Title:
BIHETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2017/122722
Kind Code:
A1
Abstract:
The present invention provides: a compound represented by formula (1) as a pharmaceutical agent which is useful as a neuroregeneration promoting agent [in the formula, R1-L- represents R1-OC(O)-, etc., R1 represents a hydrogen atom, an optionally substituted alkyl group having 1-6 carbon atoms, an optionally substituted 3- to 8-membered cycloalkyl group, etc., R2 represents a hydrogen atom, etc., and ring A represents formula (2) or formula (3) {in the formula, R3 represents a hydrogen atom, an optionally substituted alkyl group having 1-6 carbon atoms, etc., moieties represented by X, Y, and Z represent X=Y-Z, X-Y=Z, or X-Y-Z, X represents a nitrogen atom, NR4 (R4 represents a hydrogen atom, an optionally substituted alkyl group having 1-6 carbon atoms, etc.), etc., Y represents a carbon atom, etc., and Z represents a carbon atom, a nitrogen atom, etc.}]; and a pharmaceutical composition containing the compound.
Inventors:
WATANABE HITOSHI (JP)
ISOBE YOSHIAKI (JP)
KIMURA HIDENORI (JP)
FUJIWARA YUJI (JP)
ISOBE YOSHIAKI (JP)
KIMURA HIDENORI (JP)
FUJIWARA YUJI (JP)
Application Number:
PCT/JP2017/000819
Publication Date:
July 20, 2017
Filing Date:
January 12, 2017
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
C07D311/22; A61K31/352; A61K31/4192; A61K31/4709; A61K31/519; A61P9/10; A61P25/00; A61P25/02; A61P25/28; A61P27/02; A61P43/00; C07D405/04; C07D405/14; C07D471/04
Domestic Patent References:
| WO2002009756A1 | 2002-02-07 | |||
| WO2012115182A1 | 2012-08-30 | |||
| WO2002009756A1 | 2002-02-07 | |||
| WO2003062243A1 | 2003-07-31 | |||
| WO2003062440A1 | 2003-07-31 | |||
| WO2012018069A1 | 2012-02-09 | |||
| WO2012115182A1 | 2012-08-30 | |||
| WO2003099762A1 | 2003-12-04 | |||
| WO2005000838A1 | 2005-01-06 |
Foreign References:
| JP2006335683A | 2006-12-14 | |||
| JP2011046734A | 2011-03-10 | |||
| JP2016037472A | 2016-03-22 |
Other References:
CELL, vol. 75, 1993, pages 217
CELL, vol. 75, 1993, pages 1389
NATURE MEDICINE, vol. 3, no. 12, 2006, pages 1398
PLOS ONE, vol. 7, no. 11, 2012, pages e47716
"Protective Group in Organic Synthesis", 1999, JOHN WILEY & SONS INC
"Protective Group in Organic Synthesis", 1999, OHN WILEY & SONS INC
"Jikken Kagaku Kouza", vol. 22, MARUZEN, article "4th Series of Experimental Chemistry"
ANGEW. CHEM. INT. ED.,, vol. 52, 2013, pages 3421 - 3424
CHEM LETT., vol. 36, 2007, pages 1382
J. MED. CHEM., vol. 58, no. 5, 2015, pages 2195 - 2205
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TETRAHEDRON LETT., vol. 50, 2009, pages 6494 - 6497
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ORG. LETT., vol. 16, 2014, pages 3568 - 3571
"Jikken . Kagaku Kouza", vol. 22, MARUZEN, article "4th Series of Experimental Chemistry"
"Angew. Chem. Int. Ed.", vol. 52, 2013, pages: 3421 - 3424
CELL, vol. 75, 1993, pages 1389
NATURE MEDICINE, vol. 3, no. 12, 2006, pages 1398
PLOS ONE, vol. 7, no. 11, 2012, pages e47716
"Protective Group in Organic Synthesis", 1999, JOHN WILEY & SONS INC
"Protective Group in Organic Synthesis", 1999, OHN WILEY & SONS INC
"Jikken Kagaku Kouza", vol. 22, MARUZEN, article "4th Series of Experimental Chemistry"
ANGEW. CHEM. INT. ED.,, vol. 52, 2013, pages 3421 - 3424
CHEM LETT., vol. 36, 2007, pages 1382
J. MED. CHEM., vol. 58, no. 5, 2015, pages 2195 - 2205
TETRAHEDRON, vol. 63, no. 2, 2007, pages 474 - 491
BIOORG. MED. CHEM., vol. 13, 2005, pages 1661 - 1671
TETRAHEDRON LETT., vol. 50, 2009, pages 6494 - 6497
HETEROCYCLES, vol. 65, 2005, pages 2095 - 2105
ORG. LETT., vol. 16, 2014, pages 3568 - 3571
"Jikken . Kagaku Kouza", vol. 22, MARUZEN, article "4th Series of Experimental Chemistry"
"Angew. Chem. Int. Ed.", vol. 52, 2013, pages: 3421 - 3424
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
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