (m, 4H), 7.41 (d. J=6 Hz, 1H), 3.56-3. 62 (m, 1 H), 3.1-3. 18 (m, 1 H), 2.84-2. 91 (m, 1 H), 2.75-2. 8 (m, 1H), 2.66- 2.73 (m, 4H), 1.84-1. 9 (m, 4H). MS (DCI-NH3) [M+H] + at 327.

Example 36 4- (6- {2-f (2R)-2-methyl-1-pyrrolidinyllethyl}-2-naphthyl) thiomorpholine The title compound was prepared by the method of Example 27, substituting thiomorpholine in place of morpholine.'H NMR (CD30D, 300 MHz) b 7.62-7. 69 (m, 2H), 7.53 (s, 1H), 7.21-7. 3 (m, 2H), 7.13 (s, 1H), 3. 53 (m, 4H), 3.23- 4.0 (m, 1H), 3.06-3. 16 (m, 1H), 2. 82-3 01 (m, 2H), 2.73 (m, 4H), 2.25-2. 48 (m, 3H), 1.94-2. 04 (m, 1H), 1.72-1. 84 (m, 2H), 1.38-1. 41 (m, 1H), 1.11 (d, J=6 Hz, 3H). MS (DCI-NH3) (M+H) + at 341.

Example 37 1-{2-[(6-bromo-2-naphthyl)oxy]ethyl}pyrrolidine Example 37A 2-bromo-6-(2-bromoethyoxy)naphthalene A round-bottom flask containing 1.0 g (4.5 mmol) of 6-bromo-2-naphthol, 1,2-dibromoethane (135 mmol, 12 mL), potassium hydroxide (5 mL of a 40% solution) and tetrabutylammonium bromide (1.35 mmol, 0.43 g) was heated at 100°C for 3h. The reaction mixture was diluted with 150 mL of CH2CI2 and washed with water and brine, dried over sodium sulfate and concentrated under vacuum to give the desired compound in 100% as a pale brown solid ;'HNMR (300 MHz, CDC13) 8 3.70 (t, 2H), 4.40 (t, 2H), 7.05-7. 90 (m, 6H). MS (DCI) m/z 330 (M+).

Example 37B 1-{2-[(6-bromo-2-naphthyl)oxy]ethyl}pyrrolidine

In a flask containing 0.5 g (1.5 mmol) the product from Example 37A, 10 mL of pyrrolidine was added. After stirring at 80° C for 3h, the reaction mixture was concentrated under vacuum. The residue was diluted with 100 mL of CH2CI2 and washed sequentially with water, sodium bicarbonate and brine, dried and evaporated under reduced pressure. Silica gel chromatography (MeOH : CH2CI2, 95: 5) gave the desired material in 98% yield.'HNMR (300 MHz, CDC13) 8 1.80 (m, 4H), 2. 6 (m, 4H), 2.97 (t, 2H), 4.20 (t, 2H), 2.49 (m, 2H) 7.10-7. 90 (m, 6H); MS (ESI) m/z 321 (M+H) +.

Example 38 3-6- (2- (1-pyrrolidinyl) ethoxyl-2-naphthylbenzonitrile A mixture of the product from Example 37B (35 mg, 0.11 mmol), 3- cyanophenylboronic acid (22 mg, 0.15 mmol), PdCl2 (PPh3) 2 (4.2 mg, 6 mol), and isopropanol (0.5 mL) was treated with 2 M aqueous sodium carbonate (80 uL) and heated at 85 °C overnight. The mixture was cooled to room temperature and partitioned between 2 M aqueous NaOH and dichloromethane. The aqueous phase was separated and extracted with dichloromethane. The combined organic phases were filtered through diatomaceous earth, concentrated, and chromatographed through silica with a gradient of 0%/50%/50% to 10%/40%/50% methanol/ethyl acetate/dichloromethane followed by 8% methanol/ dichloromethane to provide the title compound.'HNMR (300 MHz, CD30D) 8 1. 86 (m, 4H), 2.73 (m, 4H), 3.01 (t, 2H), 4.28 (t, 2H), 7.22 (dd, 1 H), 7.31 (d, 1 H), 7.65 (t, 1 H), 7.70 (dt, 1H), 7.75 (dd, 1H), 7.85-7. 92 (m, 2H), 8.06 (dt, 1H), 8.07- 8.13 (m, 2H); MS (ESI) m/z 343 (M+H) +.

Example 39 3-f6-f2- (1-pyrrolidinyl) ethoxyl-2-naphthyl) pyridine The product from Example 37B and 3- (4, 4,5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)-pyridine were processed as described in Example 38, except that a second column chromatography was done to provide 10 mg of the title compound.'HNMR (300 MHz, CD30D) 8 1. 86 (m, 4H), 2.74 (m, 4H), 3.02 (t, 2H), 4.29 (t, 2H), 7.23 (dd, 1 H), 7.31 (d, 1 H), 7.56 (ddd, 1 H), 7.76 (dd, 1H), 7.86-

7.93 (m, 2H), 8.10 (d, 1 H), 8.20 (ddd, 1H), 8.52 (dd, 1H), 8.91 (dd, 1H) ; MS (ESI) m/z 319 (M+H) +.

Example 40 3- (6-2-r (2R)-2-methyl-1-pyrrolidinyllethoxy}-2-naphthyl) benzonitrile Example 40A (2R)-1-42- [ (6-bromo-2-naphthyl) oxylethyl}-2-methylpyrrolidine ((2R)-2-Methylpyrrolidine (L) -tartrate (541 mg, 2.3 mmol) was partitioned between aqueous 2 M NaOH (2.5 mL) and toluene (0.6 mL). The aqueous phase was separated, diluted with brine (0.3 mL), and extracted with toluene (2 x 0.3 mL). The combined organic phases were dried (Na2SO4) and carried on to the next step with a toluene rinse (0.3 mL).

The product from Example 37A (495 mg, 1.5 mmol), potassium carbonate (207 mg, 1.5 mmol), and the above toluene solution were suspended into DMF (3 mL) and heated at 50 °C overnight. The reaction mixture was brought to room temperature and partitioned between 0.2 M aqueous NaOH (20 mL) and dichloromethane (10 mL). The aqueous phase was separated and extracted with dichloromethane, and the combined organic phases were washed with 0.2 M aqueous NaOH, dried (Na2SO4), and filtered quickly through a'silica plug with a 0 to 10% methanol/dichloromethane gradient. The filtrate was partitioned between water and 2: 1 dichloromethane/hexanes. The aqueous phase was separated and extracted with 20% hexanes/dichloromethane, and the combined organic phases were concentrated and chromatographed through silica with a little hexanes/dichloromethane followed by a gradient of 0 to 10% methanol/ dichloromethane. The appropriate fractions were combined and concentrated under high vacuum to provide 451 mg of a 6: 1 mixture of title compound and starting bromide which was used in the next step without further purification; MS (ESI APCI) m/z 334/336 (M+H) +.

Example 40B 3- (6-2- [ (2R)-2-methyl-1-pyrrolidinyllethoxy}-2-naphthyl) benzonitrile

A mixture of the product from Example 40A (147 mg, approximately 0.38 mmol), 3-cyanophenylboronic acid (96 mg, 0.65 mmol), PdCl2 (PPh3) 2 (28 mg, 0.04 mmol) and isopropanol (2.5 mL) was treated with 2 M aqueous sodium carbonate (700 pL) and heated at 55 °C overnight, then at 85 °C for two days.

The mixture was cooled to room temperature and partitioned between 2 M aqueous NaOH (2 mL) and dichloromethane (10 mL). The aqueous phase was separated and extracted with dichloromethane. The combined organic phases were filtered through diatomaceous earth, concentrated, and chromatographed through silica once with a gradient of 0%/50%/50% to 10%/40%/50% methanol/ ethyl acetate/dichloromethane, and a second time with a gradient of 0%/0%/100% to 0%/50%/50% to 5%/45%/50% methanol/ethyl acetate/ dichloromethane to provide 28 mg of an orange gum ;'HNMR (300 MHz, CD30D) # 1. 10 (d, 3H), 1.48 (m, 1H), 1.75-1. 88 (m, 2H), 2.01 (m, 1H), 2.40 (m, 1H), 2. 53 (m, 1 H), 2.65 (m, 1H), 3.23-3. 38 (m, 2H), 4. 22-4. 34 (m, 2H), 7.22 (dd, 1H), 7.30 (d, 1 H), 7.65 (t, 1H), 7.70 (dt, 1 H), 7.75 (dd, 1H), 7.85-7. 92 (m, 2H), 8.06 (dt, 1 H), 8.07-8. 12 (m, 2H); MS (ESI) m/z 357 (M+H) +.

Example 41 3-(6-82-[(2R)-2-methyl-1-pyrrolid invilethoxyT-2-naphthvl) pyridine The product from Example 40A and 3- (4, 4,5, 5-tetramethyl- [1,3, 2] dioxaborolan-2-yl)-pyridine were processed as described for Example 40B, except that a single chromatography was conducted with a gradient of 0%/50%/50% to 10%/40%/50% methanol/ethyl acetate/dichloromethane followed by 8% methanol/dichloromethane to provide the title compound.

'HNMR (300 MHz, CD30D) 8 1.10 (d, 3H), 1.47 (m, 1H), 1.75-1. 88 (m, 2H), 2.02 (m, 1 H), 2.41 (m, 1 H), 2.54 (m, 1 H), 2.66 (m, 1 H), 3.22-3. 39 (m, 2H), 4. 24-4. 33 (m, 2H), 7.22 (dd, 1H), 7.31 (d, 1H), 7.55 (ddd, 1H), 7.76 (dd, 1H), 7.86-7. 94 (m, 2H), 8.10 (d, 1H), 8.21 (ddd, 1H), 8.52 (dd, 1H), 8.91 (dd, 1H) ; MS (ESI) m/z 333 (M+H) +.

Example 42 4- (2-f2- [ (2R)-2-methvl-1-pvrrolidinyl] ethyl-6-quinolinvl) benzonitrile

Example 42A ethyl (6-bromo-2-guinolinyl) acetate To a solution of diisopropylamine (19.2 g, 0.19 mole) in diethyl ether (200 mL) was added 2.5 M n-butyllithium in hexane (74 mL, 0.185 mole) at-78 °C.

The clear solution was mixed for 30 min, and followed by addition of 6-bromo-2- methyl-quinoline (13.32 g, 0.060 mole) in ether (200 mL) slowly at-78 °C. The brown solution was stirred for 0.5 hour, and ethyl chloroformate (7.45 g, 0.069 mole) in ether (50 mL) was syringed into the mixture slowly so that the internal temperature did not exceed-70 °C. The yellow reaction mixture was quenched by addition of 50 mL water, allowed to warm up to rt, and diluted with ethyl acetate (300 mL). The solution was washed with 5% sodium bicarbonate aq. solution (700 mL x 3), 25% brine (700 mL), dried over MgS04, and filtered. The organic was concentrated to-50 mL volume, and the slurry diluted with heptane (50 mL).

The slurry was stirred at 0 °C for 2h, and the solid was collected by filtration, rinsed with a ice-cold heptane: ethyl acetate (10 mL, 2: 1), dried at 50 °C under vacuum to give a yellow solid (12.0 g). Concentration of the mother liquid afforded a 2nd crop of the product (3.6 g). Total yield : 88%; mp: 100-101 °C (uncorrected); MS (ESI) : 294,296 (M+H) + ;'H-NMR (CDC13) 8 8.02 (1H, d, J=8.5 Hz), 7.94 (1 H, d, J=2.2 Hz), 7.91 (1 H, d, J=8.9 Hz), 7.74 (1 H, dd, J=8. 9, 2.2 Hz), 7.44 (1H, d, J=8.5 Hz), 4.20 (2H, q, J=7.1 Hz), 4.01 (2H, s), 1.27 (3H, t, J=7.1 Hz); 13C-NMR (CDCI3) â 169.7, 154.9, 146.0, 135.1, 132. 6, 130.5, 128.9, 127.8, 122. 3, 119.9, 61.2, 44.9, 14.5.

Example 42B 2- (6-bromo-2-guinolinyl) ethanol A 1 L round bottom flask was charged with the product from Example 42A (12.0 g, 0.0408 mole), lithium borohydride (1.78 g, 0.00816 mole) and THF (450 mL) under a nitrogen atmosphere. Ethanol (18.8 g, 0.408 mole) was added slowly at <25 °C, and the yellow mixture stirred at rt for 4 hours. Methanol (40 mL) was carefully added and the mixture was concentrated to-50 mL of volume. The mixture was diluted with ethyl acetate (250 mL), washed with 5% NåHCO3 aq.

solution, and water (300 mL). The organic layer was concentrated, azeotroped with ethyl acetate (250 mL x 2) to a volume of ~50 mL. The resulting precipitate was diluted with heptane (50 mL), stirred at room temperature overnight, and then at 5 °C for 2 hours. The solid was filtered, rinsed with heptane (20 mL), and dried at 50 °C to give 7.70 g of the product (75% yield) ; mp: 103-104°C (uncorrected) ; MS (ESI) : 251,253 (M+H) + ;'H-NMR (CDC13) 8 7.96 (1H, d, J=8.4 Hz), 7.90 (1H, d, J=2. 2 Hz), 7.84 (1H, d, J=8. 9 Hz), 7.72 (1 H, dd, J=8.9, 2.2 Hz), 7.27 (1H, d, J=8.4 Hz), 4.13 (2H, d, J=5.6 Hz), 3.19 (2H, d, J=5.6 Hz) ; 13C-NMR (CDCI3) 6 161.3, 145. 4,135. 1,132. 6,130. 1,129. 2,127. 5,122. 4,119. 5,61. 2,39. 7.

Example 42C 2- (6-bromo-2-guinolinyl) ethyl 4-methylbenzenesulfonate A 500 mL round bottom flask was charged with the product from Example 42B (7.65 g, 0.030 mole), 4-N, N-dimethylaminopyridine (0.36 g, 0.003 mole), dichloromethane (100 mL) and triethylamine (9.3 g, 0.092 mmol). p- Toluenesulfonyl chloride (11.5 g, 0.060 mole) was added in portions, and the solution was stirred at rt for 6 hours. The solution was stripped down to dryness, and the crude product was taken into ethyl acetate (150 mL) and 5% NaHCO3 aq. solution (150 mL). The upper organic was washed with water (150 mL), concentrated, azeotroped with ethyl acetate (250 mL x2) to a volume of ~ 50 mL.

The slurry was diluted with heptane (50 mL), stirred at room temperature overnight, and then at 5 °C for 8 hours. The precipitate was collected by filtration, rinsed with heptane (20 mL), dried at 50 °C under vacuum overnight to afford 10.80 g of the product as an off-white solid ; mp 107-109 °C ; MS (ESI) : 406,408 (M+H) + ; 1H-NMR (CDCI3) 6 7.92 (1H, m), 7.91 (1H, m), 7.7 (2H, m), 7.58 (2H, m), 7.25 (1 H, d, J=8.4 Hz), 7.09 (2H, m), 4.56 (2H, t, J=6.3 Hz), 3.27 (2H, t, J=6.3 Hz), 2.33 (3H, s) ; 13C-NMR (CDCl3) # 157. 2, 145.9, 144.1, 135.0, 132.5, 132. 3, 130.3, 129.2, 129.2, 127.7, 127.4, 122.5, 119.6, 69.2, 38.0, 21.8.

Example 42D 6-bromo-2-f2- ( (2R)-2-methyl-1-pyrrolidinyllethylq uinoline

(2R)-2-Methylpyrrolidine L-tartrate (7.00 g, 0.0298 mole, milled), potassium carbonate (9.04 g, 0.0655 mole, milled), and acetonitrile (190 mL) were combined and heated at 60 °C with agitation for 48 hours. The mixture was allowed to cool to 30 °C, and treated with the product from Example 42C (8.00 g, 0.0197 mole).

The reaction mixture was heated at ~60°C for 36 hours and then distilled down to ~1/4 volume, and isopropyl acetate (200 mL) was added. The mixture was washed with 5% NaHCO3 aq. solution (200 mLx2), and 25% brine (200 mL). The upper organic was dried over anhydrous sodium sulphate, filtered, and the filtrate was concentrated to dryness. The crude product was purified with a short-path silica gel column eluted with heptane: ethyl acetate: TEA (60: 40: 1) to give 5.8 g (92% yield) of product as an oil, which solidified on standing; mp 49-50 °C (uncorrected); MS (ESI) : 319,311 (M+H) + ; rH-NMR (CDCI3) ä 7.95 (1H, d, J=8.5 Hz), 7.91 (1H, d, J=2.2 Hz), 7.89 (1 H, d, J=8.9 Hz), 7.72 (1H, dd, J=8.9, 2.2 Hz), 7.35 (1H, d, J=8.5 Hz), 3.23 (2H, m), 3.18 (2H, m), 2.55 (1 H, m), 2.38 (1H, m),- 2.25 (1 H, q, J=8.9 Hz), 1.93 (1 H, m), 1.80 (1 H, m), 1.71 (1 H, m), 1.42 (1 H, m), 1.11 (3H, d, J=6.0 Hz) ; 13C-NMR (CDC13) 6 161.3, 146.1, 134.7, 132.3, 130.3, 129. 2, 127.6, 122.2, 119. 2, 59.9, 54.0, 53.6, 38.6, 33.0, 22.0, 19.4.

Example 42E 4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-6-quinolinyl)be nzonitrile The product from Example 42D (160 mg, 0.5 mmol), 4-cyanophenylboronic acid (0.75 mmol), and dichlorobis (triphenylphosphine) palladium (II) (35.1 mg, 0.05 mmol) were combined in isopropyl alcohol (5.0 mL) and 0.2 M K3PO4 aq. solution (5.0 mL, 1.0 mmol) and heated at 60 °C for 24 hours. The reaction mixture was allowed to cool to room temperature and diluted with ethyl acetate (20 mL). The organic phase was separated, washed with 5% NaHCO3 (25 mLx3), 25% brine (25 mL), dried over Na2SO4, filtered, and the filtrate concentrated to dryness. The residue was purified by column chromatography (heptane: acetone: CH2CI2 : TEA (60: 40: 5: 1) to provide the title compound. The title compound was treated with one equivalent of L-tartaric acid in IPA : ethanol to give the tartrate salt. mp 164 °C ; MS (ESI) 342 (M+H) + ;'H NMR (DMSO-d6) 8 8.40 (1H, d), 8.38 (1H, d), 8.12 (1H, d), 8.06 (1H, d), 8.04 (2H, d), 7.98 (2H, d), 7.58 (1 H,

d), 4.05 (2H, s), 3.63 (1H, m), 3.50 (1H, m), 3.33 (2H, t), 3.15 (2H, m), 2.88 (1H, m), 2.09 (1 H, m), 1.86 (2H, m), 1.55 (1 H, m), 1.29 (3H, d).

Example 43 6-(4-fluorophenyl)-2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl} quinoline The title compound was prepared using the procedure described in Example 42E substituting 4-fluorophenylboronic acid for 4-cyanophenylboronic acid. The title compound was treated with HCI. in IPA : ethyl acetate to give the dihydrochloride salt. mp 145 °C ; MS (ESI) 335 (M+H) + ;'H NMR (DMSO-d6) 5 8.88 (1H, d), 8.5 (1H, br), 8.42 (1H, d), 8.37 (1H, d), 7.97 (1H, d), 7.91 (2H, dd), 7.40 (2H, t), 3.93 (1 H, br), 3.72 (3H, br), 3.5 (2H, br), 3.26 (1 H, br), 2.2 (1 H, m), 2.0 (2H, br), 1.7 (1H, br), 1.42 (3H, br).

Example 44 3-(2-82-r (2R)-2-methyl-1-PvrrolidinyllethylT-6-quinolinyl) benzonitrile The title compound was prepared using the procedure described in Example 42E substituting 3-cyanophenylboronic acid for 4-cyanophenylboronic acid. The title compound was treated with one equivalent of L-tartaric acid in IPA : ethanol to give the tartrate salt. mp 172 °C ; MS (ESI) 342 (M+H) + ;'H NMR (DMSO-d6) 8 9.2 (1H, d), 8.61 (1H, d), 8.42 (2H, overlapping), 8.21 (1 H, d), 8.19 (1H, d), 8.17 (1H, dt), 7.82 (1 H, dt), 7.75 (1H, t), 4.88 (2H, s), 4.06 (1H,m), 3.90 (3H, m), 3.65 (2H, m), 2.40 (1H, m), 2.20 (2H, m), 1.84 (1H, m), 1.59 (3H, d).

Example 45 1-[3-(3-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-6-quinolinyl )phenyl]ethanone The title compound was prepared using the procedure described in Example 42E substituting 3-acetylphenylboronic acid for 4-cyanophenylboronic acid. The title compound was treated with HCI in IPA : ethyl acetate to give the dihydrochloride salt. mp 174-175°C ; MS (ESI) 359 (M+H) + ;'H NMR (CD30D) S 9.14 (1H, d), 8.56, 8.50 (1H,d). 8.4 (2H, m), 8.33, 7.79 (1H, t), 8.14 (1H, dd), 8.05 (1H, dt), 7.74, 7.52 (1 H, dt), 7.627. 50 (1 H, t), 4.02 (1 H, m), 3.83 (2H, m), 3.60 (2H, m),

3.41 (1 H, m), 2.62 (1H, m), 2.37 (1H, m), 2.15 (3H, m), 1.80 (1H, m), 1.53 (3H, s), 1.1 (3H, d).

Example 46 6-(4-methoxyphenyl)-2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl }quinoline The title compound was prepared using the procedure described in Example 42E substituting 4-methoxyphenylboronic acid for 4-cyanophenylboronic acid. The title compound was treated with HCI in IPA : ethyl acetate to give the dihydrochloride salt. mp 165°C (dec. ); MS (ESI) 347 (M+H) + ;'H NMR (CD30D) 8 9.12 (1H, d), 8.46 (2H, m), 8.36 (1H, d), 8.11 (1H, d), 7.80 (2H, d), 7.10 (2H, d), 4.02 (1H, m), 3.90 (3H, s), 3.82 (2H, m), 3.62 (2H, m), 3.41 (1H, m), 2.39 (2H, m), 2.18 (2H, m), 1.82 (1H, m), 1.56 (3H, d).

Example 47 2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-6-[4-(trifluoromet hyl)phenyl]quinoline The title compound was prepared using the procedure described in Example 42E substituting 4-(triflouromethyl) phenylboronic acid for 4- cyanophenylboronic acid. The title compound was treated with HO in IPA : ethyl acetate to give the dihydrochloride salt. mp 143-145 °C (dec. ); MS (ESI) 385 (M+H) + ;'H NMR (DMSO-d6) 8 8.65 (1H, d), 8.50 (1H, s), 8.23 (2H, m), 8. 09 (2H, d), 7.91 (2H, d), 7.74 (1 H, d), 4.0-3. 4 (6H, br, m), 3.22 (1H, br), 2.22 (1H, br), 2.0 (2H, m), 1.70 (1H, m), 1.44 (3H, br).

Example 48 2-f2-f (2R)-2-methyl-1-pyrrolidinyllethyl}-6-f4- (methylsulfonyl) phenyllquinoline The title compound was prepared using the procedure described in Example 42E substituting 4- (methylsulfonyl) phenylboronic acid for 4- cyanophenylboronic acid. The title compound was treated with HCI in IPA : ethyl acetate to give-the dihydrochloride salt. MS (ESI) 395 (M+H) + ;'H NMR (CD30D) 8 9.05 (1H, d), 8.56 (1 H, d), 8.45 (1H, dd), 8.38 (1H, d), 8.10 (4H, m), 8.02 (1H, d), 4.03 (1H, br, m), 3.85 (1H, br, m), 3.75 (2H, br, m), 3.62 (2H, br, m), 3.41 (1H, m), 3.18 (3H, s), 2.39 (1H, m), 2.18 (2H, m), 1.82 (1H, m), 1.57 (3H, br, d).

Example 49 6-(3,5-difluorophenyl)-2-{2-[(2R)-2-methyl-1-pyrrolidinyl]et hyl}quinoline The title compound was prepared using the procedure described in Example 42E substituting 3, 5-difluorophenylboronic acid for 4-cyanophenylboronic acid. The title compound was treated with HCI in IPA : ethyl acetate to give the dihydrochloride salt. mp 164-165 °C ; MS (ESI) 353 (M+H) + ; H NMR (DMSO-d6) 8 8.72 (1H, d), 8.59 (1H, s), 8.31 (2H, m), 7.76 (1H, d), 7.63 (2H, dd), 7.55 (1H, tt).

3,90 (1 H, br), 3.63 (2H, br, m), 3.50 (2H, br, m), 3.23 (1 H, br), 2. 9-2.6 (1H, br, m), 2.2 (1H, m), 1.98 (2H, br, m), 1.64 (1H, br, m), 1.45 (3H, br).

Example 50 (3-fluorophenyl) (2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-6-quinolinyl) methanone The product from Example 42D (320 mg, 1.0 mmol) in THF (10 mL) was treated with 2.5M n-butyllithium (0.5 mL, 1.25 mmol) at-78 °C. The solution was mixed for 15 min, and treated with a solution of 3-fluoro-N-methoxy-N- methylbenzamide (2.0 mmol) in THF (5.0 mL) at-78 °C. The mixture was allowed to warm to room temperature overnight, quenched by 1 mL ethanol, concentrated, and diluted with ethyl acetate. The mixture was washed with 5% NaHCO3 (25 mLx3), 25% brine (25 mL), dried over Na2SO4, filtered, and the filtrate was concentrated to dryness. The residue was purified by column chromatography (heptane: acetone: CH2CI2 : TEA (60: 40: 5: 1) to provide the title compound. The title compound was treated with HCI in IPA : ethyl acetate to give the dihydrochloride salt. mp 162-164 °C (dec. ); MS (ESI) 363 (M+H) + ;'H NMR (DMSO-d6) 5 8.79 (1H, d), 8.53 (1 H, d), 8.30 (1H, d), 8.21 (1 H, dd), 7.82 (1H, d), 7.6 (4H, m), 3.9 (1 H, br, m), 3.63 (2H, br, m), 3.50 (2H, br, m), 3.21 (1 H, br, m), 2.2 (1 H, m), 1.98 (2H, br, m), 1.7 (1H, br, m), 1.46 (1H, m), 1.30 (3H, d).

Example 51 2-{2-[(2R)-2-methyl-1-pyrrolindinyl]ethyl}-6-(3-pyridinyl)qu inoline Tetrakis (triphenylphosphine) palladium (0) (28.8 mg, 0.025 mmol), 2- (dicyclohexylphosphino) biphenyl (35.0 mg, 0.10 mmol), 3-pyridinylboronic acid

(0.375 mmol), and sodium carbonate (40.0 mg, 0.375 mmol) were combined in 1,2-dimethoxyethane (4 mL) and water (1.5 mL). The mixture was then treated with the product from Example 42D (80 mg, 0.25 mmol) and heated at 80°C for 24 hours. The reaction mixture was allowed to cool to room temperature and diluted with ethyl acetate (20 mL). The organic layer was separated, washed with 5% NaHCO3 (25 mLx3), 25% brine (25 mL), dried over Na2SO4, filtered, and the filtrate was concentrated to dryness. The residue was purified by column chromatography (heptane: acetone: CH2CI2 : TEA (60: 40: 5: 1) to provide the title compound. The title compound was treated with HCI in IPA : ethyl acetate to give the trihydrochloride salt. mp 205-207°C ; MS (ESI) 318 (M+H) + ;'H NMR (DMSO- d6) 8 9.48 (1H, br, s), 9.05 (1H, d), 8.96 (1H, d), 9.00 (1H, d), 8.86 (1H, br, s), 8.60 (1 H, d), 8.59 (1 H, d), 8.32 (1H, dd), 8.23 (1 H, d), 4.08 (1 H, br, m), 3.90 (2H, br, m), 3.65 (2H, br, m), 3.46 (1H, q), 2.40 (1H, m), 2.19 (2H, m), 1.84 (1 H, m), 1.58 (3H, d).

Example 52 4-(3-{2-[(2R)-2-methyl-1-pyrrolid inyllethylT-7-isoq uinolinyl) benzonitrile Example 52A ethyl (6-bromo-1-oxo-2, 3-dihydro-1H-inden-2-yl) acetate n-Butyllithium (14 mL, 2 M in pentane) was added dropwise to a solution of diisopropylamine (2.86 g, 28 mmol) in tetrahydrofuran (60 mL) cooled to-70 °C.

After 30 minutes of stirring at-70 °C, the mixture was treated with 6-bromo-1- indanone (4.8 g, 22.7 mmol), prepared according to the procedure described in J.

Org. Chem. , 49: 4226-423 (1984), in two portions over 5 minutes. After 10 minutes, the mixture was allowed to warm to-50 °C and was treated with ethyl bromoacetate (4.8 g, 28 mmol). The mixture was allowed to warm to-10 °C and was stirred at-10 to-15 °C for 1 hour. The reaction was quenched by careful addition of water (60 mL) followed by isopropyl acetate (60 mL). The organic layer was separated, washed with aqueous HCI (50 mL, prepared by adjusting the pH of water to 2 with conc. HCI), and then aqueous potassium carbonate (50

mL, 5 %). The organic layer was concentrated under vacuum to provide the title compound which was used in the next step without further purification.

Example 52B (6-bromo-1-hydroxy-2, 3-dihydro-1H-inden-2-yl) acetic acid The product from Example 52A in THF was treated with tert- butylaminoborane (1. 18 g, 13. 5 mmol) and heated at 40-45 °C for 2.5 hours. The mixture was treated with sodium hydroxide solution (1.8 g in water, 40 mL) and heating was continued for 30 minutes. The mixture was allowed to cool to room temperature and the aqueous layer was separated. The organic layer was diluted with isopropyl acetate (40 mL) and water (40 mL) and combined with the aqueous layer. The solution was cooled to 0 °C and the pH was adjusted to 2 by addition of concentrated hydrochloric acid. The mixture was filtered and the fitler cake dried at room temperature. The solid was slurried in dichloromethane (6 mL), refiltered, and redried to provide the title compound.

Example 52C methyl (5-bromo-1 H-inden-2-yl) acetate The product from Example 52B (1.35 g, 5 mmol) in methanol (12 mL) was treated with concentrated sulfuric acid (2 mL) and heated to gentle reflux. After 2 hours, additional sulfuric acid was added (1 mL) and heating was continued for another 2 hours. The mixture was concentrated under vacuum and the residue was diluted with water (15 mL). The mixture was cooled to 10 °C, filtered, and the filter cake washed with water (5 mL) and dried to provide the title compound.'H NMR (CD13) 8 3.42 (s, 2 H); 3.55 (s, 2 H); 3.74 (s, 3 H); 6.65 (m, 1 H); 7.22- 7.31 (m, 2 H), 7.44 (m, 1 H).

Example 52D 2- (5-bromo-1 H-inden-2-yl) ethanol The product from Example 52C (1.1 g, 4.1 mmol) in diethyl ether (5 mL) was added dropwise to a suspension of lithium aluminum hydride (0.125 g, 3.3 mmol) in diethyl ether (10 mL) maintaining the internal temperature below 10 °C.

After stirring for 30 minutes, the reaction mixture was diluted with diethyl ether (10 mL), cooled to 0 °C, and treated with saturated aqueous sodium sulfate dropwise.

The ethereal solution was decanted, dried with sodium sulfate, filtered, and the filtrate was concentrated to provide the title compound which was used without further purification in the next step.'H NMR (CD3) 8 2.77 (m, 2H); 3.32 (s, 2H); 3.88 (t, J=6.5 Hz, 2H); 6.56 (m, 1H), 7.23 (m, 2H); 7.40 (m, 1H).

Example 52E 2-(7-bromo-3-isoq uinolinyl) ethanol The product from Example 52D (0.85 g, 3.5 mmol) in methanol (15 mL) at- 70 °C was ozonated until a bluish color developed (-10 minutes). The mixture was treated with dimethylsulfide (0.7 mL, excess) and sodium bicarbonate (0.2 g) and allowed to warm to room temperature. After stirring for 3 hours, the mixture was treated with aqueous ammonium hydroxide (7.4 mL, 28 %). After stirring an additional 4 hours, the reaction mixture was concentrated under vacuum and then diluted with dichloromethane (20 mL). The organic layer was separated and evaporated to provide the title compound which was used without further purification in the next step.'H NMR (CDC13) b 3.13 (t, J=5.6 Hz, 2H); 4.07 (t, J=5.6 Hz, 2H); 7.47 (s, 1H) ; 7.61 (d, J=8.7 Hz, 1H) ; 7.71 (dd, J=1.9, 8.7 Hz, 1H) ; 9.04 (s, 1H) ; Anal. Calcd. for C,, HloBrNO : C, 52.41 ; H, 4.00 ; N, 5.56. Found: C, 52.51 ; H, 3.94 ; N, 5.42.

Example 52F 2- (7-bromo-3-isoguinolinyl) ethyl 4-methylbenzenesulfonate The product from Example 52E (0.51 g, 2.0 mmol), tosyl chloride (0.68 g, 3.6 mmol), triethylamine (0.55 g, 5.4 mmol), and DMAP (25 mg, 0.2 mmol) were combined in dichloromethane (20 mL) and stirred at room temperature for 6 hours. The mixture was treated with water (0.5 mL), stirred for 2 hours, and then treated with additional water (15 mL). The organic layer was separated, washed with aqueous sodium chloride solution (10 mL, 10%), evaporated in vacuo, and the residue was azeotroped with heptane (15 mL) to provide the title compound which was used in the next step without further purification.

Example 52G 7-bromo-3-82-[(2R)-2-methyl-1-pyrrolid inyllethelTisoquinoline The product from Example 52F was dissolved in a solution of (2R)-2- methylpyrrolidine (0.26 g, 3.0 mmol) in acetonitrile (20 mL). The solution was treated with potassium carbonate (0.5 g, 3.6 mmol) and heated at 50-55 °C for 20 hours a sealed flask. The mixture was allowed to cool to room temperature, filtered, and the filtrate was concentrated in vacuo. The residue was diluted with MTBE (20 mL) and water (20 mL) and the pH was adjusted to 3-3.5 with concentrated HCI. The aqueous layer was separated, extracted with MTBE (10 mL), adjusted to a pH of 8-8.5 with potassium carbonate, and extracted with isopropyl acetate (20 mL). The organic layer was separated and concentrated in vacuo. The residue was dissolved in heptane (20 mL), filtered, and the filtrate concentrated under vacuum to provide the title compound. 1H NMR (CDC13) 8 1.10 (d, J=6.1 Hz, 3H); 1.35-1. 49 (m, 1H) ; 1.62-1. 85 (m, 2H); 1. 85-1. 98 (m, 1H) ; 2.23 (q, J=8.8. Hz, 1H) ; 2.28-2. 42 (m, 1H) ; 2.46-2. 57 (m, 1H), 3.04-3. 19 (m, 2H); 3.19-3. 30 (m, 2H); 7.47 (s, 1H) ; 7.60 (d, J=8.8 Hz, 1H), 7.647. 70 (m, 1H), 8.05 (m, 1H) ; 9.09 (s, 1H) ; HRMS Calcd. for [Cl6HIgBrN2 + H+] : 319.0810. Found: 319.0795.

Example 52H 4- (3-f2- [ (2R)-2-methyl-1-pyrrolidinyllethyli-7-isoquinolinyl) benzonitrile The product from Example 52G (0.2 g, 0.6 mmol), 4-cyanophenylboronic acid (0.22 g, 1.5 mmol), bis (triphenylphosphine) palladium dichloride (55 mg, 0.08 mmol), and potassium phosphate (7 mL, 0.2 M in water) were combined in isopropanol (7 mL) and heated at 60-65 °C for 7 hours in a sealed flask. The mixture was filtered through diatomaceous earth, the filtrate was concentrated in vacuo, and then partitioned between MTBE (10 mL) and water (10 mL). The organic layer was separated, washed with aqueous sodium bicarbonate solution (5 %, 10 mL), and then extracted with a solution of 2M HCI (15 mL). The pH of the acidic aqueous layer was adjusted with base using potassium carbonate and extracted with isopropyl acetate (15 mL). The organic layer was evaporated in

vacuo and the residue was chased with heptane (10 mL) to provide the title compound. 1H NMR (CDC13) 8 1.12 (d, J=6.0 Hz, 3H); 1.37-1. 50 (m, 1H); 1.64- 1.85 (m, 2H); 1.85-1. 98 (m, 1 H) ; 2.26 (q, J=8.8. Hz, 1 H); 2.32-2. 43 (m, 1 H); 2.50-2. 60 (m, 1 H), 3.09-3. 34 (m, 4H); 7.56 (m, 1 H) ; 7.73-7. 81 (m, 4H), 7.84- 7.87 (m, 2H), 8.12 (m, 1H) ; 9.26 (s, 1H) ; HRMS Calcd. for [C23H23N3 + H+] : 342.1970. Found: 342.1974.

Example 53 3- (3-f2- [(2R)-2-methyl-1-pyrrolidinyllethyl}-7-isoquinolinyl) benzonitrile The title compound was prepared using the procedure described in Example 52H substituting 3-cyanophenylboronic acid for 4-cyanophenylboronic acid.'H NMR (CDC13) 5 1.15 (d, J=6.1 Hz, 3H); 1.39-1. 54 (m, 1H); 1.66-1. 87 (m, 2H); 1.88-2. 01 (m, 1H) ; 2.29 (q, J=8.8. Hz, 1H) ; 2.34-2. 47 (m, 1H) ; 2.52-2. 65 (m, 1H), 3.09-3. 40 (m, 4H); 7.58 (m, 1H) ; 7.61 (d, J=7.8 Hz, 1H) ; 7.64-7. 70 (m, 1H), 7.82-7. 89 (m, 2H); 7.89-7. 95 (m, 1H) ; 7.97 (m, 1H), 8.10 (m, 1H) ; 9.27 (s, 1H).

Example 54 6-2- [ (2R)-2-methyl-1-pyrrolidinyllethyl}-2- (3-pyridinyl) quinoline Example 54A (2R)-2-methyl-1- [2- (4-nitrophenyl) ethyllpyrrolidine (2R)-2-Methylpyrrolidine L-tartrate (4.0 g, 17.0 mmol), 1- (2-bromoethyl)-4- nitrobenzene (9.8 g, 43 mmol), and potassium carbonate (12 g, 85 mmol), were combined in DMF (20 mL) in a sealed tube at 50°C and stirred vigorously for 16 hours. The mixture was allowed to cool to room temperature, diluted with diethyl ether (100 mL), washed with water (2 times, 100 mL and then 50 mL), and extracted with 1 M HCI (2 times, 50 mL and 25 mL). The aqueous acidic extractions were combined, washed with diethyl ether (50 mL), cooled to 0°C, adjusted to pH 14 with 50% NaOH solution, and extracted with dichloromethane (3 times, 50 mL). The dichloromethane extractions were combined, dried (MgS04), filtered, and the filtrate concentrated to provide the title compound.'H NMR (300 MHz, CDC13) 8 1. 08 (d, J=6 Hz, 3 H), 1.43 (m, 1 H), 1.75 (m, 2 H), 1.93

(m, 1 H), 2.19 (q, J=9 Hz, 1 H), 2.34 (m, 2 H), 2.91 (m, 2 H), 3.03 (m, 1 H), 3.22 (td, J=8,3 Hz, 1 H), 7.38 (d, J=9 Hz, 2 H), 8.15 (d, J=9 Hz, 2 H); MS (DCI/NH3) m/z 235 (M+H) +.

Example 54B 4-{2-[(2R)-2-methyl-1-pyrrolid inyllethylTaniline The product from Example 54A (3.85 g, 16.4 mmol) was hydrogenated using 10% Pd/C (0.39 g) in methanol (20 mL) under 1 atm H2 for 16 hours. After the H2 was replaced with N2, the mixture was diluted with methanol (150 mL), stirred for 15 minutes, filtered, and the filtrate was concentrated to provide the title compound. 1 H NMR (300 MHz, CDC13) 8 1.11 (d, J=6 Hz, 3 H), 1.43 (m, 1 H), 1.74 (m, 2 H), 1.90 (m, 1 H), 2.25 (m, 3 H), 2.70 (m, 2 H), 2.97 (m, 1 H), 3.24 (td, J=9,3 Hz, 1 H), 3.55 (s, 2 H), 6.63 (d, J=8 Hz, 2 H), 7.01 (d, J=8 Hz, 2 H); MS (DCI/NH3) m/z 205 (M+H) +.

Example 54C 2, 2-dimethyl-N-(4-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}pheny l) propanamide The product from Example 54B (2.77 g, 14 mmol) was dissolved in anhydrous dichloromethane (70 mL) under nitrogen, treated with triethylamine (2.3 mL, 16 mmol), cooled to 0°C, treated with trimethyiacety) chloride (1.9 mL, 15 mmol), stirred at ambient temperature for 60 hours and treated with 1 M NaOH (40 mL). The layers were separated and the aqueous layer was extracted with dichloromethane (2 times, 40 mL). The combined dichloromethane layers were dried (MgS04), filtered, and the filtrate was concentrated to provide 4.0 g of the title compound.'H NMR (300 MHz, CDC13) 5 1. 10 (d, J=6 Hz, 3 H), 1.31 (s, 9 H), 1.44 (m, 1 H), 1.76 (m, 2 H), 1.92 (m, 1 H), 2.18 (q, J=9 Hz, 1 H), 2.27 (m, 2 H), 2.78 (m, 2 H), 2.99 (m, 1 H), 3.23 (td, J=9,3 Hz, 1 H), 7.17 (d, J=8 Hz, 2 H), 7.44 (d, J=8 Hz, 2 H); MS (DCI/NH3) m/z 289 (M+H) +.

Example 54D N-(2-formvl-4-82-[(2R) ^2-methyl-1-pyrrolidinyllethylTphenyl)-2, 2- dimethylpropanamide

The product from Example 54C (4.0 g, 13.9 mmol) under nitrogen in anhydrous diethyl ether (140 mL) was treated with N, N, N'N'- tetramethylethylenediamine (6.5 mL, 43 mmol), cooled to-5 °C, treated with n- butyllithium (16.7 mL of a 2.5 M solution in hexanes) over 10 minutes, stirred for 4 hours at ambient temperature, cooled to-5 °C, treated all at once with anhydrous N, N-dimethylformamide (6.5 mL, 83 mmol), stirred for 16 hours at ambient temperature, diluted with diethyl ether (100 mL), washed with water (75 mL), washed with brine, dried (MgS04), filtered, and the filtrate was concentrated. The residue was purified by chromatography on silica gel eluting with a gradient of 2%, 3.5%, 5%, and 7.5 % (9: 1 MeOH: conc NH40H) in dichloromethane to provide the title compound. 1H NMR (300 MHz, CDC13) 6 1.10 (d, J=6 Hz, 3 H), 1.35 (s, 9 H), 1.44 (m, 1 H), 1.75 (m, 2 H), 1.93 (m, 1 H), 2.19 (q, J=9 Hz, 1 H), 2.31 (m, 2 H), 2.85 (m, 2 H), 3.01 (m, 1 H), 3.23 (td, J=8,3 Hz, 1 H), 7.47 (dd, J=8, 2Hz, 1 H), 7.51 (d, J=2 Hz, 1 H), 8.71 (d, J=8 Hz, 1 H), 9.92 (s, 1 H), 11.31 (s, 1 H); MS (DCI/NH3) m/z 317 (M+H) +.

Example 54E 2-amino-5- {2-f(2R)-2-methyl-1-pyrrolidinyllethyl} benzaldehyde The product from Example 54D (2.46 g, 7.8 mmol) in 3M HCI (40 mL) was heated at 80°C for 4 hours, allowed to cool to room temperature, and carefully poured into a mixture of 1M NaOH (250 mL) and dichloromethane (75 mL). The layers were separated and the aqueous layer was extracted with dichloromethane (2 times, 75 mL). The combined dichloromethane layers were dried (MgS04), filtered, and the filtrate was concentrated. The residue was purified by chromatography on silica gel eluting with a gradient of 2%, 3.5% and 5% (9: 1 MeOH: conc NH40H) in dichloromethane to provide the title compound.'H NMR (300 MHz, CDC13) 5 1.12 (d, J=6 Hz, 3 H), 1.50 (m, 1 H), 1.76 (m, 2 H), 1.93 (m, 1 H), 2.25 (m, 3 H), 2.76 (m, 2 H), 2.99 (m, 1 H), 3.25 (td, J=9,3 Hz, 1 H), 5.99 (s, 2 H), 6.60 (d, J=8 Hz, 1 H), 7.19 (dd, J=8,2 Hz, 1 H), 7.31 (d, J=2 Hz, 1 H), 9.85 (s, 1 H); MS (DCI/NH3) m/z 233 (M+H) +.

Example 54F

6-f2-f(2R)-2-methyl-1-pyrrolidinyllethyl}-2- (3-pyridinyl) quinoline The product from Example 54E (32.5 mg, 0.14 mmol) and 3-acetylpyridine (17 mg, 0.14 mmol) were combined in ethanol (2 mL) and treated with one drop of a saturated solution of potassium hydroxide in ethanol and heated at 80 °C for 16 hours. The mixture was allowed to cool to room temperature and concentrated.

The residue was purified by chromatography on silica gel eluting with a gradient 10: 1: 1 to 6 : 1: 1 to 4 : 1: 1 ethyl acetate : formic acid : water. The fractions containing the product were collected, concentrated, and the residue repurified by chromatography on silica gel eluting with a gradient of 2%, 3.5% and 5% (9: 1 MeOH: conc NH40H) in dichloromethane to provide the title compound.'H NMR (300 MHz, CD30D) 5 1. 17 (d, J=6 Hz, 3 H), 1.47 (m, 1 H), 1.82 (m, 2 H), 2.02 (m, 1 H), 2.35 (q, J=9 Hz, 1 H), 2.47 (m, 2 H), 3.04 (m, 2 H), 3.19 (m, 2 H), 7.62 (dd, J=8,5 Hz, 1 H), 7.72 (dd, J=9,2 Hz, 1 H), 7.82 (d, J=2 Hz, 1 H), 8.04 (d, J=9 Hz, 1 H), 8.08 (d, J=9 Hz, 1 H), 8.40 (d, J=9 Hz, 1 H), 8.60 (dt, J=8,2 Hz, 1 H), 8.64 (dd, J=5,1 Hz, 1 H), 9.32 (d, J=1 Hz, 1 H); MS (DCI/NH3) m/z 318 (M+H) +.

Example 55 6-f2-r (2R)-2-methyl-1-pyrrolidinyllethyl}-2- (4-pyridinyl) quinoline The title compound was prepared using the procedure described in Example 54F substituting 4-acetylpyridine acid for 3-acetylpyridine.'H NMR (300 MHz, CDC13) 61. 14 (d, J=6 Hz, 3 H), 1.48 (m, 1 H), 1.78 (m, 2 H), 1.96 (m, 1 H), 2.25 (q, J=9 Hz, 1 H), 2.42 (m, 2 H), 3.09 (m, 3 H), 3.30 (td, J=9,3 Hz, 1 H), 7. 66 : (m, 2 H), 7.89 (d, J=9 Hz, 1 H), 8.05 (dd, J=4, 2 Hz, 2 H), 8.12 (d, J=9 Hz, 1 H), 8.23 (dd, J=9,1 Hz, 1 H), 8.78 (dd, J=4,2 Hz, 2 H); MS (DCI/NH3) m/z 318 (M+H) +.

Example 56 6--f (2R)-2-methyl-1-pyrrolidinyllethyl}-2- (2-pyridinyl) guinoline The title compound was prepared using the procedure described in Example 54F substituting 2-acetylpyridine acid for 3-acetylpyridine.'H NMR (300 MHz, CDC13) 8 1. 14 (d, J=6 Hz, 3 H), 1.46 (m, 1 H), 1.77 (m, 2 H), 1.94 (m, 1 H), 2.25 (q, J=9 Hz, 1 H), 2.40 (m, 2 H), 3.03 (m, 2 H), 3.14 (m, 1 H), 3.30 (td, J=9,3

Hz, 1 H), 7.35 (ddd, J=8,5, 1 Hz, 1 H), 7.62 (dd, J=9,2 Hz, 1 H), 7.67 (d, J=1 Hz, 1 H), 7.86 (td, J=8,2 Hz, 1 H), 8.10 (d, J=9 Hz, 1 H), 8.22 (d, J=9 Hz, 1 H), 8.53 (d, J=9 Hz, 1 H), 8.63 (d, J=8 Hz, 1 H), 8.73 (m, 1 H); MS (DCI/NH3) m/z 318 (M+H) +.

Example 57 6-f2- [ (2R)-2-methyl-1-pyrrolidinyllethyll-2- (1, 34hiazol-2-yl) quinoline The product from Example 54E (46 mg, 0.20 mmol) and 1- (1, 3-thiazol-2- yl) ethanone (52 mg, 0.41 mmol) were combined in ethanol 0.4 mL, and treated with one drop of a saturated solution of potassium hydroxide in ethanol and heated at 80 °C for 16 hours. The mixture was allowed to cool to room temperature and concentrated. The residue was purified by chromatography on silica gel eluting with a gradient of 2% and 3.5% (9: 1 MeOH: conc NH40H) in dichloromethane to provide the title compound.'H NMR (300 MHz, CDC13) # 1. 13 (d, J=6 Hz, 3 H), 1.46 (m, 1 H), 1.77 (m, 2 H), 1.93 (m, 1 H), 2.24 (q, J=9 Hz, 1 H), 2.39 (m, 2 H), 3.01 (m, 2 H), 3.11 (m, 1 H), 3.29 (td, J=9,3 Hz, 1 H), 7.48 (d, J=3 Hz, 1 H), 7.63 (m, 2 H), 7. 97 (d, J=3 Hz, 1 H), 8.06 (d, J=9 Hz, 1 H), 8.19 (d, J=9 Hz, 1 H), 8.31 (d, J=9 Hz, 1 H); (DCI/NH3) m/z 324 (M+H) +.

Example 58 <BR> <BR> 2- (2, 4-dimethyl-1, 3-thiazol-5-yl)-6-2-r (2R)-2-methyl-1-pyrrolidinyllethyl} quinoline The title compound was prepared using the procedure described in Example 57 substituting 1- (2, 4-dimethyl-1, 3-thiazol-5-yl) ethanone for 1- (1, 3- thiazol-2-yl) ethanone.'H NMR (300 MHz, CDC13) # 1. 13 (d, J=6 Hz, 3 H), 1.48 (m, 1 H), 1.76 (m, 2 H), 1.94 (m, 1 H), 2.24 (q, J=9 Hz, 1 H), 2.39 (m, 2 H), 2.72 (s, 3 H), 2.75 (s, 3 H), 3.01 (m, 2 H), 3.12 (m, 1 H), 3.29 (td, J=9, 2 Hz, 1 H), 7.62 (m, 3 H), 7.99 (d, J=9 Hz, 1 H), 8.11 (d, J=9 Hz, 1 H); (DCI/NH3) m/z 352 (M+H) +.

Example 59 6-f 2-r (2R)-2-methyl-1-pyrrolidinyllethyl}-2- (2-pyrazinyl) q uinoline The title compound was prepared using the procedure described in Example 57 substituting 1-(2-pyrazinyl) ethanone for 1- (1, 3-thiazol-2-yl) ethanone.

aH NMR (300 MHz, CDC13) 8 1. 14 (d, J=6 Hz, 3 H), 1.46 (m, 1 H), 1.78 (m, 2 H), 1.94 (m, 1 H), 2.25 (q, J=9 Hz, 1 H), 2.40 (m, 2 H), 3.05 (m, 2 H), 3.16 (m, 1 H), 3.30 (td, J=9, 3 Hz, 1 H), 7.65 (dd, J=8,2 Hz, 1 H), 7.68 (br. s. , 1 H). 8.13 (d, J=8 Hz, 1 H), 8.24 (d, J=8 Hz, 1 H), 8.46 (d, J=9 Hz, 1 H), 8.63 (d, J=2 Hz, 1 H), 8.66 (dd, J=3,2 Hz, 1 H), 9.86 (d, J=1 Hz, 1 H); (DCI/NH3) m/z 319 (M+H) +.

Example 60 <BR> <BR> <BR> <BR> <BR> <BR> 1-f6- (62- [ (2R)-2-methyl-1-pyrrolidinyllethyl)-2-guinolinyl)-2-pyridiny llethanone The title compound was prepared using the procedure described in Example 57 substituting 2, 6-diacetylpyridine for 1- (1, 3-thiazol-2-yl) ethanone.'H NMR (300 MHz, CDC13) 8 1.14 (d, J=6 Hz, 3 H), 1.48 (m, 1 H), 1.78 (m, 2 H), 1.95 (m, 1 H), 2.26 (q, J=9 Hz, 1 H), 2.41 (m, 2 H), 2.88 (s, 3 H), 3.04 (m, 2 H), 3.17 (m,, l H), 3.. 31 (td, J=9,3 Hz, 1 H), 7.64 (dd, J=9,2 Hz, 1 H), 7.69 (d, J=2 Hz, 1 H), 8.00 (t, J=8 Hz, 1 H), 8.10 (m, 2 H), 8.25 (d, J=9 Hz, 1 H), 8.66 (d, J=9 Hz, 1 H), 8.88 (dd, J=8,1 Hz, 1 H); (DCI/NH3) m/z 360 (M+H) +.

Example 61 4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-6-quinoxalinyl) benzonitrile and 4-(3-{2-[(2R)-2-methyl-1-pyrrolidinyl}-6-quinoalinyl)benzoni trile Example 61A 4-bromo-1,2-benzenediamine 4-Bromo-2-nitroaniline (10 g, 46 mmol) in THF (120 mL) was treated with 1 % Pt/C (1.0 g) and hydrogenated at room temperature under 40 psi of H2 pressure. After 2 hours, the reaction was filtered and the filtrate concentrated to provide the title compound which was used without further purification in the next step. MS 188 (M+H) + ;'H NMR (400 MHz, CDCI3) 8 6.77-6. 81 (m, 2H), 6.54 (d, J=8. 4Hz, 1 H), 3.28 (br, 4H).

Example 61 B 7-bromo-2-methylquinoxaline

and 6-bromo-2-methylquinoxaline The product from Example 61A (9. 4g, 50 mmol) in acetonitrile (100 mL) was treated with 40% aqueous pyruvic aldehyde (11.0 mL, 60 mmol) dropwise.

After stirring at room temperature for 2 hours, the mixture was concentrated and the residue was suspended in IPAc (100 mL) and filtered. The filtrate was washed with 20% brine, dried with Na2SO4, filtered, and the filtrate was concentrated. The @ residue was purified by silica gel column chromatography eluting with heptane: EtOH: MeOH (8: 2 : 1) to provide the title compounds. MS 224 (M+H) + ;'H NMR (400 MHz, CDC13) 8 8.73 (s, 1H), 8.72 (s, 1H), 8.23 (d, J=2.2 Hz, 1H), 8.18 (d, J=2.1 Hz, 1H), 7.75-7. 93 (m, 4H), 2.78 (s, 3H), 2.76 (s, 3H) ;'3C NMR (400 MHz, CDC13) 8 154.32, 153.73, 146.34, 145.83, 142.28, 141.17, 140.45, 139.34, 133.17, 132. 15, 131.15, 130.75, 130.16, 129.71, 123.66, 122.38, 22.89.

Example 61 C 4- (2-methvl-6-guinoxalinyl) benzonitrile and 4- (3-methyl-6-quinoxalinyl) benzonitrile 4-Cyanophenylboronic acid (588 mg, 4.0 mmol), cesium carbonate (2.2 g, 7.0 mmol), and cesium fluoride (608 mg, 4.0 mmol) were combined in H20 (15 mL) and treated with the products from Example 61 B (446 mg, 2.0 mmol) in toluene (10 mL) and heated at 80 °C for 3 hours. The reaction mixture was allowed to cool to room temperature and filtered through a pad of celite. The filtrate was partitioned between IPAc (60 mL) and H20 (50 mL). The organic layer was separated, washed with 20% brine, dried with Na2S04, filtered, and the filtrate was concentrated under vacuum to provide the title compounds which were used in the next step without further purification. MS 246 (M+H) + ;'H NMR (400 MHz, CDC13) 8 8.71 (s, 1 H), 8.69 (s, 1 H), 8.02-8. 20 (m, 4H), 7.84-7. 90 (m, 2H), 7.70- 7.76 (m, 8H), 2.73 (s, 6H) ; 13C NMR (400 MHz, CDC13) 8 154. 34,154. 10, 146.47, 147. 17, 143. 80, 142.93, 141. 74, 140.62, 140.39, 140. 18, 139. 16, 132. 49, 130. 16, 129. 74, 129. 25,128. 71,128. 63, 128. 06, 127. 77,127. 74, 127. 66,127. 59, 127.22, 126.73, 118. 39,118. 37, 111. 61,111. 51,22. 96.

Example 61 D 4-(2-82-r (2R)-2-methyl-1-pyrrolidinyllethylE-6-q uinoxalinyl) benzonitrile and 4-(3-82-r (2R)-2-methyl-1-pyrrolid inyllethylT-6-quinoxalinyl) benzonitrile (2R)-2-Methylpyrrolidine hydrochloride 5 (973 mg, 8.0 mmol) and 37% aqueous solution of formaldehyde (0.57 mL, 7.0 mmol) were combined in EtOH v (20 mL) and heated in a sealed tube at 85 °C for 1 hour. The mixture was allowed to cool to room temperature, treated with the products from Example 61C (500 mg, 2.0 mmol), and heated at 85 °C overnight. The mixture was allowed to cool to room and concentrated to dryness under vacuum. The residue was partitioned between IPAc (50 mL) and 20% brine (40 mL). The organic layer was separated, dried with Na2SO4, filtered, and the filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography eluting with heptane: acetone: CH2CI2 : Et3N (60: 40: 3: 1) to provide the title compounds. MS 343 (M+H) + ;'H NMR (400 MHz, CDCl3) 8 8.74 (s, 1H), 7.72 (s, 1H), 8.16 (m, 2H), 8.06 (m, 2H), 7.85 (m, 2H), 7.70 (m, 4H), 3.17 (m, 8H), 2.52 (m, 2H), 2.31 (m, 2H), 2.17 (m, 2H), 1.83 (m, 2H), 1.65 (m, 4H), 1.32 (m, 2H). 13 C NMR (400 MHz, CDC13) 8 156. 63, 156.41, 146.45, 145. 16, 143. 73, 143. 70, 141. 75, 141. 53,140. 81, 140. 60, 139.89, 139.04, 132.38, 129.66, 129.36, 128.42, 127. 68, 127.65, 127. 55, 137.13, 126.86, 118.29, 111.48, 111.40, 59.87, 53.93, 52.89, 35.83, 32.90, 21.98, 19.25.

Example 62 7- (2, 6-difluoro-3-pyridinyl)-3-f2- [ (2R)-2-methyl-1-pyrrolidinyllethyllisoguinoline Example 62A methyl 5-bromo-2-iodobenzoate To a stirred slurry of methyl 2-iodo-benzoate (5.0 g, 0.019 mol) and N- bromosuccinimide (3.74 g, 0.021 mol) in acetic acid (10 mL) was added concentrated H2SO4 (10 mL) dropwise, keeping the temperature at 20-40 °C. The mixture was stirred at room temperature for 88 hours and then heated at 50 °C for 4 hours. The mixture was cooled to 10 °C, treated with 40 g of ice water, and

extracted with 50 mL of CH2CI2. The organic phase was washed in succession with 2x50 mL 5% NaHCO3, 50 mL 10% Na2S203,50 mL water, and concentrated to colorless oil. The residue was purified by column chromatography (silica gel, 10: 90 EtOAc: hexane) to provide the title compound.'H NMR (CD3, 400 MHz) 6 7.92 (d, J=4 Hz, 1 H), 7.83 (d, J=8 Hz, 1H), 7.27 (dd, J=8,4 Hz, 1H), 3.92 (s, 3H); MS (DCI/NH3) [M+NH4] + at 358, [M+NH3 NH4] + at 375.

Example 62B (5-bromo-2-iodophenyl) methanol To a stirred mixture of NaBH4 (11.18 g, 0.296 mol) in EtOH (200 mL) at 5 °C was added the product from Example 62A (50.4 g, 0.148 mol) in THF (100 mL). The mixture was alowed to warm to room temperature and stirred for 18 hours. The mixture was treated with additional NaBH4 (8.4 g, 0.222 mol) and was stirred for 22 hours. The mixture was cooled to 0 °C, treated with 100 mL of 15 % aqueous citric acid slowly, and extracted with 600 mL of CH2CI2. The organic phase was washed with 200 mL of 15 % NaCI and concentrated to provide the title compound.'H NMR CDCl3, 400 MHz) 8 7.64 (d, J=8 Hz, 1H), 7.61 (d, J=4 Hz, 1H), 7.12 (dd, J=4,8 Hz, 1H), 4.63 (d, J=8 Hz, 2H), 1.98 (t, J=8 Hz, 1H). MS (DCI/NH3) [M+NH4] + at 330, [M+NH4-H20] + at 312.

Example 62C 5-bromo-2-iodobenzaldehyde A solution of oxalyl chloride (1.53 g, 0.012 mol) in CH2CI2 (15 mL) was cooled to-70 °C, and DMSO (1.41 g, 0.018 mol) in CH2CI2 (15 mL) was added at - 65 to-70 °C. The mixture was stirred under nitrogen for 10 minutes at-70 °C and then treated with the product from Example 62B (2.35 g, 7.5 mmol) in 60 mL CH2CI2. The slurry was stirred at-65 °C for 15 minutes and treated with triethylamine (3.8 g, 0.037 mol). The mixture was allowed to warm to-10 °C over 1 hour. The mixture was treated with 20 mL of water and allowed to warm to room temperature. The organic layer was separated and concentrated to provide the title compound.'H NMR (CD3, 400 MHz) 8 9. 97. (s, 1H), 7.97 (d, J=4 Hz,

1 H), 7.79 (d, J=8 Hz, 1 H), 7.40 (dd, J=4,8 Hz, 1H). MS (DCI/NH3) [M+NH4] + at 328.

Example 62D N-f (1 E)- (5-bromo-2-iodophenyl) methylenel-N- (tert-butyl) amine The product from Example 62C (2.28 g, 7.3 mmol) in THF (10 mL) was treated with t-butylamine (1.61 g, 22.0 mmol) and stirred under nitrogen at room temperature for 40 hours. The mixture was concentrated under reduced pressure and the residue was dissolved in 30 mL of methylene chloride. The methylene chloride was washed with 10 mL water and concentrated to provide the title compound which was used in the next step without further purification.'H NMR (CDC13, 400 MHz) 8 8.29 (s, 1 H), 8.05 (d, J=4 Hz, 1 H), 7.66 (d, J=8 Hz, 1 H), 7.19 (dd, J=4,8 Hz, 1H), 1.34 (s, 9H). MS (DCI/NH3) 366 [M+H] +.

Example 62E 2- (7-bromo-3-isoguinolinyl) ethanol The product from Example 62D (1.3 g, 3.6 mmol), 3-butyn-1-ol (0.3 g, 4.3 mmol), Cul (0.04 g, 0.2 mmol), and PdCl2 (PPh3) 2 (0.08 g, 0.1 mmol) were combined in toluene (15 mL). The mixture was treated with diisopropylamine (0.54 g, 5. 3 mmol) and stirred at room temperature for 4 hours. The mixture was then treated with additional Cul (0.07 g, 0.4 mmol) and heated at 100 °C for 4 hours. The mixture was allowed to cool to room temperature, diluted with 30 mL CH2CI2, and filtered The filtrate was washed with 2x10 mL 15 % NaCI and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, 10: 90 MeOH: CHCl3) to provide the title compound.'H NMR (CDCl3, 400 MHz) 8 9.08 (s, 1 H), 8.09 (d, J=4 Hz, 1 H), 7.73 (dd, J=8,4 Hz, 1H), 7.63 (d, J=8 Hz, 1H), 7.48 (s, 1H), 4.08 (t, J=4 Hz, 2H), 3.92 (s, 1H), 3.15 (t, J=4 Hz, 2H). 13C NMR (CDC13, 100 MHz) 8 153. 8,150. 3,134. 5,133. 8,129. 4, 127. 6, 120.0, 118.6, 62.3, 39.4. MS (DCI/NH3) 252,254 [M+H] +.

Example 62F 7-bromo-3-f2-f (2R)-2-methyl-1-pyrrolidinyllethylisoguinoline

The product from Example 62E (0.5 g, 2.0 mmol) and triethylamine (0.5 g, 4.9 mmol) were combined in THF (15 mL) at-15 °C. The mixture was treated with methanesulfonyl chloride (0.24 g, 2.1 mmol) and stirred at 0-10 °C for 2 hours. The mixture was treated with additional methanesulfonyl chloride (0.2 mmol) and stirred at room temperature for 16 hours. The mixture was treated with (2R)-2-methylpyrrolidine hydrochloride (0.72 g, 6.0 mmol) and K2CO3 (0.27 g, 2.0 mmol) in acetonitrile (25 mL) and then the mixture was heated at 60 °C for 20 hours. The mixture was allowed to cool to room temperature and was concentrated under reduced pressure. The residue was dissolved in 20 mL CH2CI2, washed with 5 mL of water and concentrated under reduced pressure.

The residue was purified by column chromatography (silica gel, 10: 90 MeOH: CHCl3) to provide the title compound.'H NMR (CDCl3, 400 MHz) 8 9.10 (s, 1H), 8.09 (d, J=4 Hz, 1H), 7.72 (dd, J=12, 4 Hz, 1H), 7.64 (d, J=12 Hz, 1H), 7.58 (s, 1 H), 3.46-3. 40 (m, 2H), 3.34-3. 29 (m, 2H), 2.91-1. 85 (m, 1 H), 2.81-2. 68 (m, 1 H), 2.59-2. 49 (m, 1H), 2.11-2. 02 (m, 1H), 2.00-1. 91 (m, 1H), 1.88-1. 79 (m, 1H), 1.71-1. 61 (m, 1H), 1.32 (d, J=8 Hz, 3H). 13C NMR (CD3, 100 MHz) 8 152.5, 150.6, 134.5, 133.6, 129.2, 127.8, 127.7, 120.0, 118.7, 61.7, 53.7, 53.4, 36.0, 32.4, 21.9, 17.9. MS (DCI/NH3) 319,321 [M+H] +.

Example 62G 7- (2, 6-difluoro-3-pyridinyl)-3-f 2-f (2R)-2-methyl-1-pyrrolidinyllethyllisoguinoline The product from Example 62F (0.30 g, 0.9 mmol), 2, 6-difluoro-3- pyridineboronic acid (0.3 g, 1.9 mmol), 2- (dicyclohexylphosphino) biphenyl (66 mg, 0.2 mmol), and PdCI2 (PPh3) 2 (66 mg, 0.1 mmol) were combined in isopropanol (15 mL). The mixture was treated with a solution of Na2CO3 (0.15 g, 1.4 mmol, in 5 mL water) and heated at 65 °C for 16 hours. After cooling to room temperature, the mixture was diluted with 20 mL of CH2CI2 and filtered. The filtrate was washed with 10 mL of 15% NaCI and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, 10: 90: 1 MeOH: CHCI3 : Et3N) to provide the title compound. 1H NMR (CDCl3, 400 MHz) 8 9.25 (s, 1H), 8.11-8. 05 (m, 2H), 7.85 (d, J=10 Hz, 1H), 7.81-7. 78 (m, 1H), 7.58 (s, 1 H), 6.98 (dd, J=10 Hz, 1H), 3.34-3. 27 (m, 2H), 3.22-3. 15 (m, 2H), 2.65-2. 56 (m,

1H), 2.45-2. 40 (m, 1H), 2.33-2. 27 (m, 1H), 2.01-1. 91 (m, 1H), 1.87-1. 80 (m, 1 H), 1.77-1. 70 (m, 1H), 1.52-1. 42 (m, 1 H), 1.16 (d, J=8 Hz, 3H) ; 13C NMR (CDC13, 400 MHz) 8 158. 9,154. 6,151. 9,144. 6,144. 5, 135.6, 130. 7, 130.2, 127.3, 126.7, 126.6, 118. 1,1006. 8,106. 5,60. 2,54. 2,54. 1,37. 5,32. 9,22. 0,19. 2.

Example 63 3-f2- [ (2R)-2-methyl-1-pyrrolidinyllethyl)-7- (3-pyridinyl) isoguinoline Example 63A 2- [7- (3-pyridinyl)-3-isoguinolinyllethanol The product from Example 62E (0.3 g, 1.2 mmol), 3-pyridineboronic acid (0. 22 g, 1.8 mmol), 2- (dicyclohexylphosphino) biphenyl (80 mg, 0.2 mmol), and PdCI2 (PPh3) 2 (80 mg, 0.1 mmol) were combined in isopropanol (15 mL) and treated with a solution of Na2CO3 (0.19 g, 1.8 mmol) in water (5 mL) and heated at 65 °C for 16 hours. After cooling to room temperature, the mixture was diluted with 20 mL of CH2CI2 and filtered. The filtrate was washed with 10 ml 15% NaCI and concentrated under reduced pressure. The residue was purifed by column chromatography (silica gel, 10: 90 MeOH : CHCt3) to provide the title compound.'H NMR (CDC13, 400 MHz) S 9.24 (s, 1 H), 8.95 (d, J=4 Hz, 1 H), 8.65 (dd, J=2,8 Hz, 1 H), 8.13 (bs, 1H), 7.98 (2 m, 1H), 7.91-7. 86 (m, 2H), 7.55 (s, 1H), 7.44-7. 41 (2d, 1H), 4.11 (t, J=4 Hz, 2H), 3.19 (t, J=4 Hz, 2H) ; 13C NMR (CD3, 400 MHz) 8 153.9, 151.7, 148. 6, 148.0, 135.9, 135.5, 135. 4, 134.2, 129. 5, 127.2, 126.9, 125. 4, 123. 5, 118.5, 62.4, 39.4.

Example 63B 3-f2-f (2R)-2-methyl-1-pyrrolidinyllethyl}-7- (3-pyridinyl) isoquinoline The product from Example 63A (0.25 g, 1.0 mmol) and triethylamine (0.15 g, 1.5 mmol) in methylene chloride (10 mL) at-5 °C were treated with methanesulfonyl chloride (0.12 g, 1.2 mmol) and stirred at 0 °C for 2 hours and then stirred at room temperature for 15 hours. The mixture was concentrated under reduced pressure and the residue was treated with K2CO3 (0.21 g, 1.5 mmol) and (2R)-2-methylpyrrolidine (0.13 g, 1.5 mmol) in acetonitrile (15 mL), and

then heated at 60 °C for 5 hours. The mixture was concentrated under reduced pressure and the residue was dissolved in 30 mL methylene chloride, washed with 10 mL 15% NaCI, and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, 10: 90: 1 MeOH: CHCI3 : Et3N) to provide the title compound. 1 H NMR (CDCI3, 400 MHz) 8 9. 27 (s, 1H), 8.95 (m, 1H), 8.64 (dd, J=2,4 Hz, 1 H), 8.12 (s, 1H), 7.98 (m, 1H), 1.90-1. 86 (m, 2H), 7.56 (s, 1H), 7.44-7. 40 (m, 1H), 3.37-3. 28 (m, 2H), 3.26-3. 18 (m, 2H), 2.68-2. 61 (m, 2H), 2.51-2. 46 (m, 1H), 2.38-2. 31 (m, 1 H), 2.00-1. 93 (m, 1H), 1.88-1. 82 (m, 1H), 1.80- 1.72 (m, 1H), 1.55-1. 46 (m, 1H), 1. 14 (d, 3H) ; 13C NMR (CDC13, 400 MHz) s 9.27 . 153. 8,151. 9,148. 4,147. 9,135. 6,135. 5,135. 4,134. 1,129. 1,127. 0,126. 9,125. 2, 123.4, 118.2, 60.4, 54.1, 54.0, 37. 2, 32.8, 21.9, 19.0.

Example 64 3-(benzyloxy)-2-methyl-6-{2-[(2R)-2-methyl-1-pyrrolidinyl]et hyl}quinoline The title compound was prepared using the procedure described in Example 57 substituting 1- (benzyloxy) acetone for 1- (1, 3-thiazol-2-yl) ethanone.'H NMR (300 MHz, CDC13) # 1. 13 (d, J=6.1 Hz, 3 H), 1.46 (m, 1 H), 1.75 (m, 1 H), 1.94 (m, 1 H), 2.23 (q, J=8.8 Hz, 1 H), 2.37 (m, 2 H), 2.70 (s, 3 H), 2.97 (m, 2 H), 3.11 (m, 1 H), 3.28 (m, 1 H), 5.20 (s, 2 H), 7.31 (s, 1 H), 7.35-7. 46 (m, 5 H), 7.50 (m, 3 H), 7.89 (d, J=8.5 Hz, 1 H); (DCI/NH3) m/z 361 (M+H) +.

Example 65 2-cvclopropvl-6-82-F (2R)-2-methvl-1-pyrrolidinyllethylTq uinoline The title compound was prepared using the procedure described in Example 57 substituting 1-cyclopropylethanone for 1- (1, 3-thiazol-2-yl) ethanone.

H NMR (300 MHz, CDC13) 8 1.02-1. 16 (m, 4 H), 1.12 (d, J=6.1 Hz, 3 H), 1.45 (m, 1 H), 1.76 (m, 2 H), 1.93 (m, 1 H), 2.23 (m, 2 H), 2.37 (m, 2 H), 2.98 (m, 2 H), 3.10 (m, 1 H), 3.28 (m, 1 H), 7.13 (d, J=8.5 Hz, 1 H), 7.50-7. 56 (m, 2 H), 7.88 (d, J=8.5 Hz, 1 H), 7.93 (d, J=8.5 Hz. 1 H); (DCI/NH3) m/z 281 (M+H) +.

Example 66 4-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-quinolinyl)be nzonitrile

The title compound was prepared using the procedure described in Example 57 substituting 4-acetylbenzonitrile for 1- (1, 3-thiazol-2-yl) ethanone.'H NMR (400 MHz, CDC13) 8 1. 13 (d, J=5.8 Hz, 3 H), 1.46 (m, 1 H), 1.73 (m, 1 H), 1.83 (m, 1 H), 1.95 (m, 1 H), 2.25 (q, J=8.6 Hz, 1 H), 2.40 (m, 2 H), 3.03 (m, 2 H), 3.14 (m, 1 H), 3.29 (dt, J=8. 4, 2.3 Hz, 1 H), 7.66 (m, 2 H), 7.81 (d, J=8.6 Hz, 2 H), 7.86 (d, J=8.3 Hz, 1 H), 8.09 (d, J=8.6 Hz, 1 H), 8.22 (d, J=8.29 Hz, 1 H), 8.29 (d, J=8.59 Hz, 2 H); (DCI/NH3) m/z 342 (M+H) +.

\ Example 67 2, 6-d imethvl-5-(6-{2-[(2R)-2-methvl-1-pyrrolidinyllethvlT-2-quino linyl) nicotinonitrile The title compound was prepared using the procedure described in Example 57 substituting 5-acetyl-2, 6-dimethylnicotinonitrile for 1- (1, 3-thiazol-2- yl) ethanone.'H NMR (300 MHz, CDC13) 8 1. 14 (d, J=6.10 Hz, 3 H), 1.48 (m, 1 H), 1.77 (m, 2 H), 1.95 (m, 1 H), 2.25 (q, J=8.70 Hz, 1 H), 2.40 (m, 2 H), 2.69 (s, 3 H), 2.82 (s, 3 H), 3.10 (m, 3 H), 3.30 (m, 1 H), 7.50 (d, J=8.48 Hz, 1 H), 7.68 (dd, J=2.03, 8.48 Hz, 1 H), 7.71 (bs, 1 H), 8.06 (d, J=8.48 Hz, 1 H), 8.06 (s, 1 H), 8.22 (d, J=8.48 Hz, 1 H); (DCI/NH3) m/z 371 (M+H) +.

Example 68 2-(3-methyl-2-pyrazinyl)-6-{2-[(2R)-2-methyl-1-pyrrolidinyl] ethyl}quinoline The title compound was prepared using the procedure described in Example 57 substituting 1- (3-methyl-2-pyrazinyl) ethanone for 1- (1, 3-thiazol-2- yl) ethanone. 1 H NMR (300 MHz, CDC13) # 1. 14 (d, J=6. 10 Hz, 3 H), 1.47 (m, 1 H), 1.77 (m, 2 H), 1.95 (m, 1 H), 2.25 (q, J=8.81 Hz, 1 H), 2.41 (m, 2 H), 2.94 (s, 3 H), 3.10 (m, 3 H), 3.31 (td, J=8.39, 2.54 Hz, 1 H), 7.66 (dd, J=8.65, 1.86 Hz, 1 H), 7.70 (d, J=2.00 Hz, 1 H), 8.02 (d, J=8.48 Hz, 1 H), 8.09 (d, J=8.48 Hz, 1 H), 8.25 (d, J=8.82 Hz, 1 H), 8.53 (m, 2 H); (DCI/NH3) m/z 333 (M+H) +.

Example 69 ethyl 5- (6-f 2-f (2R)-2-methyl-1-pyrrolidinyllethyl}-2-guinolinyl)-3- isoxazolecarboxylate

The title compound was prepared using the procedure described in Example 57 substituting ethyl 5-acetyl-3-isoxazolecarboxylate for 1- (1, 3-thiazol-2- yl) ethanone.'H NMR (300 MHz, CDC13) 8 1. 13 (d, J=6.10 Hz, 3 H), 1.45 (m, 1 H), 1.46 (t, J=7.12 Hz, 3 H), 1.77 (m, 2 H), 1.95 (m, 1 H), 2.24 (q, J=8.48 Hz, 1 H), 2.38 (m, 2 H), 2.97-3. 22 (m, 3 H), 3.29 (m, 1 H), 4.50 (q, J=7.12 Hz, 2 H), 7.46 (s, 1 H), 7.68 (m, 2 H), 8.02 (d, J=8.48 Hz, 1 H), 8.09 (d, J=8.82 Hz, 1 H), 8.25 (d, J=8.48 Hz, 1 H); (DCI/NH3) m/z 380 (M+H) +.

Example 70 5-(6-82-[(2 Rj-2-methyl-1-pyrrolidinyllethylT-2-quinolinyl)-2-thiophenec arbonitrile The title compound was prepared as the major product using the procedure described in Example 57 substituting 5-acetyl-2-thiophenecarbonitrile for 1- (1, 3- thiazol=2-yl) ethanone.'H NMR (300 MHz, CDC13) 61. 13 (d, J=5.76 Hz, 3 H), 1.46 (m, 1 H), 1.76 (m, 2 H), 1.95 (m, 1 H), 2.23 (q, J=8.59 Hz, 1 H), 2.40 (m, 2 H), 3.01 (m, 2 H), 3.14 (m, 1 H), 3.28 (dt, 1 H), 7.64 (m, 4 H), 7.77 (d, J=8.81 Hz, 1 H), 8.01 (d, J=9.15 Hz, 1 H), 8.15 (d, J=9.15 Hz, 1 H); (DCI/NH3) m/z 348 (M+H) +.

Example 71 ethyl 5-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-quinolinyl)-2 - thiophenecarboximidoate The title compound was prepared as a minor product using the procedure described in Example 57 substituting 5-acetyl-2-thiophenecarbonitrile for 1- (1, 3- thiazol-2-yl) ethanone.'H NMR (300 MHz, CDC13) 8 1. 13 (d, J=6.10 Hz, 3 H), 1.44 (t, J=7.12 Hz, 3 H), 1.46 (m, 1 H), 1.77 (m, 2 H), 1.95 (m, 1 H), 2.24 (q, J=8.82 Hz, 1 H), 2.39 (m, 2 H), 3.00 (m, 2 H), 3.12 (m, 1 H), 3.29 (m, 1 H), 4.34 (q, J=7.46 Hz, 2 H), 7.60 (m, 4 H), 7.77 (d, J=8.48 Hz, 1 H), 8.01 (d, J=9.16 Hz, 1 H), 8.10 (d, J=8.48 Hz, 1 H); (DCI/NH3) m/z 394 (M+H) +.

Example 72 2-(2,4-dimethyl-1,3-oxazol-5-yl)-6-{2-[(2R)-2-methyl-1-pyrro lidinyl]ethyl}quinoline The title compound was prepared using the procedure described in Example 57 substituting 1- (2, 4-dimethyl-1, 3-oxazol-5-yl) ethanone for 1- (1, 3-

thiazol-2-yl) ethanone.'H NMR (300 MHz, CD30D) 8 1.20 (d, J=6.10 Hz, 3 H), 1.50 (m, 1 H), 1.85 (m, 2 H), 2.05 (m, 1 H), 2.44 (m, 1 H), 2.55 (s, 3 H), 2.56 (m, 2 H), 2.65 (s, 3 H), 3.05 (m, 2 H), 3.29 (m, 2 H), 7.67 (dd, J=8. 65, 1.86 Hz, 1 H), 7.75 (d, J=1.86 Hz, 1 H), 7.80 (d, J=8.48 Hz, 1 H), 7.98 (d, J=8.48 Hz, 1 H), 8.29 (d, J=8.81 Hz, 1 H); (DCI/NH3) m/z 336 (M+H) +.

Example 73 ethyl 3-methyl-5-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-quin olinyl)-4- isoxazolecarboxylate The title compound was prepared using the procedure described in Example 57 substituting ethyl 5-acetyl-3-methyl-4-isoxazolecarboxylate for 1- (1, 3- thiazol-2-yl) ethanone.'H NMR (300 MHz, CD30D) 8 1. 18 (d, J=6.10 Hz, 3 H), 1.19 (t, J=7.12 Hz, 3 H), 1.48 (m, 1 H), 1.82 (m, 2 H), 2.03 (m, 1 H), 2.37 (m, 1 H), 2.52 (m, 2 H), 2.53 (s, 3 H), 3.07 (m, 2 H), 3.21 (m, 1 H), 3.31 (m, 1 H), 4.29 (q, J=7.12 Hz, 2 H), 7.78 (dd, J=8. 82, 2.03 Hz, 1 H), 7.89 (d, J=1.36 Hz, 1 H), 7.98 (d, J=8.48 Hz, 1 H), 8.07 (d, J=8.82 Hz, 1 H), 8.45 (d, J=8.82 Hz, 1 H); (DCI/NH3) m/z 394 (M+H) +.

Example 74 4-(7-82-[(2R)-2-methyl-1-pyrrolid inyllethylT-3-isoq uinolinyl) benzonitrile Example 74A 4- (7-bromo-3-isoquinolinyl) benzonitrile The product from Example 62D (3.6 mmol), 4-cyanophenylacetylene (4.3 mmol), Cul (0.2 mmol), PdCl2 (PPh3) 2 (0. 1 mmol), and diisopropylamine (5.3 mmol) can be combined in toluene (15 mL) and processed as described in Example 62E to provide the title compound.

Example 74B 4- [7- (2-hydroxyethyl)-3-isoguinolinyllbenzonitrile The product from Example 74A (4mmol) is dissolved in 20 mL THF and is cooled to-60 °C under nitrogen. n-BuLi (4.4 mmol) is added dropwise, and the

mixture is stirred at-60 °C for additional 30 minutes. A solution of ethylene oxide (20 mmol) in 10 ml THF is added and the mixture is allowed to warm to 10 °C and is stirred to complete the reaction. The mixture iss cooled back down to 0 °C and is slowly quenched with 2N HCI to pH=3. The solvent is removed under vacuum and the residue is dissolved in 20 mL methylene chloride, is washed with water, and is concentrated under reduced pressure. The residue is chromatographed on silica gel (5: 95 MeOH : CHCI3) to provide the title compound.

Example 74C 4-(8-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-3-isoquinolinyl )benzonitrile The product from Example 74B, methanesulfonyl chloride, and (2R)-2- methylpyrrolidine hydrochloride are processed as described in Example 62F to provide the title compound.

Example 75 6-{2-[(2R)-2-Methyl-1-pyrrolidinyl]ethyl}-2-(4-methoxyphenyl )quinoxaline and 7-82-f (2R)-2-Methyl-1-pyrrolidinyllethyll-2-(4-methoxyphenyl) quinoxaline Example 75A N-(442-[(2R)-2-Methyl-1-pyrrolidinyllethylTphenyl) acetamide The product from Example 54B (0.47 g, 2.3 mmol) in acetic acid: water (1: 1) at 0°C was treated with acetic anhydride (0.44 mL, 4.6 mmol) and heated at 100 °C for 45 minutes. The mixture was allowed to cool to room temperature, concentrated, and the residue was partitioned between 1 M NaOH and dichloromethane. The phases were separated and the aqueous phase was extracted with dichloromethane (3 times). The dichloromethane layers were combined, dried (MgS04), filtered, and the filtrate was concentrated to provide the title compound.'H NMR (300 MHz, CDC13) 8 1. 10 (d, J=6 Hz, 3 H), 1.43 (m, 1 H), 1.76 (m, 2 H), 1.92 (m, 1 H), 2.16 (s, 3 H), 2.25 (m, 3 H), 2.77 (m, 2 H), 2.99 (m, 1 H), 3.23 (td, J=9,3 Hz, 1 H), 7.16 (d, J=8 Hz, 2 H), 7.40 (d, J=8 Hz, 2 H); (DCI/NH3) m/z 247 (M+H) +.

Example 75B N- (4-f2-r (2R)-2-methyl-1-pyrrolidinyllethyl}-2-nitrophenyl) acetamide The product from Example 75A (0.58 g, 2.4 mmol) in acetic anhydride (2.2 mL) and concentrated sulfuric acid (0.16 mL) was cooled to 0 °C and treated dropwise with 90 % nitric acid (0.115 mL, 2.4 mmol). After stirring at ambient temperature for 16 hours, the mixture was diluted with water, cooled to 0 °C, the pH adjusted using 1 M NaOH, and extracted with dichloromethane (3 times). The combined dichloromethane layers were dried (MgS04), filtered, and the filtrate was concentrated to provide the title compound. 1H NMR (300 MHz, CDC13) 8 1.08 (d, J=6 Hz, 3 H), 1.43 (m, 1 H), 1.74 (m, 2 H), 1.92 (m, 1 H), 2.18 (q, J=9 Hz, 1 H), 2.28 (s, 3 H), 2.32 (m, 1 H), 2.84 (m, 2 H), 3.02 (m, 1 H), 3. 21 (td, J=8,3 Hz, 1 H), 7.51 (dd, J=9,2 Hz, 1 H), 8.07 (d, J=2 Hz, 1 H), 8.65 (d, J=9 Hz, 1 H), 10.23 (s, 1 H); (DCI/NH3) m/z 292 (M+H) +.

Example 75C 4-42-f (2R)-2-methyl-1-pyrrolidinyllethyl)-2-nitroaniline The product from Example 75B (0.60 g, 2.1 mmol) in 3M HCI (12 mL) was heated at 80 °C for 2 hours, cooled to 0 °C, the pH was adjusted by the slow addition of 1 M NaOH, and extracted with dichloromethane (4 times). The combined dichloromethane layers were dried (MgS04), filtered, and the filtrate was concentrated to provide the title compound.'H NMR (300 MHz, CDC13) 6 1.13 (d, J=6 Hz, 3 H), 1.47 (m, 1 H), 1.77 (m, 2 H), 1.95 (m, 1 H), 2.29 (m, 3 H), 2.76 (dd, J=9, 7 Hz, 2 H), 3.00 (m, 1 H), 3.25 (td, J=8,3 Hz, 1 H), 5.97 (s, 2 H), 6.75 (d, J=9 Hz, 1 H), 7.26 (dd, J=9,2 Hz, 1 H), 7.96 (d, J=2 Hz, 1 H); (DCI/NH3) m/z 250 (M+H) +.

Example 75D 4-82-[(2R)-2-methyl-1-pyrrolidinyllethylT-1, 2-benzenediamine The title compound was prepared using the procedure described in Example 54B substituting the product from Example 75C for the product from Example 54A to provide the title compound.'H NMR (300 MHz, CDC13) 8 1.15 (d,

J=6 Hz, 3 H), 1.47 (m, 1 H), 1.83 (m, 3 H), 2.30 (m, 3 H), 2.70 (m, 2 H), 3.00 (m, 1 H), 3.27 (m, 5 H), 6.59 (m, 3 H); (DCI/NH3) m/z 220 (M+H) +.

Example 75E 6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}quinoxaline The product from Example 75D (14.6 mg, 0.067 mmol) was treated with 0.075 mL of a 1 M solution of glyoxal in ethanol (made by diluting 0.4 g of a 40 % weight solution of glyoxal in water with ethanol to a total volume of 6.9 mL) and heated at 80 °C for 16 hours. The mixture was allowed to cool to room temperature and concentrated. The residue was chromatographed on silica gel eluting with a gradient of 2% and 3.5% (9: 1 MeOH: conc NH40H) in dichloromethane to provide the title compound.'H NMR (300 MHz, CD30D) 8 1.15 (d, J=6 Hz, 3 H), 1.47 (m, 1 H), 1.80 (m, 2 H), 2.03 (m, 1 H), 2.34 (q, J=9 Hz, 1 H), 2.48 (m, 2 H), 3.07 (m, 2 H), 3.25 (m, 2 H), 7.80 (dd, J=9,2 Hz, 1 H), 7.95 (d, J=2 Hz, 1 H), 8.04 (d, J=9 Hz, 1 H), 8.84 (d, J=2 Hz, 1 H), 8.86 (d, J=2 Hz, 1 H); (DCI/NH3) m/z 242 (M+H) +.

Example 75F 6-{2-[(2R)-2-Methyl-1-pyrrolidinyllethyl}-2-(4-methoxyphenyl ) quinoxaline and 742-[(2R)-2-Methvl-1-pyrrolidinyllethylT-2-(4-methoxyphenyl) quinoxaline The product from Example 75D and oxo (4-methoxyphenyl) acetaldehyde (chemical abstracts number 16208-17-6) is processed as described in Example 75E to provide the title compounds.

Example 76 2- [ (2R)-2-methyl-1-pyrrolidinyllethyl}-2-phenylguinoxaline and 7-82-r (2 R)-2-methvl-1-pyrrolidinvllethvlT-2-phenylquinoxaline The product from Example 75D and oxo (phenyl) acetaldehyde is processed as described in Example 75E to provide the title compounds.

Example 77 6-82-[(2R)-2-methyl-1-pyrrolidinyllethylT-2-(3-pyrid inyl) quinazoline Example 77A N- (2-formyl-4-f2-f (2R)-2-methyl-1-pyrrolidinyllethyllphenyl) nicotinamide The product from Example 54E (35 mg, 0.15 mmol) and triethylamine (0.051 mL, 0.36 mmol) were combined in dichloromethane (0.5 mL) and treated with nicotinoyl chloride hydrochloride (30 mg, 0.17 mmol). After stirring at ambient temperature for 16 hours, the mixture was concentrated and the residue purified by chromatography on silica gel eluting with a gradient of 2% and 3.5% (9: 1 MeOH: conc NH40H) in dichloromethane to provide the title compound.'H NMR (300 MHz, CDCI3) 6 1.11 (d, J=6 Hz, 3 H), 1.45 (m, 1 H), 1.77 (m, 2 H), 1.94 (m, 1 H), 2.22 (q, J=9 Hz, 1 H), 2.35 (m, 2 H), 2.90 (m, 2 H), 3.06 (m, 1 H), 3.25 (m, 1 H), 7.48 (dd, J=8,5 Hz, 1 H), 7.56 (dd, J=8,2 Hz, 1 H), 7.60 (d, J=2 Hz, 1 H), 8.34 (dt, J=8, 2 Hz, 1 H), 8.83 (m, 2 H), 9.32 (d, J=2 Hz, 1 H), 9.99 (s, 1 H), 12.09 (s, 1 H); MS (DCI/NH3) m/z 338 (M+H) +.

Example 77B 642-f (2R)-2-methyl-1-pyrrolidingl1ethylT-2-(3-pyridinyl) quinazoline The product from Example 77A (25 mg, 0.074 mmol) in saturated aqueous ammonium chloride (3 mL) was heated at 80 °C for 16 hours. The mixture was allowed to cool to-room temperature, adjusted to pH 14 with 1 M NaOH, and extracted with dichloromethane (3 times). The combined dichloromethane layers were dried (MgS04), filtered, and the filtrate was concentrated. The residue was purified by chromatography on silica gel eluting with a gradient of 2% and 3. 5% (9: 1 MeOH: conc NH40H) in dichloromethane to provide the title compound.'H NMR (300 MHz, CDC13) 8 1. 13 (d, J=6 Hz, 3 H), 1.47 (m, 1 H), 1.75 (m, 2 H), 1.96 (m, 1 H), 2.25 (q, J=9 Hz, 1 H), 2.41 (m, 2 H), 3.10 (m, 3 H), 3.29 (m, 1 H), 7.45 (dd, J=8,5 Hz, 1 H), 7.78 (d, J=1 Hz, 1 H), 7.83 (dd, J=8,2 Hz, 1 H), 8.03 (d, J=8 Hz, 1 H), 8.73 (d, J=4 Hz, 1 H), 8.85 (dt, J=8,2 Hz, 1 H), 9.43 (d, J=1 Hz, 1 H), 9.80 (s, 1 H); MS (DCI/NH3) m/z 319 (M+H) +.

Example 78 6-Methyl-2-{6-[2-((2R)-2-methyl-pyrroldin-1-yl)-ethyl]-napht halen-2-yl}-2H- pyridazin-3-one The title compound was prepared by the method of Example 31 F, substituting 1- [2- (6-bromo-naphthalen-2-yl)-ethyl]- (2R)-2-methyl-pyrrolidine (Example 2B, 60 mg, 0.19 mmol) in place of 2- (6-bromo-naphthalen-2-yl)-ethanol (Example 31 E) and substituting 6-methyl-2H-pyridazin-3-one (41.5 mg, 0.38 mmol, 2 equiv. ) in place of 2H-pyridazin-3-one. Column chromatography (95: 5 : trace dichloromethane/methanol/NH40H) provided free base product that was dissolved in Et20. HCI gas was bubbled into this solution to provide the monohydrochloride salt of the title compound (25 mg, 34% yield).'H NMR (CD30D, 300 MHz) 5 8.08 (d, J=2 Hz, 1H), 7.98 (s, 1H), 7.95 (s, 1H), 7.88-7. 92 (m, 1H), 7.67 (dd, J=2,8 Hz, 1H), 7.54 (dd, J=2,8 Hz, 1H), 7.48 (d, J=9 Hz, 1H), 7.05 (d, J=9 Hz, 1H), 3.85-3. 70 (m, 2H), 3.60-3. 51 (m, 1H), 3.40-3. 15 (m, 4H), 2.42 (s, 3H), 2.42-2. 26 (m, 1 H), 2.25-1. 99 (m, 2H), 1.85-1. 67 (m, 1 H), 1.49 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] +at 348.

Example 79 5-f6-[2-((2R)-2-Methvl-perrolidin-1-yl)-ethyll-naphthalen-2- elE-pyrimidine-2- carbonitrile Example 79A 5-Bromo-pyrimidine-2-carbonitrile A mixture of 5-bromo-2-iodopyrimidine (1.85 g, 6.49 mmol) and CuCN (0.64 g, 7.14 mmol, 1.1 equiv. ) in pyridine (13 mL) was stirred at 80 °C for 3 hours, then an additional 15 hours at room temperature. Volatiles were removed under reduced pressure and the residue was partitioned between dichloromethane and brine. The organic layer was dried (MgS04) and filtered.

The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (95: 5 hexane/ethyl acetate) to provide the title

intermediate as an off-white solid (0.63 g, 53% yield). M. p. 119.6-121. 5 °C, 1H NMR (CDC13, 300 MHz) 5 8.93 (s, 2H). MS (DCI-NH3) [M+NH4] + at 201.

Example 79B 5-Trimethylstannanyl-pyrimidine-2-carbonitrile A mixture of 5-bromo-pyrimidine-2-carbonitrile (Example 79A, 276 mg, 1.50 mmol), hexamethyiditin (639 mg, 1.95 mmol, 1.3 equiv.) and Pd (PPh3) 4 (55 mg, 0.15 mrnol, 0.1 equiv. ) in toluene (5 mL) was stirred at reflux for 3 hours, then an additional 15 hours at room temperature under a dry nitrogen atmosphere.

Volatiles were removed under reduced pressure and the residue was partitioned between dichloromethane and aqueous KF (10 g in 100 mL). The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (100% dichloromethane) to provide the title intermediate as a white solid (219 mg, 54% yield).'H NMR (CDC13, 300 MHz) o 8.81 (s, 2H), 0.45 (s, 9H). MS (DCI-NH3) [M+H] + at 270, [M+NHQ] + at 287.

Example 79C 5-f6- (2-Hydroxy-ethyl)-naphthalen-2-yll-pyrimidine-2-carbonitrile A mixture of 5-trimethylstannanyl-pyrimidine-2-carbonitrile (Example 79B, <BR> <BR> <BR> <BR> 200 mg, 0.75 mmol, 1.1 equiv. ), 2- (6-bromo-naphthalen-2-yl)-ethanol (Example 31 E, 171 mg, 0.679 mmol), cesium fluoride (227 mg, 1.49 mmol, 2.2 equiv. ) and Pd [P (t-Bu) 3] 2 (10.4 mg, 0.02 mmol, 0.03 equiv. ) in p-dioxane (10 mL) was stirred at 85 °C for 72 hours. Volatiles were removed under reduced pressure and the residue was partitioned between ethyl acetate and aqueous KF (10 g in 100 mL).

The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (70: 30 hexane/ethyl acetate) to provide the title intermediate as a white solid (35.5 mg, 19% yield).'H NMR (CD30D, 300 MHz) 6 9.33 (s, 2H), 8.31 (d, J=2 Hz, 1H), 7.99 (t, J=9 Hz, 1 H), 7.94 (s, 1 H), 7.86 (dd, J=2,9 Hz, 1 H), 7.79 (br s, 1 H), 7.50 (dd, J=2, 9 Hz, 1H), 3.88 (t, J=7 Hz, 2H), 3.02 (t, J=7 Hz, 2H). MS (DCI-NH3) [M+H] at 276, [M+N H4] + at 293.

Example 79D 5-f6- (2- ( (2R)-2-Methyl-pyrrolidin-1-yl)-ethyll-naphthalen-2-yl)-pyrim idine-2- carbonitrile The title compound was prepared by the methods of Examples 3B and 3C substituting 5- [6- (2-hydroxy-ethyl)-naphthalen-2-yl]-pyrimidine-2-carbonitrile (Example 79C, 35.5 mg, 0.13 mmol) in place of 1- {3- [6- (2-hydroxyethyl)-2- \ naphthyl]phenyl}ethanone (Example 3A) for the mesylate formation and substituting the crude mesylate thus formed (-45 mg, 0.13 mmol) in place of 2- [6- (3-acetylphenyl)-2-naphthyl] ethyl methanesulfonate (Example 3B). Column chromatography (97: 3 : trace dichloromethane/methanol/NH40H) provided free base product that was dissolved in Et20. HCI gas was bubbled into this solution to provide the monohydrochloride salt of the title compound (3.8 mg, 9% yield over two steps).'H NMR (CD30D, 300 MHz) 5 9.33 (s, 2H), 8.36 (d, J=2 Hz, 1 H), 8.06 (dd, J=2,8 Hz, 2H), 8.07-7. 90 (m, 2H), 7.58 (dd, J=2,8 Hz, 1H), 3.85-3. 69 (m, 2H), 3.63-3. 51 (m, 1H), 3.44-3. 18 (m, 4H), 2.43-2. 31 (m, 1H), 2.25-2. 01 (m, 2H), 1.85-1. 71 (m, 1H), 1.50 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] +at 343, [M+NH4] + at 360.

Example 80 1-f6-f2- (2 (R)-Methyl-pyrrolidin-1-yl)-ethyll-naphthalen-2-yl}-1 H-pyridin-2-one Example 80A 1-[6-(2-Hydroxy-ethyl)-naphthalen-2-YI1-1 H-pyridin-2-one A mixture of 2- (6-bromo-naphthalen-2-yl)-ethanol (Example 31 E, 100 mg, 0.40 mmol), 2-hydroxy-pyridine (57 mg, 0.60 mmol, 1.5 equiv.), copper powder (25 mg, 0.40 mmol), and K2CO3 (165 mg, 1.20 mmol, 3 equiv. ) in pyridine (2 mL) was stirred at reflux under a dry nitrogen atmosphere for 18 hr. The reaction mixture was cooled to room temperature then concentrated under reduced pressure. Residual pyridine was removed by repeated evaporation with toluene.

The residue was partitioned between ethyl acetate and aqueous NH40H (2 X 50 mL) then washed with brine. The organic layer was dried (MgSO4), filtered, and the filtrate was concentrated under reduced pressure. The residue was purified

by column chromatography (100% ethyl acetate) to provide the title intermediate as a white solid (30 mg, 28% yield).'H NMR (CDC13, 300 MHz) 5 7.80 (d, J=9 Hz, 1 H), 7.72 (d, J=9 Hz, 1 H), 7.71 (s, 1 H), 7.63 (s, 1 H), 7.42 (dd, J=2,8 Hz, 1H), 7.39-7. 30 (m, 3H), 6.62 (dd, J=1, 10 Hz, 1H), 6.20 (dt, J=1, 6 Hz, 1H), 3.84 (t, J=6 Hz, 2H), 2.95 (t, J=6 Hz, 2H). MS (DCI-NH3) [M+H] + at 266, [M+NH4] + at 283.

Example 80B 1-{6-[2-(2(R)-Methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl }-1H-pyridin-2-one Methanesulfonyl chloride (0.01 mL, 0.136 mmol, 1.2 equiv. ) was added dropwise via a syringe to a stirred,-30 °C solution of 1- [6- (2-hydroxy-ethyl)- naphthalen-2-yI]-1H-pyridin-2-one (Example 80A, 30 mg, 0.113 mmol) and Et3N (0.024 mL, 0.17 mmol, 1.5 equiv. ). After two hours stirring at room temperature, the reaction mixture was concentrated under reduced pressure. The residue was partitioned between EtOAc and saturated aqueous Na2CO3. The organic extract was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure and the residue was crystallized from Et2O/hexane (20 mg, 52% yield).

This mesylate (20 mg, 0.058 mmol), (2R)-2-methylpyrrolidine (14.9 mg, 0.058 mmol, 3.0 equiv. ), and cesium carbonate (19 mg, 0.058 mmol) in anhydrous acetonitrile (3.5 mL) were stirred in a sealed tube at 60 °C for 18 hours. The reaction mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (97: 3 : trace, dichloromethane/methanol/NH40H). Fractions containing product were combined and concentrated under reduced pressure to provide the free base. This free base was dissolved in Et20 and HCI gas was bubbled in to precipitate the hydrochloride salt of the title compound.'H NMR (CD30D, 300 MHz) 6 8.08-7. 96 (m, 2H), 7.93 (s, 2H), 7.76-7. 66 (m, 2H), 7.60-7. 51 (m, 2H), 6.70 (d, J=9 Hz, 1 H), 6.56 (dt, J=1, 6 Hz, 1H), 3.83-3. 68 (m, 2H), 3.64-3. 49 (m, 1H), 3.43-3. 18 (m, 4H), 2.43-2. 30 (m, 1H), 2.22-2. 02 (m, 2H), 1.84-1. 69 (m, 1H), 1.49 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 333.

Example 81 <BR> <BR> <BR> <BR> 5-6-r2- (2 (R)-Methyl-pyrrolidin-1-yl)-ethyll-naphthalen-2-yll-nicotino nitrile<BR> <BR> <BR> <BR> <BR> <BR> <BR> <BR> <BR> <BR> <BR> <BR> Example 81A<BR> <BR> <BR> <BR> <BR> 5-f6-(2-Hvd roxy-ethvl)-naphthalen-2-yl1-nicotinonitrile A mixture of 5- (4, 4,5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)-nicotinonitrile <BR> <BR> <BR> <BR> (220 mg, 0.956 mmol, 1.2 equiv. ), 2-(6-bromo-naphthalen-2-yl)-ethanol (Example 31 E, 200 mg, 0.8 mmol), Na2CO3 (253 mg, 2.39 mmol, 3 equiv.), biphenyl-2-yl- dicyclohexyl-phosphane (7 mg, 0.02 mmol, 0.025 equiv. ), and PdCI2 (PPh3) 2 (27.9 mg, 0.04 mmol, 0.05 equiv. ) in isopropanol (20 mL) and water (8 mL) was stirred at 80 °C for one hour. The reaction mixture was then concentrated under reduced pressure and the residue was partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure to give a crude solid that was purified by column chromatography (1: 1 hexane/ethyl acetate) to provide the title intermediate (166 mg, 76% yield). 1H NMR (CD30D, 300 MHz) # 9. 19 (d, J=2 Hz, 1H), 8.88 (d, J=2 Hz, 1H), 8.57 (t, J=2 Hz, 1H), 8.20 (d, J=2 Hz, 1H), 7.99-7. 90 (m, 2H), 7.79 (dd, J=2, 9 Hz, 1 H), 7.76 (br s, 1 H), 7.48 (dd, J=2,9 Hz, 1 H), 3.88 (t, J=7 Hz, 2H), 3.02 (t, J=7 Hz, 2H). MS (DCI-NH3) [M+H] +at 275, [M+NH4]+ at 292. <BR> <BR> <BR> <BR> <BR> <BR> <P> Example 81 B<BR> <BR> <BR> <BR> <BR> <BR> Methanesulfonic acid 2-[6-(5-cyano-pyridin-3-yl)-naphthalen-2-vl]-ethyl ester Methanesulfonyl chloride (0.056 mL, 0.726 mmol, 1.2 equiv. ) was added to a stirred,-30 °C solution of 5-[6-(2-hydroxy-ethyl)-naphthalen-2-yl]-nicotinonitrile (Example 81A, 190 mg, 0.539 mmol) under a dry nitrogen atmosphere.

Triethylamine (0.13 mL, 0.908 mmol, 1.5 equiv. ) was added dropwise to the chilled solution, then the reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure to give the title intermediate (192 mg, 90% yield NMR (CDCI3, 300 MHz) # 9.22 (d, J=2 Hz, 1H), 8.90 (d, J=2 Hz, 1 H), 8.60 (t, J=2 Hz, 1 H), 8.25 (br s, 1 H), 8.00 (t, J=8 Hz, 2H), 7.87-7. 81 (m, 2H),

7.52 (dd, J=2,8 Hz, 1 H), 7.31-7. 25 (m, 1 H), 4.55 (t, J=6 Hz, 2H), 3.25 (t, J=6 Hz, 2H), 2.95 (s, 3H). MS (DCI-NH3) [M+H] + at 353, [M+NH4]+ at 370.

Example 81 C 5-f6- [2- (2 (R)-Methyl-pyrrolidin-1-yi)-ethyll-naphthalen-2-yi)-nicotino nitrile<BR> Methanesulfonic acid 2-[6-(5-cyano-pyrid in-3-yl)-naphthalen-2-yl]-ethyl ester (Example 81 B, 190 mg, 0.54 mmol), (2R)-2-methylpyrrolidine (138 mg, 1.62 mmol, 3. 0 equiv. ), and cesium carbonate (176 mg, 0.54 mmol) in anhydrous acetonitrile (6 mL) were stirred in a sealed tube at 50 °C for 18 hours. The reaction mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was washed with brine, then dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (98: 2 : trace dichloromethane/methanol/NH40H). Fractions containing product were combined and concentrated under reduced pressure to provide the free base of the title compound as a white solid (105.9 mg, 57% yield).

This free base was dissolved in methanol and treated with excess dioxane-HCI.

Ether was added to induce crystallization of the dihydrochloride salt of the title compound.'H NMR (CD30D, 300 MHz) 5 9.26 (br s, 1 H), 8.97 (br s, 1 H), 8.68 (s, 1 H), 8.29 (s, 1 H), 8.05 (s, 1 H), 8.02 (s, 1 H), 7.90 (br s, 1 H), 7.88 (dd, J=2, 9Hz, 1H), 7.56 (d, J=8 Hz, 1 H), 3.84-3. 49 (m, 7H), 2.45-2. 30 (m, 1H), 2.27-1. 99 (m, 2H), 1.84-1. 69 (m, 1 H), 1.50 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H]+ at 342.

Example 82 4-Methyl-1-6- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyll-naphthalen-2-vl}-1 H-pvridin-2- one Example 82A 1- [6- (2-Hyd roxy-ethyl)-naphthalen-2-yll-4-methyl-1 H-pyrid in-2-one A mixture of 2- (6-bromo-naphthalen-2-yl)-ethanol (Example 31 E, 200 mg, 0.796 mmol), 2-hydroxy-4-methyl-pyridine (130 mg, 1.195 mmol, 1.5 equiv. ), copper powder (50.6 mg, 0.796 mmol), and K2CO3 (330.2 mg, 2.389 mmol, 3 equiv. ) in pyridine (5 mL) was stirred at reflux under a dry nitrogen atmosphere for

62 hr. The reaction mixture was cooled to room temperature then concentrated under reduced pressure. Residual pyridine was removed by repeated evaporation with toluene. The residue was partitioned between ethyl acetate and aqueous NH40H then washed with brine (3 X 50 mL). The organic layer was dried (MgS04), filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (100% ethyl acetate) to provide the title intermediate as a white solid (70 mg, 31% yield).'H NMR (CD30D, 300 MHz) 5 7. 94 (d, J=9 Hz, 1H), 7.88 (d, J=9 Hz, 1 H), 7.84 (d, J=2 Hz, 1 H), 7.80 (br s, 1 H), 7.59 (d, J=7 Hz, 1 H), 7.49 (dd, J=2,9 Hz, 1H), 7.44 (dd, J=2,9 Hz, 1H), 6.49 (br s, 1 H), 6.40 (dd, J=2,7 Hz, 1H), 3.87 (t, J=7 Hz, 2H), 3.04 (t, J=7 Hz, 2H), 2.32 (s, 3H). MS (DCI-NH3) [M+H] + at 280.

Example 82B <BR> <BR> <BR> 4-Methyl-1-{6-[2-(2 (R)-methyl-pyrrolidin-1-yl)-ethyll-naphthalen-2-yl}-1 H-pvridin-2- one Methanesulfonyl chloride (0.03 mL, 0.301 mmol, 1.2 equiv. ) was added dropwise via a syringe to a stirred, 0 °C solution of 1- [6- (2-hydroxy-ethyl)- naphthalen-2-yl]-4-methyl-1H-pyridin-2-one (Example 82A, 70 mg, 0.251 mmol) in anhydrous THF (10 mL) under a dry nitrogen atmosphere. Triethylamine (1.0 mL, 7.175 mmol, 28.6 equiv. ) was then added. After two hours of stirring at 0 °C, the reaction mixture was concentrated under reduced pressure. The residue was partitioned between EtOAc and saturated aqueous Na2CO3. The organic extract was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure. This crude mesylate (-89 mg, 0.249 mmol), (2R)-2-methylpyrrolidine (64 mg, 0.747 mmol, 3.0 equiv. ), and cesium carbonate (81 mg, 0.249 mmol) in anhydrous acetonitrile (5 mL) were stirred in a sealed tube at 50 °C for 18 hours.

The reaction mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (97: 3 : trace dichloromethane/methanol/NH40H). Fractions containing product were combined and concentrated under reduced pressure to provide the free base.

This free base was dissolved in Et20 and the solution was treated with HCI- dioxane to precipitate the hydrochloride salt of the title compound (15 mg, 16% yield). 1H NMR (CD30D, 300 MHz) 5 8.00 (d, J=9 Hz, 1H), 7.98 (d, J=9 Hz, 1H), 7.93-7. 89 (m, 2H), 7.62 (d, J=7 Hz, 1H), 7.56 (dd, J=2,9 Hz, 1H), 7.51 (dd, J=2,9 Hz, 1H), 6.52 (br s, 1 H), 6.45 (dd, J=2,7 Hz, 1 H), 3.83-3. 68 (m, 2H), 3.61-3. 49 (m, 1H), 3.43-3. 17 (m, 4H), 2.43-2. 30 (m, 1H), 2.33 (s, 3H), 2.24-1. 99 (m, 2H), 1.83-1. 69 (m, 1 H), 1.49 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 347.

Example 83 2-6-f2- ( (2R)-2-Methyl-pyrrolidin-1-yl)-ethyll-naphthalen-2-yl-pyrazi ne Example 83A 2-(6-Pyrazin-2-yl-naphthalen-2-yl)-ethanol A mixture of 2-tributylstannanyl-pyrazine (323 mg, 0.876 mmol, 1.1 equiv. ), 2-(6-bromo-naphthalen-2-yl)-ethanol (Example 31E, 200 mg, 0.796 mmol), cesium fluoride (266 mg, 1.75 mmol, 2.2 equiv. ) and Pd [P (t-Bu) 3] 2 (12.2 mg, 0.024 mmol, 0.03 equiv. ) in p-dioxane (10 mL) was stirred at 85 °C for 2.5 hours. Volatiles were removed under reduced pressure and the residue was partitioned between ethyl acetate and aqueous KF (10 g in 100 mL). The organic layer was washed consecutively with saturated aqueous Na2CO3 and brine, then dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (1: 1 hexane/ethyl acetate) to provide the- title intermediate as a beige solid (42.5 mg, 21% yield).'H NMR (CD30D, 300 MHz) 5 9.25 (d, J=1 Hz, 1 H), 8.72-8. 70 (m, 1H), 8.58 (d, J=2 Hz, 1H), 8.54 (d, J=3 Hz, 1H), 8.17 (dd, J=2,9 Hz, 1H), 7.97 (d, J=2 Hz, 1H), 7.94 (d, J=2 Hz, 1H), 7.77 (br s, 1 H), 7.48 (dd, J=2,8 Hz, 1 H), 3.88 (t, J=7 Hz, 2H), 3.02 (t, J=7 Hz, 2H). MS (DCI-NH3) [M+H] + at 251, [M+NH4] + at 268.

Example 83B 2-{6-[2-((2R)-2-Methyl-pyrrolind-1-yl)-ethyl]-naphthalen-2-y l}-pyrazine Methanesulfonyl chloride (0.005 mL, 0.067 mmol, 1.2 equiv. ) was added dropwise via a syringe to a stirred, 0 °C solution of 2- (6-pyrazin-2-yl-naphthalen-2-

yl)-ethanol (Example 83A, 14 mg, 0.056 mmol) in anhydrous THF (10 mL) under a dry nitrogen atmosphere. Triethylamine (0.023 mL, 0.167 mmol, 3 equiv. ) was then added. After 18 hours at-20 °C, the reaction mixture was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure. This crude mesylate (-18 mg, 0.056 mmol), (2R)-2-methylpyrrolidine (190 mg, 2.237 mmol, 40 equiv. ), and cesium carbonate (182 mg, 0.559 mmol, 10 equiv. ) in anhydrous acetonitrile (5 mL) were stirred in a sealed tube at 40 °C for 62 hours. The reaction mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (97: 3 : trace dichloromethane/methanol/NH40H). Fractions containing product were combined and concentrated under reduced pressure to provide the free base.

This free base was dissolved in methanol and the solution was treated with HCI gas. The hydrochloride salt of the title compound was obtained on evaporation of solvent (4.5 mg, 23% yield). 1H NMR (CD30D, 300 MHz) 5 9.29 (br s, 1H), 8.79- 8.74 (m, 1 H), 8.64 (br s, 1 H), 8.58 (d, J=2 Hz, 1H), 8.24 (dd, J=2,9 Hz, 1 H), 8.03 (t, J=9 Hz, 2H), 7.90 (br s, 1 H), 7.55 (dd, J=2,9 Hz, 1 H), 3.84-3. 68 (m, 2H), 3.64- 3. 49 (m, 1H), 3.44-3. 17 (m, 4H), 2.43-2. 30 (m, 1 H), 2.27-2. 00 (m, 2H), 1.84-1. 68 (m, 1 H), 1.50 (d, J=7 Hz, 3H). MS (DCI-NH3) [M+H] + at 318.

Example 84 2-86-[2-((2R)-2-Methvl-2, 5-dihydro-pvrrol-1-vl)-ethYll-naphthalen-2-vlE-2H pyridazin-3-one Example 84A (2S)-2-Hydroxymethyl-2, 5-dihvdro-pyrrole-1-carboxylic acid ter-butyl ester The title intermediate can be prepared reductively from the corresponding carboxylic acid or its methyl ester.

From the carboxylic acid: Employing the literature (Rodriguez, M. , et. al., Tetrahedron Letters, 1991,32 (7), 923-926) procedure ; 2, 5-Dihydro-pyrrole-1, (2R)-2-dicarboxylic acid 1-tert-butyl ester (970 mg, 4.549 mmol) was dissolved in

anhydrous DME (5 mL). This solution was chilled to-20 °C under a dry nitrogen atmosphere. To this stirred solution was slowly added first 4-methyl-morpholine (0.5 mL, 4.549 mmol) then isobutyl chloroformate (0.6 mL, 4.549 mmol). After stirring at-20 °C for one minute, a solution of sodium borohydride (516 mg, 13.647 mmol, 3 equiv. ) in water (5 mL) was rapidly added and stirring was continued while the reaction mixture warmed to-5 °C where it was maintained for 25 minutes. The reaction mixture was then diluted with water and extracted with \ ethyl acetate. The organic layer was washed with brine, dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (4: 1 hexane/ethyl acetate) to give the title intermediate (386 mg, 42% yield).'H NMR (CD3, 300 MHz) 5 5.90-5. 72 (m, 1 H), 5.69-5. 56 (m, 1 H), 4.80-4. 60 (m, 1 H), 4.28-3. 99 (m, 2H), 3.78 (dd, J=2,9 Hz, 1 H), 3.65-3. 51 (m, 1 H), 1.49 (s, 9H). MS (DCI-NH3) [M+H] + at 200, [M+NH4] + at 217.

From the methyl carboxylate : Sodium borohydride (333 mg, 8.80 mmol, 2 equiv. ) was added in one lot to a stirred, 0 °C solution of 2, 5-dihydro-pyrrole-1, (2R)-2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (1.0 g, 4.40 mmol) in THF (3 mL) and methanol (2 mL). The reaction mixture was stirred at 0 °C for 15 min then at room temperature for 18 hr. After an aqueous work-up as above and column chromatography as above the title intermediate was obtained (524 mg, 60% yield).

Example 84B (2R)-2-Methyl-2, 5-dihydro-pyrrole-1-carboxylic acid ter-butyl ester Methanesulfonyl chloride (0.24 mL, 3.13 mmol, 1.2 equiv. ) was added dropwise to a stirred, 0 °C solution of (2S)-2-hydroxymethyl-2, 5-dihydro-pyrrole-1- carboxylic acid tert-butyl ester (Example 84A, 520 mg, 2.61 mmol) and triethylamine (1.1 mL, 7.83 mmol, 3 equiv. ) in anhydrous THF (50 mL) under a dry nitrogen atmosphere. The reaction mixture was stirred at 0 °C for 15 min then at room temperature for 18 hours. The reaction mixture was concentrated under reduced pressure and the residue was partitioned between ethyl acetate and water. The organic layer was washed with saturated aqueous Na2CO3, then dried

(MgS04), and filtered. The filtrate was concentrated under reduced pressure and the crude mesylate (-660 mg, 91 % yield) was immediately reduced: A solution of the crude mesylate (-660 mg, 2.38 mmol) in THF (10 mL) was stirred at 0 °C under a dry nitrogen atmosphere. Lithium triethylborohydride (1.0 M in THF, 7.14 mL, 7.14 mmol, 3 equiv. ) was added dropwise. Stirring at 0 °C was continued for 20 min after the addition, then the reaction mixture was stirred at room temperature for 18 hours. The reaction was quenched by the careful, sequential addition of water (1.38 mL), 3 N NaOH (2.75 mL), and 30% aqueous hydrogen peroxide (2.75 mL). After stirring for 30 min, the reaction was treated with saturated aqueous Na2SO3 and stirred vigorously overnight. The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (gradient: 100% hexane to 95: 5 hexane/ethyl acetate) to provide the title intermediate (282 mg, 65% yield).'H NMR (CDC13, 300 MHz) 5 5.77-5. 62 (m, 2H), 4.63-4. 42 (m, 1H), 4.27-3. 98 (m, 2H), 1.48 (s, 9H), 1.34-1. 19 (m, 3H). MS (DCI-NH3) [M+H] + at 184, [M+NH4] +at201.

Example 84C (2R)-2-Methyl-2, 5-dihydro-1 H-pyrrole Trifluoroacetic acid (1.8 mL, 22.92 mmol, 15 equiv. ) was added dropwise to a stirred, room temperature solution of (2R)-2-methyl-2, 5-dihydro-pyrrole-1- carboxylic acid ter-butyl ester (Example 84B, 280 mg, 1.528 mmol) in dichloromethane (5 mL). The reaction mixture was stirred at room temperature under a dry nitrogen atmosphere for 18 hours. The reaction mixture was concentrated under reduced pressure to give the crude title intermediate as its trifluoroacetic acid salt (~300 mg, 100% yield).'H NMR (CD30D, 300 MHz) 5 5.92 (s, 2H), 4. 9-4. 49 (m, 1H), 4.12-3. 97 (m, 2H), 1.44 (d, J=7 Hz, 3H). MS (DCI- NH3) [M+H] + at 84.

Example 84D <BR> <BR> <BR> 6-f 2- ( (2 R)-2-Methyl-2, 5-d ihvd ro-pyrrol-1-vl)-ethyll-naphthalen-2-vl-2H-<BR> <BR> <BR> <BR> <BR> <BR> pyridazin-3-one

A mixture of methanesulfonic acid 2- [6- (6-oxo-6H-pyridazin-1-yl)- naphthalen-2-yl]-ethyl ester (Example 31 G, 205 mg, 0.595 mmol), (2R)-2-methyl- 2, 5-dihydro-1 H-pyrrole, trifluoroacetic acid salt (Example 84C,-300 mg, 1.52 mmol, 2.55 equiv. ), and cesium carbonate (1.49 g, 4.56 mmol, 3 equiv. ) in anhydrous acetonitrile (10 mL) was stirred in a sealed tube at room temperature for 90 hours then at 45 °C for another 18 hours. The reaction mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous Na2CO3. The aqueous layer was washed with ethyl acetate, and the combined organic extracts were dried (MgS04) and filtered.

The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (98: 2 : trace dichloromethane/ methanol/NH40H). Fractions containing product were combined and concentrated under reduced pressure to provide the free base product (69 mg, 35% yield).'H NMR (CD30D, 300 MHz) 5 8.04 (dd, J=2,4 Hz, 1 H), 8.04 (d, J=2 Hz, 1 H), 7.92 (d, J=9 Hz, 1 H), 7.88 (d, J=9 Hz, 1 H), 7.79 (br s, 1 H), 7.62 (dd, J=2,9 Hz, 1 H), 7.51 (dd, J=3,9 Hz, 1H), 7.48 (dd, J=2,9 Hz, 1 H), 7.12 (dd, J=2,9 Hz, 1 H), 5.83-5. 68 (m, 2H), 3.91-3. 81 (m, 1H), 3.66-3. 54 (m, 1H), 3.40-3. 30 (m, 1H), 3.21-3. 08 (m, 1H), 3.08-2. 91 (m, 2H), 2.86-2. 73 (m, 1H), 1.22 (d, J=7 Hz, 3H). MS (DCI-NH3) [M+H] + at 332.

Example 85 4- (6- {2-r (2-Dimethylamino-ethyl)-methyl-aminol-ethyl}-naphthalen-2-yl )- benzonitrile Example 85A Methanesulfonic acid 2- [6- (4-cyano-phenyl)-naphthalen-2-yll-ethyl ester A stirred, 0 °C solution of 4- [6- (2-hydroxyethyl)-2-naphthyl] benzonitrile (Example 1F, 460 mg, 1.683 mmol) and triethylamine (0.94 mL, 6.732 mmol, 4 equiv. ) in anhydrous THF (10 mL) was treated with methanesulfonyl chloride (0.17 mL, 2.188 mmol, 1.3 equiv. ) under a dry nitrogen atmosphere. The reaction mixture was stirred at room temperature for one hour, then the reaction mixture was diluted with water and extracted with ethyl acetate (3 X 20 mL). The combined organic extracts were washed with saturated aqueous Na2CO3 and

then with brine. The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure to give the title intermediate (305 mg, 52% yield).'H NMR (CDC13, 300 MHz) 5 8.04 (d, J=2 Hz, 1H), 7.94-7. 87 (m, 2H), 7.84-7. 69 (m, 6H), 7.43 (dd, J=2,8 Hz, 1 H), 4.54 (t, J=7 Hz, 2H), 3.26 (t, J=7 Hz, 2H), 2.88 (s, 3H). MS (DCI-NH3) [M+NH4] +at 369.

Example 85B 4- (6- {2-f (2-Dimethylamino-ethyl)-methyl-aminol-ethyh-naphthalen-2-vl) - benzonitrile A mixture of methanesulfonic acid 2- [6- (4-cyano-phenyl)-naphthalen-2-yl]- ethyl ester (Example 85A, 150 mg, 0.427 mmol) and N, N, N'- trimethylethylenediamine (0.17 mL, 1.280 mmol, 3 equiv. ) in anhydrous acetonitrile (1 mL) was stirred at room temperature in a sealed tube for 66 hours.

The reaction mixture was partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (gradient: 98: 2 to 97: 3 : trace dichloromethane/methanol/NH40H) to give the free base product (28.7 mg, 19% yield). The free base was dissolved in methanol and treated with a methanol solution containing one equivalent of L- tartaric acid. The tartrate salt of the title compound crystallized from the methanol solution.'H NMR (CD30D, 300 MHz) 5 8.17 (d, J=2 Hz, 1H), 7.97-7. 82 (m, 4H), 7.86-7. 77 (m, 4H), 7.48 (dd, J=2,8 Hz, 1H), 4.39 (s, tartrate, 2H), 3.17-2. 90 (m, 8H), 2.69 (s, 6H), 2.54 (s, 3H). MS (DCI-NH3) [M+H] + at 358.

Example 86 4-6-r2- (4-Methyl-piperazin-1-yl)-ethyll-naphthalen-2-yl}-benzonitri le A mixture of methanesulfonic acid 2- [6- (4-cyano-phenyl)-naphthalen-2-yl]- ethyl ester (150 mg, 0.427 mmol) and 1-methylpiperazine (0.14 mL, 1.280 mmol, 3 equiv. ) in anhydrous acetonitrile (1 mL) was stirred at room temperature in a sealed tube for 66 hours. The reaction mixture was partitioned between ethyl acetate and saturated aqueous Na2CO3. The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (97: 3 : trace

dichloromethane/methanol/NH40H) to give the free base product.'H NMR (CD30D, 300 MHz) 5 8.16 (br s, 1H), 7.97-7. 89 (m, 4H), 7.86-7. 81 (m, 2H), 7.79 (dd, J=2, 8 Hz, 2H), 7.74 (br s, 1 H), 7.44 (dd, J=2,8 Hz, 1 H), 3.05-2. 97 (m, 2H), 2.77-2. 43 (m, 10H), 2.31 (s, 3H). MS (DCI-NH3) [M+H] + at 356.

The free base was dissolved in methanol and treated with a methanol solution containing one equivalent of L-tartaric acid. The tartrate salt of the title compound crystallized from the methanol solution (101 mg, 66% yield).

Example 87 2-(2,5-Dimethyl-furan-3-yl)-6- {2-[ (2R)-2-methyl-1-pyrrolidinyllethyl}-quinoline The title compound was prepared using the procedure described in Example 57 using 1- (2, 5-dimethyl-furan-3-yl)-ethanone for 1- (1, 3-thiazol-2-yl)- ethanone.'H NMR (300 MHz, CD30D) b 1.19 (d, J=6 Hz, 3 H), 1.51 (m, 1 H), 1.84 (m, 2 H), 2.06 (m, 1 H), 2.31 (s, 3 H), 2.48 (m, 3 H), 2.63 (s, 3 H), 3.06 (m, 3 H), 3.21 (m, 1 H), 7.33 (d, J=9 Hz, 1 H), 7.34 (d, J=3 Hz, 1 H), 7.72 (dd, J= 9 Hz, J=3 Hz, 1 H), 7.82 (s, 1H), 8.16 (d, J=9 Hz, 1 H), 8.39 (d, J=3 Hz, 1 H); (DCI/NH3) m/z 335 (M+H) +.

Example 88 6-f2-j (2R)-2-methyl-1-pyrrolidinyllethyl-2- (4-methylsulfanyl-phenyl)-guinoline The title compound was prepared using the procedure described in Example 57 using 1- (4-methylsulfanyl-phenyl)-ethanone for 1- (1, 3-thiazol-2-yl)- ethanone.'H NMR (300 MHz, CD30D) 6 1. 17 (d, J=6 Hz, 3 H), 1.48 (m, 1 H), 1.84 (m, 2 H), 2.05 (m, 1 H), 2.49 (m, 3 H), 2.55 (s, 3 H), 2.63 (s, 3 H), 3.06 (m, 2 H), 3.17 (m, 1 H), 3.21 (m, 1 H), 7.41 (d, J=9 Hz, 2 H), 7.68 (dd, J=9 Hz, J=3 Hz, 1 H), 7.77 (d, J=3 Hz, 1 H), 7.94 (d, J=9 Hz, 1 H), 8.03 (d, J=9 Hz, 1 H), 8.05 (d, J=9 Hz, 1 H), 8.33 (d, J=9 Hz, 1 H) ; (DCI/NH3) m/z 363 (M+H) +.

Example 89 2-(6-Methyl-pyridin-3-yl)-6-{2-[(2R)-2-methyl-1-pyrrolidinyl lethylSquinoline The title compound was prepared using the procedure described in Example 57 using 1-(6-methyl-pyridin-3-yl)-ethanone (reference : S. P. Tanis et al.,

J. Med. Chem. 39,1996, 5053-5063) for 1- (1, 3-thiazol-2-yl)-ethanone.'H NMR (300 MHz, CD30D) 8 1. 17 (d, J=6 Hz, 3 H), 1.48 (m, 1 H), 1.84 (m, 2 H), 2.04 (m, 1 H), 2.38 (m, 1 H), 2.49 (m, 3 H), 2.63 (s, 3 H), 3.06 (m, 2 H), 3.19 (m, 1 H), 7.47 (d, J=9 Hz, 1 H), 7.70 (dd, J=9 Hz, J=3 Hz, 1 H), 7.80 (d, J=3 Hz, 1 H), 8.00 (d, J=9 Hz, 1 H), 8.07 (d, J=9 Hz, 1 H), 8.37 (d, J=9 Hz, 1 H), 8.47 (dd, J=9 Hz, J=3 Hz, 1 H), 9.17 (d, J=3 Hz, 1 H); (DCI/NH3) m/z 332 (M+H) +.

Example 90 <BR> <BR> <BR> <BR> 2- (1, 3-Dimethyl-1 H-pyrazol-4-yl)-642- [ (2R)-2-methyl-1-pyrrolidinyllethyl-quinoline The title compound was prepared using the procedure described in Example 57 using 1- (1, 3-dimethyl-1H-pyrazol-4-yl)-ethanone (reference : P.

Schenone et al., J. Heterocycl. Chem. 19,1982, 1355-1361) for 1- (1, 3-thiazol-2- yl)-ethanone.'H NMR (300 MHz, CD30D) 8 1. 32 (d, J=6 Hz, 3 H), 1.63 (m, 1 H), 1.97 (m, 2 H), 2.17 (m, 1 H), 2.60 (s, 3 H), 2.85 (m, 2 H), 3.12 (m, 3 H), 3.47 (m, 2 H), 3.90 (s, 3 H), 7.66 (dd, J=9 Hz, J=3 Hz, 1 H), 7.69 (d, J=9 Hz, 1 H), 7.76 (d, J=2 Hz, 1 H), 7.96 (d, J=9 Hz, 1 H), 8.12 (s, 1 H), 8.22 (d, J=9 Hz, 1 H); (DCI/NH3) m/z 335 (M+H) +.

Example 91 6-f 2-r (2R)-2-methyl-1-pyrrolidinyllethyl}-2-thiophen-3-yl-quinolin e The title compound was prepared using the procedure described in Example 57 using 1-thiophen-3-yl-ethanone (reference : E. Campaigne et al., J.

Amer. Chem. Soc. 70, 1948, 1555) for 1- (1, 3-thiazol-2-yi)-ethanone.'H NMR (300 MHz, CD30D) 8 1. 27 (d, J=6 Hz, 3 H), 1.61 (m, 1 H), 1.92 (m, 2 H), 2.12 (m, 1 H), 2.70 (m, 2 H), 3.06 (m, 3 H), 3.24 (m, 1 H), 3.45 (m, 1 H), 7.56 (dd, J=9 Hz, J=9 Hz, 1 H), 7.68 (dd, J=9 Hz, J=3 Hz, 1 H), 7.78 (s, 1H), 7.88 (d, J=6 Hz, 1 H), 7.94 (d, J=9 Hz, 1 H), 8.03 (d, J=9 Hz, 1 H), 8.18 (m, 1 H), 8.28 (d, J=9 Hz, 1 H); (DCI/NH3) m/z 323 (M+H) +.

Example 92 6-82-[(2R)-2-methyl-1-pyrrolidinvllethylT-2-Pvrimid in-5-vl-quinoline

The title compound was prepared using the procedure described in Example 57 using 1-pyrimidin-5-yl-ethanone (reference : I. I. Naumenko et al., Chem. Heterocycl. Compd. (Engl. Transl.) 17,1981, 710-714) for 1- (1, 3-thiazol-2- yl)-ethanone.'H NMR (300 MHz, CD30D) 5 1. 16 (d, J=6 Hz, 3 H), 1.50 (m, 1 H), 1.84 (m, 2 H), 2.04 (m, 1 H), 2.35 (m, 1 H), 2.46 (m, 2 H), 3.12 (m, 3 H), 3.21 (m, 1 H), 7.74 (dd, J=9 Hz, J=3 Hz, 1 H), 7.82 (d, J=3 Hz, 1 H), 8.10 (d, J=6 Hz, 2 H), 8.43 (d, J=9 Hz, 1 H), 9.25 (s, 1 H), 9.56 (s, 2 H); (DCI/NH3) m/z 319 (M+H) +.

' Example 93 2- (2, 6-Dimethyl-pyridin-3-yl)-6- {2- (2R)-2-methyl-1-pyrrolidinyllethyl}-q uinoline The title compound was prepared using the procedure described in Example 57 using 1- (2, 6-dimethyl-pyridin-3-yl)-ethanone (reference K. Franke Angew. Chem. 67, 1955, 395) for 1- (1, 3-thiazol-2-yl)-ethanone.'H NMR (300 MHz, CD30D) 8 1. 17 (d, J=6 Hz, 3 H), 1.48 (m, 1 H), 1.82 (m, 2 H), 2.01 (m, 1 H), 2.35 (m, 1 H), 2.47 (m, 2 H), 2.54 (s, 3 H), 2.59 (s, 3 H), 3.07 (m, 3 H), 3.19 (m, 1 H), 7.29 (d, J=9 Hz, 1 H), 7.63 (d, J=9 Hz, 1 H), 7.73 (dd, J=9 Hz, J=3 Hz, 1 H), 7.81 (d, J=6 Hz, 1 H), 7.84 (d, J=3 Hz, 1 H), 8.00 (d, J=9 Hz, 1 H), 8.40 (d, J=9 Hz, 1 H); (DCI/NH3) m/z 346 (M+H) +.

Example 94 1-[2,6-Dimethyl-5-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl} -quinolin-2-yl)-pyridin-3- yll-ethanone The title compound was prepared using the procedure described in Example 57 using 3, 5-diacetyl-2, 6-dimethylpyridine for 1- (1, 3-thiazol-2- yl) ethanone. The product was dissolved in water and treated with two equivalents of L-tartaric acid. The solvent was removed via lyopholization to give the ditartrate salt of the product as a white foam.'H NMR (CD30D) b ppm 1.49 (d, J=6.78 Hz, 3 H), 1.81 (m, 1 H), 2.13 (m, 2 H), 2.35 (m, 1 H), 2.60 (s, 3 H), 2.64 (s, 3 H), 2.76 (s, 3 H), 3.36 (m, 4 H), 3.59 (m, 1 H), 3.74 (m, 2 H), 4.47 (s, 4 H), 7.77 (d, J=8.48 Hz, 1 H), 7.82 (dd, J=8. 65, 1.87 Hz, 1 H), 7.99 (d, J=1.70 Hz, 1 H), 8.10 (d, J=8.82 Hz, 1 H), 8.32 (s, 1 H), 8.47 (d, J=8.48 Hz, 1 H). MS (DCI-NH3) [M+H] + at 388.

Example 95 6-82-[(2R)-2-methvl-1-pyrrolid inyllethylT-2-(2H-pvrazol-3-yl)-q uinoline The title compound was prepared using the procedure described in Example 57 using 1- (1H-pyrazol-5-yl) ethan-1-one hydrochloride for 1- (1, 3-thiazol- 2-yl) ethanone and using 5 drops of the saturated solution of potassium hydroxide in ethanol.'H NMR (CDC13) 8 ppm 1.14 (d, J=6.10 Hz, 3 H), 1.48 (m, 1 H), 1.77 (m, 2 H), 1.93 (m, 1 H), 2.25 (q, J=8.82 Hz, 1 H), 2.40 (m, 2 H), 3.01 (m, 2 H), 3.14 (m ; 1 H), 3.30 (m, 1 H), 6.92 (s, 1 H), 7.61 (m, 1 H), 7.63 (s, 1 H), 7.70 (d, J=2.03 Hz, 1 H), 7.81 (d, J=8.82 Hz, 1 H), 8.02 (d, J=8.48 Hz, 1 H), 8.14 (d, J=8. 48 Hz, 1 H). MS (DCI-NH3) [M+H] + at 307.

Example 96 2-(3-Bromo-isoxazol-5-yl)-6-{2-[(2R)-2-methyl-1-pyrrolidinyl ]ethyl}-quinoline The title compound was prepared using the procedure described in Example 57 using 1- (3-bromo-isoxazol-5-yi)-ethanone (reference: M. D. Amici et al., J. Org. Chem. 1989,54 (11), 2646-2650) for 1-(1, 3-thiazol-2-yl) ethanone. 1H NMR (CDC13) 8 ppm 1.13 (d, J=6.10 Hz, 3 H), 1.47 (m, 1 H), 1.78 (m, 2 H), 1.95 (m, 1 H), 2.24 (q, J=8.59 Hz, 1 H), 2.40 (m, 2 H), 3.08 (m, 3 H), 3.29 (m, 1 H), 7.14 (s, 1 H), 7.67 (dd, 1 H), 7.69 (s, 1 H), 7.96 (d, J=8.48 Hz, 1 H), 8.06 (d, J=9.16 Hz, 1 H), 8.24 (d, J=8.48 Hz, 1 H). MS (DCI-NH3) [M+H] +at 386.

Example 97 2- (6-Chloro-pyridin-3-yl)-6-f2- [(2R)-2-methyl-1-pyrrolidinyllethyl}-quinoline The title compound was prepared using the procedure described in Example 57 using 1- (6-chloro-3-pyridinyl)-1-ethanone for 1- (1, 3-thiazol-2- yl) ethanone.'H NMR (CDC13) 8 ppm 1.14 (d, J=5.76 Hz, 3 H), 1.47 (m, 1 H), 1.78 (m, 2 H), 1.94 (m, 1 H), 2.25 (q, J=8.70 Hz, 1 H), 2.40 (m, 2 H), 3.03 (m, 2 H), 3.15 (m, 1 H), 3.30 (m, 1 H), 7.48 (d, J=8.48 Hz, 1 H), 7.65 (dd, 1 H), 7.67 (s, 1 H), 7.83 (d, J=8.48 Hz, 1 H), 8.08 (d, J=8.48 Hz, 1 H), 8.21 (d, J=8.48 Hz, 1 H), 8.51 (dd, J=8.31, 2.54 Hz, 1 H), 9.11 (dd, J=2.71, 0.68 Hz, 1 H). MS (DCI-NH3) [M+H] + at 352.

Example 98 2-(3,5-Dimethyl-thiophen-2-yl)-6-{2-[(2R)-2-methyl-1-pyrroli dinyl]ethyl}-quinoline The title compound was prepared using the procedure described in Example 57 using 1- (3, 5-dimethyl-2-thienyl) ethan-1-one for 1- (1, 3-thiazol-2- yl) ethanone. 1H NMR (CDC13) # ppm 1.14 (d, J=6.10 Hz, 3 H), 1.47 (m, 1 H), 1.77 (m, 2 H), 1.95 (m, 1 H), 2.25 (m, 1 H), 2.39 (m, 2 H), 2.49 (s, 3 H), 2.54 (s, 3 H), 3.00 (m, 2 H), 3.11 (m, 1 H), 3.29 (m, 1 H), 6.64 (s, 1 H), 7.56 (dd, 1 H), 7.58 (s, 1 H), 7. 63 (d, J=8.82 Hz, 1 H), 7.99 (d, J=8.14 Hz, 1 H), 8.05 (d, J=8.82 Hz, 1 H).

MS (DCI-NH3) [M+H] + at 351.

Example 99 6-82-r (2R)-2-methyl-1-pyrrolidinyllethyl}-2-thiophen-2-yl-q uinoline The title compound was prepared using the procedure described in Example 57 using 2-acetylthiophene for 1-(1, 3-thiazol-2-yl) ethanone. 1H NMR (CD3) 8 ppm 1.15 (d, J=6.10 Hz, 3 H), 1.49 (m, 1 H), 1.77 (m, 2 H), 1.96 (m, 1 H), 2.26 (q, J=8.70 Hz, 1 H), 2.41 (m, 2 H), 3.02 (m, 2 H), 3.14 (m, 1 H), 3.30 (m, 1 H), 7.15 (dd, J=5.09, 3.73 Hz, 1 H), 7.45 (dd, J=5.09, 1.02 Hz, 1 H), 7.58 (dd, 1 H), 7.59 (s, 1 H), 7.71 (dd, J=3.73, 1.02 Hz, 1 H), 7.77 (d, J=8.82 Hz, 1 H), 8.01 (d, J=8.48 Hz, 1 H), 8.08 (d, J=8.82 Hz, 1 H). MS (DCI-NH3) [M+H] + at 323.

Example 100 2-Furan-3-yl-6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-quino line The title compound was prepared using the procedure described in Example 57 using 1-furan-3-yl-ethanone (reference: J. M. McNamara et al., Tetrahedron 1984,40 (22), 4685-4692) for 1- (1, 3-thiazol-2-yl) ethanone. 1H NMR (CDC13) 8 ppm 1.14 (d, J=6.10 Hz, 3 H), 1.47 (m, 1 H), 1.77 (m, 2 H), 1.95 (m, 1 H), 2.25 (q, J=8.82 Hz, 1 H), 2.40 (m, 2 H), 3.01 (m, 2 H), 3.14 (m, 1 H), 3.35 (m, 1 H), 7.10 (dd, J=1.87, 0.85 Hz, 1 H), 7.54 (t, J=1.70 Hz, 1 H), 7.57 (d, J=8.48 Hz, 1 H), 7.58 (dd, 1 H), 7.60 (s, 1 H), 8.00 (d, J=8.14 Hz, 1 H), 8.07 (d, J=7.80 Hz, 1 H), 8.13 (m, 1 H). MS (DCI-NH3) [M+H] + at 307.

Example 101

2-(4,5-Dihydro-thiazol-2-yl)-6-{2-[(2R)-2-methyl-1-pyrrolidi nyl]ethyl}-quinoline The title compound was prepared using the procedure described in Example 57 using 2-acetyl-2-thiazoline for 1- (1, 3-thiazol-2-yl) ethanone.'H NMR (CDC13) 5 ppm 1.13 (d, J=6.10 Hz, 3 H), 1.46 (m, 1 H), 1.76 (m, 2 H), 1.94 (m, 1 H), 2.24 (q, J=8. 59 Hz, 1 H), 2.40 (m, 2 H), 3.02 (m, 2 H), 3.13 (m, 1 H), 3.29 (m, 1 H), 3.41 (t, J=8.48 Hz, 2 H), 4.60 (t, J=8.48 Hz, 2 H), 7.63 (dd, J=8. 48, 2.03 Hz, 1 H), 7.65 (s, 1 H), 8.11 (d, J=8.82 Hz, 1 H), 8.13 (s, 2 H). MS (DCI-NH3) [M+H] + at 326.

Example 102 1-r4-(6-82-f (2R)-2-methyl-1-pyrrolid inyllethylT-q uinolin-2-yl)-phenyll-ethanone The title compound was prepared using the procedure described in Example 57 using 1, 4-diacetylbenzene for 1- (1, 3-thiazol-2-yl) ethanone.'H NMR (CD3) 8 ppm 1.15 (d, J=5.76 Hz, 3 H), 1.48 (m, 1 H), 1.79 (m, 2 H), 1.95 (m, 1 H), 2.26 (q, 1 H), 2.42 (m, 2 H), 2.67 (s, 3 H), 3.04 (m, 2 H), 3.15 (m, 1 H), 3.31 (m, 1 H), 7.64 (dd, J=8.48, 2.03 Hz, 1 H), 7.67 (s, 1 H), 7.90 (d, J=8.48 Hz, 1 H), 8.11 (m, 3 H), 8.20 (d, J=8.48 Hz, 1 H), 8.27 (m, 2 H). MS (DCI-NH3) [M+H] +at 359.

Example 103 <BR> <BR> <BR> <BR> 3- (6-f 2- ( (2R)-2-methyl-1-pyrrolidinyllethyl}-quinolin-2-yl)-2-trifluo romethyl-pyridin- 4-ol The title compound was prepared using the procedure described in Example 57 using 1- roxy-2-trifluoromethyl-pyrid in-3-yl)-ethanone (reference: L. S. Vasil'ev et al., Russ. Chem. Bi. 1996,45 (11), 2574-2577) for 1- (1, 3-thiazol-2-yl) ethanone.'H NMR (CD30D) 8 ppm 1.43 (d, J=6.44 Hz, 3 H), 1.73 (m, 1 H), 2.06 (m, 2 H), 2.29 (m, 1 H), 3.10-3. 75 (m, 7 H), 6.93 (d, J=5.76 Hz, 1 H), 7.52 (d, J=8.48 Hz, 1 H), 7.70 (dd, J=8.65, 1.87 Hz, 1 H), 7.88 (d, J=1.70 Hz, 1 H), 8.01 (d, J=8.82 Hz, 1 H), 8.23 (d, J=6.10 Hz, 1 H), 8.33 (d, J=8.48 Hz, 1 H).

MS (DCI-NH3) [M+H] + at 402.

Example 104

2- (3, 5-Dimethyl-1H-pyrazol-4-yl)-6-f2-r (2R)-2-methyl-1-pyrrolidinyllethylI'quinoline The title compound was prepared using the procedure described in Example 54F using 1- (3, 5-dimethyl-1H-pyrazol-4-yl)-ethanone (reference: E. E.

Emelina et al., Russ. J. Org. Chem. 1994,30 (10), 1637-1639) for 3-acetylpyridine.

'H NMR (CDC13) 8 ppm 1.17 (d, J=5.76 Hz, 3 H), 1.51 (m, 1 H), 1.80 (m, 2 H), 1.97 (m, 1 H), 2.28 (m, 1 H), 2.44 (m, 2 H), 2.51 (s, 3 H), 2.51 (s, 3 H), 3.05 (m, 2 H), 3.15 (m, 1 H), 3.32 (m, 1 H), 7.47 (d, J=8.48 Hz, 1 H), 7.59 (dd, J=8.48, 2.03 Hz, 1 Hj, 7.63 (s, 1 H), 8.01 (d, J=8.81 Hz, 1 H), 8.10 (d, J=8.81 Hz, 1 H). MS (DCI-NH3) [M+H] + at 335.

Example 105 6-2- [(2R)-2-methyl-1-pyrrolidinyllethyl}-2- (1 H-pyrazol-4-yl)-quinoline The title compound was prepared using the procedure described in Example 57 using 1- (1H-pyrazol-4-yl)-ethanone (reference: G. Heinisch et al., Monatsh. Chem. 1988, 119, 253-262) for 1- (1, 3-thiazol-2-yl) ethanone.'H NMR (CDC13) 8 ppm 1.16 (d, J=6.10 Hz, 3 H), 1.48 (m, 1 H), 1.76 (m, 1 H), 1.94 (m, 2 H), 2.29 (q, J=8.36 Hz, 1 H), 2.44 (m, 2 H), 3.02 (m, 2 H), 3.22 (m, 1 H), 3.38 (m, 1 H), 7.53 (d, J=8.48 Hz, 1 H), 7.56 (s, 1 H), 7.57 (dd, 1 H), 7.97 (d, J=7.46 Hz, 1 H), 8.00 (d, J=8.14 Hz, 1 H), 8.08 (s, 2 H), 11.14 (br. s, 1 H). MS (DCI-NH3) [M+H] + at 307.

Example 106 2, 6-Dimethyl-5-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-quin olin-2-yl)-nicotinamide Example 106A 5-Acetyl-2, 6-dimethyl-1, 4-dihydro-pyridine-3-carbonitrile A mixture of 3-aminocrotonitrile (2. 0 g, 24 mmol), 2,4-pentanedione (4.9 g, 49 mmol), paraformaldehyde (1.5 g, 49 mmol) and piperidine (12 drops) in ethanol (100 mL) was heated to reflux for 4 hours, cooled and concentrated to dryness.

The residue was treated with diethyl ether (150 mL). The solid was collected and washed with ether. The solid was triturated with dichloromethane (2 x 100 mL).

The combined dichloromethane triturations were concentrated to provide 2.5 g of

the title compound.'H NMR (DMSO-d6) 8 ppm 1.92 (t, J=1.02 Hz, 3 H), 2.09 (s, 3 H), 2.10 (s, 3 H), 3.20 (s, 2 H), 8.65 (s, 1 H). MS (DCI-NH3) [M+H] + at 177.

Example 106B 5-acetyl-2, 6-d imethyinicotinonitrile The product from Example 106A (1.0 g, 5.7 mmol) was treated with toluene (15 mL), treated with barium manganate (3.0 g, 12 mmol), stirred over night at ambient temperature and filtered. The filtrate was concentrated and chromatographed (using 20: 1 and then 3: 2 hexane: ethyl acetate) to provide 0.9 g of the title compound.'H NMR (CD3) # ppm 2.60 (s, 3 H), 2.79 (s, 3 H), 2.79 (s, 3 H), 8.16 (s, 1 H). MS (DCI-NH3) [M+H] +at 175.

Example 106C 2, 6-Dimethyl-5-(6-82-[(2R)-2-methyl-1-PvrrolidinyllethylT-quin olin-2-yl)-nicotinamide The title compound was prepared using the procedure described in Example 57 using 5-acetyl-2, 6-dimethylnicotinonitrile for 1- (1, 3-thiazol-2- yl) ethanone providing the product from Example 67 which eluted first and the title compound which eluted second.'H NMR (CDC13) 8 ppm 1.18 (d, J=5.43 Hz, 3 H), 1.53 (m, 1 H), 1.80 (m, 2 H), 1. 98 (m, 1 H), 2.2-2. 6 (m, 3H), 2.65 (s, 3 H), 2.78 (s, 3 H), 3.09 (m, 2 H), 3.19 (m, 1 H), 3.33 (m, 1 H), 5.75 (s, 1 H), 5.90 (s, 1 H), 7.52 (d, J=8.48 Hz, 1 H), 7.66 (dd, J=8.65, 1.87 Hz, 1 H), 7.71 (s, 1 H), 7.94 (s, 1 H), 8.06 (d, J=8.82 Hz, 1 H), 8.19 (d, J=8.14 Hz, 1 H). MS (DCI-NH3) [M+H] + at 389.

Example 107 2-[2-(2R-Methyl-pyrrolidin-1-yl)-ethyl]-6-pyridin-4-yl-quino line The title compound was prepared using the procedure described in Example 51 using 4-pyridinylboronic acid for 3-pyridinylboronic acid. The title compound was treated with HCI in ethyl acetate to give the corresponding trihydrochloride salt. mp 145-147 °C (uncorrected); MS (ESI) 318 (M+H) + ;'H NMR (trihydrochloride, CD30D, 400 MHz) 8 9. 12 (1H, m), 9.03 (2H, d), 8.94 (1H, d), 8.65 (2H, d), 8.61 (1H, d), 8.53 (1H, d), 8.12 (1H, d), 4.10 (1H, br), 3.90 (1H,

br), 3.80 (1H, br), 3.62 (2H, br), 3.42 (1H, m), 2.40 (1H, m), 2.3-2. 1 (3H, m), 1.82 (1H, br, m), 1.58 (3H, d).

Example 108 6- (6-Methoxy-pyridin-3-yl)-2- [2 (R)- (2-methyl-pyrrolidin-1-yl)-ethyll-quinoline The title compound was prepared using the procedure described in Example 51 using 6-methoxy-pyridin-3-ylboronic acid for 3-pyridinylboronic acid.

The title compound was treated with L-tartaric acid in IPA to give the corresponding tartrate. mp 132-134 °C (uncorrected); MS (ESI) 348 (M+H) + ;'H NMR (tartrate, DMSO-d6, 400 MHz) 8 8.62 (1 H, d), 8.37 (1 H, d), 8.24 (1 H, d), 8.18 (1H, dd), 8.08 (1 H, dd), 8.04 (1H, d), 7.52 (1H, d), 6.94 (1 H, d), 4. 05, 3.90 (2H, s), 3.80-3. 4 (3H, m), 3.32 (3H, m), 3.04 (1H, q), 2.13 (1H, m), 1.90 (2H, m), 1.60 (1H, m), 1.35, 1.03 (3H, d).

Example 109 6- (2, 6-Difluoro-pyridin-3-yl)-2- [2- (2R-methyl-pyrrolidin-1-yl)-ethyll-q uinoline The title compound was prepared using the procedure described in Example 51 using 2, 6-difluoro-pyridin-3-ylboronic acid for 3-pyridinylboronic acid.

The title compound was treated with L-tartaric acid in IPA to give the corresponding tartrate. mp 142-143 °C (uncorrected); MS (ESI) 354 (M+H) + ;'H NMR (tartrate, DMSO-d6, 400 MHz) 8 8.62 (1 H, q), 8.60 (1 H, d), 8.21 (1 H, s), 8.08 (1 H, d), 7.94 (1 H, d), 8.04 (1 H, d), 7.59 (1 H, d), 7.35 (1 H, dd), 4.00 (2H, s), 3. 80- 3.4 (3H, m), 3.38 (1H, m), 3.25 (2H, m), 2.96 (1 H, q), 2.12 (1H, m), 1.89 (2H, m), 1. 59 (1 H, m), 1.32 (3H, d).

Example 110 6-(6-Chloro-pyridin-3-yl)-2-[2-(2(R)-methyl-pyrrolidin-1-yl) -ethyl]quinoline The title compound was prepared using the procedure described in Example 51 using 2-chloro-5-trimethylstannanyl-pyridine for 3-pyridinylboronic acid. The title compound was treated with L-tartaric acid in IPA to give the corresponding tartrate. mp 167-168 °C (uncorrected); MS (ESI) 352 (M+H) + ;'H NMR (tartrate, CD30D, 400 MHz) 8 8.87 (1H, d), 8.40 (1H, d), 8.05 (1H, d), 8.02

(1H, dd), 8.13 (1 H, d), 8.08 (1H, dd), 7.59 (1H, d), 7.57 (1H, d), 4.40 (2H, s), 4.05 (1 H, br, m), 3.78 (1H, br, m), 3.63 (1 H, br, m), 3.6-3. 4 (3H, m), 3.35 (1H, m), 2.35 (1H, m), 2.14 (2H, m), 1.82 (1H, m), 1.58, 1.15 (3H, d).

Example 111 6- (2, 6-(2,6-Dichloro-pyridin-3-yl)-2-[2-(2(R)-methyl-pyrrolidin-1 -yl)-ethyl]-quinoline The title compound was prepared using the procedure described in Example 51 using 2, 6-dichloro-pyridin-3-ylboronic acid for 3-pyridinylboronic acid.

The title compound was treated with HCI in ethyl acetate to give the corresponding dihydrochloride. mp 105-107 °C (uncorrected); MS (ESI) 386 (M+H) + ;'H NMR (dihydrochloride, DMSO-d6, 400 MHz) 8 8. 52 (1H, d), 8.19 (1H, s), 8.15 (1H, d), 8.10 (1 H, d), 7.94 (1H, dd), 7.75 (1H, d), 7.68 (1H, d), 3.90 (2H, br, m), 3.66 (1H, br, m), 3.50 (3H, br, m), 3.22 (1 H, br, m), 2.22 (1H, br, m), 1.96 (2H, br, m), 1.66 (1H, br, m), 1.45 (3H, br, d).

Example 112 2-[2-(2(R)-Methyl-pyrrolidin-1-yl)-ethyl]-6-pyrazin-2-yl-qui noline The title compound was prepared using the procedure described in Example 51 using 2-tri-tert-butylstannanyl-pyrazine for 3-pyridinylboronic acid.

MS (ESI) 319 (M+H) + ; 1H NMR (CDCI3, 400 MHz) 8 9.20 (1H, d), 8.70 (1H, t), 8.58 (1H, d), 8.50 (1H, d), 8.37 (1H, dd), 8.20 (1H, d), 8.19 (1H, d), 7.43 (1H, d), 3.4-3. 2 (4H, m), 2.65 (1 H, br, m), 2.45 (1H, br, m), 2.34 (1H, br, m), 1.95 (1H, br,- m), 1.82 (1H, br, m), 1.75 (1H, br, m), 1.50 (1 H, br, m), 1.15 (3H, d).

Example 113 2-[2-(2(R)-Methyl-pyrrolidin-1-yl)-ethyl]-6-pyrimidin-5-yl-q uinoline The title compound was prepared using the procedure described in Example 51 using 5-tri-tert-butylstannanyl-pyrimidine for 3-pyridinylboronic acid.

The title compound was treated with HCI in ethyl acetate to give the corresponding trihydrochloride. mp 160-162 °C (uncorrected); MS (ESI) 319 (M+H) + ;'H NMR (trihydrochloride, DMSO-d6, 400 MHz) 8 9.32 (2H, s), 9.26 (1H, s), 8.70 (1H, d), 8.52 (1H, d), 8.38 (1H, dd), 8.30 (1H, d), 7.82 (1H, d), 3.92 (1H,

m), 3.65 (3H, br, m), 3.50 (2H, br, m), 3.22 (1 H, br, m), 2.10 (1 H, m), 2.00 (2H, br, m), 1.70 (1H, br, m), 1.50 (3H, br, d).

Example 114 6-(2,4-Dimethoxy-pyrimidin-5-yl)-2-[2-(2(R)-methyl-pyrrolidi n-1-yl)-ethyl]-quinoline The title compound was prepared using the procedure described in Example 51 using 2, 6-dimethoxypyrimidin-5-ylboronic acid for 3-pyridinylboronic acid. MS (ESI) 379 (M+H) + ;'H NMR (CD3, 400 MHz) 8 8.34 (1H, s), 8.10 (1H, d), 8.07 (1H, d), 7.88 (1H, d), 7.82 (1 H, dd), 7.38 (1H, d), 4.06 (3H, s), 4.05 (3H, s), 3.30 (2H, m), 3.22 (2H, m), 2.60 (1H, m), 2.42 (1 H, m), 2.30 (1 H, q), 1.95 (1 H, m), 1.80 (1H, m), 1.72 (1H, m), 1.43 (1H, m), 1.13 (3H, d).

Example 115 <BR> <BR> <BR> <BR> Dimethyl- (4-f2-f2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyll-quinolin-6-yl)-phenyl)-am ine The title compound was prepared using the procedure described in Example 51 using 4-dimethylaminophenylboronic acid for 3-pyridinylboronic acid.

The title compound was treated with L-tartaric acid in IPA to give the corresponding tartrate. mp 155-156 °C (uncorrected); MS (ESI) 360 (M+H) + ;'H NMR (tartrate, DMSO-d6, 400 MHz) 8 8.30 (1H, d), 8.10 (1H, d), 8.02 (1H, dd), 7.95 (1 H, d), 7.68 (2H, d), 7.47 (1 H, d), 6.83 (2H, d), 4.00 (2H, s), 3.60 (1H, m), 3.48 (1H, m), 3.27 (2H, m), 3.12 (2H, m), 2.97 (6H, s), 2.82 (1H, m), 2.08 (1H, m), 1.83 (2H, m), 1.52 (1H, m), 1.28 (3H, d).

Example 116 1-(4-{2-[2-(2(R)-Methyl-pyrrolidin-1-yl)-ethyl]-quinolin-6-y l}-phenyl)-ethanone The title compound was prepared using the procedure described in Example 51 using 4-acetylphenylboronic acid for 3-pyridinylboronic acid. The title compound was treated with L-tartaric acid in IPA to give the corresponding tartrate. mp 152-154 °C (uncorrected); MS (ESI) 359 (M+H) + ;'H NMR (tartrate, CD30D, 400 MHz) 8 8.40 (1H, d), 8.24 (1 H, s), 8.11 (2H, d), 8.09 (2H, m), 7.92 (2H, d), 7.55 (1H, d), 4.39 (2H, s), 4.01 (1H, m), 3.79 (1H, m), 3.63 (1H, m), 3.53

(1H, m), 3.50 (2H, m), 3.31 (1H, m), 2.64 (3H, s), 2.38 (1H, m), 2.12 (2H, m), 1.82 (1 H, m), 1.58 (3H, d).

Example 117 6- 4-Chloro-phenyl)-2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyll-quinoline The title compound was prepared using the procedure described in Example 51 using 4-chlorophenylboronic acid for 3-pyridinylboronic acid. The title compound was treated with HCI in ethyl acetate to give the corresponding dihydrochloride. mp 154-155 °C (uncorrected); MS (ESI) 351 (M+H) + ;'H NMR (dihydrochloride, DMSO-d6, 400 MHz) 5 8.70 (1 H, d), 8.43 (1 H, s), 8.27 (2H, s), 7.90 (2H, d), 7.81 (1 H, d), 7.60 (2H, d), 3.90 (1 H, br, m), 3.63 (3H,, br, m), 3.50 (2H, br, m), 3.23 (1 H, br, m), 2.20 (1 H, s), 2.00 (2H, m), 1.68 (1 H, m), 1.42 (3H, br, d). <BR> <BR> <BR> <BR> <BR> <BR> <BR> <P> Example 118<BR> <BR> <BR> <BR> <BR> <BR> 6- (2 6-Dimethyl-pyridin-3-yl)-2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyll-quinoline The title compound was prepared using the procedure described in Example 51 using 2, 6-dimethyl-3- (4, 4, 5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)- pyridine for 3-pyridinylboronic acid. The title compound was treated with HCI in ethyl acetate to give the corresponding trihydrochloride. mp 176-177 °C (uncorrected); MS (ESI) 346 (M+H) + ;'H NMR (trihydrochloride, CD30D, 400 MHz) # 9. 08 (1 H, d), 8.46 (2H, d), 8.42 (1H, d), 8.18 (1H, dd), 8.14 (1H, d), 7.89 (1H, d), 4.08 (1 H, m), 3.90 (1 H, m), 3.82 (2H, m), 3.65 (2H, br, m), 3.42 (1 H, m), 2.87 (3H, s), 2.75 (3H, s), 2.39 (1H, m), 2.18 (2H, br, m), 1.83 (1H, br, m), 1.58 (3H, d).

Example 119 6-(5-Methoxy-pyridin-3-yl)-2-[2-(2(R)-methyl-pyrrolidin-1-yl )-ethyl]-quinoline The title compound was prepared using the procedure described in Example 51 using 3-methoxy-5- (4, 4,5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)- pyridine for 3-pyridinylboronic acid. MS (ESI) 348 (M+H) + ; 1H NMR (CDC13, 400 MHz) 6 8.57 (1 H, s), 8.34 (1H, d), 8.12 (2H, d), 7.96 (1 H, d), 7.90 (1 H, dd), 7.48 (1H, dd), 7.40 (1 H, d), 3.95 (3H, s), 3. 76, 3.63 (1H, m), 3.4-3. 2 (3H, m), 2. 64 (1H,

m), 2.45 (1 H, m), 2.32 (1H, q), 1.95 (1 H, m), 1.82 (1 H, m), 1.73 (1H, m), 1.45 (1H, m), 1. 15 (3H, d).

Example 120 <BR> <BR> <BR> 6- (3, 5-Dimethyl-isoxazol-4-yl)-2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyll-quinoline The title compound was prepared using the procedure described in Example 51 using 3, 5-dimethyl-isoxazol-4-ylboronic acid for 3-pyridinylboronic acid. The title compound was treated with HCI in ethyl acetate to give the corresponding trihydrochloride. mp 174-175 °C (uncorrected); MS (ESI) 336 (M+H) + ;'H NMR (trihydrochloride, DMSO-d6, 400 MHz) 8 8.72 (1H, d), 8.30 (1H, d), 8.18 (1 H, d), 7.97 (1H, dd), 7.83 (1H, d), 3.90 (1H, br, m), 3.65 (2H, br, m), 3.52 (2H, br, m), 3.23 (1 H, br, m), 2.50 (3H, s), 2.32 (3H, s), 2.20 (2H, br, m), 2.00 (2H, br, m), 1.70 (1 H, br, m), 1.45 (3H, br, d).

Example 121 4-{2-[2-(2(R)-Methyl-pyrrolidin-1-yl)-ethyl]-quinolin-6-yl}- benzoic acid methyl ester The title compound was prepared using the procedure described in Example 51 using 4-methoxycarbonylphenylboronic acid for 3-pyridinylboronic acid. The title compound was treated with HCI in ethyl acetate to give the corresponding dihydrochloride. mp 172-174 °C (uncorrected); MS (ESI) 375 (M+H) + ;'H NMR (diihydrochloride, DMSO-d6, 400 MHz) 8 8.86 (1H, d), 8. 60 (1H, s), 8.39 (2H, s), 8.12 (2H, d), 8.04 (2H, d), 7.95 (1H, d), 3.95 (1H, br, m), 3.90 (3H, s), 3.70 (2H, br, m), 3.52 (2H, br, m), 3.24 (1 H, br, m), 2.20 (2H, m), 2.00 (2H, br, m), 1.68 (1 H, br, m), 1.45 (3H, br, d).

Example 122 2-[2-(2(R)-Methyl-pyrroldin-1-yl)-ethyl]-6-(4-methylsulfanyl -phenyl)-quinoline The title compound was prepared using the procedure described in Example 51 using 4-methylsulfanylphenylboronic acid for 3-pyridinylboronic acid.

The title compound was treated with HCI in ethyl acetate to give the corresponding dihydrochloride. mp 158-159 °C (uncorrected); MS (ESI) 363 (M+H) + ;'H NMR (dihydrochloride, DMSO-d6, 400 MHz) 8 8.79 (1H, d), 8.43 (1H,

s), 8.31 (2H, br, s), 7.88 (1H, d), 8.02 (2H, d), 7.43 (2H, d), 3.95 (1H, br, m), 3.67 (2H, br, m), 3.50 (3H, br, m), 3.23 (1H, br, m), 2. 53 (3H, s), 2.20 (1H, m), 2.00 (2H, br, m), 1.68 (1H, br, m), 1.45 (3H, br, d).

Example 123 6- (6-Fluoro-pyridin-3-yl)-2- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyll-quinoline The title compound was prepared using the procedure described in Example 51 using 2-fluoro-5- (4, 4,5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)- pyridine for 3-pyridinylboronic acid. The title compound was treated with HCI in ethyl acetate to give the corresponding trihydrochloride. mp 162-163 °C (uncorrected); MS (ESI) 336 (M+H) + ;'H NMR (trihydrochloride, DMSO-d6, 400 MHz) 6 8.93 (1H, d), 8.77 (1H, d), 8.58 (1H, d), 8.50 (1H, td), 8.40 (2H, m), 7.96 (1H, d), 7.40 (1H, dd), 3.95 (1H, br, m), 3.71 (2H, br, m), 3.52 (2H, br, m), 3.24 (1H, br, m), 3.05 (1 H, m), 2.20 (1H, m), 2.00 (2H, br, m), 1.68 (1 H, br, m), 1.45 (3H, br, d).

Example 124 5-{2-[2-(2(R)-Methyl-pyrrolidin-1-yl)-ethyl]-quinolin-6-yl}- nicotinonitrile The title compound was prepared using the procedure described in Example 51 using 5- (4, 4,5, 5-tetramethyl-[1, 3,2] dioxaborolan-2-yl)-nicotinonitrile for 3-pyridinylboronic acid. The title compound was treated with L-tartaric acid in IPA to give the corresponding tartrate. mp 100-102 °C ; MS (ESI) 343 (M+H) + ;'H NMR (tartrate, DMSO-d6, 400 MHz) 6 9.36 (1H, d), 9.05 (1H, d), 8.81 (1H, dd), 8.49 (1H, d), 8.37 (1 H, d), 8.20 (1H, dd), 8.09 (1H, d), 7.59 (1 H, d), 4. 04 (2H, s), 3.65 (1H, m), 3.49 (1H, m), 3.36 (2H, m), 3.17 (2H, m), 2.89 (1H, m), 2.09 (1 H, m), 1.88 (2H, br, m), 1.56 (1 H, br, m), 1.28, 1.05 (3H, d).

Example 125 2, 2,4-Dimethoxy-5-{6-[2-((2R)-methyl-pyrrolidin-1-yl)-ethyl]-n aphthalen-2-yl}- pyrimidine Example 125A

2-[6-(2,4-Dimethoxy-pyrimidin-5-yl)-naphthalen-2-yl]-ethanol A mixture of the product from Example 1 E (. 1020 g, 0.41 mmol), 2,4- dimethoxypyrimidin-5-yl-boronic acid (. 0920 g, 0.50 mmol), dichlorobis (triphenylphosphine)-palladium (II) (. 0096 g, 0.014 mmol), and K3PO4 H20 in isopropyl alcohol (5 mL) and H20 (2 mL) was stirred at 65 °C for 2 hours. The reaction mixture was cooled to room temperature then concentrated under reduced pressure. The residue was partitioned between brine and ethyl acetate.

The aqueous layer was washed with ethyl acetate, and the combined organic extracts were dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (7: 3 hexane/ethyl acetate). Fractions containing product were combined to provide (0.0376 g, 30% yield).'H NMR (CDC13, 300 MHz), 8 8.37 (s, 1H), 7.95 (s, 1H), 7.86-7. 82 (d, J=6 Hz, 2H), 7.71 (s, 1 H), 7.64-7. 59 (d, J=9 Hz, 1 H), 7.46-7. 6 (s, J=9 Hz, 1 H), 4.08 (s, 3H), 4.06 (s, 3H), 3.89-3. 84 (t, J=7.5 Hz, 2H), 3.30-2. 98 (t, J=7.5 Hz, 2H). MS (DCI-NH3) [M+H] + at 311.

Example 125B Methanesulfonic acid 2- [6- (2, 4-dimethoxy-pyrimidin-5-yl)-naphthalen-2-yl]-ethyl ester The compound was prepared by the method in Example 3B, using 2- [6- (2, 4-dimethoxy-pyrimidin-5-yl)-naphthalen-2-yl]-ethanol for 1- {3- [6- (2- hydroxyethyl)-2-naphthyl] phenyl} ethanone (39 mg, 84% yield).'H NMR (CD30D, 300 M. Hz), 8 8.38 (s, 1H), 7.98 (s, 1H), 7.9-7. 86 (d, J=9 Hz, 2H), 7.7 (s, 1H), 7.66- 7.61 (d, J=6 Hz, 1H), 7.49-7. 44 (d, J=6 Hz, 1H), 4.57-4. 52 (t, J=7.5 Hz, 2H), 4.08 (s, 3H), 4.06 (s, 3H), 3.27-3. 19 (t, J=7.5 Hz, 2H). MS (DCI-NH3) [M+H]'at 389,.

Example 125C 2, 4-Dimethoxv-5-86-r2-((2R)-methvl-pvrrolid in-1-yl)-ethyll-naphthalen-2-yl}- pyrimidine The title compound was prepared by the method in Example 3C using, methanesulfonic acid 2- [6- (2, 4-dimethoxy-pyrimidin-5-yl)-napthalen-2-yl]-ethyl ester for 2- [6- (3-acetylphenyl)-2-naphthyl] ethyl methanesulfonate (0.0063 g ; 14% yield). 1H NMR (CD30D, 300 MHz), 8 8.38 (s, 1H), 7.98 (s, 1H), 7.9-7. 86 (d, J=9

Hz, 2H), 7.7 (s, 1H), 7.66-7. 61 (d, J=6 Hz, 1H), 7.49-7. 44 (d, J=6 Hz, 1H), 4.08 (s, 3H), 4.06 (s, 3H), 3.18-3. 11 (m, 2H), 3.09-2. 96 (m, 2H), 2.51-2. 4 (m, 2H), 2.39- 2.31 (m, 1H), 2.10-1. 91 (m, 1H), 1.89-1. 76 (m, 2H), 1.55-1. 4 (m, 1H), 1.15 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 378.

Example 126 2, 6-Difluoro-3-{6-[2-((2R)-2-methyl-pyrrolidin-1-yl)-ethyl-nap hthalen-2-yl}-pyridine Example 126A 2- [6- (2, 6-Difluoro-pyridin-3-yl)-naphthalen-2-yl1-ethanol The compound was prepared by the method in Example 125A using 2,6- difluoropyrid-3-yl-boronic acid for 2, 4-dimethoxypyrimidin-5-yl-boronic acid (23 mg, 20% yield NMR (CD30D, 300 MHz), # 8.32-8. 25 (m, 1H), 8.04, (s, 1H), 7.91-7. 87 (m, 2H), 7. 74, (s, 1 H), 7.67-7. 62 (d, J=6 Hz, 1 H), 7.48-7. 45 (d, J=6.6 Hz, 1H), 7.15-7. 1 (d, J=5.4 Hz, 1H), 3.92-3. 85 (t, J=6 Hz, 2H), 3.06-2. 99 (t, J=6 Hz, 2H). MS (DCI-NH3) [M+H] + at 286.

Example 126B Methanesulfonic acid 2- [6- (2, 6-difluoro-pyridin-3-yl)-naphthalen-2-yll-ethyl ester The compound was prepared using the method in Example 3B using, 2- [6- (2, 6-difluoro-pyridin-3-yl)-naphthanlen-2-yl]-ethanol for 1-{3-[6-(2-hydroxyethyl)-2- naphthyl] phenyl} ethanone (24 mg, 82% yield).'H NMR (CD30D, 300 MHz), 6 8.34-8. 25 (m, 1H), 8.05 (s, 1H), 7.97-7. 9 (m, 2H), 7.82 (s, 1H), 7.72-7. 67 (d, J=6 Hz, 1H), 7.54-7. 48 (d, J=7.8 Hz, 1H), 7.17-7. 11 (d, J=6 Hz, 1H), 4.57-4. 52 (t, J=6 Hz, 2H), 4.15-4. 06 (t, J=6 Hz, 2H), 2.94 (s, 3H). MS (DCI-NH3) [M+NH4] + at 381.

Example 126C 2, 6-Difluoro-3-{6-[2-((2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-na pthanlen-2-yl}-pyridine The title compound was prepared using the method in Example 3C using, methanesulfonic acid 2- [6- (2, 6-difluoro-pyridin-3-yl)-naphthalen-2-yl]-ethyl ester for2- [6- (3-acetylphenyl)-2-naphthyl] ethyl methanesulfonate.'H NMR (CD30D, 300 MHz), 8 8.34-8. 25 (m, 1 H), 8.05 (s, 1 H), 7.97-7. 9 (m, 2H), 7.82 (s, 1H), 7.72-

7.67 (d, J=6 Hz, 1H), 7.54-7. 48 (d, J=7.8 Hz, 1H), 7.17-7. 11 (d, J=6 Hz, 1H), 3.18- 3.11 (m, 2H), 3.09-2. 96 (m, 2H), 2.51-2. 4 (m, 2H), 2.39-2. 31 (m, 1H), 2.10-1. 91 (m, 1H), 1.89-1. 76 (m, 2H), 1.55-1. 4 (m, 1H), 1.15 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 353.

Example 127 Cyclopropyl-(3-{6-[2-((2R)2-methyl-pyrrolidin-1-yl)-ethyl]-n aphthanlen-2-yl}-phenyl)- methanone Example 127A (3-Bromo-phenyl)-cyclopropyl-methanone A mixture of 1- (3-bromo-phenyl)-4-chloro-1-oxo-butane (1.0 g, 3.82 mmol) and a 1.0 M solution of sodium bis (trimethylsilyl) amide (4.21 mL, 4.21 mmol, 1.1 equiv. ) in toluene (10 mL) was stirred at room temperature for 3 h. The reaction mixture was concentrated under reduced pressure and the residue was partitioned between ethyl acetate and brine. The organic layer was dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (98: 2 hexane/ethyl acetate) to provide the title intermediate (0.53 g, 62% yield).'H NMR (CD03. 300 MHz), 6.

8.14 (t, J=1.7 Hz, 1H) 7.95-7. 92 (m, 1H), 7.71-7. 67 (m, 1H), 7.36 (t, J=7.8 Hz, 1 H), 2.66-2. 58 (m, 1 H), 1.29-1. 24 (m, 2H), 1.11-1. 05 (m, 2H). MS (DCI-NH3) [M+H] + at 225.

Example 127B (3-{6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-naphthanlen -2-yl}-phenyl)- cyclopropyl-methanone The compound was prepared using the method in 26C substituting (3- bromo-phenyl)-cyclopropyl-methanone in place of 5-bromopyrimidine (71 mg, 61% yield). 1H NMR (CDC13, 300 MHz), 6 8.35 (s, 1H) 8.09-8. 02 (m, 2H), 7.94- 7.87 (m, 3H), 7.79-7. 71 (m, 2H), 7.83-7. 58 (t, J=8.1 Hz, 1H), 7.45-7. 4 (d, J=7.5 Hz, 1H), 4.03-3. 96 (q, J=6 Hz, 2H), 3.1-3. 04 (t, J=6 Hz, 2H), 2.71-2. 69 (m, 1H),

1.35-1. 28 (m, 2H), 1.15-1. 08 (m, 2H), 0.87 (s, 9H), -. 02 (s, 3H). MS (DCI-NH3) [M+H] + at 431.

Example 127C cyclopropyl-{3-[6-(2-hydroxy-ethyl)-naphthalen-2-yl]-phenyl} -methanone The compound was prepared by the method in 26D using (3- {6- [tert-butyl- d imethyl-silanyloxy)-ethyl]-naphthalen-2-yl}-phenyl)-cyclopro pyl-methanone for 5- [6-(2-{[tert-butyl (dimethyl) silyl] oxy} ethyl)-2-naphthyl] pyrimidine (71 mg, 61% yield).

'H NMR (CD3, 300 MHz), 8 8.35 (s, 1H) 8.09-8. 02 (m, 2H), 7.94-7. 87 (m, 3H), 7.79-7. 71 (m, 2H), 7.83-7. 58 (t, J=8.1 Hz, 1H), 7.45-7. 4 (d, J=7.5 Hz, 1H), 4.03- 3.96 (q, J=6 Hz, 2H), 3.1-3. 04 (t, J=6 Hz, 2H), 2.71-2. 69 (m, 1H), 1.35-1. 28 (m, 2H), 1.15-1. 08 (m, 2H). MS (DCI-NH3) [M+H] + at 317.

Example 127D <BR> <BR> <BR> <BR> Methanesulfonic acid 2-f6- (3-cyclopropanecarbonyl-phenyl)-naphthalen-2-yl1-ethvl ester The compound was prepared using the method in 3B using cyclopropyl- {3- [6- (2-hydroxy-ethyl)-naphthalen-2-yl]-phenyl}-methanone for 1- {3- [6- (2- hydroxyethyl)-2-naphthyl] phenyl} ethanone (68 mg, 76% yield).'H NMR (CD3, 300 MHz), 8 8.35 (s, 1 H) 8.09-8. 02 (m, 2H), 7.94-7. 87 (m, 3H), 7.79-7. 71 (m, 2H), 7.83-7. 58 (t, J=8.1 Hz, 1H), 7.45-7. 4 (d, J=7.5 Hz, 1 H), 4.1-4. 05 (t, J=6 Hz, 2H), 3.6 (s, 3H), 3.17-3. 02 (t, J=6 Hz, 2H), 2.71-2. 69 (m, 1H), 1.35-1. 28 (m, 2H), 1. 15- 1.08 (m, 2H). MS (DCI-NH3) [M+NH4] + at 412.

Example 127E <BR> <BR> <BR> <BR> Cyclopropyl-(346-[2-((2 R) 2-methyl-pyrrolid in-1-yl)-ethyll-naphthalen-2-yl}-phenyl)- methanone The title compound was prepared using the method in 3C using methane sulfonic acid 2- [6- (3-cyclopropanecarbonyl-phenyl)-naphthalen-2-yl]-ethyl ester for 2- [6- (3-acetylphenyl)-2-naphthyl] ethyl methanesulfonate (3.9 mg, 6% yield).'H NMR (CD30D, 300 MHz), 8 8.35 (s, 1H) 8.09-8. 02 (m, 2H), 7.94-7. 87 (m, 3H), 7.79-7. 71 (m, 2H), 7.83-7. 58 (t, J=8.1 Hz, 1H), 7.45-7. 4 (d, J=7.5 Hz, 1H), 3.29-

3.18 (m, 1H), 3.09-2. 91 (m, 3H), 2.6-2. 39 (m, 3H), 2.1-1. 98 (m, 1H), 2.9-2. 77 (m, 1H), 2.58-2. 42 (m, 1H), 1.35-1. 32 (m, 2H), 1.22-1. 12 (m, 6H), 1.96-1. 83 (m, 1H).

MS (DCI-NH3) [M+H] + at 384.

Example 128 3-Methoxy-6-{6-[2-((2R)2-methyl-pyrrolidin-1-yl)-ethyl]-napt hanlen-2-yl}-pyridazine Example 128A 3-{6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-naphthanlen- 2-yl}-6-methoxy- pyridazine The compound was prepared using the method in 26C using 3-chloro-6- methoxy-pyridazine for 5-bromopyrimidine (64 mg, 76% yield). 1H NMR (CDCb, 300 MHz), 8 8.43 (s, 1 H), 8.24-8. 2 (d, J=7.5 Hz, 1 H), 7.96-7. 81 (m, 3H), 7,63 (s, 1H), 7.44-7. 41 (d, J=6 Hz, 1H), 7.12-7. 07 (d, J=9 Hz, 1 H), 4.96-4. 86 (m, 2H), 4.22 (s, 3H), 3.03-2. 91 (m, 2H), 0.87 (s, 9H),-0. 02 (s, 6H). MS (DCI-NH3) [M+H] + at 395. <BR> <BR> <BR> <BR> <BR> <BR> <P> Example 128B<BR> <BR> <BR> <BR> <BR> <BR> 2-[6-(6-Methoxy-pyridazin-3-yl)-naphthalen-2-yll-ethanol The compound was prepared by the method in 26D using 3- [6- [2 (tert-butyl- <BR> <BR> <BR> <BR> dimethyl-silanyloxy)-ethyl]-naphthalen-2-yl}-6-methoxy-pyrid azine for 5-[6-(2-{[tert- butyl (dimethyl) silyl] oxy} ethyl)-2-naphthyl] pyrimidine (6.7 mg, 37% yield). 1H NMR- (CDC13, 300 MHz), # 8.43 (s, 1H), 8.24-8. 2 (d, J=7.5 Hz, 1H), 7.96-7. 81 (m, 3H), 7.63 (s, 1H), 7.44-7. 41 (d, J=6 Hz, 1H), 7. 12-7. 07 (d, J=9 Hz, 1H), 4.22 (s, 3H), 4.03 (q, J=5.4 Hz, 2H), 3.09-3. 04 (d, J=5.4 Hz, 2H). MS (DCI-NH3) [M+H] + at 281.

Example 128C Methanesulfonic acid 2-[6-(6-methoxy-pyridazin-3-yl)-naphthalen-2-yl]-ethyl ester The compound was prepared by the method in Example 3B using 2- [6- (6- methoxy-pyridazin-3-yl)-naphthalen-2-yl}-ethanol for 1-{3-[6-(2-hydroxyethyl)-2- naphthyl] phenyl} ethanone (14 mg, 64% yield). 1H NMR (CDC13, 300 MHz), 8 8.43 (s, 1 H), 8.24-8. 2 (d, J=7.5 Hz, 1 H), 7.96-7. 81 (m, 3H), 7.63 (s, 1 H), 7.44-7. 41 (d,

J=6 Hz, 1 H), 7.12-7. 07 (d, J=9 Hz, 1 H), 4.57-4. 52 (t, J=6 Hz, 2H), 4.22 (s, 3H), 4.15-4. 06 (t, J=6 Hz, 2H) 2.94 (s, 3H). MS (DCI-NH3) [M+NH4] + at 359.

Example 128D 3-Methoxy-6-{6-[2-((2R)2-methyl-pyrrolidin-1-yl)-ethyl]-naph thalen-2-yl}-pyridazine The title compound was prepared using the method in 1 H using methanesulfonic acid 2-[6-(6-methoxy-pyridazin-3-yl)-naphthalen-2-yl]-ethyl ester for 2- [6- (4-cyanophenyl)-2-naphthyl] ethyl 4-methylbenzenesulfonate (3 mg, 22% yield).'H NMR (CD30D, 300 MHz), 8 8.43 (s, 1H), 8.24-8. 2 (d, J=7.5 Hz, 1H), 7.96-7. 81 (m, 3H), 7.63 (s, 1H), 7.44-7. 41 (d, J=6 Hz, 1H), 7.12-7. 07 (d, J=9 Hz, 1H), 4.17 (s, 3H), 3.18-3. 11 (m, 2H), 3.09-2. 96 (m, 2H), 2.51-2. 4 (m, 2H), 2.39- 2.31 (m, 1H), 2.10-1. 91 (m, 1H), 1.89-1. 76 (m, 2H), 1.55-1. 4 (m, 1H), 1.15 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+NH4] + at 348.

Example 129 4-86-92-(2-Methyl-piperid in-1-yl)-ethyll-naphthalen-2-ylT-benzonitrile The title compound was prepared by the method described in Example 1 H using 2-methylpiperidine in place of (2R)-2-methylpyrrolidine (9 mg, 8.4% yield).

'H NMR (CD30D, 300 MHz), 5 8.17 (s, 1H), 7.97-7. 91 (m, 4H), 7.87-7. 75 (m, 4H), 7.45 (d, J=6 Hz, 1H), 3.13-2. 86 (m, 5H), 2.55-2. 49 (m, 2H), 1.81-1. 67 (m, 4H), 1.46-1. 33 (m, 2H), 1.08 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 355.

Example 130 4-86-r2-((2R)-2-Ethyl-pyrrolidin-1-yl)-ethvil-naphthalen-2-y lE-benzonitrile The title compound was prepared by the method in 1 H using (2R)-2- ethylpyrrolidine for (2R)-2-methylpyrrolidine (13 mg, 7.5% yield).'H NMR (CD30D, 300 MHz), 5 8. 17 (s, 1H), 7.97-7. 91 (m, 4H), 7.87-7. 75 (m, 4H), 7.45 (d, J= 6 Hz, 1H), 3.29-3. 17 (m, 2H), 3.19-2. 95 (m, 2H), 2.49-2. 42 (m, 2H), 2.41-2. 31 (m, 1H), 2.14-1. 99 (m, 1H), 1.89-1. 78 (m, 2H), 1.63-1. 42 (m, 2H), 1.31-1. 2 (m, 1H),. 99-. 89 (m, 3H). MS (DCI-NH3) [M+H] + at 355.

Example 131

2-{6-[2-((2S)-2-Methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2- yl}-2H-pyridazin-3-one The title compound was prepared by the method in Example 31 H substituting (2S)-2-methylpyrrolidine in place of (2R)-2-methylpyrrolidine (42 mg, 30% yield).'H NMR (HCI salt, CD30D, 300 MHz), # 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H), 7.68-7. 62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1 H), 3.32-3. 20 (m, 2H), 3.16-2. 99 (m, 2H), 3.83-3. 51 (m, 3H), 2.17-2. 02 (m, 1 H), 1.95-1. 82 (m, 2H), 1.52-1. 48 (m, 1 H), 1.23 (d, J=2 Hz, 3H). MS (DCI-NH3) [M+H] + at 334.

Example 132 2- (6- (2-Piperidin-1-yl-ethyl)-naphthalen-2-yl1-2H-pyridazin-3-one The title compound was prepared by the method in Example 31 H substituting piperidine in place of (2R)-2-methylpyrrolidine (42 mg, 50% yield). 1H NMR (CD30D, 300 MHz), 8 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H), 7.68-7. 62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 3.1-3. 0 (m, 2H), 2. 84-2.75 (m, 2H), 2.63-2. 58 (m, 4H) 1.74-1. 60 (m, 4H), 1.60-1. 51 (m, 2H). MS (DCI-NH3) [M+H] + at 334.

Example 133 2-86-r2-(tert-Butyl-methyl-amino)-ethyll-naphthalen-2-ylT-2H -pyridazin-3-one The title compound was prepared by the method in Example 31 H substituting methyl (t-butyl) amine in place of (2R)-2-methylpyrolidine (26 mg, 31 % yield).'H NMR (CD30D, 300 MHz), 5 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H), 7.68-7. 62 (m, 1 H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 3.1 (s, 3H), 3.01-2. 9 (m, 4H), 1.23 (s, 9H). MS (DCI-NH3) [M+H] + at 336.

Example 134 2-f6- (2-Diethylamino-ethyl)-naphthalen-2-yl1-2H-pyridazin-3-one The title compound was prepared by the method in Example 31 H substituting diethylamine in place of (2R)-2-methylpyrrolidine (11mg, 14% yield).

'H NMR (CD30D, 300 MHz), 8 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H),

7.68-7. 62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 3.1 (m, 4H), 3.0- 2.91 (m, 4H), 1. 26-1.19 (m, 6H). MS (DCI-NH3) [M+H] + at 322.

Example 135 2-[(6-(2-Morpholin-4-yl-ethyl)-naphthalen-2-yl]-2H-pyridazin -3-one The title compound was prepared by the method in Example 31 H substituting morpholine in place of (2R)-2-methylpyrrolidine (27mg, 34% yield). 1H NMR (CD3OD, 300 MHz), # 8.12-8.06 (m, 2H), 7.97-7.89 (m, 2H), 7.82 (s, 1H), 7.68-7. 62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 3.75-3. 69 (m, 2H), 3.69-3. 62 (m, 1H), 3. 61- 3. 49 (m, 1 H), 3.06-2. 99 (m, 2H), 2.75-2. 71 (m, 2H), 2.61-2. 58 (m, 4H). MS (DCI-NH3) [M+H] + at 336.

Example 136 2-{6-[2-(Ethyl-methyl-amino)-ethyl]-naphthalen-2-yl}-2H-pyri dazin-3-one The title compound was prepared by the method in Example 31 H using ethylmethylamine for (2R)-2-methylpyrrolidine (30 mg, 37% yield).'H NMR (CD30D, 300 MHz), # 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H), 7.68- 7.62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 3. 07-2. 98 (m, 2H), 2.85-2. 77 (m, 2H), 2.69-2. 6 (m, 2H), 2.41 (s, 3H), 1.17 (t, J=6 Hz, 3H). MS (DCI- NH3) [M+H] + at 308.

Example 137 <BR> <BR> <BR> <BR> 2-86-[2-((2S)-2-Fluoromethyl-pyrrolidin-1-yl)-ethyl1-naphtha len-2-ylT-2H-pyridazin- 3-one The title compound was prepared by the method in Example 31 H substituting (S)-2-fluoromethylpyrrolidine in place of (2R)-2-methylpyrrolidine (21 mg, 24% yield).'H NMR (CD30D, 300 MHz), 8 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H), 7.68-7. 62 (m, 1 H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 4.58-4. 51 (m, 2H), 4.48-4. 29 (d, J=36 Hz, 1H), 3.33-3. 21 (m, 2H), 3.06-2. 99 (m, 2H), 2.8-2. 71 (m, 1 H), 2.54-2. 42 (m, 1 H), 2.02-1. 95 (m, 1 H), 1.88-1. 79 (m, 1 H), 1.71-1. 59 (m, 1 H), 1.33-1. 29 (m, 1 H). MS (DCI-NH3) [M+H]+ at 352.

Example 138 2-f6-f2- ( (2S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethyll-naphthalen-2-yl }-2H- pyridazin-3-one The title compound was prepared by the method in Example 31 H substituting (S)-prolinol in place of (2R)-2-methylpyrrolidine (67 mg, 32% yield).

'H NMR (CD30D, 300 MHz), 8 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H), 7.68-7. 62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 3.66 (m, 2H), 3.17-3. 0 (m, 3H), 2.99-2. 93 (m, 1 H), 2.79-2. 73 (m, 1 H), 2.11-2. 02 (m, 1 H), 1.97- 1. 82 (m, 3H), 1.8-1. 72 (m, 1 H). MS (DCI-NH3) [M+H] + at 350.

Example 139 2-{6-[2-((R)-2-Ethyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl }-2H-pyridazin-3-one The title compound was prepared by the method in Example 31 H substituting (2R)-2-ethylpyrrolidine in place of (2R)-2-methylpyrrolidine (3.1 mg, 5.7% yield).'H NMR (CD30D, 300 MHz), 6 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H), 7.68-7. 62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 3.29-3. 17 (m, 2H), 3.19-2. 95 (m, 2H), 2.49-2. 42 (m, 2H), 2.41-2. 31 (m, 1H), 2.14- 1.99 (m, 1H0, 1.89-1. 78 (m, 2H), 1.63-1. 42 (m, 2H), 1,31-1. 2 (m, 1H),. 99-. 89 (m, 3H). MS (DCI-NH3) [M+H] + at 348.

Example 140 2- [6- (2-Azetidin-1-yl-ethyl)-naphthalen-2-yl]-2H-pyridazin-3-one The title compound was prepared by the method in Example 31 H substituting azetidine in place of (2R)-2-methylpyrrolidine (1.3 mg, 2.5% yield).'H NMR (CD30D, 300 MHz), 8 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H), 7.68-7. 62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 3.44-3. 2 (m, 6H), 1.36-1. 29 (m, 2H), 1.18-1. 23 (d, J=4.5 Hz, 2H). MS (DCI-NH3) [M+H] + at 306.

Example 141 2-{6-[2-((2S)-2-Fluoromethyl-azetidin-1-yl)-ethyl]-naphthale n-2-yl}-2H-pyridazin-3- one

The title compound was prepared by the method in Example 31 H substituting (2S)-2-fluoromethylazetidine in place of (2R)-2-methylpyrrolidine (1.7 mg, 3.4% yield). 1H NMR (CD30D, 300 MHz), 8 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H), 7.68-7. 62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 3.24-2. 8 (m, 5H), 2.76-2. 62 (m, 1H), 2.09-1. 93 (m, 1H), 1.68-1. 53 (m, 1H), 1.3-1. 2 (m, 2H), . 98-. 91 (m, 1 H). MS (DCI-NH3) [M+H] + at 337.

Example 142 <BR> <BR> <BR> <BR> 2-86-[2-((2S)-2-Hyd roxemethyl-azetid in-1-yl)-ethyll-naphthalen-2-ylT-2H-pyridazin- 3-one The title compound was prepared by the method in Example 31 H using (2S)-2-hydroxymethylazetidine for (2R)-2-methylpyrrolidine (2 mg, 3.7% yield). 1H NMR (CD30D, 300 MHz), ? 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H), 7.68-7. 62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 4.08-3. 98 (m, 1H), 4.0-3. 73 (m, 3H), 3.55-3. 45 (m, 1 H), 3.42-3. 34 (m, 1H), 3.24-3. 14 (m, 1H), 3.09-2. 98 (m, 2H), 2.33-2. 98 (m, 2H), 1.34-1. 22 (m, 1 H). MS (DCI-NH3) [M+H] + at 336.

Example 143 2-{6-[2-((2R, 5R)-2,5-Dimethyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl}-2H -pyridazin- 3-one The title compound was prepared by the method in Example 31 H using (2R, 5R)-2, 5-dimethylpyrrolidine for (2R)-2-methylpyrrolidine (2 mg, 3.7% yield).

1H NMR (CD30D, 300 MHz), 8 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H), 7.68-7. 62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 3.51-3. 49 (m, 1H), 3.15-3. 05 (m, 1H), 2.39-2. 28 (m, 4H), 1.86-1. 76 (m, 4H), 1.39-1. 46 (d, J=5.1 Hz, 6H). MS (DCI-NH3) [M+H] + at 348.

Example 144 2-{6-[2-((2R, 5R)-2,6-Dimethyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yl}-2H -pyridazin- 3-one

The title compound was prepared by the method in Example 31 H substituting (2R, 6S)-2, 6-dimethylpiperidine in place of (2R)-2-methylpyrrolidine (1.2 mg, 2.4% yield).'H NMR (CD30D, 300 MHz), 8 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H), 7.68-7. 62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 3.61-3. 18 (m, 7H), 2.1-1. 91 (m, 1H), 1.9-1. 84 (m, 1H), 1.74-1. 58 (m, 3H) 1.5- 1.44 (d, J=3.6 Hz, 6H). MS (DCI-NH3) [M+H] + at 362.

Example 145 <BR> <BR> <BR> <BR> 2-{6-[2-((R)-3-Hyd roxy-piperidin-1-yl)-ethyl]-naphthalen-2-yl}-2H-pyridazin-3- one The title compound was prepared by the method in Example 31 H substituting (3R) -3-hydroxypiperidine in place of (2R)-2-methylpyrrolidine (1.3 mg, 2.8% yield).'H NMR (CD30D, 300 MHz), # 8.12-8. 06 (m, 2H), 7.97-7. 89 (m, 2H), 7.82 (s, 1H), 7.68-7. 62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2,12 Hz, 1H), 3.78-3. 67 (m, 1H), 3.1-2. 99 (m, 3H), 2.91-2. 81 (m, 1H), 2.8-2. 72 (m, 2H), 2,22- 2.01 (m, 1H), 1.99-1. 89 (m, 1 H), 1.86-1. 78 (m, 1H), 1.69-1. 54 (m, 1 H), 1.36-1. 22 (m, 1 H). MS (DCI-NH3) [M+H] + at 350.

Example 146 2-{6-[2-((R)-2-Methyl-piperidin-1-yl)-ethyl]-naphthalen-2-yl }-2H-pyridazin-3-one The title compound was prepared by the method in Example 31 H substituting (R)-2-methylpiperidine in place of (2R)-2-methylpyrrolidine (9.2 mg, 1.8% yield).'H NMR (CD30D, 300 MHz), 8 8.12-8. 06 (m, 2H), 7. 97-7.89 (m, 2H), : 7.82 (s, 1H), 7.68-7. 62 (m, 1H), 7.55-7. 46 (m, 2H), 7.15 (dd, J=2, 12 Hz, 1H), 3.14-2. 88 (m, 5H), 2.66-2. 49 (m, 2H), 1.8-1. 56 (m, 4H), 1.46-1. 34 (m, 2H), 1.22- 1.19 (d, J=4.8 Hz, 3H). MS (DCI-NH3) [M+H] + at 348.

Example 147 2, 2,6-Dimethyl-3-{6-[2-((2R)-2-methyl-pyrrolidin-1-yl)-ethyl]- naphthalen-2-yl}- pyridine Example 147A 2- [6- (2, 6-Dimethyl-pyridin-3-yl)-naphthalen-2-yl]-ethanol

The compound was prepared by the method in Example 1 F substituting 2, 6-dimethylpyridyl-3-boronic acid in place of para-cyanophenyl boronic acid (78 mg, 35% yield). 1H NMR (CD3OD, 300 MHz), 8 8.09-8. 05 (m, 1H), 7.99-7. 87 (m, 2H), 7.82-7. 79 (m, 1 H), 7.66-7. 62 (m, 1H), 7.53-7. 44 (m, 2H), 7.22-7. 13 (m, 1 H), 4. 84-4. 51 (t, J=6 Hz, 2H), 3.05-2. 98 (t, J=6 Hz, 2H), 2.56 (s, 3H), 2.06 (s, 3H). MS (DCI-NY3) [M+H]+ aT 278.

Example 147B Methanesulfonic acid 2- [6- (2, 6-dimethyl-pyridin-3-yl)-naphthalen-2-yl]-ethyl ester The compound was prepared by the method in Example 3B substituting 2- [6-(2,6-dimethyl-pyridin-3-yl)-naphthalen-2-yl]-ethanol in place of 4- [6- (2-hydroxy- ethyl)-naphthalen-2-yl]-benzonitrile (. 9763 g, 97% yield).'H NMR (CD30D, 300 MHz), 8 8.09-8. 05 (m, 1 H), 7.99-7. 87 (m, 2H), 7.82-7. 79 (m, 1 H), 7.66-7. 62 (m, 1H), 7.53-7. 44 (m, 2H), 7.22-7. 13 (m, 1H), 4.57-4. 52 (t, J=7.5 Hz, 2H), 4.08 (s, 3H), 3.27-3. 19 (t, J=7.5 Hz, 2H). MS (DCI-NH3) [M+H] + at 356.

Example 147C 2, 6-Dimethyl-3-{6-[2-((2R)-2-methyl-pyrrolidin-1-yl)-ethvil-na phthalen-2-yl}- pyridine The title compound was prepared by the method in Example 3C substituting methanesulfonic acid 2- [6- (2, 6-dimethyl-pyridin-3-yl)-naphthalen-2-yl]- ethyl ester in place of methanesulfonic acid 2- [6- (4-cyano-phenyl)-naththalen-2- yl]-ethyl ester (12 mg, 12% yield).'H NMR (CD30D, 300 MHz), 8 8.09-8. 05 (m, 1H), 7.99-7. 87 (m, 2H), 7.82-7. 79 (m, 1H), 7.66-7. 62 (m, 1H), 7.53-7. 44 (m, 2H), 7.22-7. 13 (m, 1H), 4.08 (s, 3H), 4.06 (s, 1H), 3.18-3. 11 (m, 2H), 3.09-2. 96 (m, 2H), 2.55 (s, 3H), 2.45 (s, 3H), 2.51-2. 4 (m, 2H), 2.39-2. 31 (m, 1H), 2.10-1. 91 (m, 1H), 1.89-1. 76 (m, 2H), 1.55-1. 4 (m, 1H), 1.15 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 345.

Example 148 5-{6-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-y l}-thiazole

Example 148A 2- (6-Thiazol-5-yl-naphthalen-2-yl)-ethanol A mixture of the product from Example 1 E (206 mg, 0. 82mmol), 2- trimethylsilyl-5-tributylytin-thiazole (369 mg, 0.82 mmol), dichlorobis- (triphenylphosphine)-palladium (II) (30 mg, 0.43 mmol), and lithium chloride (123 mg, 2.9 mmol), were stirred at 100 °C in 25 mL toluene overnight. The reaction was cooled to room temperature then diluted with 5 mL aqueous KF. The aq.

\ layer was extracted with ethyl acetate. The organic layer was dried over MgS04 and solid was removed by filtration. The resulting brown oil was purified by column chromatography 1: 1 hexane/ethyl acetate (. 081 g, 39% yield).'H NMR (CC13D, 300 MHz), 8 8.84 (s, 1H), 8.16 (s, 1H), 8.0 (s, 1H), 7.89-7. 82 (m, 2H), 7.71-7. 66 (m, 2H), 7.45-7. 4 (m, 1H), 4.1-3. 94 (t, J=5.7 Hz, 2H), 3.09-3. 02 (t, J=5.7 Hz, 2H). MS (DCI-NH3) [M+H] + at 256.

Example 148B Methanesulfonic acid 2-(6-thiazol-5-yl-naphthalen-2-yl)-ethyl ester The compound was prepared by the method in Example 3B substituting 2- (6-thiazol-5-yl-naphthalen-2-yl)-ethanol in place of 4- [6- (2-hydroxy-ethyl)- naphthalen-2-yl]-benzonitrile (91 mg, 86% yield).'H NMR (CC13D, 300 MHz), 8 8.84 (s, 1H), 8.16 (s, 1H), 8.0 (s, 1H), 7.89-7. 82 (m, 2H), 7.71-7. 66 (m, 2H), 7.45- 7.4 (m, 1H), 4.57-4. 52 (t, J=7.5 Hz, 2H), 4.08 (s, 3H), 3.27-3. 19 (t, J=7.5 Hz, 2H).

MS (DCI-NH3) [M+H] + at 334.

Example 148C 5-{6-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-y l}-thiazole The title compound was prepared by the method in Example 3C substituting methanesulfonic acid 2- (6-thiazol-5-yl-naphthalen-2-yl)-ethyl ester in place of methanesulfonic acid 2- [6- (4-cyano-phenyl)-naththalen-2-yl]-ethyl ester (53 mg, 50% yield).'H NMR (CD30D, 300 MHz), 8 8.84 (s, 1H), 8.16 (s, 1H), 8.0 (s, 1 H), 7. 89-7. 82 (m, 2H), 7.71-7. 66 (m, 2H), 7.45-7. 4 (m, 1 H), 4.08 (s, 3H), 4.06 (s, 1H), 3.18-3. 11 (m, 2H), 3.09-2. 96 (m, 2H), 2.55 (s, 3H), 2.45 (s, 3H), 2.51-2. 4

(m, 2H), 2.39-2. 31 (m, 1 H), 2.10-1. 91 (m, 1 H), 1.89-1. 76 (m, 2H), 1.55-1. 4 (m, 1H), 1.15 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 323.

Example 149 2- {6- [2- ( (R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-yi}-pyrimi dine Example 149A 2-[6-(tert-Butyl-dimethyl-silanyloxyethyl)-naphthalen-2-yl]- pyrimidine The compound was prepared by the method in Example 26C substituting 2-bromopyrimidine in place of 5-bromopyrimidine (157 mg, 60% yield), 1 H NMR (CD30D, 300 MHz), 8 8.95 (s, 1H), 8.92-8. 89 (m, 2H), 8.54-8. 51 (m, 1H), 8.07- 7.94 (m, 3H), 7.55-7. 51 (m, 1H), 7.42-7. 38 (m, 1 H), 4. 96-4. 86 (m, 2H), 3.03-2. 91 (m, 2H), 0.87 (s, 9H), -0. 02 (s, 6H). MS (DCI-NH3) [M+H] + at 365.

Example 149B (6-Pyrimidin-2-yl-naphthalen-2-yf)-ethanol The compound was prepared by the method in Example 26D substituting 2 [6- [ (tert-butyl-dimethyl-silanyloxy] ethyl)-naphthalen-2-yl]-pyrimidine in place of 5- [6-(2-{[tert-butyl (dimethyl) silyl] oxy} ethyl)-2-naphthyl]-pyrimidine (56 mg, 72% yield.

1H NMR (CD30D, 300 MHz), 8 8.95 (s, 1H), 8.92-8. 89 (m, 2H), 8.54-8. 51 (m, 1H), 8.07-7. 94 (m, 3H), 7.55-7. 51 (m, 1H), 7.42-7. 38 (m, 1H), 4.1-3. 94 (t, J=5.7 Hz, 2H), 3.09-3. 02 (t, J=5.7 Hz, 2H). MS (DCI-NH3) [M+H]+ at 237.

Example 149C Methanesulfonic acid 2-(6-pyrimidin-2-vl-naphthalen-2-yl)-ethyl ester The title compound was prepared by the method of Example 3B, using the product from Example 149B in place of the product from Example 3A to give an off-white solid.

Example 149D 2-{6-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-y l}-pyrimidine

The title compound was prepared by the method of Example 3C using the product from Example 149C in place of the product from Example 3B (56 mg, 41% yield). 1H NMR (CD30D, 300 MHz), 8 8.95 (s, 1H), 8.92-8. 89 (m, 2H), 8.54- 8.51 (m, 1H), 8.07-7. 94 (m, 3H), 7.55-7. 51 (m, 1H), 7.42-7. 38 (m, 1 H), 3.24-3. 28 (m, 1 H), 3.12-3. 01 (m, 1H), 2.75-2. 55 (m, 3H), 2.45-2. 34 (m, 2H), 2.09-1. 98 (m, 1H), 1.91-1. 78 (m, 2H), 1.56-1. 41 (m, 1H), 1.19 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 318.

Example 150 3-Chloro-6-{6-[2-((R)-2-ethyl-pyrrolidin-1-yl)-ethyl]-naphth alen-2-yl}-pyridazine Example 150A 3-[6-(tert-Butyl-dimethyl-silanyloxyethyl)-naphthalen-2-yl]- 6-chloro-pyridazine The compound was prepared using the method in Example 26C using 3,6- dichloropyridazine for 5-bromopyrimidine (63 mg, 32% yield).'H NMR (CD30D, 300 MHz), 8 8.63 (s, 1 H), 8.37-8. 33 d, J=9 Hz, 1 H), 8.29-8. 24 (d, J=9 Hz, 1 H), 8.09-8. 02 (m, 1 H), 7.94-7. 88 (m, 1 H), 7.89-7. 79 (m, 1 H), 7.49-7. 43 (m, 2H), 4.96- 4.86 (m, 2H), 3.03-2. 91 (m, 2H), 0.87 (s, 9H), -0. 02 (s, 6H). MS (DCI-NH3) [M+H] + at 400.

Example 150B [6- loro-pyridazin-3-yl)-naphthalen-2-yl]-methanol The compound was prepared using the method in Example 26D using 2 [6- <BR> <BR> <BR> (tert-butyl-dimethyl-silanyloxyethyl)-naphthalen-2-yl]-6-chl oro-pyridazine for 5- [6- (2-{[tert-butyl (dimethyl) silyl] oxy} ethyl)-2-naphthyl] pyrimidine (29 mg, 68% yield).

H NMR (CD30D, 300 MHz), 8 8.63 (s, 1H), 8.37-8. 33 (d, J=9 Hz, 1H), 8.29-8. 24 (d, J=9 Hz, 1H), 8.09-8. 02 (m, 1H), 7.94-7. 88 (m, 1 H), 7.89-7. 79 (m, 1H), 7.49- 7.43 (m, 2H), 4.1-3. 94 (t, J=5.7 Hz, 2H), 3.09-3. 02 (t, J=5.7 Hz, 2H). MS (DCI- NH3) [M+H] + at 271.

Example 150C Methanesulfonic acid 6-(6-chloro-pyridazin-3-yl)-naphthalen-2-ylethyl ester

The title compound was prepared by the method of Example 3B, using the product from Example 150B in place of the product from Example 3A to give an off-white solid.

Example 150D 3-Chloro-6-{6-[2-((R)-2-methyl-pyrroldin-1-yl)-ethyl]-naphth alen-2-yl}-pyridazine The title compound was prepared by the method of Example 3C using the product from Example 150C in place of the product from Example 3B (3.2 mg, 16% yield).'H NMR (CD30D, 300 MHz), 88. 63 (s, 1H), 8.37-8. 33 d, J=9 Hz, 1H), 8.29-8. 24 (d, J=9 Hz, 1H), 8.09-8. 02 (m, 1H), 7.94-7. 88 (m, 1H), 7.89-7. 79 (m, 1H), 7.49-7. 43 (m, 2H), 3.24-3. 28 (m, 1H), 3.12-3. 01 (m, 1H), 2.75-2. 55 (m, 3H), 2.45-2. 34 (m, 2H), 2.09-1. 98 (m, 1H), 1.91-1. 78 (m, 2H), 1.56-1. 41 (m, 1 H), 1.19 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 352.

Example 151 5-{6-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-naphthalen-2-y l}-pyrimid in-2-ylamine Example 151A 5-r6- (tert-Butyl-dimethyl-silanyloxyethyl)-naphthalen-2-yll-pyrim idin-2-ylamine The compound was prepared using the method in Example 26C using 2- amino-5-iodopyrimidine for 5-bromopyrimidine (85 mg, 46% yield NMR (CD30D, 300 MHz), 8 8.79 (s, 2H), 8.1 (s, 1H), 7.98-7. 95 (m, 2H), 7.84 (s, 1H), 7.77-7. 74 (d, J=6 Hz, 1H), 7.52-7. 47 (d, J=6 Hz, 1H), 4.96-4. 86 (m, 2H), 3.03-2. 91 (m, 2H), 0.87 (s, 9H), -0.02 (s, 6H). MS (DCI-NH3) [M+H] + at 380. <BR> <BR> <BR> <BR> <BR> <BR> <BR> <BR> <P> Example 151 B<BR> <BR> <BR> <BR> <BR> <BR> <BR> <BR> [6- (2-Amino-pyrimidin-5-yl)-naphthalen-2-yl]-ethanol The compound was prepared using the method in Example 26D using 5- [6- (tert-butyl-dimethyl-silanyloxyethyl)-naphthalen-2-yl]-pyrim idin-2-ylamine for 5- [6- (2- { [tert-butyl (dimethyl) silyl] oxy} ethyl)-2-naphthyl] pyrimidine (29 mg, 68% yield).

'H NMR (CD30D, 300 MHz), 8 8.79 (s, 2H), 8.1 (s, 1H), 7.98-7. 95 (m, 2H), 7.84

(s, 1H), 7.77-7. 74 (d, J=6 Hz, 1 H), 7.52-7. 47 (d, J=6 Hz, 1 H), 4.1-3. 94 (t, J=5.7 Hz, 2H), 3.09-3. 02 (t, J=5.7 Hz, 2H). MS (DCI-NH3) [M+H] + at 252.

Example 151C Methanesulfonic acid 6-(2-amino-pyrimidin-5-yl)-naphthalen-2-ylethyl ester The title compound was prepared by the method of Example 3B, using the product from Example 151B in place of the product from Example 3A to give an off-white solid. <BR> <BR> <BR> <BR> <BR> <BR> <BR> <P> Example 151D<BR> <BR> <BR> <BR> <BR> <BR> 5-{6-[2-((R)-2-Methyl-pyrrol idin-1-yl)-ethyl]-naphthalen-2-yl}-pyrimid in-2-ylamine The title compound was prepared by the method of Example 3C using the product from Example 151 C in place of the product from Example 3B (5.4 mg, 23% yield NMR (CD30D, 300 MHz), 8 8.79 (s, 2H), 8.1 (s, 1H), 7.98-7. 95 (m, 2H), 7.84 (s, 1 H), 7.77-7. 74 (d, J=6 Hz, 1 H), 7.52-7. 47 (d, J=6 Hz, 1 H), 3.24-3. 28 (m, 1H), 3.12-3. 01 (m, 1H), 2.75-2. 55 (m, 3H), 2.45-2. 34 (m, 2H), 2.09-1. 98 (m, 1H), 1.91-1. 78 (m, 2H), 1.56-1. 41 (m, 1H), 1.19 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 333.

Example 152 2-Methyl-5- {6-f2- ( (2R) 2-meth rl-pyrrolidin-1-yl)-ethyll-naphthalen-2-yl}-pyridine Example 152A 5- [6- (tert-Butyl-dimethyl-silanyloxyethyl)-naphthalen-2-yl]-2-met hyl-pyridine The compound was prepared using the method in Example 26C using 5- bromo-2-methylpyridine for 5-bromopyrimidine (61 mg, 26% yield).'H NMR (CD30D, 300 MHz), 8 9.13 (s, 1H), 9.88-9. 84 (d, J=9, 1H), 8.35 (s, 1H), 8.1-7. 98 (m, 3H), 7.94-7. 89 (m, 2H), 7.62-7. 57 (d, J=6 Hz, 1H), 4.96-4. 86 (m, 2H), 3.03- 2.91 (m, 2H), 2.66 (s, 3H), 0.87 (s, 9H),-0. 02 (s, 6H). MS (DCI-NH3) [M+H] + at 378.

Example 152B

[6- (6-Methyl-pyridin-3-yl)-naphthalen-2-yl]-ethanol The compound was prepared by the method in Example 26D substituting 5- [6- (tert-butyl-dimethyl-silanyloxyethyl)-naphthalen-2-yl]-2-met hyl-pyridine in place of 5-[6-(24 [tert-butyl (dimethyl) silyl] oxy} ethyl)-2-naphthyl] pyrimidine (29 mg, 68% yield).'H NMR (CD30D, 300 MHz), 8 9.13 (s, 1H), 9.88-9. 84 (d, J=9, 1H), 8.35 (s, 1H), 8.1-7. 98 (m, 3H), 7.94-7. 89 (m, 2H), 7.62-7. 57 (d, J=6 Hz, 1H), 4.1- 3.94 (t, J=5.7 Hz, 2H), 3.09-3. 02 (t, J=5.7 Hz, 2H), 2.64 (s, 3H). MS (DCI-NH3) [M+H] at 250.

Example 152C Methanesulfonic acid 6-(6-methyl-pyridin-3-yl)-naphthalen-2-ylethyl ester The title compound was prepared by the method of Example 3B, using the product from Example 152B in place of the product from Example 3A to give an off-white solid.

Example 152D 2-Methyl-5-{6-[2-((2R)2-methyl-pyrrolidin-1-yl)-ethyl]-napht halen-2-yl}-pyridine The title compound was prepared by the method of Example 3C substituting the product from Example 152C in place of the product from Example 3B (4.8 mg, 17% yield). 1H NMR (CD30D, 300 MHz), 8 9.13 (s, 1H), 9.88-9. 84 (d, J=9 Hz, 1 H), 8.35 (s, 1H), 8.1-7. 98 (m, 3H), 7.94-7. 89 (m, 2H), 7.62-7. 57 (d, J=6 Hz, 1 H), 3.24-3. 28 (m, 1H), 3.12-3. 01 (m, 1H), 2.84 (s, 3H), 2.75-2. 55 (m, 3H), 2.45-2. 34 (m, 2H), 2.09-1. 98 (m, 1H), 1.91-1. 78 (m, 2H), 1.56-1. 41 (m, 1H), 1.19 (d, J=6 Hz, 3H). MS (DCI-NH3) [M+H] + at 331.

Example 153 3-Bromo-7- (2-pyrrolidin-1-yl-ethyl)- [1, 5] naphthyridine Example 153A 3, 7-Dibromo-1, 5-naphthyridine To a stirred solution of 1.3 g (10 mmol) of 1,5-naphthyridine in 60 mL of CCI4 was added 4.30 g (23 mmol) of bromine in 6 mL of CCI4 and the mixture was

refluxed for 1 hr. Pyridine (0.79 g, 10 mmol) in 10 mL of CCI4 was added over a period of 0.5 hr to the refluxing mixture and the mixture was heated for an additional 12 hr, cooled and filtered. The dark green solid was treated with 100 mL of 10% solution of NaOH for 1 hr and the resulting solution was extracted with chloroform. The chloroform and the CC14 reaction solution were combined, dried over Na2SO4 filtered and evaporated under reduced pressure. The residue was chromatographed using 5% ethyl acetate in CCI4 (25% yield). M. p. 238-239 °C.

'H NMR (CDC13, 300 MHz) 6 8.80 (m, 2H), 9.10 (m, 2H). MS (ESI) [M+H] +at 288.

Example 153B Tributyl- (2-ethoxy-vinyl)-stannane The title compound was prepared as described by Wollenberg et al J. Am.

Chem. Soc. 1977,99, 7365.

Example 153C 3-Bromo-7- (2-ethoxy-vinyl)- [1, 5] naphthyridine A solution of 3, 7-dibromo-1,5-naphthyridine (0.5 g, 1.74 mmol), tributyl-2- ethoxy-vinylstannane (1.91 mmol, 0.69 g), LiCI (8.7 mmol, 0.37 g) and 0.085 g of PdCI2 (PPh3) 2 in 50 mL of toluene was heated at 95 °C for 16 hr. After cooling off, 20 mL of a 2 M solution of KF was added to the mixture and stirring was continued for 0.5 hr. The mixture was diluted with 100 mL of CH2CI2 and washed successively with a saturated solution of sodium bicarbonate, brine and water.

The organic layer was dried over sodium sulfate, filtered and evaporated under reduced pressure. The residue was chromatographed using 5% MeOH in CH2CI2 to give the desired material in 55% yield. 1H NMR (CDC13, 300 MHz) 6 1.40 (m, 3H), 4.05 (m, 2H), 5.85 (s, 1H), 7.25 (s, 1H), 8.15 (m, 1H), 8.55 (m, 1H), 8.85 (m, 2H). MS (ESI) [M+H] + at 280.

Example 153D (7-Bromo- [1, 5] naphthyridin-3-yl)-acetaldehyde To a mixture of the product from Example 153C (0.25 g, 0. 89 mmol) in 15 mL of THF was added 1.5 mL of HCI (6N). The mixture was heated to reflux for 5

hr, cooled and the pH adjusted to 8.0 with NaOH. The mixture was diluted with 75 mL of CH2CI2 and washed successively with a saturated solution of sodium bicarbonate, brine and water. The organic layer was dried over sodium sulfate, filtered and evaporated under reduced pressure to give the desired product in 95% yield.'H NMR (CD3, 300 MHz) 5 3.75 (m, 2H), 8.25 (m, 1H), 8.60 (m, 1H), 8.85 (m, 1 H), 9.00 (m, 1 H), 9.90 (s, 1 H). MS (ESI) [M+H] + at 252.

Example 153E 3-Bromo-7-(2-pyrrolidin-1-yl-ethyl)-[1, 5] naphthyridine To a stirred solution of the product from Example 153D (0. 1 g, 0.4 mmol), acetic acid (0.4 mmol, 0.025 g) and pyrrolidine (0.44 mmol, 0.031 g) in dry THF (5 ml) NaBH (OAc) 3 was added (0.6 mmol, 0.127 g). After 12 hr at room temperature the mixture was diluted with 50 mL of CH2CI2 and washed successively with a saturated solution of sodium bicarbonate, brine and water. The organic layer was dried over sodium sulfate, filtered and evaporated under reduced pressure. The residue was purified over silica using 10% MeOH in CH2CI2. The desired compound was obtained in 40%.'H NMR (CDCI3, 300 MHz) 5 1.60 (m, 4H), 2.20 (m, 4H), 2.75 (m, 4H), 8.30 (m, 1 H), 8.40 (m, 1 H), 8.90 (m, 1 H), 9.05 (m, 1 H). MS (ESI) [M+H] + at 307.

Example 154 3-Bromo-7- [2- (2R-2-methyl-pyrrolidin-1-yl)-ethyl]- [1, 5] naphthyridine The title compound was prepared by the method described in Example 153E, using (2R)-2-methylpyrrolidine in place of pyrrolidine.'H NMR (CDC13, 300 MHz) 5 1.20 (d, J=7 Hz, 3H), 1.50 (m, 4H), 2.20 (m, 2H), 2.40 (m, 1 H), 2.60 (m, 2H), 2.75 (m, 2H), 8.25 (m, 1H), 8.45 (m, 1H), 8.85 (m, 1H), 9.15 (m, 1H). MS (ESI) [M+H] + at 321.

Example 155 3-Bromo-7- (2-piperidin-1-yl-ethyl)- [1, 5] naphthyridine The title compound was prepared by the method described in Example 153E, using piperidine in place of pyrrolidine.'H NMR (CDC13, 300 MHz) 5 1.45-

1.60 (m, 6H), 1.50 (m, 4H), 2.30 (m, 4H), 8.30 (m, 1 H), 8.40 (m, 1 H), 8.95 (m, 1H), 9.10 (m, 1H). MS (ESI) [M+H] + at 321.

Example 156 3- (2, 6-Dimethyl-pyridin-3-yl)-7- [2- (2R-2-methyl-pyrrolidin-1-yl)-ethyl]- [1, 5] naphthyridine The product from Example 154 (50 mg, 0.16 mmol), 2, 6-dimethyl-3- (4,4, 5, 5-tetramethyl-[1, 3,2] dioxaborolan-2-yl)-pyridine (0.21 mmol, 0.048 g), Pd (PPh3) 2CI2 (0.007 g, 0.008 mmol), and 1 M Na2CO3 (0.42 mL, 0.42 mmol) in isopropanol (5 mL) was heated to 90 °C under a dry nitrogen atmosphere for 24 hr. After cooling, the reaction mixture was filtered through diatomaceous earth and concentrated under reduced pressure. The crude material was purified by column chromatography using a mixture of dichloromethane/methanol/NH40H (90: 10: 1) to afford the product (53% yield).'H NMR (DMSO-D6, 300 MHz) b 1. 25 (d, J=7 Hz, 3H), 1.55 (m, 2H), 1.60 (m, 2H), 2.25 (m, 2H), 2.35 (m, 1 H), 2.50 (s, 3H), 2.55 (s, 3H), 2.60-2. 70 (m, 4H), 7.20 (m, 1 H), 7.95 (m, 1 H), 8.30 (m, 1 H), 8.70 (m, 1 H), 8.90 (m, 1 H), 9.25 (m, 1 H). MS (ESI) [M+H] + at 347.

Example 157 3- (2, 4-Dimethoxy-pyrimidin-5-yl)-7- [2- (2R-2-methyl-pyrrolidin-1-yl)-ethyl]- [1, 5] naphthyridine The title compound was prepared by the method described in Example 156, using 2, 4-dimethoxypyrimidin-5-ylboronic acid in place of 2, 6-dimethyl-3- (4, 4, 5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)-pyridine.'H NMR (CDCI3, 300 MHz)- 5 1.20 (d, J=7 Hz, 3H), 1.50 (m, 2H), 1.65 (m, 2H), 2.20 (m, 2H), 2.35 (m, 1 H), 2.65-2. 70 (m, 4H), 3.85 (s, 6H), 8.30 (m, 1H), 8.70 (m, 1H), 8.80 (s, 1H), 8.90 (m, 1 H), 9.25 (m, 1 H). MS (ESI) [M+H] + at 380.

Example 158 3- (2, 6-Dimethyl-pyridin-3-yl)-7- (2-pyrrolidin-1-yl-ethyl)- [1, 5] naphthyridine The title compound was prepared by the method described in Example 156, using the product from Example 153E in place of the product from Example 154.'H NMR (CDC13, 300 MHz) 5 1.55 (m, 4H), 2.35 (m, 4H), 2.50 (s, 3H), 2.55

(s, 3H) 2. 60-2. 70 (m, 4H), 7.25 (m, 1 H), 7.90 (m, 1 H), 8.30 (m, 1 H), 8.70 (m, 1 H), 8.90 (m, 1 H), 9.25 (m, 1 H). MS (ESI) [M+H] + at 333.

Example 159 3- (2, 4-Dimethoxy-pyrimidin-5-yl)-7- (2-pyrrolidin-1-yl-ethyl)- [1, 5] naphthyridine The title compound was prepared by the method described in Example 156, using 2, 4-dimethoxypyrimidin-5-ylboronic acid and the product from Example 153E in place of 2, 6-dimethyl-3- (4, 4,5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)- pyridine and the product from Example 154.'H NMR (CDCI3, 300 MHz) 5 1.55 (m, 2H), 1.65 (m, 2H), 2.50 (m, 4H), 2.60-2. 65 (m, 4H), 3.80 (s, 3H), 3.85 (s, 3H), 8.35 (m, 1H), 8.70 (m, 1H), 8.85 (s, 1 H), 8.90 (m, 1 H), 9.20 (m, 1H). MS (ESI) [M+H] + at 366.

Example 160 3- (2, 6-Dimethyl-pyridin-3-yl)-7- (2-piperidin-1-yl-ethyl)- [1, 5] naphthyridine The title compound was prepared by the method described in Example 156, using the product from Example 155 in place of the product from Example 154. 1H NMR (CDCI3, 300 MHz) 5 1.45-160 (m, 6H), 2.75 (m, 4H), 2.30 (s, 3H), 2.35 (s, 3H) 2.55-2. 65 (m, 4H), 7.20 (m, 1H), 7.95 (m, 1H), 8.20 (m, 1H), 8.65 (m, 1H), 8.95 (m, 1H), 9.15 (m, 1H). MS (ESI) [M+H] + at 347.

Example 161 3- (2, 4-Dimethoxy-pyrimidin-5-yl)-7- (2-piperidin-1-yl-ethyl)- [1, 5] naphthyridine The title compound was prepared by the method described in Example 156, using 2, 4-dimethoxypyrimidin-5-ylboronic acid and the product from Example 155 in place of 2,6-dimethyl-3-(4, 4,5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)- pyridine and the product from Example 154. 1H NMR (CDC13, 300 MHz) 6 1.40- 1.55 (m, 6H), 2.45 (m, 4H), 2.65 (m, 4H), 3.70 (s ; 3H), 3.80 (s, 3H), 8.35 (m, 1 H), 8.75 (m, 1 H), 8.80 (s, 1 H), 8.95 (m, 1 H), 9.30 (m, 1 H). MS (ESI) [M+H] + at 380.

Example 162 3-f2- (2 (R)-Methvl-pvrrolidin-1-yl)-ethyll-7-pyridin-4-yl-isoquinoli ne

The title compound was prepared by the method described in Example 62G, using 4-pyridineboronic acid in place of 2, 6-difluoro-3-pyridineboronic acid.

'H NMR (CDC13, 400 MHz) # 9.29 (s, 1H), 8.71 (dd, 2H), 8.20 (d, 1H), 7.93 (dd, 1H), 7.88 (d, J=8 Hz, 1H), 7.62-7. 61 (m, 3H), 3.41-3. 34 (m, 2H), 3.28-3. 25 (m, 2H), 2.84-2. 79 (m, 1H), 2.79-2. 69 (m, 1H), 2.61-2. 50 (m, 1 H), 2.43-2. 37 (m, 1H), 2.04-1. 50 (m, 3H), 1.22 (m, 3H). 13C NMR (CDCI3, 400 MHz) 5 152.1, 150.1, 147.0, 136.1, 136.0, 128.7, 127.0, 125.6, 121.4, 118.4, 60.8, 53.9, 46.2, 36.9, 32.7, 22., 18.7, 10.4. MS (DCI-NH3) [M+H]+ at 318.

Example 163 7- (6-Methoxy-pyridin-3-yl)-3- [2- (2 (R)-methyl-pyrrolidin-1-yl)-ethyll-isoquinoline The title compound was prepared by the method described in Example 62G, using 2-methoxy-5-pyridineboronic acid in place of 2, 6-difluoro-3- pyridineboronic acids NMR (CDC13, 400 MHz) 5 9.24 (s, 1H), 9. 49 (d, J=3 Hz, 1H), 8.04 (s, 1H), 7.89 (dd, J=3,12 Hz, 1H), 7.83 (s, 2H), 7.55 (s, 1 H), 6.87 (d, J=12 Hz, 1H), 4.01 (s, 3H), 3.35-3. 15 (m, 4H), 2.67-2. 58 (m, 2H), 2.45-2. 28 (m, 2H), 2.00-1. 46 (m, 3 H), 1.17 (d, 3H). 13C NMR (CDCI3, 400 MHz) 5 163. 4, 151.8, 144.9, 137.1, 135. 7, 135. 2, 129.1, 128.9, 127.2, 126.7, 124.3, 118. 1, 110.9, 60. 3, 54.1, 53.8, 46.3, 37. 2, 32.9, 22.0, 19.2. MS (DCI-NH3) [M+H] +at 347.

Example 164 3- [2- (2 (R)-Methyl-pyrrolidin-1-yl)-ethyll-7-pyrimidin-5-yl-isoguino line The title compound was prepared by the method described in Example 62G, using 5- (4, 4,5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)-pyrimidine in place of 2, 6-difluoro-3-pyridineboronic acid. 1 H NMR (CDC13, 400 MHz) 5 9.29 (s, 1 H), 9.26 (s, 1 H), 9.07 (s, 2H), 8.15 (s, 1 H), 7.93 (d, J=12 Hz, 1H), 7.87 (dd, J=3,12 Hz, 1 H), 7.64 (s, 1 H), 3.44-3. 28 (m, 4H), 2.91-2. 41 (m, 3H), 2.07-1. 54 (m, 4H), 1.30 (d, J=8 Hz, 3H). 13C NMR (CDC13, 400 MHz) 5 157.3, 154.6, 152.0, 135.9, 133. 3, 132.2, 128.5, 127.5, 127.0, 125.6, 118.5, 61. 1, 53.9, 53. 8, 36.7, 32.6, 21.9, 18.5. MS (DCI-NH3) [M+H]+ at 319.

Example 165 7- (6-Fluoro-pyridin-3-yl)-3-f2- (2 (R)-methyl-pyrrolidin-1-vl)-ethyll-isoguinoline

The title compound was prepared by the method described in Example 62G, using 2-fluoro-5- (4, 4,5, 5-tetramethyl-[1, 3,2] dioxaborolan-2-yl)-pyridine in place of 2, 6-difluoro-3-pyridineboronic acid.'H NMR (CDC13, 400 MHz) 5 9.26 (s, 1H), 8.53 (m, 1H), 8.11-8. 06 (m, 2H), 7.88 (d, J=8 Hz, 1H), 7.84 (d, J=8 Hz, 1H), 7.61 (s, 1H), 7.06 (dd, J=4,12 Hz, 1H), 3.40-3. 26 (m, 3H), 2.88-2. 82 (m, 1H), 2.79-2. 72 (m, 1 H), 2.63-2. 58 (m, 1 H), 2.46-2. 39 (m, 1 H), 2.06-1. 52 (m, 4H), 1.27 (d, 3H). 13C NMR (CDCI3, 400 MHz) # 164.0, 161.6, 153.2, 151.9, 145.7, 145.5, 139.5, 139.4, 135.5, 134.5, 133.7, 133.6, 129.0, 127.0, 127.0, 125.2, 116.3, 109.7, 109.3, 60.9, 53.8, 46.2, 36. 7, 32.6, 21.9, 18.5. MS (DCI-NH3) [M+H] +at 336.

Example 166 5-f 3- [2- (2 (R)-Methyl-pyrrolidin-1-yl)-ethyll-isoquinolin-7-yl-nicotino nitrile The title compound was prepared by the method described in Example 62G, using 5- (4, 4,5, 5-tetramethyl-[1, 3,2] dioxaborolan-2-yl)-nicotinonitrile in place of 2, 6-difluoro-3-pyridineboronic acid.'H NMR (CDCI3, 400 MHz) b 9.30 (s, 1H), 9.15 (d, J=2 Hz, 1H), 8.90 (d, J=2 Hz, 1H), 8.26 (m, 1 H), 8.16 (d, J=2 Hz, 1H), 7.94 (d, J=8 Hz, 1H), 7.86 (dd, J=2,12 Hz, 1H), 7.65 (s, 1H), 3.44-3. 29 (m, 3H), 2.93-2. 88 (q, J=8 Hz, 1 H), 2.82-2. 75 (m, 1 H), 2.66-2. 60 (m, 1 H), 2.49-2. 42 (m, 1H), 2.07-1. 54 (m, 4H), 1.29 (d, J=8 Hz, 3H). 13C NMR (CDC13, 400 MHz) 6 154.0, 152.0, 151. 0, 150.5, 136.9, 135.9, 135.7, 133. 4, 128.5, 127. 5, 126. 9, 125.9, 118.2, 116.1, 110. 0, 61.0, 53.8, 53.7, 36.6, 32.5, 21.9, 18.2. MS (DCI-NH3) [M+H] + at 343.

Example 167 7- (3-Chloro-pyridin-4-yl)-3-[2-(2(R)-methyl-pyrrolidin--1yl)-e thyl]-isoquinoline The title compound was prepared by the method described in Example 62G, using 3-chloro-4-pyridineboronic acid in place of 2, 6-difluoro-3- pyridineboronic acids NMR (CDC13, 400 MHz) 5 9.25, (s, 1 H), 8.72 (s, 1 H), 8.57 (d, J=4 Hz, 1H), 8.05 (s, 1H), 7.88 (d, J=8 Hz, 1H), 7.78 (dd, J= 2,12, Hz, 1 H), 7.65 (s, 1 H), 7.37 (d, J=4 Hz, 1 H), 3.47-3. 27 (m, 4H), 2.87-2. 47 (m, 3H), 2.08-1. 60 (m, 4H), 1.31 (d, J=8 Hz, 3H). 13C NMR (CDC13, 400 MHz) # 153.4, 151.9, 149.6, 147.5, 146.1, 135. 7, 134.3, 130.4, 129.7, 127.6, 126. 4, 126.0, 124. 9, 118.4, 61.1, 53.6, 53.5, 35.3, 35.0, 32.4, 32.3, 21.7, 18.1. MS (DCI-NH3) [M+H] +

at 352.

Example 168 7-Bromo-3-f2-((2R)-2-methyl-pyrrolidin-1-yl)-ethyll-cinnolin -4-ol Example 168A 4-Bromo-1-iodo-2-nitro-benzene 't NaN02 (0.83 g, 12.00 mmol) was gradually added to conc. H2SO4 (9 mL).

The resulting mixture was stirred and heated to 70 °C for 15 minutes then cooled to room temperature (r. t. ). Next, 4-bromo-2-nitroaniline (2.4 g, 11.00 mmol) was dissolved in glacial acetic acid (22 mL) and added dropwise to the HSO3NO solution, while maintaining reaction temperature below 40 °C. After addition, the resulting mixture was stirred at r. t. for 30 minutes and poured into a 70 °C solution of Kl (2.0 g, 12.00 mmol) dissolved in 20 mL of water. The temperature was maintained while stirring for 20 minutes and then diluted with 150 mL water and filtered. The precipitate was washed with 50 mL water and dried under vacuum to provide the product in 86% yield as an orange solid, which was used without further purification.'H NMR (CD3, 300 MHz) 5 8.00 (d, J=3 Hz, 1H), 7.91 (d, J=9 Hz, 1 H), 7.42 (dd, J=3,9 Hz, 1 H). MS (DCI-NH3) [M+H] + at 328.8.

Example 168B 5-Bromo-2-iodo-phenylamine To a 15-18 °C stirred solution of SnCl2 (5. 20g, 27.44 mmol), dissolved in 10 mL conc. HCI, was quickly added a solution of Example 168A (1.8 g, 5.49 mmol) in ethanol (14 mL). The resulting mixture was heated to 55 °C for 15 minutes, cooled in an ice bath, made basic by addition of a saturated KOH solution, and extracted with 250 mL CHC13. The organic phase was dried with Na2SO4, filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (100% hexanes to 50/50 hexanes/dichloromethane) to provide the product as a white solid in 74% yield.

'H NMR (CDC13, 300 MHz) 5 7.47 (d, J=9 Hz, 1H), 6.88 (d, J=3 Hz, 1H), 6.62 (dd, J=3,9 Hz, 1 H), 4.00 (bs, 1 H). MS (DCI-NH3) [M] + at 297.

Example 168C 5-Bromo-2-f4- ( (2R)-2-methyl-pyrrolidin-1-yl)-but-1-ynyll-phenylamine A solution of Example 168B (0.2 g, 0.67 mmol), 1-but-3-ynyl- (2R)-2-methyl- pyrrolidine (7.4 mL as a 0.1 M solution in acetonitrile, 0.74 mmol), and triethylamine (10 mL, 72.0 mmol) was degassed with nitrogen for 10 minutes while stirring at r. t. Next, Pd (PPh3) 2CI2 (0.010 g, 0.013 mmol) and Cul (0.003 g, 0.013 mmol) were added and the resulting mixture was degassed for an additional 10 minutes, sealed, and stirred at r. t. for 18 hours. Contents were then concentrated under reduced pressure and the residue was dissolved in 100 mL dichloromethane, washed twice with each: 50 mL sat. NaHCO3, 50 mL water, and 50 mL brine, dried with Na2SO4, and concentrated under reduced pressure. The crude material was purified by column chromatography (100% dichloromethane to 95: 5 dichloromethane/methanol) to afford the product in 30% yield as a light yellow oil.'H NMR (CD30D, 300 MHz) 5 7.03 (d, J=9 Hz, 1H), 6.88 (d, J=3 Hz, 1H), 6.68 (dd, J=3,9 Hz, 1H), 3.41-3. 20 (m, 2H), 2.79-2. 52 (m, 5H), 2.12-2. 04 (m, 1 H), 1.92-1. 82 (m, 2H), 1.56-1. 47 (m, 1H), 1.25 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 308.

Example 168D 7-Bromo-3-r2-((2R)-2-methyl-pyrrolidin-1-yl)-ethyll-cin nolin4-ol To a mixture of Example 168C (0.10 g, 0.325 mmol) in 2 mL of water was added 1.5 mL 6 M HCI. The resulting solution was cooled to 0 °C and NaN02 (0.034 g, 0.488 mmol), dissolved in 1 mL water, was added dropwise. The resulting mixture was stirred for 30 minutes at 0 °C and subsequently heated to 90 °C for one hour. After cooling, contents were filtered and the precipitate was washed with 10 mL water and dried under reduced pressure to provide the product in 47% yield as a brown solid in HCI salt form, which was used without further purification.'H NMR (CD30D, 300 MHz) 6 8.10 (d, J=9 Hz, 1H), 7.82 (d, J=3 Hz, 1 H), 7.60 (dd, J=3, 9 Hz, 1H), 3.89-3. 76 (m, 2H), 3.58-3. 53 (m, 1H) 3.42- 3.23 (m, 4H), 2.38-2. 30 (m, 1H), 2.16-2. 06 (m, 2H), 1.83-1. 75 (m, 1 H), 1.51 (d, J=6 Hz, 3H). MS (ESI) [M] + at 336.

Example 169 4-f 3-f2- (2-Methyl-pyrrolidin-1-yl)-ethyll-cinnolin-7-yl}-benzonitril e Example 169A 4- (2-Amino-4-bromo-phenyl)-but-3-yn-1-ol The title compound was prepared using the procedure described in Example 168C, using 3-butyn-1-ol instead of 1-but-3-ynyl- (2R)-2-methyl- pyrrolidine. 1 H NMR (CD30D, 300 MHz) 5 7.03 (d, J=9 Hz, 1 H), 6.88 (d, J=3 Hz, 1 H), 6.68 (dd, J=3,9 Hz, 1 H), 3.73 (t, J= 6Hz, 2H), 2.65 (t, J= 6Hz, 2H). MS (DCI- NH3) [M] + at 240 [M+NH3] + at 257.

Example 169B 7-Bromo-3- (2-hydroxy-ethyl)-cinnolin-4-ol The title compound was prepared by the method described in Example 168D, using the product from Example 169A in place of the product from Example 168C. 1H NMR (CD30D, 300 MHz) # 8.07 (d, J=9 Hz, 1H), 7.77 (d, J=3 Hz, 1H), 7.54 (dd, J=3,9 Hz, 1H), 3.92 (t, J=6 Hz, 2H), 3.02 (t, J=6 Hz, 2H). MS (DCI-NH3) [M] + at 269.

Example 169C 7-Bromo-4-chloro-3- (2-chloro-ethyl)-cinnoline To a stirred mixture of the product from Example 169B (0.20 g, 0.744 mmol) in chlorobenzene (5 mL) was added POC13 (0-l'O mL, 1.11 mmol) and anhydrous pyridine (0.018 mL, 0.223 mmol). The resulting mixture was heated to 100 °C for 1 hour, cooled to r. t. , and subsequently concentrated under reduced pressure. The residue was neutralized with 10 mL of a sat. K2CO3 solution, extracted twice with 25 mL dichloromethane, and concentrated. The crude material was purified by column chromatography (50: 50 hexanes/dichloromethane to 100% dichloromethane) to afford the product in 42% yield as a brown solid.'H NMR (CD3, 300 MHz) 6 8.14 (d, J=9 Hz, 1 H), 7.54 (d, J=3 Hz, 1H), 7.49 (dd,

J=3,9 Hz, 1 H), 3.95 (t, J=6 Hz, 2H), 3.28 (t, J=6 Hz, 2H). MS (DCI-NH3) [M+H] + at 307.

Example 169D 4- 3- (2-Chloro-ethvl)-cinnolin-7-yll-benzonitrile A mixture of the product from Example 169C (0.095 g, 0.312 mmol), 4-cyanophenylboronic acid (0.046 g, 0.343 mmol) ; Pd (PPh3) 2CI2 (0. 011 g, 0.016 mol), and 1 M Na2CO3 (0.778 mL, 0.778 mmol) in de-gassed isopropanol/toluene (5 mL, 1: 1) was heated to 90 °C under a dry nitrogen atmosphere for 24 hours. After cooling, the reaction mixture was diluted with 20 mL water, extracted twice with 25 mL dichloromethane, and concentrated under reduced pressure. The crude material was purified by column chromatography (100% dichloromethane to 99: 1 dichloromethane/methanol) to afford the product in 50% yield as a brown-orange solid.'H NMR (CD3, 300 MHz) # 8.76 (d, J=3 Hz, 1 H), 8.02 (dd, J=3, 9 Hz, 1 H), 7.96 (d, J=9 Hz, 1 H), 7.87 (q, J=9 Hz, 4H), 7.80 (s, 1H), 4.14 (t, J=6 Hz, 2H), 3.69 (t, J=6 Hz, 2H). MS (DCI-NH3) [M-CI] + at 258, [M+H] + at 294.

Example 169E 4-{3-[2-((rac)-2-Methyl-pyrrolidin-1-yl)-ethyl]-cinnolin-7-y l}-benzonitrile Racemic 2-methylpyrrolidine (0.5 mL, neat) was added to the product from Example 169D (0.01 g, 0.034 mmol) and heated to 65 °C in a sealed tube for 18 hours. After cooling, the reaction mixture was concentrated under reduced pressure and purified by column chromatography (100% dichloromethane to 95: 5 dichloromethane/methanol) to afford the product in 43% yield as a brown-yellow semi-solid. rH NMR (CD30D, 300 MHz) 5 8.72 (m, 1H), 8.20 (dd, J=3,9 Hz, 1H), 8.16 (s, 1H), 8.11 (d, J=9 Hz, 1H), 8.06 (d, J=9 Hz, 2H), 7.91 (d, J=9 Hz, 2H), 3.58-3. 46 (m, 4H), 2.85-2. 65 (m, 2H), 2.57-2. 51 (m, 1H), 2.03-1. 90 (m, 1H), 1.89- 1.83 (m, 2H), 1.56-1. 50 (m, 1 H), 1.21 (d, J=6 Hz, 3H). MS (ESI) [M+H] +at 343.

-Example 170 7-Bromo4-ch loro-3-[2-((2R)-2-methyl-pyrrolid in-1-yl)-ethyll-cinnoline

The title compound was prepared by the method described in Example 169C, using the product from Example 168D in place of the product from Example 169B.'H NMR (CD30D, 300 MHz) 6 8.69 (d, J=3Hz, 1H), 8.21 (d, J=9 Hz, 1H), 8.07 (dd, J=3,9 Hz, 1H), 3.63-3. 58 (m, 2H), 3.46-3. 30 (m, 2H), 2.73-2. 64 (m, 1 H), 2.55-2. 42 (m, 2H), 2.06-1. 95 (m, 1H), 1.84-1. 77 (m, 2H), 1.48-1. 41 (m, 1H), 1.14 (d, J=6 Hz, 3H). MS (ESI) [M] + at 354.

\ Example 171 <BR> <BR> <BR> <BR> <BR> 4-f4-Hydroxy-3-f2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyll-cinnolin-7-yl}-benzoni trile A mixture of the product from Example 168D (0. 30g, 0.805 mmol), 4-cyanophenylboronic acid (0.15 g, 1.05 mmol), Pd (PPh3) 2C12 (0.03 g, 0.04 mmol), and 1 M Na2CO3 (2.01 mL, 2.01 mmol) in isopropanol (15 mL) was heated to 90 °C under a dry nitrogen atmosphere for 2 days. After cooling, the reaction mixture was filtered through celite and concentrated under reduced pressure. The crude material was purified by column chromatography (100% dichloromethane to 90: 10 dichloromethane/methanol) to afford the product in 33% yield as a light brown solid.'H NMR (CD30D, 300 MHz) 6 8.29 (d, J=9 Hz, 1H), 7.95 (q, J=9 Hz, 4H), 7.83 (d, J=3 Hz, 1H), 7.75 (dd, J=3,9 Hz, 1H), 3.49-3. 42 (m, 2H), 3.17-3. 12 (m, 2H), 2.78-2. 73 (m, 2H), 2.62-2. 59 (m, 1H), 2.12-2. 09 (m, 1H), 1.92-1. 84 (m, 2H), 1.61-1. 53 (m, 1H), 1.25 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 359.

Example 172 4-f 4-Isopropoxy-3-f 2- ( (2R)-2-methvl-pyrrolidin-1-vl)-ethyll-cinnolin-7-vl}- benzonitrile The title compound was prepared by the method described in Example 171, using the product from Example 170 in place of the product from Example 168D.'H NMR (CD30D, 300 MHz) 5 8.69 (d, J=3 Hz, 1H), 8.32 (d, J=9 Hz, 1H), 8.19 (dd, J=3,9 Hz, 1H), 8.06 (d, J=9 Hz, 2H), 7.92, (d, J=9 Hz, 2H), 4.88-4. 77 (m, 1H), 3.71-3. 49 (m, 4H), 3.06-2. 91 (m, 2H), 2.81-2. 73 (m, 1H), 2.19-2. 10 (m, 1H), 1.97-1. 90 (m, 2H), 1.61-1. 53 (m, 1H), 1.48 (d, J=6 Hz, 6H), 1.25 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 401.

Example 173 4-{3-[2-(4-Methyl-piperazin-1-yl)-ethyl]-cinnolin-7-yl}-benz onitrile The title compound was prepared by the method described in Example 169E, using 1-methylpiperazine in place of 2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 5 8.70 (m, 1H), 8.19 (dd, J=3,9 Hz, 1H), 8.13 (s, 1H), 8.11-8. 01 (m, 3H), 7.91 (d, J=9 Hz, 2H), 3.44 (t, J=6 Hz, 2H), 2.95 (t, J=6 Hz, 2H), 2.75-2. 45 (m, 8H), 2.28 (s, 3H). MS (ESI) [M+H] +at 358.

Example 174 4- [3- (2-Piperidin-1-yl-ethyl)-cinnolin-7-yll-benzonitrile The title compound was prepared by the method described in Example 169E, using piperidine in place of 2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) o8. 70 (m, 1H), 8.19 (dd, J=3,9 Hz, 1H), 8.13 (s, 1H), 8.12-8. 04 (m, 3H), 7.91 (d, J=9 Hz, 2H), 3.44 (t, J=6 Hz, 2H), 2.91 (t, J=6 Hz, 2H), 2.61 (m, 4H), 1.65 (m, 4H), 1.51 (m, 2H). MS (ESI) [M+H]+ at 343.

Example 175 4-f3- (2-Pyrrolidin-1-yl-ethyl)-cinnolin-7-yll-benzonitrile The title compound was prepared by the method described in Example 169E, using pyrrolidine in place of 2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 5 8.71 (m, 1H), 8.20 (dd, J=3,9 Hz, 1H), 8.15 (s, 1H), 8.11 (d, J=9 Hz, 1 H), 8.06 (d, J=9 Hz, 2H), 7.92 (d, J=9 Hz, 2H), 3.50 (t, J=9 Hz, 2H), 3.21 (t, J=9 Hz, 2H), 2.85 (m, 4H), 1.90 (m, 4H). MS (ESI) [M+H] + at 329.

Example 176 443-[2-((2R)-2-Methvl-pyrrolidin-1-yl)-ethyll-cin nolin-7-ylT-benzonitrile (2R)-2-methylpyrrolidine (L) -tartrate (. 100g, 0.425 mmol) was partitioned between toluene (0.5 mL) and 5 M NaOH/brine (1: 1,1 mL total). The organic phase was then added to the product from Example 169D (0.01 g, 0.034 mmol) and heated to 85 °C in a sealed tube for 48 hours. After cooling, the reaction mixture was concentrated under reduced pressure and purified by column chromatography (100% dichloromethane to 95: 5 dichloromethane/methanol) to

afford the product in 27% yield as a yellow solid.'H NMR (CD30D, 300 MHz) 5 8.73 (m, 1H), 8.21 (dd, J=3,9 Hz, 1H), 8.14 (s, 1H), 8.12 (d, J=9 Hz, 1H), 8.06 (d, J=9 Hz, 2H), 7.92 (d, J=9 Hz, 2H), 3.72-3. 48 (m, 4H), 3.15-2. 90 (m, 2H), 2.86-2. 75 (m, 1H), 2.21-2. 10 (m, 1H), 1.98-1. 91 (m, 2H), 1.67-1. 60 (m, 1H), 1.31 (d, J=6 Hz, 3H). MS (ESI) [M+H]+ at 343.

Example 177 4-f3- [2- ( (2R)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethyll-cinnolin-7-yll- benzonitrile The title compound was prepared by the method described in Example 169E, using pyrrolidin-(2R)-2-yl-methanol in place of 2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) # 8.71 (m, 1H), 8.19 (dd, J=3,9 Hz, 1H), 8.15 (s, 1H), 8.10 (d, J=9 Hz, 1H), 8.06 (d, J=9 Hz, 2H), 7.91 (d, J=9 Hz, 2H), 3.58-3. 43 (m, 4H), 2.92 (m, 1H), 2.73 (m, 1H), 2.48 (m, 1H), 2.01-1. 92 (m, 2H), 1.85-1. 67 (m, 4H). MS (ESI) [M+H] + at 359.

Example 178 4-r3-(2-Morpholin4-yl-ethyl)-cinnolin-7-yll-benzonitrile The title compound was prepared by the method described in Example 169E, using morpholine in place of 2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 5 8.70 (m, 1H), 8.19 (dd, J=3,9 Hz, 1H), 8.14 (s, 1H), 8.10 (d, J=9 Hz, 1H), 8.05 (d, J=9 Hz, 2H), 7.91 (d, J=9 Hz, 2H), 3.70 (t, J=4.5 Hz, 4H), 3.44 (t, J=9 Hz, 2H), 2.94 (t, J=9 Hz, 2H), 2.61 (t, J=4.5 Hz, 4H). MS (ESI) [M+H] + at 345.

Example 179 4-{3-[2-(4-Methyl-piperidin-1-yl)-ethyl-cinnolin-7-yl}-benzo nitrile The title compound was prepared by the method described in Example 169E, using 4-methylpiperidine in place of 2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 6 8.71 (m, 1H), 8.19 (dd, J=3,9 Hz, 1H), 8.13 (s, 1H), 8.10 (d, J=9 Hz, 1H), 8.05 (d, J=9 Hz, 2H), 7.91 (d, J=9 Hz, 2H), 3.47 (t, J=6 Hz, 2H), 3.14 (m, 2H), 3.00, (m, 2H), 2.26 (m, 2H), 1.73, (m, 2H), 1.48-1. 44 (m, 1H), 1.32-1. 28 (m, 2H), 0.96 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 357.

Example 180

4-83-r2-(EthVl-methyl-amino)-ethvll-cinnolin-7-ylT-benzonitr ile The title compound was prepared by the method described in Example 169E, using ethyl-methyl-amine in place of 2-methylpyrrolidine.'H NMR (CD30D, 300 MHz) 6 8.70 (m, 1H), 8.19 (dd, J=3,9 Hz, 1H), 8.13 (s, 1H), 8.10 (d, J=9 Hz, 1 H), 8.06 (d, J=9 Hz, 2H), 7.91 (d, J=9 Hz, 2H), 3.43 (t, J=6 Hz, 2H), 2.99 (t, J=6 Hz, 2H), 2.61 (q, J=9 Hz, 2H), 2.40 (s, 3H), 1.12 (t, J=9 Hz, 3H). MS (ESI) [M+H] + at 317.

Example 181 <BR> <BR> <BR> <BR> 7- (2, 6-Dimethyl-pyridin-3-yl)-3-f 2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyll-cinnoline A mixture of the product from Example 169C (0.100 g, 0.328 mmol), 2,6- dimethyl-3- (4, 4,5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)-pyridine (0.077 g, 0.328 mmol), Pd (PPh3) 2CI2 (0.012 g, 0.017 mmol), and 1 M Na2CO3 (0.820 mL, 0.820 mmol) in de-gassed isopropanol/toluene (5 mL, 1: 1) was heated to 90 °C under a dry nitrogen atmosphere for 24 hours. After cooling, the reaction mixture was filtered, diluted with 20 mL water, extracted twice with 25 mL dichloromethane, and concentrated under reduced pressure. Next, (2R)-2-methylpyrrolidine (L) - tartrate (. 100 g, 0.425 mmol) was partitioned between toluene (0.5 mL) and 5M NaOH/brine (1: 1,1 mL total). The toluene phase (0.5 mL) was subsequently added to a solution of the above crude material in acetonitrile (3 mL) and the resulting mixture was heated to 85 °C in a sealed tube for 48 hours. Upon cooling, the mixture was concentrated under reduced pressure and purified by column chromatography (100% dichloromethane to 95 : 5 dichloromethane/methanol) to provide the title compound. 1H NMR (CD30D, 300 MHz) 5 8.38 (m, 1H), 8.19 (s, 1 H), 8.06 (d, J=9 Hz, 1H), 7.84 (dd, J=3,9 Hz, 1H), 7.76 (d, J=9 Hz, 1H), 7.27 (d, J=9 Hz, 1 H), 3.52-3. 28 (m, 4H), 2.78-2. 62 (m, 2H), 2.59 (s, 3H), 2. 52 (s, 3H), 2.46-2. 39 (m, 1H), 2.08-1. 98 (m, 1H), 1.86-1. 78 (m, 2H), 1.56-1. 42 (m, 1 H), 1.18 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 347.

Example 182 <BR> <BR> <BR> 7- (2, 4-Dimethoxy-pyrimidin-5-yl)-3-r2- ( (2R)-2-methyl-pyrrolidin-1-yl)-ethyll-<BR> <BR> <BR> <BR> <BR> <BR> cinnoline

The title compound was prepared by the method described in Example 181, using 2, 4-dimethoxypyrimidine-5-boronic acid in place of 2, 6-dimethyl-3- (4,4, 5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)-pyridine.'H NMR (CD30D, 300 MHz) 6 8. 59 (m, 1H), 8.56 (s, 1H), 8.16 (s, 1H), 8.06-8. 00 (m, 2H), 4.12 (s, 3H), 4.08 (s, 3H), 3.58-3. 38 (m, 4H), 2.87-2. 52 (m, 3H), 2.16-2. 05 (m, 1H), 1.91-1. 83 (m, 2H), 1.58-1. 47 (m, 1 H), 1.22 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 380.

Example 183 7-(6-Methoxy-pyrid in-3-yl)-3-[2-((2R)-2-methyl-pyrrolid in-1-yl)-etheI1-cinnoline The title compound was prepared by the method described in Example 181, using 2-methoxy-5-pyridine boronic acid in place of 2,6-dimethyl-3-(4, 4,5, 5- tetramethyl-[1, 3, 2] dioxaborolan-2-yl)-pyridine.'H. NMR (CD30D, 300 MHz) 5 8.64 (m, 2H), 8.23-7. 98 (m, 3H), 8.12 (d, J=9 Hz, 1H), 6.99 (d, J=9 Hz, 1H), 4.01 (s, 3H), 3.82-3. 46 (m, 4H), 3.26-3. 20 (m, 2H), 3.04-2. 98 (m, 1 H), 2.38-2. 24 (m, 1 H), 2.17-2. 04 (m, 2H), 1.78-1. 70 (m, 1H), 1.42 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 349.

Example 184 3-{3-[2-((2R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-cinnolin-7-yl }-benzonitrile The title compound was prepared by the method described in Example 181, using 3-cyanophenyl boronic acid in place of 2,6-dimethyl-3-(4, 4,5, 5- tetramethyl-[1, 3,2] dioxaborolan-2-yl)-pyridine.'H NMR (CD30D, 300 MHz) 6 8. 73 : (m, 1 H), 8.28-8. 13 (m, 5H), 7.83 (dd, J=3,9 Hz, 1H), 7.76 (d, J=9 Hz, 1H), 3.82- 3.60 (m, 4H), 3.41-3. 28 (m, 2H), 3.18-3. 06 (m, 1H), 2.36-2. 21 (m, 1H), 2.13-2. 02 (m, 2H), 1.78-1. 71 (m, 1 H), 1.41 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 343.

Example 185 5-{3-[2-((2R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-cinnolin-7-yl }-nicotinonitrile The title compound was prepared by the method described in Example 181, using 5- (4, 4,5, 5-tetramethyl- [1, 3, 2]dioxaborolan-2-yl)-nicotinonitrile in place of 2, 6-dimethyl-3-(4,4, 5, 5-tetramethyl-(1, 3,2] dioxaborolan-2-yl)-pyridine.'H NMR (CD30D, 300 MHz) 6 9.36 (m, 1 H), 9.03 (m, 1 H), 8.84 (s, 1 H), 8.78 (m, 1 H), 8.28- 8.24 (m, 2H), 8.19 (d, J=9 Hz, 1H), 4.16-3. 97 (m, 1H), 3.82-3. 57 (m, 5H), 3.38-

3.26 (m, 1H), 2.41-2. 32 (m, 1H), 2.29-2. 17 (m, 2H), 1.84-1. 78 (m, 1H), 1.43 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 344.

Example 186 7-(4-Fluoro-phenyl)-3-[2-((2R)-2-methyl-pyrrolidin-1-yl)-eth yl]-cinnoline The title compound was prepared by the method described in Example 181, using 4-fluorophenyl boronic acid in place of 2,6-dimethyl-3-(4, 4,5, 5- tetramethyl- [1, 3,2] dioxaborolan-2-yl)-pyridine.'H NMR (CD30D, 300 MHz) # 8.62 (m, 1H), 8. 21-8.07 (m, 3H), 7.92-7. 87 (m, 2H), 7.33-7. 25 (m, 2H), 4.03-3. 95 (m, 1H), 3.83-3. 53 (m, 5H), 3.07-2. 99 (m, 1 H), 2.41-2. 30 (m, 1H), 2.18-2. 10 (m, 2H), 1.82-1. 77 (m, 1 H), 1.43 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 336.

Example 187 2-{3-[2-((2R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-cinnolin-7-yl }-pyrrole-1-carboxylic acid tert-butyl ester The title compound was prepared by the method described in Example 181, using 1- (t-butoxycarbonyl) pyrrole-2-boronic acid in place of 2, 6-dimethyl-3- (4,4, 5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)-pyridine. 1H NMR (CD30D, 300 MHz) 5 8.36 (m, 1H), 8.19 (s, 1H), 7.96 (d, J=9 Hz, 1H), 7.87 (dd, J=3,9 Hz, 1H), 7.47 (m, 1H), 6.47 (m, 1H), 6.37 (m, 1H), 4.03-3. 95 (m, 1H), 3.82-3. 51 (m, 5H), 3.27-3. 23 (m, 1H), 2.38-2. 27 (m, 1H), 2.18-2. 06 (m, 2H), 1.82-1. 77 (m, 1H), 1.42 (d, J=6 Hz, 3H), 1.38 (s, 9H). MS (ESI) [M+H] + at 407.

Example 188 (3-{3-[2-((2R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-cinnolin-7-y l}-phenyl)-methanol The title compound was prepared by the method described in Example 181, using 3- (hydroxymethyl) phenyl boronic acid in place of 2, 6-dimethyl-3- (4,4, 5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)-pyridine.'H NMR (CD30D, 300 MHz) 6 8.62 (m, 1H), 8.19-8. 03 (m, 3H), 7.83-7. 76 (m, 2H), 7.57-7. 43 (m, 2H), 4.76 (s, 2H), 3.58-3. 38 (m, 4H), 2.84-2. 45 (m, 3H), 2.12-2. 02 (m, 1H), 1. 92-1. 82 (m, 2H), 1.57-1. 46 (m, 1 H), 1.21 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 348.

Example 189

7-(3,5-Difluoro-phenyl)-3-[2-((2R)-2-methyl-pyrrolidinl-1-yl )-ethyl]-cinnoline The title compound was prepared by the method described in Example 181, using 3, 5-difluorophenyl boronic acid in place of 2,6-dimethyl-3-(4, 4,5, 5- tetramethyl- [1, 3, 2]dioxaborolan-2-yl)-pyridine. 1H NMR (CD30D, 300 MHz) 5 8.60 (m, 1 H), 8.22 (s, 1 H), 8.10-8. 03 (m, 2H), 7.81-7. 75 (m, 1H), 7.23-7. 17 (m, 2H), 4.05-3. 96 (m, 1H), 3.82-3. 51 (m, 5H), 3.27-3. 23 (m, 1H), 2.38-2. 27 (m, 1H), 2.18- 2.06 (m, 2H), 1.82-1. 77 (m, 1 H), 1.42 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 354.

Example 190 3-[2-((2R)-2-Methvl-pvrrolidin-1-yl)-ethyll-7-thiophen-3-yl- cinnoline The title compound was prepared by the method described in Example 181, using 3-thiophene boronic acid in place of 2,6-dimethyl-3-(4, 4,5, 5- tetramethyl-[1, 3,2] dioxaborolan-2-yl)-pyridine.'H NMR (CD30D, 300 MHz) 5 8.63 (m, 1H), 8.28 (dd, J=3,9 Hz, 1H), 8.18 (s, 1H), 8.05 (m, 2H), 7.76 (m, 1H), 7.63 (m, 1H), 4.05-3. 96 (m, 1H), 3.83-3. 52 (m, 5H), 3.27-3. 23 (m, 1H), 2.41-2. 30 (m, 1 H), 2.18-2. 06 (m, 2H), 1.83-1. 77 (m, 1H), 1.43 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 324.

Example 191 7-(4-Chloro-phenyl)-3-[2-((2R)-2-methyl-pyrrolidin-1-yl)-eth yl]-cinnoline The title compound was prepared by the method described in Example 181, using 4-chlorophenyl boronic acid in place of 2,6-dimethyl-3-(4, 4,5, 5- tetramethyl-[1, 3,2] dioxaborolan-2-yl)-pyridine.'H NMR (CD30D, 300 MHz) 5 8.64 (m, 1H), 8.21-8. 06 (m, 3H), 7.88-7. 82 (m, 2H), 7.60-7. 54 (m, 2H), 4.03-3. 96 (m, 1 H), 3.83-3. 53 (m, 5H), 3.07-2. 99 (m, 1H), 2.41-2. 30 (m, 1H), 2.18-2. 09 (m, 2H), 1.82-1. 76 (m, 1 H), 1.44 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 352.

Example 192 7-(4-Ethoxy-phenyl)-3-[2-((2R)-2-methyl-pyrrolidin-1-yl)-eth yl]-cinnoline The title compound was prepared by the method described in Example 181, using 4-ethoxyphenyl boronic acid in place of 2,6-dimethyl-3-(4, 4,5, 5- tetramethyl-[1, 3,2] dioxaborolan-2-yl)-pyridine.'H NMR (CD30D, 300 MHz) 6 8.59 (m, 1H), 8.21 (dd, J=3, 9 Hz, 1H), 8.18 (s, 1H), 8.06 (d, J=9 Hz, 1H), 7.82-7. 78 (m,

2H), 7.10-7. 06 (m, 2H), 4.14 (q, J=6 Hz, 2H), 4.05-3. 97 (m, 1H), 3.83-3. 55 (m, 5H), 3.07-2. 98 (m, 1H), 2.41-2. 30 (m, 1H), 2.19-2. 07 (m, 2H), 1.82-1. 76 (m, 1 H), 1.44 (t, J=6 Hz, 3H), 1.41 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 362.

Example 193 3-[2-((2R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-7-(1H-pyrrol-2-y l)-cinnoline To a solution of the product from Example 187 (0.007 g, 0.017 mmol) in tetrahydrofuran (2 mL), was added NaOMe (0.03 mL, 25% in methanol) and stirred at r. t. for 3 hours. The reaction mixture was then concentrated under reduced pressure, re-dissolved in water (2 mL), extracted with ethyl acetate (2 mL), dried with Na2SO4, and concentrated to afford the product in 76% yield as a yellowish solid.'H NMR (CD30D, 300 MHz) # 8.31 (m, 1 H), 8.02 (dd, J=3, 9 Hz, 1H), 7.90 (s, 1H), 7.79 (d, J=9 Hz, 1H), 6.89 (m, 1H), 6.71 (m, 1H), 6.18 (m, 1H), 3.33-3. 19 (m, 4H), 2.53-2. 22 (m, 3H), 1.96-1. 87 (m, 1H), 1.77-1. 64 (m, 2H), 1.43- 1.37 (m, 1H), 1.06 (d, J=6 Hz, 3H). MS (ESI) [M+H] + at 307.

Example 194 <BR> <BR> <BR> <BR> 2- (1, 5-Dimethyl-1H-pyrazol-4-yl)-6-f2- ( (2R)-2-methyl-1-pyrrolidinyllethyl-quinoline The title compound was prepared using the procedure described in Example 57 using 1- (1, 5-dimethyl-1H-pyrazol-4-yl)-ethanone (reference P.

Schenone et al., J. Heterocycl. Chem. 19,1982, 1355-1361) for 1- (1, 3-thiazol-2- yl)-ethanone. 1H NMR (300 MHz, CD30D) # 1. 20 (d, J=6 Hz, 3 H), 1.5 (m, 1 H), 1.84 (m, 2H), 2.07 (m, 1 H), 2.60 (m, 3 H), 2.72 (s, 3 H), 3.05 (m, 2 H), 3.23 (m, 1 H), 3.35 (m, 1 H), 3.1 (s, 3 H), 7.64 (dd, J=9 Hz, J=3 Hz, 1 H), 7.69 (d, J=9 Hz, 1 H), 7.73 (d, J=1.70 Hz, 1 H), 7.94 (d, J=9 Hz, 1 H), 7.96 (d, J=1.70 Hz, 1 H), 8.22 (d, J=9 Hz, 1 H); (DCI/NH3) m/z 335 (M+H) +.

Example 195 Determination of Biological Activity To determine the effectiveness of representative compounds of this invention as histamine-3 receptor ligands (H3 receptor ligands), the following tests were conducted according to methods previously described (European Journal of

Pharmacology, 188: 219-227 (1990); Journal of Pharmacology and Experimental Therapeutics, 275 : 598-604 (1995); Journal of Pharmacology and Experimental Therapeutics, 276: 1009-1015 (1996); and Biochemical Pharmacology, 22: 3099- 3108 (1973)).

Briefly, male Sprague-Dawley rat brain cortices were homogenized (1g tissue/10 mL buffer) in 50 mM Tris-HCI/5 mM EDTA containing protease inhibitor cocktail (Calbiochem) using a poltron set at 20,500 rpm. Homogenates were ' centrifuged for 20 minutes at 40, 000xg. The supernatant was decanted, and pellets were weighed. The pellet was resuspended by poltron homogenization in 40 mL 50 mM Tris-HCI/5 mM EDTA with protease inhibitors and centrifuged for 20 minutes at 40, 000xg. The membrane pellet was resuspended in 6.25 volumes (per gram wet weight of pellet) of 50 mM Tris-HCI/5 mM EDTA with protease inhibitors and aliquots flash frozen in liquid N2 and stored at-70 °C until used in assays. Rat cortical membranes (12 mg wet weight/tube) were incubated with (3H)-N-a-methylhistamine (-0. 6 nM) with or without H3 receptor antagonists in a total incubation volume of 0.5 mL of 50 mM Tris-HCI/5 mM EDTA (pH 7.7). Test compounds were dissolved in DMSO to provide a 20 mM solution, serially diluted and then added to the incubation mixtures prior to initiating the incubation assay by addition of the membranes. Thioperamide (3 uM) was used to determine nonspecific binding. Binding incubations were conducted for 30 minutes at 25 °C and terminated by addition of 2 mL of ice cold 50 mM Tris-CI (pH 7.7) and filtration through 0.3% polyethylenimine-soaked Unifilter plates (Packard). These filters were washed 4 additional times with 2 mL of ice-cold 50 mM Tris-CI and dried for 1 hour. Radioactivity was determined using liquid scintillation counting techniques. Results were analyzed by Hill transformation and Ki values were determined using the Cheng-Prusoff equation.

Generally, representative compounds of the invention demonstrated binding affinities in the above assay from about 810 nM to about 0.12 nM.

Preferred compounds of the invention bound to histamine-3 receptors with binding affinities from about 100 nM to about 0.12 nM. More preferred compounds of the invention bound to histamine-3 receptors with binding affinities from about 20 nM to about 0.12 nM.

Compounds of the invention are histamine-3 receptor ligands that modulate function of the histamine-3 receptor by altering the activity of the receptor. These compounds may be inverse agonists that inhibit the basal activity of the receptor or they may be antagonists that completely block the action of receptor-activating agonists. These compounds may also be partial agonists that partially block or partially activate the histamine-3 receptor receptor or they may be agonists that activate the receptor.

It is understood that the foregoing detailed description and accompanying examples are merely illustrative and are not to be taken as limitations upon the scope of the invention, which is defined solely by the appended claims and their equivalents. Various changes and modifications to the disclosed embodiments will be apparent to those skilled in the art. Such changes and modifications, including without limitation those relating to the chemical structures, substituents, derivatives, intermediates, syntheses, formulations and/or methods of use of the invention, may be made without departing from the spirit and scope thereof.