Title:
BIOINTERFACE WITH MACRO- AND MICRO- ARCHITECTURE
Document Type and Number:
WIPO Patent Application WO2005079257
Kind Code:
A3
Abstract:
Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture.The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the foreign body capsule. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.
Inventors:
CARR-BRENDEL VICTORIA (US)
SIMPSON PETER C (US)
BRAUKER JAMES H (US)
SIMPSON PETER C (US)
BRAUKER JAMES H (US)
Application Number:
PCT/US2005/004058
Publication Date:
June 08, 2006
Filing Date:
February 09, 2005
Export Citation:
Assignee:
DEXCOM INC (US)
CARR-BRENDEL VICTORIA (US)
SIMPSON PETER C (US)
BRAUKER JAMES H (US)
CARR-BRENDEL VICTORIA (US)
SIMPSON PETER C (US)
BRAUKER JAMES H (US)
International Classes:
A61F2/00; A61F13/00; A61L31/10; A61L31/14; A61L31/16
Foreign References:
| US6702857B2 | 2004-03-09 | |||
| US5741330A | 1998-04-21 | |||
| US6442413B1 | 2002-08-27 | |||
| US6001067A | 1999-12-14 | |||
| US5458631A | 1995-10-17 | |||
| US5964745A | 1999-10-12 |
Other References:
BRAUKER J.H. ET AL: "Neovascularization of synthetic membranes directed by membrane architecture.", JOURNAL OF BIOMATERIALS, vol. 29, 1995, pages 1517 - 1524, XP002997412
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