Title:
BINDING DOMAINS FROM PLASMODIUM VIVAX AND PLASMODIUM FALCIPARUM ERYTHROCYTE BINDING PROTEINS
Document Type and Number:
WIPO Patent Application WO1996040766
Kind Code:
A3
Abstract:
The present invention provides isolated polypeptides useful in the treatment and prevention of malaria caused by Plasmodium falciparum or P. vivax. In particular, the polypeptides are derived from the binding domains of the proteins in the DBL family as well as the sialic acid binding protein (SABP) on P. falciparum merozoites. The polypeptides may also be derived from the Duffy antigen binding protein (DABP) on P. vivax merozoites.
Inventors:
SIM KIM LEE
CHITNIS CHETAN
MILLER LOUIS H
PETERSON DAVID S
SU XIN-ZHUAN
WELLEMS THOMAS E
CHITNIS CHETAN
MILLER LOUIS H
PETERSON DAVID S
SU XIN-ZHUAN
WELLEMS THOMAS E
Application Number:
PCT/US1996/009508
Publication Date:
February 06, 1997
Filing Date:
June 07, 1996
Export Citation:
Assignee:
US HEALTH (US)
International Classes:
C12N15/09; A61K39/015; A61P33/02; C07K14/445; C12N5/10; C12N15/30; C12P21/02; A61K39/00; C12R1/91; (IPC1-7): C07K14/445; C12N15/30; A61K39/015
Domestic Patent References:
| WO1995007353A2 | 1995-03-16 |
Other References:
K. SIM ET AL.: "Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum", SCIENCE, vol. 264, 1994, pages 1941 - 1944, XP002021139
C. CHITNIS ET AL.: "Identification of the erythrocyte-binding domains of Plasmodium vivax and Plasmodium knowlesi proteins involved in erythrocyte invasion", J. EXP. MED., vol. 180, 1994, pages 497 - 506, XP000615205
X. SU ET AL.: "The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes", CELL, vol. 82, 1995, pages 89 - 100, XP002021140
P. BORST ET AL.: "Antigenic variation in malaria", CELL, vol. 82, 1995, pages 1 - 4, XP002021141
C. CHITNIS ET AL.: "Identification of the erythrocyte-binding domains of Plasmodium vivax and Plasmodium knowlesi proteins involved in erythrocyte invasion", J. EXP. MED., vol. 180, 1994, pages 497 - 506, XP000615205
X. SU ET AL.: "The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes", CELL, vol. 82, 1995, pages 89 - 100, XP002021140
P. BORST ET AL.: "Antigenic variation in malaria", CELL, vol. 82, 1995, pages 1 - 4, XP002021141
Download PDF: