Title:
BIODEGRADABLE INVERTED-OPAL STRUCTURE, METHOD FOR PRODUCTION OF THE SAME, USE OF THE SAME, AND MEDICAL IMPLANT COMPRISING THE SAME
Document Type and Number:
WIPO Patent Application WO/2007/086306
Kind Code:
A1
Abstract:
[PROBLEMS] To provide: an inverted-opal structure which is excellent in biodegradability, biocompatibility and pH-responsibility, has specific light-reflective properties due to three-dimensionally ordered voids formed therein, can response to the change in pH rapidly to release a substance autonomously and intermittently, and can be determined on its release of a substance in accordance with the biodegradation thereof by an optical means rapidly in a simple manner; a method for production of the inverted-opal structure; a medical implant comprising the inverted-opal structure; a method for enlarging the diameter of a void in the inverted-opal structure; and, regarding a substance carried on the inverted-opal structure, a method for determining the amount of the substance released from the inverted-opal structure. [MEANS FOR SOLVING PROBLEMS] Disclosed is a biodegradable inverted-opal structure which comprising an aliphatic polyester. Also disclosed is a method for production of the biodegradable inverted-opal structure, wherein the method comprises the steps of: (1) producing a colloidal crystal from a silica particle or a polystyrene particle; (2) immersing the colloidal crystal in a solution of a monomer constituting the aliphatic polyester; (3) thermally polymerizing the monomer under pressurized conditions to form a composition of the colloidal crystal coated with the aliphatic polyester; and (4) removing the silica particle from the composition by etching or removing the polystyrene particle from the composition by causing the polystyrene particle to be dissolved into an organic solvent, thereby producing the biodegradable inverted-opal structure.
Inventors:
FUJISHIMA MUSASHI (JP)
UCHIDA KUMAO (JP)
UCHIDA KUMAO (JP)
Application Number:
PCT/JP2007/050722
Publication Date:
August 02, 2007
Filing Date:
January 18, 2007
Export Citation:
Assignee:
UNIV KINKI (JP)
FUJISHIMA MUSASHI (JP)
UCHIDA KUMAO (JP)
FUJISHIMA MUSASHI (JP)
UCHIDA KUMAO (JP)
International Classes:
C08J9/26; A61K47/34; A61L27/00; B01J13/00; C08J9/36; C08K3/36; C08L67/00; C08L101/16
Foreign References:
| JPS618107A | 1986-01-14 | |||
| JP2004168895A | 2004-06-17 | |||
| JP2004027195A | 2004-01-29 | |||
| JP2006501124A | 2006-01-12 | |||
| JP2004170447A | 2004-06-17 |
Attorney, Agent or Firm:
KIYOHARA, Yoshihiro (Kita-ku Osaka-shi, Osaka04, JP)
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