Title:
BIFUNCTIONAL FUSION PROTEIN MOLECULE CONTAINING ANTI-HUMAN IL-17 ANTIBODY AND TACI
Document Type and Number:
WIPO Patent Application WO/2022/258045
Kind Code:
A1
Abstract:
A bifunctional fusion protein molecule containing an anti-human IL-17 antibody and TACI, comprising (a) an anti-human IL-17 antibody or antigen-binding fragment capable of blocking IL-17A/IL17RA binding, and (b) a TACI fusion protein or fragment capable of binding to BAFF/APRIL, and a preparation method therefor and an application thereof (for example, being used for the treatment of autoimmune diseases such as autoimmune encephalomyelitis).
Inventors:
FU YAYUAN (CN)
CHAI XIAOJUAN (CN)
CAO ZHUOXIAO (CN)
TANG RENHONG (CN)
REN JINSHENG (CN)
CHAI XIAOJUAN (CN)
CAO ZHUOXIAO (CN)
TANG RENHONG (CN)
REN JINSHENG (CN)
Application Number:
PCT/CN2022/098128
Publication Date:
December 15, 2022
Filing Date:
June 10, 2022
Export Citation:
Assignee:
SHANDONG SIMCERE BIOPHARMACEUTICAL CO LTD (CN)
JIANGSU SIMCERE PHARM CO LTD (CN)
JIANGSU SIMCERE PHARM CO LTD (CN)
International Classes:
C07K19/00; A61K38/17; A61K39/395; A61P19/02; A61P29/00; A61P37/02
Foreign References:
| CN109796534A | 2019-05-24 | |||
| CN107257692A | 2017-10-17 | |||
| CN104220455A | 2014-12-17 | |||
| CN105770891A | 2016-07-20 | |||
| CN105168123A | 2015-12-23 | |||
| CN101323643A | 2008-12-17 | |||
| US20140255406A1 | 2014-09-11 |
Other References:
GERD R. BURMESTER, EUGEN FEIST, THOMAS DÖRNER: "Emerging cell and cytokine targets in rheumatoid arthritis", NATURE REVIEWS RHEUMATOLOGY, NATURE PUBLISHING GROUP, GB, vol. 10, no. 2, 12 November 2013 (2013-11-12), GB , pages 77 - 88, XP055407927, ISSN: 1759-4790, DOI: 10.1038/nrrheum.2013.168
YANG SIMIN; WANG QINGTONG; LIU KANGKANG: "Inhibitory effect of rh TACI-Ig on anti-CD3 antibody induced T lymphocytes proliferation and activation", ACTA UNIVERSITATIS MEDICINALIS ANHUI, vol. 51, no. 7, 6 June 2016 (2016-06-06), pages 919 - 925, XP009541778, ISSN: 1000-1492, DOI: 10.19405/j.cnki.issn1000-1492.2016.07.001
YANG SIMIN; WANG QINGTONG; LIU KANGKANG: "Inhibitory effect of rh TACI-Ig on anti-CD3 antibody induced T lymphocytes proliferation and activation", ACTA UNIVERSITATIS MEDICINALIS ANHUI, vol. 51, no. 7, 6 June 2016 (2016-06-06), pages 919 - 925, XP009541778, ISSN: 1000-1492, DOI: 10.19405/j.cnki.issn1000-1492.2016.07.001
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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