Title:
BIOLOGICALLY-ACTIVE DNA-BINDING SITES AND RELATED METHODS
Document Type and Number:
WIPO Patent Application WO2005088306
Kind Code:
A3
Abstract:
The invention relates to the identification of biologically-active DNA-binding sites to which a protein of interest binds in a cell. The invention also relates to the identification of agents and conditions which alter the biologically-active DNA-binding sites to which a protein binds. One aspect of the invention also provides methods for identifying pathways that are regulated by transcriptional regulators and for modulating the activity of the pathways.
Inventors:
HARBISON CHRISTOPHER (US)
YOUNG RICHARD A (US)
GORDON DAVID B (US)
FRAENKEL ERNEST (US)
YOUNG RICHARD A (US)
GORDON DAVID B (US)
FRAENKEL ERNEST (US)
Application Number:
PCT/US2005/007249
Publication Date:
November 03, 2005
Filing Date:
March 03, 2005
Export Citation:
Assignee:
WHITEHEAD BIOMEDICAL INST (US)
HARBISON CHRISTOPHER (US)
YOUNG RICHARD A (US)
GORDON DAVID B (US)
FRAENKEL ERNEST (US)
HARBISON CHRISTOPHER (US)
YOUNG RICHARD A (US)
GORDON DAVID B (US)
FRAENKEL ERNEST (US)
International Classes:
C12Q1/68; G01N33/53; (IPC1-7): C12Q1/68; G01N33/53
Domestic Patent References:
| WO2005054461A2 | 2005-06-16 | |||
| WO2004097577A2 | 2004-11-11 | |||
| WO2004087965A2 | 2004-10-14 | |||
| WO2004053106A2 | 2004-06-24 | |||
| WO2002014550A2 | 2002-02-21 | |||
| WO2001016378A2 | 2001-03-08 |
Foreign References:
| US6109776A | 2000-08-29 |
Other References:
MUKHERJEE ET AL: "Rapid analysis of the DNA binding specificities of transcription factors with DNA microarrays.", NATURE GENETICS, vol. 36, no. 12, December 2004 (2004-12-01), pages 1331 - 1339, XP002342489
ODOM D T ET AL: "CONTROL OF PANCREAS AND LIVER GENE EXPRESSION BY HNF TRANSCRIPTION FACTORS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 303, no. 5662, 27 February 2004 (2004-02-27), pages 1378 - 1381, XP001205726, ISSN: 0036-8075
BAR JOSEPH ET AL: "Computational discovery of gene modules and regulatory networks", NATURE BIOTECHNOLOGY, vol. 21, no. 11, November 2003 (2003-11-01), pages 1337 - 1342, XP002342488
LEE T I ET AL: "Transcriptional regulatory networks in Saccharomyces cerevisiae", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 298, no. 5594, 25 October 2002 (2002-10-25), pages 799 - 804, XP002327643, ISSN: 0036-8075
WYRICK ET AL: "Deciphering gene expression regulatory networks.", CURRENT OPINION IN GENETICS AND DEVELOPMENT, vol. 12, April 2002 (2002-04-01), pages 130 - 136, XP002342490
WEINMANN A S ET AL: "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, NEW YORK, US, vol. 16, no. 2, 15 January 2002 (2002-01-15), pages 235 - 244, XP002327644, ISSN: 0890-9369
HARTEMINK A J ET AL: "COMBINING LOCATION AND EXPRESSION DATA FOR PRINCIPLED DISCOVERY OF GENETIC REGULATORY NETWORK MODELS", PROCEEDINGS OF THE PACIFIC SYMPOSIUM ON BIOCOMPUTING, 2002, pages 437 - 449, XP009046817
ODOM D T ET AL: "CONTROL OF PANCREAS AND LIVER GENE EXPRESSION BY HNF TRANSCRIPTION FACTORS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 303, no. 5662, 27 February 2004 (2004-02-27), pages 1378 - 1381, XP001205726, ISSN: 0036-8075
BAR JOSEPH ET AL: "Computational discovery of gene modules and regulatory networks", NATURE BIOTECHNOLOGY, vol. 21, no. 11, November 2003 (2003-11-01), pages 1337 - 1342, XP002342488
LEE T I ET AL: "Transcriptional regulatory networks in Saccharomyces cerevisiae", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 298, no. 5594, 25 October 2002 (2002-10-25), pages 799 - 804, XP002327643, ISSN: 0036-8075
WYRICK ET AL: "Deciphering gene expression regulatory networks.", CURRENT OPINION IN GENETICS AND DEVELOPMENT, vol. 12, April 2002 (2002-04-01), pages 130 - 136, XP002342490
WEINMANN A S ET AL: "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, NEW YORK, US, vol. 16, no. 2, 15 January 2002 (2002-01-15), pages 235 - 244, XP002327644, ISSN: 0890-9369
HARTEMINK A J ET AL: "COMBINING LOCATION AND EXPRESSION DATA FOR PRINCIPLED DISCOVERY OF GENETIC REGULATORY NETWORK MODELS", PROCEEDINGS OF THE PACIFIC SYMPOSIUM ON BIOCOMPUTING, 2002, pages 437 - 449, XP009046817
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