Title:
BIO-REDUCIBLE SELF-ASSEMBLED LIQUID CRYSTALLINE BLOCK COPOLYMER FOR DRUG DELIVERY
Document Type and Number:
WIPO Patent Application WO/2016/061310
Kind Code:
A3
Abstract:
A copolymer comprising a first block and a second block is presented. The first block comprises a repeat unit selected from that of polyacrylate, polymethacrylate, polynorbonene, polycyclopentene, polycyclooctene, polysiloxane, polyester, and polypeptide, or combinations thereof, wherein a steroid moiety is attached the unit sideway. The second block has the formula R2-R3-, wherein R2 is polyalkylene oxide, polyester, or polypeptide moiety; and R3 is a disulfide linker moiety. The disclosure includes biodegradable amphiphilic liquid crystalline copolymers that can readily self-assemble to nanoparticles in aqueous solutions and also allow for encapsulation of hydrophobic pharmaceutically active molecules.
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Inventors:
LU XIULING (US)
KASI RAJESWARI (US)
TRAN THANH-HUYEN (US)
NGUYEN CHI THANH (US)
KASI RAJESWARI (US)
TRAN THANH-HUYEN (US)
NGUYEN CHI THANH (US)
Application Number:
PCT/US2015/055660
Publication Date:
May 26, 2017
Filing Date:
October 15, 2015
Export Citation:
Assignee:
UNIV CONNECTICUT (US)
International Classes:
C08G65/08; C08F299/04; C08G75/14
Foreign References:
| US20130096288A1 | 2013-04-18 |
Other References:
ZHOU, YUXIANG ET AL.: "Synthesis and characterization of polycholesteryl methacrylate-polyhydroxyethyl methyacrylate block copolymers.", JOURNAL OF POLYMER SCIENCE PART A: POLYMER CHEMISTRY., vol. 46, no. 20, 15 September 2008 (2008-09-15), pages 6801 - 6809, XP055383451
RANUCCI, ELISABETTA ET AL.: "Poly (amidoamine) conjugates with disulfide- linked cholesterol pendants self-assembling into redox-sensitive nanoparticles.", BIOMACROMOLECULES., vol. 9, no. 10, 2008, pages 2693 - 2704, XP055052273
ZHOU, YUXIANG ET AL.: "Polymers comprising cholesterol: synthesis, self-assembly, and applications.", MATERIALS., vol. 2, no. 2, 2009, pages 636 - 660, XP055383453
NGUYEN, CHI THANH ET AL.: "Redox-sensitive nanoparticles from amphiphilic cholesterol-based block copolymers for enhanced tumor intracellular release of doxorubicin.", NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE., vol. 11, no. 8, 2015, pages 2071 - 2082, XP029322062
RANUCCI, ELISABETTA ET AL.: "Poly (amidoamine) conjugates with disulfide- linked cholesterol pendants self-assembling into redox-sensitive nanoparticles.", BIOMACROMOLECULES., vol. 9, no. 10, 2008, pages 2693 - 2704, XP055052273
ZHOU, YUXIANG ET AL.: "Polymers comprising cholesterol: synthesis, self-assembly, and applications.", MATERIALS., vol. 2, no. 2, 2009, pages 636 - 660, XP055383453
NGUYEN, CHI THANH ET AL.: "Redox-sensitive nanoparticles from amphiphilic cholesterol-based block copolymers for enhanced tumor intracellular release of doxorubicin.", NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE., vol. 11, no. 8, 2015, pages 2071 - 2082, XP029322062
Attorney, Agent or Firm:
LIBBY, Jelena, Janjic (US)
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