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Title:
BIOLOGICAL ORTHOGONAL REAGENT, ACTIVATOR AND PRECURSOR, AND BIOLOGICAL ORTHOGONAL REAGENT KIT
Document Type and Number:
WIPO Patent Application WO/2016/149899
Kind Code:
A1
Abstract:
Disclosed are a biological orthogonal precursor, a biological orthogonal reagent, a biological orthogonal activator, and a biological orthogonal reagent kit used for a biomarker. The biological orthogonal precursor of the present invention contains a hydroxylamine functional group that at least has multiple functions, can be used as a positioning group in a coupling reaction, and is used as a biological orthogonal group. The biological orthogonal reagent kit of the present invention comprises the biological orthogonal reagent comprising a second biological orthogonal group, of the present invention, or comprises a biological orthogonal activator capable of directly or indirectly generating a first biological orthogonal group, of the present invention.

Inventors:
HONG, Mei (University Town, Lishui Road Xili Town, Nanshan Distric, Shenzhen Guangdong 5, 518055, CN)
ZHAO, Jing (University Town, Lishui Road Xili Town, Nanshan Distric, Shenzhen Guangdong 5, 518055, CN)
DUAN, Pingping (University Town, Lishui Road Xili Town, Nanshan Distric, Shenzhen Guangdong 5, 518055, CN)
CHEN, Ying (University Town, Lishui Road Xili Town, Nanshan Distric, Shenzhen Guangdong 5, 518055, CN)
CHEN, Bo (University Town, Lishui Road Xili Town, Nanshan Distric, Shenzhen Guangdong 5, 518055, CN)
Application Number:
CN2015/074897
Publication Date:
September 29, 2016
Filing Date:
March 23, 2015
Export Citation:
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Assignee:
PEKING UNIVERSITY SHENZHEN GRADUATE SCHOOL (University Town, Lishui Road Xili Town, Nanshan Distric, Shenzhen Guangdong 5, 518055, CN)
International Classes:
A61K47/48
Domestic Patent References:
WO2003063797A22003-08-07
Foreign References:
CN104262283A2015-01-07
Other References:
FENG, TIAN ET AL.: "A General Approach to Site-Specific Antibody Drug Conjugates", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAN, vol. 111, no. 5, 4 February 2014 (2014-02-04), XP055122307, ISSN: 1091-6490
HOWARD, C.H. ET AL.: "Ketone Isosteres of 2-N-Acetamidosugars as Substrates for Metabolic Cell Surface Engineering", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 123, no. 6, 20 January 2001 (2001-01-20), pages 1242 - 1243, XP008055622, ISSN: 0002-7863
WANG, YUE ET AL.: "Rapid Site-Specific Protein Labeling Based on Diels-Alder Bioorthogonal Reactions", ACTA CHIMICA SINICA, vol. 70, no. 21, 31 December 2012 (2012-12-31), pages 2208 - 2212, XP055315426, ISSN: 0567-7351
ANOUK, D. ET AL.: "Nucleophilic Catalysis of Hydrazone Formation and Transimination: Implications for Dynamic Covalent Chemistry", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, 18 November 2006 (2006-11-18), pages 15602 - 15603, XP055011780, ISSN: 0002-7863
Attorney, Agent or Firm:
SHENZHEN ZHONGYI PATENT AND TRADEMARK OFFICE (4th FL. West, Old Special Zone Newspaper BuildingNo. 1014, Shennan Rd., C., Futia, Shenzhen Guangdong 8, 518028, CN)
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