Title:
BIODEGRADABLE COMPOUND, LIPID PARTICLE, LIPID PARTICLE-CONTAINING COMPOSITION, AND KIT
Document Type and Number:
WIPO Patent Application WO/2019/176079
Kind Code:
A1
Abstract:
[Problem] To provide a biodegradable compound that has a structure degraded in cells, a lipid particle comprising the biodegradable compound and a medicinal composition containing the lipid particle. [Solution] According to one embodiment, provided is a compound which is represented by formula (1): P-[X-R-Y-R'-Q]2 (1) (wherein: P represents an alkylene oxide having an ether bond; X represents a divalent linking group having a tertiary amine structure; R represents a divalent linking group; R' represents a single bond or a C1-C6 alkylene; and Q represents a fat-soluble vitamin residue, a sterol residue or a C12-C22 aliphatic hydrocarbon group) and characterized by containing at least one biodegradable group in the structure thereof. This compound can be blended with another lipid or a lipid capable of inhibiting aggregation so as to give a lipid particle. Moreover, this lipid particle is applicable to a medicinal composition for delivering an active agent to cells.
More Like This:
| WO2004110364 | THIOTUNGSTATE ANALOGUES AND USES THEREOF |
| JP2013530164 | Fourth dialkanolamine ester |
Inventors:
ISHIHARA MITSUKO (JP)
AKAHOSHI EIICHI (JP)
NAITO KATSUYUKI (JP)
AKAHOSHI EIICHI (JP)
NAITO KATSUYUKI (JP)
Application Number:
PCT/JP2018/010376
Publication Date:
September 19, 2019
Filing Date:
March 16, 2018
Export Citation:
Assignee:
TOSHIBA KK (JP)
International Classes:
C07C219/06; A61K48/00; C07C219/08; C07C219/10; C07C235/10; C07C327/30; C07C327/36; C07D207/08; C07J41/00; C12N15/00
Domestic Patent References:
| WO2017100744A1 | 2017-06-15 | |||
| WO2013073480A1 | 2013-05-23 | |||
| WO2000012454A1 | 2000-03-09 | |||
| WO2017201349A1 | 2017-11-23 |
Foreign References:
| JP2002529439A | 2002-09-10 | |||
| DE3231403A1 | 1983-03-10 | |||
| US4218234A | 1980-08-19 | |||
| JP2007197855A | 2007-08-09 | |||
| JP2012508235A | 2012-04-05 | |||
| JP6093710B2 | 2017-03-08 | |||
| US6320017B1 | 2001-11-20 | |||
| US5820873A | 1998-10-13 | |||
| US5534499A | 1996-07-09 | |||
| US5885613A | 1999-03-23 | |||
| JP3920330B2 | 2007-05-30 |
Other References:
ZHOU, KEJIN ET AL.: "Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 113, no. 3, 2016, pages 520 - 525, XP055636373, ISSN: 0027-8424
KUMAR, PRABHAT ET AL.: "In-plane modulated smectic A vs smectic 'A' lamellar structures in poly(ethyl or propyl ether imine) dendrimers", POLYMER, vol. 86, 2016, pages 98 - 104, XP029438171, ISSN: 0032-3861, doi:10.1016/j.polymer.2016.01.043
See also references of EP 3792246A4
KUMAR, PRABHAT ET AL.: "In-plane modulated smectic A vs smectic 'A' lamellar structures in poly(ethyl or propyl ether imine) dendrimers", POLYMER, vol. 86, 2016, pages 98 - 104, XP029438171, ISSN: 0032-3861, doi:10.1016/j.polymer.2016.01.043
See also references of EP 3792246A4
Attorney, Agent or Firm:
NAGAI Hiroshi et al. (JP)
Download PDF:
Previous Patent: MANUFACTURING METHOD AND MANUFACTURING DEVICE FOR TRANSPARENT ELECTRODE
Next Patent: FRAUD DETECTION SYSTEM AND FRAUD DETECTION DEVICE
Next Patent: FRAUD DETECTION SYSTEM AND FRAUD DETECTION DEVICE