Title:
BIOLOGIC FEMALE CONTRACEPTIVES
Document Type and Number:
WIPO Patent Application WO/2011/138776
Kind Code:
A3
Abstract:
This invention provides, inter alia, commensal organisms engineered to express antibody fragments, which inhibit sperm motility or fertilization and compositions comprising the same. The present invention provides for the use of the engineered commensal organisms or compositions comprising the same as effective contraceptive means in females.
Inventors:
TEITELBAUM RACHEL (IL)
Application Number:
PCT/IL2011/000352
Publication Date:
March 29, 2012
Filing Date:
May 04, 2011
Export Citation:
Assignee:
HERVANA LTD (IL)
TEITELBAUM RACHEL (IL)
TEITELBAUM RACHEL (IL)
International Classes:
A61K39/00; A61K39/395
Foreign References:
| US20050003510A1 | 2005-01-06 | |||
| US20100074908A1 | 2010-03-25 |
Other References:
NAZ.: "Development of genetically engineered human sperm immunocontraceptives.", J REPROD IMMUNOL., vol. 83, no. 1-2, 2009, pages 145 - 150
LEFEVRE ET AL.: "Characterization and isolation of SOB2, a human sperm protein with a potential role in oocyte membrane binding.", MOL HUM REPROD., vol. 3, no. 6, 1997, pages 507 - 516
ZHU ET AL.: "Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects.", PROC NATL ACAD SCI U S A, vol. 94, no. 9, 1997, pages 4704 - 4709
MENGE ET AL.: "Characterization of monoclonal antibodies against human sperm antigens by immunoassays including sperm function assays and epitope evaluation.", AM J REPROD IMMUNOL MICROBIOL., vol. 13, no. 4, 1987, pages 108 - 114
LEFEVRE ET AL.: "Characterization and isolation of SOB2, a human sperm protein with a potential role in oocyte membrane binding.", MOL HUM REPROD., vol. 3, no. 6, 1997, pages 507 - 516
ZHU ET AL.: "Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects.", PROC NATL ACAD SCI U S A, vol. 94, no. 9, 1997, pages 4704 - 4709
MENGE ET AL.: "Characterization of monoclonal antibodies against human sperm antigens by immunoassays including sperm function assays and epitope evaluation.", AM J REPROD IMMUNOL MICROBIOL., vol. 13, no. 4, 1987, pages 108 - 114
Attorney, Agent or Firm:
WOLFF BREGMAN AND GOLLER (Jerusalem, IL)
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