Title:
BIFONAZOLE PHARMACEUTICAL COMPOSITION AND LIVER-PROTECTING EFFECT THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/220044
Kind Code:
A2
Abstract:
Disclosed are a bifonazole pharmaceutical composition and a liver-protecting effect thereof. The bifonazole pharmaceutical composition contains bifonazole and a natural product compound (I) separated from dried fritillaria thunbergii bulbs and having a novel structure. The bifonazole and the compound (I) increase the GSH content in mouse liver tissue, decrease the MDA content, inhibit TG accumulation, and have a certain liver-protecting effect. When used together, the bifonazole and the compound (I) have a better treatment effect, may be developed into a liver-protecting drug, and have prominent substantive features and represent notable progress with respect to the prior art.
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Inventors:
CUI KUNFENG (CN)
Application Number:
PCT/CN2017/097769
Publication Date:
December 28, 2017
Filing Date:
August 17, 2017
Export Citation:
Assignee:
ZHAO JIYONG (CN)
International Classes:
C07D493/04; A61K31/365; A61K31/4174; A61P1/16
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