BIFUNCTIONAL ORGANIC CHIRAL CATALYST COMPOUND WITH SUPERIOR STEREOSELECTIVITY, METHOD FOR PREPARING SAME, AND METHOD FOR PREPARING CHIRAL AMINO ACIDS FROM AZLACTONE USING SAME

WIPO Patent Application WO/2010/131881

A2

The present invention relates to a method for obtaining chiral amino acid esters having high stereoselectivity from racemic or chiral azlactone, and provides a derivatized bifunctional organic chiral catalyst compound used in the method, and a method for preparing the compound. Conventional preparation methods have the drawbacks of a long reaction period at a low temperature being required to obtain N-acyl amino acid esters having a high enantioselectivity, and the optical selectivity of the obtained compound is not sufficient for industrialization. The catalyst compound according to the present invention can be easily synthesized from cinchona alkaloids. The present invention enables N-acyl amino acid esters having a high enantioselectivity to be obtained in a remarkably economical and simple manner, and enables various (R)-type N-acyl amino acid esters not found in nature to be prepared with high optical purity, and can thus be valuably utilized as a technique for industrialization.

SOGN CHOONGEUI (KR)
LEE JIWOONG (KR)
RYU TAEHI (KR)
BAE HANYONG (KR)
OH JOONGSUK (KR)

PCT/KR2010/002966

November 18, 2010

May 10, 2010

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UNIV SUNGKYUNKWAN FOUND (KR)
SOGN CHOONGEUI (KR)
LEE JIWOONG (KR)
RYU TAEHI (KR)
BAE HANYONG (KR)
OH JOONGSUK (KR)

C07D403/14; C07D263/20; C07D403/12

WO2007123853A2

2007-11-01

US20090023708A1

2009-01-22

DAWOOL PATENT AND LAW FIRM (KR)
특허법인다울 (KR)

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