Title:
BINDING PROTEINS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/019957
Kind Code:
A3
Abstract:
The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
Inventors:
MONDAL KALYANI (US)
LI BETTY CHAN (US)
CHEN YU (US)
ARORA TARUNA (US)
MATERN HUGO (US)
SHEN WENYAN (US)
LI BETTY CHAN (US)
CHEN YU (US)
ARORA TARUNA (US)
MATERN HUGO (US)
SHEN WENYAN (US)
Application Number:
PCT/US2016/044704
Publication Date:
March 09, 2017
Filing Date:
July 29, 2016
Export Citation:
Assignee:
NGM BIOPHARMACEUTICALS INC (US)
International Classes:
A61K39/395; C07K14/71; C07K16/18
Domestic Patent References:
| WO2015100366A1 | 2015-07-02 |
Foreign References:
| US20110135657A1 | 2011-06-09 | |||
| US20150210764A1 | 2015-07-30 |
Other References:
FOLTZ ET AL.: "Treating diabetes and obesity with an FGF21-mimetic antibody activating the pKlotho/FGFR1c receptor complex", SCI. TRANSL. MED., vol. 4, no. 162, 28 November 2012 (2012-11-28), pages 1 - 11, XP009166047
ZHOU ET AL.: "Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19", CANCER RES, vol. 74, no. 12, 11 April 2014 (2014-04-11), pages 3306 - 3316, XP055346595
ZHOU ET AL.: "Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19", CANCER RES, vol. 74, no. 12, 11 April 2014 (2014-04-11), pages 3306 - 3316, XP055346595
Attorney, Agent or Firm:
MCNICHOLAS, Janet M. et al. (US)
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