BIOLOGICAL HEART VALVE WITH BOTH ANTICOAGULATION AND ANTI-CALCIFICATION PROPERTIES, AND PREPARATION METHOD THEREFOR

Title:

BIOLOGICAL HEART VALVE WITH BOTH ANTICOAGULATION AND ANTI-CALCIFICATION PROPERTIES, AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2021/239080

Kind Code:

A1

Abstract:

Disclosed are a biological heart valve with both anticoagulation and anti-calcification properties, and a preparation method therefor. The specific process of the method comprises: using glutaraldehyde to conduct a cross-linking treatment on a biological heart valve, and using functional molecules containing amine groups to conduct a functional modification treatment on the biological heart valve at least once before and/or after the cross-linking treatment, such that the functional molecules are fixed onto the biological heart valve in a chemically grafted manner so as to obtain a biological heart valve with both anticoagulation and anti-calcification functions. The biological heart valve prepared from the present invention not only has good mechanical properties, but also has excellent anticoagulation and anti-calcification effects.

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Inventors:

WANG YUNBING (CN)
LI GAOCAN (CN)
YANG LI (CN)

Application Number:

PCT/CN2021/096560

Publication Date:

December 02, 2021

Filing Date:

May 27, 2021

Export Citation:

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Assignee:

VENUS MEDTECH HANGZHOU INC (CN)

International Classes:

A61L27/36; A61F2/24; A61L27/50; A61L33/04; A61L33/06; A61L33/10; A61L33/12

Domestic Patent References:

WO1988001155A1

1988-02-25

Foreign References:

CN111569152A	2020-08-25
CN109172867A	2019-01-11
CN103705980A	2014-04-09
CN1961971A	2007-05-16
CN101947147A	2011-01-19
KR20160028253A	2016-03-11

Attorney, Agent or Firm:

SHINY INTELLECTUAL PROPERTY FIRM (CN)

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