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Title:
BIFUNCTIONAL FUSION PROTEIN AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/177733
Kind Code:
A1
Abstract:
Provided are a bifunctional fusion protein and pharmaceutical use thereof. Specifically, provided are a bifunctional fusion protein comprising an SIRPγ peptide variant and an anti-human PD-L1 antibody, an SIRPγ peptide variant, and pharmaceutical use thereof. The bifunctional fusion protein can specifically bind PD-L1 and CD47 to block the binding of PD-L1 or CD47 to a receptor or ligand thereof. In addition, also provided are preparation and application of the bifunctional fusion protein, and treatment of cancers and immune-related diseases.

Inventors:
GU XIAOLING (CN)
YE XIN (CN)
HU BING (CN)
GE HU (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2020/077907
Publication Date:
September 10, 2020
Filing Date:
March 05, 2020
Export Citation:
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Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K19/00; A61K39/395; A61P35/00; C12N15/62
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Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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