Title:
BIO-DETECTION CHIP AND DETECTION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/210104
Kind Code:
A1
Abstract:
A bio-detection chip and a detection method thereof. The bio-detection chip comprises: an upper substrate (01) and a lower substrate (02) opposite to each other, a reference electrode (03), a driving electrode (04), a first dielectric layer (05), a second dielectric layer (06), a first hydrophobic layer (07), and a second hydrophobic layer (08). The reference electrode (03) is formed on a surface of the upper substrate (01) facing the lower substrate (02); the driving electrode (04) is formed on a surface of the lower substrate (02) facing the upper substrate (01); the first dielectric layer (05), the first hydrophobic layer (07), the second hydrophobic layer (08), and the second dielectric layer (06) are disposed between the reference electrode (03) and the driving electrode (04) in sequence. The bio-detection chip further comprises multiple microcapsules (10) arranged between the first hydrophobic layer (07) and the second hydrophobic layer (08). Each microcapsule (10) encloses multiple charged microspheres (102), each of which has a first biomolecule on the surface thereof for specific binding to a second biomolecule entering the bio-detection chip, thus causing a change in color, wherein either the first biomolecule or the second biomolecule is a biomolecule to be tested; the microspheres (102) move close to the upper substrate (01) when a voltage is applied between the reference electrode (03) and the driving electrode (04). The detection result of biomolecule detection can be visually observed.
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Inventors:
GENG YUE (CN)
CAI PEIZHI (CN)
PANG FENGCHUN (CN)
GU LE (CN)
CAI PEIZHI (CN)
PANG FENGCHUN (CN)
GU LE (CN)
Application Number:
PCT/CN2018/084088
Publication Date:
November 22, 2018
Filing Date:
April 23, 2018
Export Citation:
Assignee:
BOE TECHNOLOGY GROUP CO LTD (CN)
BEIJING BOE OPTOELECTRONICS TECH CO LTD (CN)
BEIJING BOE OPTOELECTRONICS TECH CO LTD (CN)
International Classes:
G01N33/543; B01L3/00; G01N21/78
Foreign References:
| CN107159327A | 2017-09-15 | |||
| CN105233887A | 2016-01-13 | |||
| CN105466985A | 2016-04-06 | |||
| CN105572398A | 2016-05-11 | |||
| US6169394B1 | 2001-01-02 |
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
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