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Title:
BIFUNCTIONAL POLYPEPTIDE COMPOSITIONS AND METHODS FOR TREATMENT OF METABOLIC AND CARDIOVASCULAR DISEASES
Document Type and Number:
WIPO Patent Application WO/2011/084808
Kind Code:
A3
Abstract:
The present invention relates to compositions comprising combinations of biologically active proteins linked to extended recombinant polymer, methods of production of the compositions and their use in treatment of metabolic and cardiovascular diseases, disorders and conditions.

Inventors:
SILVERMAN JOSHUA (US)
SCHELLENBERGER VOLKER (US)
STEMMER WILLEM P (US)
CLELAND JEFFREY L (US)
Application Number:
PCT/US2010/061590
Publication Date:
October 13, 2011
Filing Date:
December 21, 2010
Export Citation:
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Assignee:
AMUNIX OPERATING INC (US)
SILVERMAN JOSHUA (US)
SCHELLENBERGER VOLKER (US)
STEMMER WILLEM P (US)
CLELAND JEFFREY L (US)
International Classes:
A61K38/16; C12P21/04
Foreign References:
US20080312157A12008-12-18
US20090099031A12009-04-16
Other References:
SCHELLENBERER ET AL.: "A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner.", NAT. BIOTECHNOL., vol. 27, no. 12, 15 November 2009 (2009-11-15), pages 1186 - 1190
KOHN ET AL.: "Random-coil behavior and the dimensions of chemically unfolded proteins.", PROC. NATL. ACAD. SCI. USA, vol. 101, no. 34, 2004, pages 12491 - 12496, XP008157744, DOI: doi:10.1073/pnas.0403643101
Attorney, Agent or Firm:
HUANG, Tao et al. (650 Page Mill RoadPalo Alto, CA, US)
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