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Title:
BIFLAVONOID-COPPER COMPLEX, PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/153330
Kind Code:
A1
Abstract:
Disclosed in the present invention are a biflavonoid-copper complex, a preparation method and an application thereof. In the present invention, amentoflavone is used as a ligand and a copper ion is used as a central ion, an amentoflavone-copper complex being obtained by means of a reaction; the structure of the complex is characterized by using an infrared spectrum, an ultraviolet-visible absorption spectrum and high resolution mass spectrometry. At the same time, the present invention studies the anti-tumor and anti-oxidation activity of the amentoflavone-copper complex. MTT assay shows that the amentoflavone-copper complex has better anti-tumor activity, the anti-tumor activity being greater than that of amentoflavone; a pyrogallol autoxidation method and 2, 2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method both show that the anti-oxidation activity of the amentoflavone-copper complex is greater than that of amentoflavone. The formation of a biflavonoid-copper complex increases the anti-tumor and anti-oxidation activity of amentoflavone, which is expected to be used for drug development.

Inventors:
XU, Li (Biotechnology Building, No. 159 Longpan Road Xuanwu DistrictNanjing, Jiangsu 7, 210037, CN)
YANG, Shilong (Biotechnology Building, No. 159 Longpan Road Xuanwu DistrictNanjing, Jiangsu 7, 210037, CN)
CAO, Fuliang (Biotechnology Building, No. 159 Longpan Road Xuanwu DistrictNanjing, Jiangsu 7, 210037, CN)
LU, Wen (Biotechnology Building, No. 159 Longpan Road Xuanwu DistrictNanjing, Jiangsu 7, 210037, CN)
TANG, Ying (Biotechnology Building, No. 159 Longpan Road Xuanwu DistrictNanjing, Jiangsu 7, 210037, CN)
ZHOU, Mengyi (Biotechnology Building, No. 159 Longpan Road Xuanwu DistrictNanjing, Jiangsu 7, 210037, CN)
XUE, Huayu (Biotechnology Building, No. 159 Longpan Road Xuanwu DistrictNanjing, Jiangsu 7, 210037, CN)
Application Number:
CN2018/076736
Publication Date:
August 30, 2018
Filing Date:
February 13, 2018
Export Citation:
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Assignee:
NANJING FORESTRY UNIVERSITY (Biotechnology Building, No. 159 Longpan Road Xuanwu DistrictNanjing, Jiangsu 7, 210037, CN)
International Classes:
C07F1/08; A61P35/00; A61P39/06
Domestic Patent References:
WO2013152313A12013-10-10
Foreign References:
CN106749344A2017-05-31
CN101857583A2010-10-13
US20060024691A12006-02-02
Other References:
QAMAR UDDIN ET AL.: "The Biflavonoid, Amentoflavone Degrades DNA in the Presence of Copper Ions", TOXICOLOGY IN VITRO, vol. 18, no. 4, 31 August 2004 (2004-08-31), pages 435 - 440, XP055532214, Retrieved from the Internet
Attorney, Agent or Firm:
NANJING SHENYUN INTELLECTUAL PROPERTY OFFICE (GENERAL PARTNERSHIP) (Room 801, Main Building of Jinsiwei Mansion No.173 LongPan Road Xuanwu districtNanjing, Jiangsu 2, 210042, CN)
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