Title:
BIOLOGICAL LOW-MOLECULAR WEIGHT DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2004/024686
Kind Code:
A1
Abstract:
It is pointed out that the existing crosslinking agents and condensing agents having been employed in biological adhesives and in treating medical devices such as cardiac valves, which are non-natural products synthesized artificially, are not metabolized in vivo and exhibit toxicity to living bodies. Therefore, these products can be used only in a restricted amount and for limited purposes in the clinical field. It is intended to provide biological low-molecular weight derivatives obtained by modifying a carboxyl group of a biological low-molecular weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide or derivatives thereof and crosslinked high-molecular weight compounds obtained by crosslinking various high-molecular weight compounds with the use of the above derivative.
Inventors:
TAGUCHI TETSUSHI (JP)
KOBAYASHI NAOTOSHI (JP)
TANAKA JUNZO (JP)
SAITO HIROSHI (JP)
KOBAYASHI NAOTOSHI (JP)
TANAKA JUNZO (JP)
SAITO HIROSHI (JP)
Application Number:
PCT/JP2003/011669
Publication Date:
March 25, 2004
Filing Date:
September 11, 2003
Export Citation:
Assignee:
NAT INST FOR MATERIALS SCIENCE (JP)
FURUUCHI CHEMICAL CORP (JP)
TAGUCHI TETSUSHI (JP)
KOBAYASHI NAOTOSHI (JP)
TANAKA JUNZO (JP)
SAITO HIROSHI (JP)
FURUUCHI CHEMICAL CORP (JP)
TAGUCHI TETSUSHI (JP)
KOBAYASHI NAOTOSHI (JP)
TANAKA JUNZO (JP)
SAITO HIROSHI (JP)
International Classes:
A61L24/00; A61L27/00; C07C233/03; C07C235/06; C07D285/00; C07C235/80; C07D207/02; C07D207/408; C07D207/46; C08H1/00; (IPC1-7): C07D207/46; C08J3/24
Domestic Patent References:
| WO2001091814A2 | 2001-12-06 |
Foreign References:
| JPS6169759A | 1986-04-10 |
Other References:
SAKAMOTO TAKESHI; LI HAO; KIKUGAWA YASUO: "A total synthesis of nannochelin A. A short route to optically active N. omega.-hydroxy-.alpha.-amino acid derivatives", CHEMISTRY, vol. 61, no. 24, 1996, pages 8496 - 8499, XP002973803
Attorney, Agent or Firm:
Nishi, Yoshiyuki (Suite 211 26-32, Nakahara 4-chome, Isogo-k, Yokohama-shi Kanagawa, JP)
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