Title:
BIOLOGICAL MACROMOLECULAR TARGET-SPECIFIC COMPLEMENT INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/228052
Kind Code:
A1
Abstract:
A fusion protein of a biological macromolecular target-specific complement inhibitor comprising (i) a CRIg extracellular domain, (ii) a complement inhibiting domain, and (iii) a synergetic domain, a preparation method therefor and a use thereof, and a pharmaceutical composition comprising the fusion protein. The fusion protein not only has an obvious targeted complement inhibiting effect, but also facilitates improving druggability and/or production, and thus can be used for treating and preventing a plurality of human diseases related to abnormal complement activation.
Inventors:
HU WEIGUO (CN)
Application Number:
PCT/CN2021/092861
Publication Date:
November 18, 2021
Filing Date:
May 10, 2021
Export Citation:
Assignee:
SHANGHAI COMGEN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K19/00; C12N15/62
Foreign References:
| CN104231085A | 2014-12-24 | |||
| CN103349777A | 2013-10-16 | |||
| CN2021092861W | 2021-05-10 | |||
| CN202010393721A | 2020-05-11 |
Other References:
YU SHI, WEN YAO , LI SUN , GUOMIN LI , HAIMEI LIU , PEIPEI DING , WEIGUO HU , HONG XU: "The new complement inhibitor CRIg/FH ameliorates lupus nephritis in lupus-prone MRL/lpr mice", BMC NEPHROLOGY, vol. 20, no. 1, 42, 1 December 2019 (2019-12-01), pages 1 - 8, XP055866407, DOI: 10.1186/s12882-019-1599-0
MORGAN B PAUL; HARRIS CLAIRE L: "Complement, a target for therapy in inflammatory and degenerative diseases", NATURE REVIEWS DRUG DISCOVERY, vol. 14, no. 12, 23 October 2015 (2015-10-23), pages 857 - 877, XP037075472, DOI: 10.1038/nrd4657
WAGNER ERIC; FRANK MICHAEL M: "Therapeutic potential of complement modulation", NATURE REVIEWS DRUG DISCOVERY, vol. 9, no. 1, 4 December 2009 (2009-12-04), pages 43 - 56, XP037115017, ISSN: 1474-1776, DOI: 10.1038/nrd3011
XU HUAN;ZHOU MEI-LING;GE LIN;WANG ZHI-MING: "The Application of Human Serum Albumin in Protein and Peptide Drugs Half-life Extension", CHINA BIOTECHNOLOGY, vol. 39, no. 1, 31 December 2019 (2019-12-31), pages 82 - 89, XP009531762, DOI: 10.13523/j.cb.20190111
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
AUSUBE ET AL.: "Current Protocols in Molecular Biology", 1993, GREENE PUBLISHING AND WILEY-INTERSCIENCE
QIAO Q. ET AL.: "A novel CRIg-targeted complement inhibitor protects cells from complement damage", FASEB J., vol. 28, no. 11, November 2014 (2014-11-01), pages 4986 - 99
MORGAN B PAUL; HARRIS CLAIRE L: "Complement, a target for therapy in inflammatory and degenerative diseases", NATURE REVIEWS DRUG DISCOVERY, vol. 14, no. 12, 23 October 2015 (2015-10-23), pages 857 - 877, XP037075472, DOI: 10.1038/nrd4657
WAGNER ERIC; FRANK MICHAEL M: "Therapeutic potential of complement modulation", NATURE REVIEWS DRUG DISCOVERY, vol. 9, no. 1, 4 December 2009 (2009-12-04), pages 43 - 56, XP037115017, ISSN: 1474-1776, DOI: 10.1038/nrd3011
XU HUAN;ZHOU MEI-LING;GE LIN;WANG ZHI-MING: "The Application of Human Serum Albumin in Protein and Peptide Drugs Half-life Extension", CHINA BIOTECHNOLOGY, vol. 39, no. 1, 31 December 2019 (2019-12-31), pages 82 - 89, XP009531762, DOI: 10.13523/j.cb.20190111
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
AUSUBE ET AL.: "Current Protocols in Molecular Biology", 1993, GREENE PUBLISHING AND WILEY-INTERSCIENCE
QIAO Q. ET AL.: "A novel CRIg-targeted complement inhibitor protects cells from complement damage", FASEB J., vol. 28, no. 11, November 2014 (2014-11-01), pages 4986 - 99
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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