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Title:
BIFLAVONOID-COPPER COMPLEX, PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/153330
Kind Code:
A1
Abstract:
Disclosed in the present invention are a biflavonoid-copper complex, a preparation method and an application thereof. In the present invention, amentoflavone is used as a ligand and a copper ion is used as a central ion, an amentoflavone-copper complex being obtained by means of a reaction; the structure of the complex is characterized by using an infrared spectrum, an ultraviolet-visible absorption spectrum and high resolution mass spectrometry. At the same time, the present invention studies the anti-tumor and anti-oxidation activity of the amentoflavone-copper complex. MTT assay shows that the amentoflavone-copper complex has better anti-tumor activity, the anti-tumor activity being greater than that of amentoflavone; a pyrogallol autoxidation method and 2, 2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method both show that the anti-oxidation activity of the amentoflavone-copper complex is greater than that of amentoflavone. The formation of a biflavonoid-copper complex increases the anti-tumor and anti-oxidation activity of amentoflavone, which is expected to be used for drug development.

Inventors:
XU LI (CN)
YANG SHILONG (CN)
CAO FULIANG (CN)
LU WEN (CN)
TANG YING (CN)
ZHOU MENGYI (CN)
XUE HUAYU (CN)
Application Number:
CN2018/076736
Publication Date:
August 30, 2018
Filing Date:
February 13, 2018
Export Citation:
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Assignee:
UNIV NANJING FORESTRY (CN)
International Classes:
C07F1/08; A61P35/00; A61P39/06
Domestic Patent References:
WO2013152313A12013-10-10
Foreign References:
CN106749344A2017-05-31
CN101857583A2010-10-13
US20060024691A12006-02-02
Other References:
QAMAR UDDIN ET AL.: "The Biflavonoid, Amentoflavone Degrades DNA in the Presence of Copper Ions", TOXICOLOGY IN VITRO, vol. 18, no. 4, 31 August 2004 (2004-08-31), pages 435 - 440, XP055532214, Retrieved from the Internet
Attorney, Agent or Firm:
NANJING SHENYUN INTELLECTUAL PROPERTY OFFICE (GENERAL PARTNERSHIP) (CN)
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