Title:
BIFUNCTIONAL COMPOUNDS FOR DEGRADING KRAS G12D VIA UBIQUITIN PROTEASOME PATHWAY
Document Type and Number:
WIPO Patent Application WO/2024/050742
Kind Code:
A1
Abstract:
Providing certain bifunctional compounds that cause degradation of K-ras G12D via ubiquitin proteasome pathway and are therefore useful for the treatment of diseases mediated by K-ras G12D. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
Inventors:
SUN YONGFENG (CN)
FU JIPING (US)
ZENG HAIQIANG (CN)
FU JIPING (US)
ZENG HAIQIANG (CN)
Application Number:
PCT/CN2022/117697
Publication Date:
March 14, 2024
Filing Date:
September 08, 2022
Export Citation:
Assignee:
NIKANG THERAPEUTICS INC (US)
SUN YONGFENG (CN)
SUN YONGFENG (CN)
International Classes:
C07D471/04; A61K31/517; A61K31/519; A61P35/00; C07D487/04
Domestic Patent References:
| WO2021207172A1 | 2021-10-14 | |||
| WO2022105859A1 | 2022-05-27 | |||
| WO2022105857A1 | 2022-05-27 | |||
| WO2022148422A1 | 2022-07-14 | |||
| WO2022087335A1 | 2022-04-28 | |||
| WO2022111521A1 | 2022-06-02 |
Foreign References:
| CN112218859A | 2021-01-12 | |||
| CN114621231A | 2022-06-14 |
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
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