Title:
BIOABSORBABLE POLYMER CONTAINING 2-HDROXYACID MONOMERS
Document Type and Number:
WIPO Patent Application WO2004038030
Kind Code:
A3
Abstract:
Genetically engineered organisms for production of PHA copolymers containing 2-hydroxyacid monomers and the methods of making and using thereof have been developed. The copolymers containing 2-hydroxyacid monomers can be synthesized via biosynthesis by the action of a PHA polymerase in a living cell. By changing the genetic background of the cells, one can control specific metabolic pathways allowing control of the level of glycolic acid co-monomer in the PHA polymer.
More Like This:
Inventors:
MARTIN DAVID P (US)
SKRALY FRANK A (US)
SKRALY FRANK A (US)
Application Number:
PCT/US2003/014573
Publication Date:
October 05, 2006
Filing Date:
May 07, 2003
Export Citation:
Assignee:
METABOLIX INC (US)
TEPHA INC (US)
TEPHA INC (US)
International Classes:
C12P7/62; A01H1/00; C07H21/04; C08G63/06; C12N1/00; C12N1/21; C12N9/10; C12N9/16; C12N15/00; C12P1/00
Foreign References:
| US5973100A | 1999-10-26 | |||
| US6329183B1 | 2001-12-11 |
Other References:
TSUGE T. ET AL.: "Molecular cloning of two (R)-specific enoyl-CoA hydratase genes from Pseudomonas aeruginosa and their use for polyhydroxyalkanoate synthesis", FEMS MICROBIOL. LETT., vol. 184, no. 2, 15 March 2000 (2000-03-15), pages 193 - 198, XP001014519
ANDERSON A.J. ET AL.: "Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates", MICROBIOL. REV., vol. 54, no. 4, December 1990 (1990-12-01), pages 450 - 472, XP008068189
ZINN M. ET AL.: "Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate", ADV. DRUG DELIV. REV., vol. 53, no. 1, 3 December 2001 (2001-12-03), pages 5 - 21, XP003000228
SUDESH K. ET AL.: "Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters", PROG. POLYM. SCI., vol. 25, no. 10, December 2000 (2000-12-01), pages 1503 - 1555, XP003000229
ANDERSON A.J. ET AL.: "Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates", MICROBIOL. REV., vol. 54, no. 4, December 1990 (1990-12-01), pages 450 - 472, XP008068189
ZINN M. ET AL.: "Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate", ADV. DRUG DELIV. REV., vol. 53, no. 1, 3 December 2001 (2001-12-03), pages 5 - 21, XP003000228
SUDESH K. ET AL.: "Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters", PROG. POLYM. SCI., vol. 25, no. 10, December 2000 (2000-12-01), pages 1503 - 1555, XP003000229
Download PDF:
Previous Patent: METHOD OF TRANSFERRING GENE INTO T CELLS
Next Patent: APPARATUS FOR THE PRODUCTION OF ALCOHOL
Next Patent: APPARATUS FOR THE PRODUCTION OF ALCOHOL