Title:
CD8α BINDING POLYPEPTIDE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/268225
Kind Code:
A1
Abstract:
Provided is a CD8α binding polypeptide. The CD8α binding polypeptide contains at least one variable domain, and compared with an amino acid sequence as represented by SEQ ID NO:1, the amino acid sequence of the variable domain has substitutions, deletions or additions of one or several amino acids. Further provided are a composition containing the CD8α binding polypeptide and the use thereof in the diagnosis and/or treatment of various diseases including, for example, tumors.
Inventors:
XU TAO (CN)
WANG CHAO (CN)
YANG YANLING (CN)
SUN YAN (CN)
QI HAO (CN)
DU HAIJING (CN)
MIAO LIYAN (CN)
WANG YAN (CN)
QIN SONGBING (CN)
WANG CHAO (CN)
YANG YANLING (CN)
SUN YAN (CN)
QI HAO (CN)
DU HAIJING (CN)
MIAO LIYAN (CN)
WANG YAN (CN)
QIN SONGBING (CN)
Application Number:
PCT/CN2022/101541
Publication Date:
December 29, 2022
Filing Date:
June 27, 2022
Export Citation:
Assignee:
SUZHOU SMARTNUCLIDE BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07K16/28; A61K51/10; G01N33/53
Domestic Patent References:
| WO2021046159A1 | 2021-03-11 | |||
| WO1994004678A1 | 1994-03-03 |
Foreign References:
| CN114230665A | 2022-03-25 | |||
| CN113956357A | 2022-01-21 | |||
| CN110997013A | 2020-04-10 | |||
| CN109970858A | 2019-07-05 | |||
| CN202010703962A | 2020-07-21 |
Other References:
REYNOLDS JOHN, NORGAN VICKI A., BHAMBRA UPINDER, SMITH JENNIFER, COOK H. TERENCE, PUSEY CHARLES D.: "Anti-CD8 Monoclonal Antibody Therapy Is Effective in the Prevention and Treatment of Experimental Autoimmune Glomerulonephritis", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, WILLIAMS AND WILKINS, BALTIMORE, MD., US, vol. 13, no. 2, 31 December 2002 (2002-12-31), US , pages 359 - 369, XP009541985, ISSN: 1046-6673, DOI: 10.1681/ASN.V132359
MILLERETAL, JOUR. OF IMMUNOLOGY, vol. 170, 2003, pages 4854 - 4861
WARD ET AL.: "Binding Activities of a Repertoire of Single Immunoglobulin Variable Domains Secreted From Escherichia coli", NATURE, vol. 341, 1989, pages 544 - 546
HUSTON ET AL.: "Protein Engineering of Antibody Binding Sites: Recovery of Specific Activity in an Anti-Digoxin Single-Chain Fv Analogue Produced in Escherichia coli", PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883, XP000872837, DOI: 10.1073/pnas.85.16.5879
NGUYEN V. K., THE EMBO JOURNAL, vol. 19, 2000, pages 921 - 930
MUYLDERMANS S., J BIOTECHNOL., vol. 74, 2001, pages 277 - 302
VANLANDSCHOOT P. ET AL., ANTIVIRAL RESEARCH, vol. 92, 2011, pages 389 - 407
HAMERS-CASTERMAN CATARHOUCH TMUYLDERMANS SROBINSON GHAMERS CSONGA EBBENDAHMAN NHAMERS R.: "Naturally occurring antibodies devoid of light chains", NATURE, vol. 363, 1993, pages 446 - 448, XP002535892, DOI: 10.1038/363446a0
CHOTHIALESK, J.MOL.BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 877 - 883
PADLAN, FASEB J., vol. 9, 1995, pages 133 - 139
MACCALLUM, JMOI BIOL, vol. 262, no. 5, 1996, pages 732 - 45
"Computational Molecular Biology", 1988, OXFORD UNIVERSITY PRESS
"Biocomputing: Informatics and Genome Projects", 1993, ACADEMIC PRESS
"Computer Analysis of Sequence Data", 1994, HUMANA PRESS
VON HEINJE, G.: "Sequence Analysis in Molecular Biology", vol. 20, 1987, ACADEMIC PRESS
"Sequence Analysis Primer", 1991, M STOCKTON PRESS
"Remington: The Science & Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
AUSUBEL PROTOCOLS IN MOLECULAR BIOLOGY: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR PRESS
JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 2 - 19
"The Handbook of Pharmaceutical Salts; Properties, Selection, and Use.", 2002, VERLAG
"Remington's Pharmaceutical Sciences", 1995, pages: 1447 - 1676
MILLERETAL, JOUR. OF IMMUNOLOGY, vol. 170, 2003, pages 4854 - 4861
WARD ET AL.: "Binding Activities of a Repertoire of Single Immunoglobulin Variable Domains Secreted From Escherichia coli", NATURE, vol. 341, 1989, pages 544 - 546
HUSTON ET AL.: "Protein Engineering of Antibody Binding Sites: Recovery of Specific Activity in an Anti-Digoxin Single-Chain Fv Analogue Produced in Escherichia coli", PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883, XP000872837, DOI: 10.1073/pnas.85.16.5879
NGUYEN V. K., THE EMBO JOURNAL, vol. 19, 2000, pages 921 - 930
MUYLDERMANS S., J BIOTECHNOL., vol. 74, 2001, pages 277 - 302
VANLANDSCHOOT P. ET AL., ANTIVIRAL RESEARCH, vol. 92, 2011, pages 389 - 407
HAMERS-CASTERMAN CATARHOUCH TMUYLDERMANS SROBINSON GHAMERS CSONGA EBBENDAHMAN NHAMERS R.: "Naturally occurring antibodies devoid of light chains", NATURE, vol. 363, 1993, pages 446 - 448, XP002535892, DOI: 10.1038/363446a0
CHOTHIALESK, J.MOL.BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 877 - 883
PADLAN, FASEB J., vol. 9, 1995, pages 133 - 139
MACCALLUM, JMOI BIOL, vol. 262, no. 5, 1996, pages 732 - 45
"Computational Molecular Biology", 1988, OXFORD UNIVERSITY PRESS
"Biocomputing: Informatics and Genome Projects", 1993, ACADEMIC PRESS
"Computer Analysis of Sequence Data", 1994, HUMANA PRESS
VON HEINJE, G.: "Sequence Analysis in Molecular Biology", vol. 20, 1987, ACADEMIC PRESS
"Sequence Analysis Primer", 1991, M STOCKTON PRESS
"Remington: The Science & Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
AUSUBEL PROTOCOLS IN MOLECULAR BIOLOGY: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR PRESS
JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 2 - 19
"The Handbook of Pharmaceutical Salts; Properties, Selection, and Use.", 2002, VERLAG
"Remington's Pharmaceutical Sciences", 1995, pages: 1447 - 1676
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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