Title:
BIODEGRADABLE COVALENT MATRICES FOR THE ORAL DELIVERY OF INSULIN DIRECTED TO THE COLON, ACTIVATED BY MICROBIOTA, AND PRODUCTION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/105212
Kind Code:
A3
Abstract:
The present invention describes a covalent biomaterial which is formed by gelling feruloylated arabinoxylans that are biodegradable and which can be used for the oral administration of insulin directed to the colon. The present invention also relates to a method for producing enzymatically covalently crosslinked particles. The aforementioned pharmaceutical composition is suitable for use in the biomedical or pharmaceutical industry as a non-invasive treatment for the oral administration of insulin or insulin analogs for patients with type 1 diabetes.
Inventors:
MARTÍNEZ-LÓPEZ ANA LUISA (MX)
CARVAJAL-MILLÁN ELIZABETH (MX)
SOTELO-CRUZ NORBERTO (MX)
MICARD VALERIE (FR)
RASCÓN CHU AGUSTÍN (MX)
PRAKASH SATYA (CA)
LIZARDI-MENDOZA JAIME (MX)
LÓPEZ-FRANCO YOLANDA LETICIA (MX)
CANETT-ROMERO RAFAEL (MX)
TOLEDO-GUILLÉN ALMA ROSA (MX)
CARVAJAL-MILLÁN ELIZABETH (MX)
SOTELO-CRUZ NORBERTO (MX)
MICARD VALERIE (FR)
RASCÓN CHU AGUSTÍN (MX)
PRAKASH SATYA (CA)
LIZARDI-MENDOZA JAIME (MX)
LÓPEZ-FRANCO YOLANDA LETICIA (MX)
CANETT-ROMERO RAFAEL (MX)
TOLEDO-GUILLÉN ALMA ROSA (MX)
Application Number:
PCT/MX2016/000170
Publication Date:
November 09, 2017
Filing Date:
December 19, 2016
Export Citation:
Assignee:
CENTRO DE INVESTIGACIÓN EN ALIMENTACIÓN Y DESARROLLO A C (MX)
MARTÍNEZ-LÓPEZ ANA LUISA (MX)
CARVAJAL-MILLÁN ELIZABETH (MX)
SOTELO-CRUZ NORBERTO (MX)
MICARD VALERIE (FR)
RASCÓN CHU AGUSTÍN (MX)
PRAKASH SATYA (CA)
LIZARDI-MENDOZA JAIME (MX)
LÓPEZ-FRANCO YOLANDA LETICIA (MX)
CANETT-ROMERO RAFAEL (MX)
TOLEDO-GUILLÉN ALMA ROSA (MX)
MARTÍNEZ-LÓPEZ ANA LUISA (MX)
CARVAJAL-MILLÁN ELIZABETH (MX)
SOTELO-CRUZ NORBERTO (MX)
MICARD VALERIE (FR)
RASCÓN CHU AGUSTÍN (MX)
PRAKASH SATYA (CA)
LIZARDI-MENDOZA JAIME (MX)
LÓPEZ-FRANCO YOLANDA LETICIA (MX)
CANETT-ROMERO RAFAEL (MX)
TOLEDO-GUILLÉN ALMA ROSA (MX)
International Classes:
A61K9/62; A61K9/51; A61K31/175; C07H13/08; C12N9/02; C12N9/08
Domestic Patent References:
| WO2001049320A2 | 2001-07-12 |
Other References:
BERLANGA-REYES, CLAUDIA M. ET AL.: "Maize arabinoxilan gels as protein delivery matrices", MOLECULES, vol. 14, no. 4, 8 April 2009 (2009-04-08), pages 1475 - 1482, XP055437409, Retrieved from the Internet [retrieved on 20171207]
GUEVARA-BRETON, N. A. ET AL.: "encapsulación: técnicas and aplicaciones in the industria alimentaria", TEMAS SELECTOS OF INGENIERÍA OF ALIMENTOS, vol. 2, 2008, pages 36 - 49, XP055437412, [retrieved on 20171207]
NINO-MEDINA GUILLERMO ET AL.: "Feruloylated arabinoxylans and arabinoxylan gels: structure, sources and applications", PHYTOCHEMISTRY REVIEWS MAR 2010, vol. 9, no. 1, 28 February 2010 (2010-02-28), pages 111 - 120, XP019794059, ISSN: 1568-7767
KUMAR VIKAS ET AL.: "Dietary Roles of Non-Starch Polysachharides in Human Nutrition: A Review", CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, vol. 52, no. 10, October 2011 (2011-10-01), pages 899 - 935, XP055437415, ISSN: 1040-8398
MOZHAEV, VADIM V. ET AL.: "Catalytic activity and denaturation of enzymes in waterlorganic cosolvent mixtures", EUR. J. BIOCHEM., vol. 184, February 1989 (1989-02-01), pages 597 - 602, XP055437419
GUEVARA-BRETON, N. A. ET AL.: "encapsulación: técnicas and aplicaciones in the industria alimentaria", TEMAS SELECTOS OF INGENIERÍA OF ALIMENTOS, vol. 2, 2008, pages 36 - 49, XP055437412, [retrieved on 20171207]
NINO-MEDINA GUILLERMO ET AL.: "Feruloylated arabinoxylans and arabinoxylan gels: structure, sources and applications", PHYTOCHEMISTRY REVIEWS MAR 2010, vol. 9, no. 1, 28 February 2010 (2010-02-28), pages 111 - 120, XP019794059, ISSN: 1568-7767
KUMAR VIKAS ET AL.: "Dietary Roles of Non-Starch Polysachharides in Human Nutrition: A Review", CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, vol. 52, no. 10, October 2011 (2011-10-01), pages 899 - 935, XP055437415, ISSN: 1040-8398
MOZHAEV, VADIM V. ET AL.: "Catalytic activity and denaturation of enzymes in waterlorganic cosolvent mixtures", EUR. J. BIOCHEM., vol. 184, February 1989 (1989-02-01), pages 597 - 602, XP055437419
Attorney, Agent or Firm:
PÉREZ-ARELLANO, Raymundo (MX)
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