Title:
BIODEGRADABLE MICROBEADS COMPRISING DEXTRAN METHACRYLATE AND BIOCOMPATIBLE ANIONIC POLYMER, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2014/116043
Kind Code:
A1
Abstract:
The present invention provides biodegradable microbeads for transarterial chemoembolization, a preparation method therefor, and a method for treating cancer by using the same. The microbeads of the present invention are made from a biocompatible and biodegradable polymer, and are thus safe when being applied to the human body, and can effectively inhibit the growth of tumors by effectively blocking a blood vessel supplying nutrients to liver tumors and continuously releasing an anticancer drug adsorbed on the surface of the beads. Therefore, the present invention can be useful for the chemoembolization of liver cancer.
Inventors:
LEE DON HAENG (KR)
YANG SU-GEUN (KR)
LI YIXIAN (KR)
YANG SU-GEUN (KR)
LI YIXIAN (KR)
Application Number:
PCT/KR2014/000678
Publication Date:
July 31, 2014
Filing Date:
January 23, 2014
Export Citation:
Assignee:
UTAH INHA DDS & ADVANCED THERAPEUTICSRES CT (KR)
International Classes:
A61K9/16; A61K47/30; A61K47/36; A61K47/48
Foreign References:
| US20120269722A1 | 2012-10-25 | |||
| US20020192289A1 | 2002-12-19 | |||
| US20110020427A1 | 2011-01-27 | |||
| KR20110106440A | 2011-09-28 |
Other References:
LIMA, A. C. ET AL.: "Synthesis of temperature-responsive dextran-MA/PNIPAAm particles for controlled drug delivery using superhydrophobic surfaces", PHARMACEUTICAL RESEARCH, vol. 28, 2011, pages 1294 - 1305
GADALETA, C. D. ET AL.: "Trans-arterial chemoembolization as a therapy for liver tumours: New clinical developments and suggestions for combination with angiogenesis inhibitors", CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY, vol. 80, 2011, pages 40 - 53
GADALETA, C. D. ET AL.: "Trans-arterial chemoembolization as a therapy for liver tumours: New clinical developments and suggestions for combination with angiogenesis inhibitors", CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY, vol. 80, 2011, pages 40 - 53
Attorney, Agent or Firm:
YANG, Boo-Hyun (Chungdong Building1922, Nambusunhwan-r, Gwanak-gu Seoul 151-832, KR)
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