Title:
BIFLAVONOID-IRON COMPLEX, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/153328
Kind Code:
A1
Abstract:
Disclosed are a biflavonoid-iron complex, a preparation method therefor and use thereof. In the present invention, the amentoflavone-iron complex is obtained by the reaction of the amentoflavone as a ligand and iron ions as central ions, and the structure of the complex is characterized with infrared spectroscopy, ultraviolet-visible absorption spectrometry and high resolution mass spectrometry. Meanwhile, anti-tumor and antioxidant activities of the amentoflavone-iron complex are studied in the present invention. The MTT assay shows that the amentoflavone-iron complex has better anti-tumor activities which are stronger than those of amentoflavone; and pyrogallol self-oxidation method and the ABTS assay show that the antioxidant activities of the amentoflavone-iron complex are stronger than those of the amentoflavone itself. The formation of the biflavonoid-iron complex increases the anti-tumor and antioxidant activities of the amentoflavone, and it is expected that the complex will assist in the development of medicaments.
Inventors:
XU LI (CN)
YANG SHILONG (CN)
CAO FULIANG (CN)
ZHOU MENGYI (CN)
TANG YING (CN)
LU WEN (CN)
JIANG WEINA (CN)
YANG SHILONG (CN)
CAO FULIANG (CN)
ZHOU MENGYI (CN)
TANG YING (CN)
LU WEN (CN)
JIANG WEINA (CN)
Application Number:
PCT/CN2018/076732
Publication Date:
August 30, 2018
Filing Date:
February 13, 2018
Export Citation:
Assignee:
UNIV NANJING FORESTRY (CN)
International Classes:
C07F15/02; A61K31/555; A61P35/00; A61P39/06
Foreign References:
| CN106892946A | 2017-06-27 | |||
| CN106883273A | 2017-06-23 | |||
| CN106749344A | 2017-05-31 | |||
| CN106905371A | 2017-06-30 | |||
| CN106905353A | 2017-06-30 | |||
| CN101891783A | 2010-11-24 |
Other References:
SELVARAJ, S. ET AL.: "Flavonoid-Metal Ion Complexes: A Novel Class of Therapeutic Agents", MEDICINAL RESEARCH REVIEWS, vol. 34, no. 4, 29 August 2013 (2013-08-29), pages 677 - 702, XP055535101
KASPRZAK, M.M. ET AL.: "Properties and Applications of Flavonoid Metal Complexes", RSC ADV., vol. 5, no. 57, 12 May 2015 (2015-05-12), pages 45853 - 45877, XP055535103
KASPRZAK, M.M. ET AL.: "Properties and Applications of Flavonoid Metal Complexes", RSC ADV., vol. 5, no. 57, 12 May 2015 (2015-05-12), pages 45853 - 45877, XP055535103
Attorney, Agent or Firm:
NANJING SHENYUN INTELLECTUAL PROPERTY OFFICE (GENERAL PARTNERSHIP) (CN)
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