Title:
BILE ACID SYNTHESIS PROMOTER, COMPOSITION FOR PROMOTING BILE ACID SYNTHESIS AND FOOD COMPOSITION FOR PROMOTING BILE ACID SYNTHESIS
Document Type and Number:
WIPO Patent Application WO/2018/168333
Kind Code:
A1
Abstract:
[Problem] To provide a novel medicine that is capable of promoting cholesterol metabolism to thereby treat, ameliorate or prevent various symptoms associated with increase in blood cholesterol level. [Solution] The present inventors newly found that arctigenin has an effect of promoting the conversion of cholesterol into bile acid. The present invention provides a bile acid synthesis promoter, a composition for promoting bile acid synthesis and a food composition for promoting bile acid synthesis each comprising arctigenin and/or arctiin as active ingredient(s).
Inventors:
WATANABE SHIMPEI (JP)
INAMASU SATOSHI (JP)
WATANABE MITSUHIRO (JP)
TAKASHINA YOKO (JP)
INAMASU SATOSHI (JP)
WATANABE MITSUHIRO (JP)
TAKASHINA YOKO (JP)
Application Number:
PCT/JP2018/005630
Publication Date:
September 20, 2018
Filing Date:
February 19, 2018
Export Citation:
Assignee:
KRACIE HOLDINGS LTD (JP)
International Classes:
A61K31/341; A23L33/105; A61K31/7048; A61K36/28; A61K36/634; A61P3/06; A61P43/00
Foreign References:
| CN101002815A | 2007-07-25 | |||
| JP2010095456A | 2010-04-30 |
Other References:
XU, XIAOLIN ET AL.: "Arctigenin promotes cholesterol efflux from THP-1 macrophages through PPAR-y/LXR-a signaling pathway", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 441, no. 2, 2013, pages 321 - 326, XP028772351
CHO, SUNG-HEE ET AL.: "Effects of forsythia fruit extracts and lignin on lipid metabolism", BIOFACTORS, vol. 22, 2004, pages 161 - 163, XP055628497
HAN, YO-HAN ET AL.: "Anti-obesity effects of Arctii Fructus (Arctium lappa) in white/brown adipocytes and high-fat diet-induced obese mice", FOOD & FUNCTION, vol. 7, no. 12, 2016, pages 5025 - 5033, XP055555806
MIYAZAWA, MITSUO ET AL.: "Inhibitory Compounds of alpha-Glucosidase Activity from Arctium lappa L.", JOURNAL OLEO SCIENCE, vol. 54, no. 11, 2005, pages 589 - 594, XP055555807
XIANG ZUO: "Effects of Arctigenin on alpha-glucosidase Activity", MODERN CHINESE MEDICINE, vol. 11, no. 5, 2009, pages 28 - 29,38, XP009517003, DOI: 10.13313/j.issn.1673-4890.2009.05.011
BARTRAM, HANS-PETER ET AL.: "Effect of Starch Malabsorption on Fecal Bile Acids and Neutral Sterols in Humans: Possible Implications for Colonic Carcinogenesis", CANCER RESEARCH, vol. 51, 15 August 1991 (1991-08-15), pages 4238 - 4242, XP055555809
HEPATOLOGY, vol. 56, no. 3, 2012, pages 1034 - 1043
See also references of EP 3597185A4
CHO, SUNG-HEE ET AL.: "Effects of forsythia fruit extracts and lignin on lipid metabolism", BIOFACTORS, vol. 22, 2004, pages 161 - 163, XP055628497
HAN, YO-HAN ET AL.: "Anti-obesity effects of Arctii Fructus (Arctium lappa) in white/brown adipocytes and high-fat diet-induced obese mice", FOOD & FUNCTION, vol. 7, no. 12, 2016, pages 5025 - 5033, XP055555806
MIYAZAWA, MITSUO ET AL.: "Inhibitory Compounds of alpha-Glucosidase Activity from Arctium lappa L.", JOURNAL OLEO SCIENCE, vol. 54, no. 11, 2005, pages 589 - 594, XP055555807
XIANG ZUO: "Effects of Arctigenin on alpha-glucosidase Activity", MODERN CHINESE MEDICINE, vol. 11, no. 5, 2009, pages 28 - 29,38, XP009517003, DOI: 10.13313/j.issn.1673-4890.2009.05.011
BARTRAM, HANS-PETER ET AL.: "Effect of Starch Malabsorption on Fecal Bile Acids and Neutral Sterols in Humans: Possible Implications for Colonic Carcinogenesis", CANCER RESEARCH, vol. 51, 15 August 1991 (1991-08-15), pages 4238 - 4242, XP055555809
HEPATOLOGY, vol. 56, no. 3, 2012, pages 1034 - 1043
See also references of EP 3597185A4
Attorney, Agent or Firm:
AIHARA, Reiji (JP)
Download PDF:
Previous Patent: HEAT EXCHANGER
Next Patent: SETTING DEVICE, COMMUNICATION DEVICE, AND SETTING SYSTEM
Next Patent: SETTING DEVICE, COMMUNICATION DEVICE, AND SETTING SYSTEM