Title:
BIOLOGICAL ASSEMBLY METHOD FOR FARADAY WAVE MULTI-WAVELENGTH SYNTHESIS AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2023/005676
Kind Code:
A1
Abstract:
Provided are a biological assembly method for Faraday wave multi-wavelength synthesis and an application. The present method has the advantages that a system is easy to build, manipulation is simple, patterns are dynamically adjustable, biocompatibility is good, etc. The present method is different from a cell manipulation principle under a single wavelength condition in an existing acoustic biological assembly method; sine or cosine signals having different wavelengths are synthesized, so that a single-wavelength assembly mode in a conventional Faraday wave frequency domain is improved into a multi-wavelength assembly mode, complex and arbitrary pattern arrangement of liquid-bottom multi-scale cells is achieved, and thus the method is more suitable for the requirement for complex arrangement of cells in tissue engineering and biological manufacturing, and has huge application prospects and commercial value.
Inventors:
CHEN PU (CN)
GU LONGJUN (CN)
ZHENG LIXIN (CN)
WANG HENG (CN)
ZHOU JINSHENG (CN)
GU LONGJUN (CN)
ZHENG LIXIN (CN)
WANG HENG (CN)
ZHOU JINSHENG (CN)
Application Number:
PCT/CN2022/105626
Publication Date:
February 02, 2023
Filing Date:
July 14, 2022
Export Citation:
Assignee:
SHENZHEN CONVERGENCE BIO MFG CO LTD (CN)
International Classes:
C12N13/00; C12N5/00; C12N5/09
Domestic Patent References:
| WO2016069493A2 | 2016-05-06 | |||
| WO2019038453A1 | 2019-02-28 |
Foreign References:
| CN113604463A | 2021-11-05 | |||
| US20160145566A1 | 2016-05-26 |
Other References:
CHEN PU, SINAN GÜVEN, OSMAN BERK USTA, MARTIN L. YARMUSH, UTKAN DEMIRCI: "Biotunable Acoustic Node Assembly of Organoids", ADVANCED HEALTHCARE MATERIALS, vol. 4, no. 13, 7 July 2015 (2015-07-07), pages 1937 - 1943, XP093029597, DOI: 10.1002/adhm.201500279
SERPOOSHAN, V. ET AL.: "Bioacoustic-enabled patterning of human iPSC-derived cardiomyocytes into 3D cardiac tissue", BIOMATERIALS, vol. 131, 28 March 2017 (2017-03-28), XP029991664, DOI: 10.1016/j.biomaterials.2017.03.037
GUEX A.G., DI MARZIO N., EGLIN D., ALINI M., SERRA T.: "The waves that make the pattern: a review on acoustic manipulation in biomedical research", MATERIALS TODAY BIO, vol. 10, 1 March 2021 (2021-03-01), pages 100110, XP093029599, ISSN: 2590-0064, DOI: 10.1016/j.mtbio.2021.100110
SHAO X., BEVILACQUA G., CIARLETTA P., SAYLOR J. R., BOSTWICK J. B.: "Experimental observation of Faraday waves in soft gels", PHYSICAL REVIEW E, vol. 102, no. 6, 1 December 2020 (2020-12-01), XP093029602, ISSN: 2470-0045, DOI: 10.1103/PhysRevE.102.060602
SERPOOSHAN, V. ET AL.: "Bioacoustic-enabled patterning of human iPSC-derived cardiomyocytes into 3D cardiac tissue", BIOMATERIALS, vol. 131, 28 March 2017 (2017-03-28), XP029991664, DOI: 10.1016/j.biomaterials.2017.03.037
GUEX A.G., DI MARZIO N., EGLIN D., ALINI M., SERRA T.: "The waves that make the pattern: a review on acoustic manipulation in biomedical research", MATERIALS TODAY BIO, vol. 10, 1 March 2021 (2021-03-01), pages 100110, XP093029599, ISSN: 2590-0064, DOI: 10.1016/j.mtbio.2021.100110
SHAO X., BEVILACQUA G., CIARLETTA P., SAYLOR J. R., BOSTWICK J. B.: "Experimental observation of Faraday waves in soft gels", PHYSICAL REVIEW E, vol. 102, no. 6, 1 December 2020 (2020-12-01), XP093029602, ISSN: 2470-0045, DOI: 10.1103/PhysRevE.102.060602
Attorney, Agent or Firm:
WUHAN KEHAO INTELLECTUAL PROPERTY ATTORNEYS(SPECIAL GENERAL PARTNERSHIP) (CN)
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