Title:
BIOCOMPATIBLE POLYCARBONATE POLYURETHANE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/060897
Kind Code:
A1
Abstract:
The present application provides biocompatible polycarbonate polyurethane, a preparation method therefor, and use thereof. The biocompatible polycarbonate polyurethane comprises a reaction product of stereospecific polymerization of the following raw material components: (a) an isocyanate composition, (b) an isocyanate-containing reactive group component, an optional (c) hydroxyl or amino-terminated compound, (d) a chain extender, (e) a modification component, and an optional (f) cross-linking agent, wherein a polyurethane chain segment obtained by the reaction of the components (a), (b), and (d) contains an active site. The biocompatible polycarbonate polyurethane provided in the present application has relatively good biocompatibility, and a sensor prepared by using the biocompatible polycarbonate polyurethane as an outer membrane exhibits excellent performance in in vitro tests.
Inventors:
CHENG RONGEN (CN)
QIAN CHENG (CN)
LIU JIAMEI (CN)
ZHOU JING (CN)
QIAN CHENG (CN)
LIU JIAMEI (CN)
ZHOU JING (CN)
Application Number:
PCT/CN2023/113659
Publication Date:
March 28, 2024
Filing Date:
August 18, 2023
Export Citation:
Assignee:
DIASCIENCE MEDICAL CO LTD (CN)
International Classes:
C08G18/10; A61L31/10; A61L31/14; C08G18/12; C08G18/32; C08G18/44; C08G18/50; C08G18/61; C08G18/66; C08G18/76; C08G18/83
Domestic Patent References:
| WO2013030148A1 | 2013-03-07 | |||
| WO2021184843A1 | 2021-09-23 |
Foreign References:
| CN115417963A | 2022-12-02 | |||
| CN106674486A | 2017-05-17 | |||
| CN109561856A | 2019-04-02 |
Other References:
LI PEICHUANG, CAI WANHAO, LI XIN, WANG KEBING, ZHOU LEI, YOU TIANXUE, WANG RUI, CHEN HANG, ZHAO YUANCONG, WANG JIN, HUANG NAN: "Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants", REGENERATIVE BIOMATERIALS, vol. 7, no. 5, 1 October 2020 (2020-10-01), pages 491 - 504, XP093148921, ISSN: 2056-3418, DOI: 10.1093/rb/rbaa037
GAO, BIN ET AL.: "Grafting of Phosphorylcholine Functional Groups on Polycarbonate Urethane Surface for Resisting Platelet Adhesion", MATERIALS SCIENCE AND ENGINEERING C, vol. 33, no. 3, 14 March 2013 (2013-03-14), XP028584724, ISSN: 0928-4931, DOI: 10.1016/j.msec.2013.03.007
GAO, BIN ET AL.: "Grafting of Phosphorylcholine Functional Groups on Polycarbonate Urethane Surface for Resisting Platelet Adhesion", MATERIALS SCIENCE AND ENGINEERING C, vol. 33, no. 3, 14 March 2013 (2013-03-14), XP028584724, ISSN: 0928-4931, DOI: 10.1016/j.msec.2013.03.007
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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