Title:
BIOLOGICALLY ACTIVE MATERIALS
Document Type and Number:
WIPO Patent Application WO2000078355
Kind Code:
A3
Abstract:
The invention relates to a polymer drug conjugate for the treatment of cancer comprising a succinoylated dextrin wherein said succinoylation enhances the in vivo stability of said conjugate.
Inventors:
DUNCAN RUTH (GB)
HRECZUK-HIRST DALE (GB)
GERMAN LISA (GB)
HRECZUK-HIRST DALE (GB)
GERMAN LISA (GB)
Application Number:
PCT/GB2000/002216
Publication Date:
February 21, 2002
Filing Date:
June 19, 2000
Export Citation:
Assignee:
ML LAB PLC (GB)
DUNCAN RUTH (GB)
HRECZUK HIRST DALE (GB)
GERMAN LISA (GB)
DUNCAN RUTH (GB)
HRECZUK HIRST DALE (GB)
GERMAN LISA (GB)
International Classes:
A61K31/704; A61K45/00; A61K47/48; A61K51/00; A61K51/06; A61P35/00; (IPC1-7): A61K47/48; A61K51/06
Domestic Patent References:
| WO1998056424A1 | 1998-12-17 | |||
| WO1996035720A1 | 1996-11-14 | |||
| WO1995005199A1 | 1995-02-23 |
Foreign References:
| EP0477931A1 | 1992-04-01 |
Other References:
ARRANZ F ET AL: "ADDUCTS OF SUCCINYLATED DEXTRAN-BENZOCAINE. SYNTHESIS AND CONTROLLED RELEASE BEHAVIOUR", MAKROMOLEKULARE CHEMIE, RAPID COMMUNICATIONS,CH,HUTHIG UND WEPF VERLAG. BASEL, vol. 13, no. 9, 1 September 1992 (1992-09-01), pages 403 - 407, XP000301002
SHEN ET AL: "cis-Aconityl spacer between daunomycin and macromolecular carriers: a model of pH-sensitive linkage releasing drug from a lysosomotropic conjugate", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,US,ACADEMIC PRESS INC. ORLANDO, FL, vol. 102, no. 3, 15 October 1981 (1981-10-15), pages 1048 - 1054, XP002114459, ISSN: 0006-291X
HRECZUK-HIRST D.H. ET AL: "Synthesis and characterisation of dextrin-doxorubicin conjugates: A new anticancer treatment", PROCEEDINGS OF THE CONTROLLED RELEASE SOCIETY, 1999, VOL. -, NO. 26, PAGE(S) 1086-1087, United States, XP001002321
SHEN ET AL: "cis-Aconityl spacer between daunomycin and macromolecular carriers: a model of pH-sensitive linkage releasing drug from a lysosomotropic conjugate", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,US,ACADEMIC PRESS INC. ORLANDO, FL, vol. 102, no. 3, 15 October 1981 (1981-10-15), pages 1048 - 1054, XP002114459, ISSN: 0006-291X
HRECZUK-HIRST D.H. ET AL: "Synthesis and characterisation of dextrin-doxorubicin conjugates: A new anticancer treatment", PROCEEDINGS OF THE CONTROLLED RELEASE SOCIETY, 1999, VOL. -, NO. 26, PAGE(S) 1086-1087, United States, XP001002321
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