Title:
BIFIDOBACTERIUM LONGUM FOR PREVENTING AND/OR TREATING IDIOPATHIC HYPERTENSION
Document Type and Number:
WIPO Patent Application WO/2022/068545
Kind Code:
A1
Abstract:
A Bifidobacterium longum strain CCFM 752 is preserved at the Guangdong Microbial Culture Collection Center, having the preservation number GDMCC No. 61157 and the preservation date 21 August 2020. The invention also relates to an application of said Bifidobacterium longum in the preparation of a product for the prevention and/or treatment of cardiovascular disease. The Bifidobacterium longum prevents idiopathic hypertension specifically by: (1) significant reduction of intracellular O2
-levels, H2O
2 levels, and NADPH oxidase activity in A7R5 cells after angiotensin II stimulation; (2) significant elevation of CAT enzymatic activity in A7R5 cells, SHR aorta, and SHR serum; (3) significant reduction of SHR blood pressure levels; (4) significant reduction of SHR aortic vascular wall ROS level, NADPH oxidase activity, collagen level, and thickness index; (5) significant elevation of eNOS viability in the SHR aortic vascular wall.
Inventors:
LU WENWEI (CN)
CHEN WEI (CN)
WANG YUSHENG (CN)
ZHAI QIXIAO (CN)
ZHAO JIANXIN (CN)
ZHANG HAO (CN)
CHEN WEI (CN)
WANG YUSHENG (CN)
ZHAI QIXIAO (CN)
ZHAO JIANXIN (CN)
ZHANG HAO (CN)
Application Number:
PCT/CN2021/117241
Publication Date:
April 07, 2022
Filing Date:
September 08, 2021
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
A23C9/123; C12N1/20; A23C11/00; A23C13/16; A23C15/12; A23C17/02; A23C19/032; A23C19/06; A23C20/02; A23C21/02; A23L33/135; A61K35/745; A61P9/00; A61P9/12; C12R1/01
Foreign References:
| CN111979161A | 2020-11-24 | |||
| CN109055269A | 2018-12-21 | |||
| CN104046573A | 2014-09-17 | |||
| CN109652349A | 2019-04-19 | |||
| CN103865856A | 2014-06-18 |
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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