Title:
BIOLOGICALLY ACTIVE SILVER-COATED PROTEINS
Document Type and Number:
WIPO Patent Application WO2006080017
Kind Code:
A3
Abstract:
Silver-coated proteins, being dissolvable or suspendable in aqueous media and/or retaining a biological activity of the protein and a process for preparing same are disclosed. Further disclosed are modified proteins which have a reducing moiety attached to the surface thereof and a process for preparing same. The modified proteins can be utilized for obtaining the silver-coated proteins. Further disclosed are a pharmaceutical composition containing and a method of treating bacterial and fungal infections utilizing biologically active silver-coated hydrogen peroxide producing enzymes such as glucose oxidase. Further disclosed are conductive elements that comprise the silver-coated proteins disclosed herein and electronic circuits containing same. Further disclosed are electrodes having the silver-coated proteins deposited thereon and biosensor systems utilizing same for determining a level of an analyte in a liquid sample.
Inventors:
FREEMAN AMIHAY (IL)
SHACHAM-DIAMAND YOSI (IL)
MOSCOVICH-DAGAN HILA (IL)
HADAR NOA (IL)
SHACHAM-DIAMAND YOSI (IL)
MOSCOVICH-DAGAN HILA (IL)
HADAR NOA (IL)
Application Number:
PCT/IL2006/000115
Publication Date:
September 14, 2006
Filing Date:
January 26, 2006
Export Citation:
Assignee:
UNIV RAMOT (IL)
FREEMAN AMIHAY (IL)
SHACHAM-DIAMAND YOSI (IL)
MOSCOVICH-DAGAN HILA (IL)
HADAR NOA (IL)
FREEMAN AMIHAY (IL)
SHACHAM-DIAMAND YOSI (IL)
MOSCOVICH-DAGAN HILA (IL)
HADAR NOA (IL)
International Classes:
G01N33/532; A61K31/28; A61K38/16; C07K14/00; G01N33/543
Domestic Patent References:
| WO1986001410A1 | 1986-03-13 | |||
| WO1993015117A1 | 1993-08-05 |
Foreign References:
| GB2171104A | 1986-08-20 | |||
| US20040082766A1 | 2004-04-29 | |||
| EP0359428A1 | 1990-03-21 |
Other References:
BECKER RO: "Silver ions in the treatment of local infections", METAL-BASED DRUGS, vol. 6, no. 4-5, 1999, pages 311 - 314, XP008063656, ISSN: 0793-0291
FERAPONTOVA E ET AL.: "Effect of cysteine mutations on direct electron transfer of horseradish peroxidase on gold", BIOSENSORS AND BIOELECTRONICS, vol. 17, no. 11-12, December 2002 (2002-12-01), pages 953 - 963, XP002379013, ISSN: 0956-5663
FERAPONTOVA E ET AL.: "Effect of cysteine mutations on direct electron transfer of horseradish peroxidase on gold", BIOSENSORS AND BIOELECTRONICS, vol. 17, no. 11-12, December 2002 (2002-12-01), pages 953 - 963, XP002379013, ISSN: 0956-5663
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