Title:
BIOACTIVE SUBSTANCE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/170971
Kind Code:
A1
Abstract:
A bioactive substance conjugate, a preparation method therefor and the use thereof. The present invention relates to a ligand drug conjugate, as represented by formula XV, a preparation method therefor, and the use thereof in the prevention and/or treatment of diseases related to cell activity abnormality, including, but not limited to, the use in the prevention and/or treatment of tumor diseases.
Inventors:
CAI JIAQIANG (CN)
Application Number:
PCT/CN2022/073822
Publication Date:
August 18, 2022
Filing Date:
January 25, 2022
Export Citation:
Assignee:
MEDILINK THERAPEUTICS SUZHOU CO LTD (CN)
International Classes:
A61K47/68; A61K39/00; A61P35/00; C07K16/28
Domestic Patent References:
WO2019114666A1 | 2019-06-20 | |||
WO2020219287A1 | 2020-10-29 | |||
WO2018177393A1 | 2018-10-04 | |||
WO2019195665A1 | 2019-10-10 | |||
WO2020033702A1 | 2020-02-13 | |||
WO2008066691A2 | 2008-06-05 | |||
WO2021168379A1 | 2021-08-26 | |||
WO2021027674A1 | 2021-02-18 | |||
WO2021021543A1 | 2021-02-04 | |||
WO2021006619A1 | 2021-01-14 | |||
WO2020151384A1 | 2020-07-30 | |||
WO2020140094A1 | 2020-07-02 | |||
WO2020103100A1 | 2020-05-28 | |||
WO2020102779A1 | 2020-05-22 | |||
WO2020063673A1 | 2020-04-02 | |||
WO2020047257A1 | 2020-03-05 | |||
WO2020041626A1 | 2020-02-27 | |||
WO2019225787A1 | 2019-11-28 | |||
WO2019226017A1 | 2019-11-28 | |||
WO2018209346A1 | 2018-11-15 | |||
WO2018177393A1 | 2018-10-04 | |||
WO2016106004A1 | 2016-06-30 | |||
WO2016044383A1 | 2016-03-24 | |||
WO2016033225A2 | 2016-03-03 | |||
WO2015181267A1 | 2015-12-03 | |||
WO2011109400A2 | 2011-09-09 | |||
WO2004093894A2 | 2004-11-04 | |||
WO2002010187A1 | 2002-02-07 | |||
WO2001018021A1 | 2001-03-15 |
Foreign References:
CN106163559A | 2016-11-23 | |||
CN109963870A | 2019-07-02 | |||
CN202110178136A | 2021-02-09 | |||
CN202110340806A | 2021-03-30 | |||
CN202110825932A | 2021-07-21 | |||
CN202110825922A | 2021-07-21 | |||
CN202110825906A | 2021-07-21 | |||
US10808032B2 | 2020-10-20 | |||
EP3911682A1 | 2021-11-24 | |||
CN112521512A | 2021-03-19 | |||
CN111662384A | 2020-09-15 | |||
CN111454357A | 2020-07-28 | |||
CN110684790A | 2020-01-14 | |||
CN110642948A | 2020-01-03 | |||
US20190338030A1 | 2019-11-07 | |||
CN110305213A | 2019-10-08 | |||
US9150656B2 | 2015-10-06 | |||
US20120294796A1 | 2012-11-22 | |||
CN101104639A | 2008-01-16 | |||
CN103319599A | 2013-09-25 | |||
US7560111B2 | 2009-07-14 | |||
CN103189392A | 2013-07-03 | |||
US3817837A | 1974-06-18 | |||
US3850752A | 1974-11-26 | |||
US3939350A | 1976-02-17 | |||
US3996345A | 1976-12-07 | |||
US4277437A | 1981-07-07 | |||
US4275149A | 1981-06-23 | |||
US4366241A | 1982-12-28 | |||
US4816567A | 1989-03-28 | |||
CN104755494A | 2015-07-01 | |||
CN103687945A | 2014-03-26 | |||
CN109069633A | 2018-12-21 |
Other References:
CHAPOVAL, A.I. ET AL.: "B7H3: A costimulatory molecule for T cell activation and IFN production", NATURE IMMUNOLOGY, vol. 2, no. 3, 2001, pages 269 - 274, XP002958730, DOI: 10.1038/85339
ZHAO, L. ET AL.: "Early Detection of Hepatocellular Carcinoma in Patients with Hepatocirrhosis by Soluble B7H3", JOURNAL OF GASTROINTESTINAL SURGERY, vol. 21, no. 5, pages 807 - 812, XP036214739, DOI: 10.1007/s11605-017-3386-1
MOD. PATHOL., vol. 23, no. 8, August 2010 (2010-08-01), pages 1104 - 12
J NEUROONCO, vol. 97, no. 3, 2010, pages 409 - 18
DICK, L. W. ET AL.: "100", BIOTECHNOL. BIOENG., pages 1132 - 1143
MORIMOTO ET AL., J. BIOCHEM. BIOPHYS. METHODS, vol. 24, 1992, pages 107 - 117
BRENNAN ET AL., SCIENCE, vol. 242, no. 81, 1988, pages 423 - 426
HUDSON, CURR. OPIN. IMMUNOL., vol. 11, 1999, pages 548 - 557
LITTLE ET AL., IMMUNOL. TODAY, vol. 21, 2000, pages 364 - 370
CARTER ET AL., BIO/TECHNOLOGY, vol. 10, 1992, pages 163 - 167
ACIERNO ET AL., J MOL BIOL., vol. 374, no. 1, 2007, pages 130 - 46
PROTEIN ENG., vol. 8, 1995, pages 725 - 731
MEYERSMILLER, COMPUT. APPL. BIOSCI., vol. 4, 1988, pages 11 - 17
MORRISON ET AL., PNAS, vol. 81, 1984, pages 6851 - 6855
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, pages 6444 - 6448
"Pluckthun", vol. 113, 1994, SPRINGER-VERLAG, article "The Pharmacology of Monoclonal Antibodies", pages: 269 - 315
CHOI ET AL., EUR. J. IMMUNOL., vol. 31, 2001, pages 94 - 106
HU ET AL., CANCER RES., vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL., 2001
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 329
PRESTA, CURR OP STRUCT BWL, vol. 2, 1992, pages 593 - 596
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
ANALYTICAL BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
CLACKSON ET AL., NATURE, vol. 352, pages 624 - 628
MARKS ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 222, 1991, pages 581 - 597
J. SAMBROOK ET AL.: "Molecular Cloning: Laboratory Handbook", 1989, COLD SPRING HARBOR LABORATORY PRESS
F. M. AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS, INC.
ZHAO, L. ET AL.: "Early Detection of Hepatocellular Carcinoma in Patients with Hepatocirrhosis by Soluble B7H3", JOURNAL OF GASTROINTESTINAL SURGERY, vol. 21, no. 5, pages 807 - 812, XP036214739, DOI: 10.1007/s11605-017-3386-1
MOD. PATHOL., vol. 23, no. 8, August 2010 (2010-08-01), pages 1104 - 12
J NEUROONCO, vol. 97, no. 3, 2010, pages 409 - 18
DICK, L. W. ET AL.: "100", BIOTECHNOL. BIOENG., pages 1132 - 1143
MORIMOTO ET AL., J. BIOCHEM. BIOPHYS. METHODS, vol. 24, 1992, pages 107 - 117
BRENNAN ET AL., SCIENCE, vol. 242, no. 81, 1988, pages 423 - 426
HUDSON, CURR. OPIN. IMMUNOL., vol. 11, 1999, pages 548 - 557
LITTLE ET AL., IMMUNOL. TODAY, vol. 21, 2000, pages 364 - 370
CARTER ET AL., BIO/TECHNOLOGY, vol. 10, 1992, pages 163 - 167
ACIERNO ET AL., J MOL BIOL., vol. 374, no. 1, 2007, pages 130 - 46
PROTEIN ENG., vol. 8, 1995, pages 725 - 731
MEYERSMILLER, COMPUT. APPL. BIOSCI., vol. 4, 1988, pages 11 - 17
MORRISON ET AL., PNAS, vol. 81, 1984, pages 6851 - 6855
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, pages 6444 - 6448
"Pluckthun", vol. 113, 1994, SPRINGER-VERLAG, article "The Pharmacology of Monoclonal Antibodies", pages: 269 - 315
CHOI ET AL., EUR. J. IMMUNOL., vol. 31, 2001, pages 94 - 106
HU ET AL., CANCER RES., vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL., 2001
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 329
PRESTA, CURR OP STRUCT BWL, vol. 2, 1992, pages 593 - 596
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
ANALYTICAL BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
CLACKSON ET AL., NATURE, vol. 352, pages 624 - 628
MARKS ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 222, 1991, pages 581 - 597
J. SAMBROOK ET AL.: "Molecular Cloning: Laboratory Handbook", 1989, COLD SPRING HARBOR LABORATORY PRESS
F. M. AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS, INC.
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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