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Title:
BIOCOMPATIBLE PERITONEAL DIALYSATE
Document Type and Number:
WIPO Patent Application WO/2017/213256
Kind Code:
A1
Abstract:
A biocompatible peritoneal dialysate according to the present invention is a sterilized biocompatible peritoneal dialysate composed of an acidic first solution containing icodextrin and a second solution containing a pH modifier, wherein the pH value of the biocompatible peritoneal dialysate after the mixing of the sterilized first solution with the sterilized second solution is 6.0 to 7.5.

Inventors:
NAKAMOTO Hidetomo (22-8, Hayamiya 1-chome Nerima-k, Tokyo 85, 〒1790085, JP)
OKADA Hirokazu (No. 2101, 17-9 Iidabashi 2-chome, Chiyoda-k, Tokyo 72, 〒1020072, JP)
OOMORI Shinji (1500 Inokuchi, Nakai-machi, Ashigarakami-gu, Kanagawa 51, 〒2590151, JP)
JINNOUCHI Yuri (1500 Inokuchi, Nakai-machi, Ashigarakami-gu, Kanagawa 51, 〒2590151, JP)
NISHITANI Hiroshi (1727-1 Tsuijiarai, Showa-cho, Nakakoma-gu, Yamanashi 53, 〒4093853, JP)
Application Number:
JP2017/021496
Publication Date:
December 14, 2017
Filing Date:
June 09, 2017
Export Citation:
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Assignee:
TERUMO KABUSHIKI KAISHA (44-1, Hatagaya 2-chome Shibuya-k, Tokyo 72, 〒1510072, JP)
International Classes:
A61K47/36; A61K9/08; A61K47/02; A61K47/12; A61M1/28; A61P7/08
Domestic Patent References:
2014-06-05
Foreign References:
JP2000051348A2000-02-22
JP2007524629A2007-08-30
JP2014050577A2014-03-20
Other References:
TERABAYASHI, T. ET AL.: "Vascular endothelial growth factor receptor-3 is a novel target to improve net ultrafiltration in methylglyoxal- induced peritoneal injury", LAB. INVEST., vol. 95, no. 5, 2015, pages 1029 - 1043
LEI, P. ET AL.: "Poly(ADP-ribose) polymerase-1 in high glucose-induced epithelial-mesenchymal transition during peritoneal fibrosis", INT. J. MOL. MED., vol. 29, no. 3, 2012, pages 472 - 478, XP055455366
CONTI, G. ET AL.: "Glycated adducts induce mesothelial cell transdifferentiation: role of glucose and icodextrin dialysis solutions", J. NEPHROL., vol. 21, no. 3, 2008, pages 426 - 437, XP055455376
Attorney, Agent or Firm:
MUKAIYAMA Shoichi (Room No. 502, Marunouchi Office Forum 1-30, Marunouchi 2-chome, Naka-ku, Nagoya-sh, Aichi 02, 〒4600002, JP)
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