Title:
BIOMARKER COMPOSITION FOR DIAGNOSING CANCER METASTASIS, CONTAINING AWP1
Document Type and Number:
WIPO Patent Application WO/2017/034173
Kind Code:
A1
Abstract:
The present invention relates to a biomarker composition for diagnosing cancer metastasis, containing AWP1, the composition being usable as a clinical indicator for cancer metastasis by identifying a decrease in the expression of AWP1 in cancers that easily metastasize in comparison to cancers that have not metastasized. In addition, it is ascertained that cancer growth and metastasis are increased when the expression of AWP1, having used siRNA, is inhibited and that, when AWP1 is overexpressed, cancer metastasis is inhibited by reducing cancer growth and migration, and thus AWP1 can be used as a cancer metastasis inhibitor.
Inventors:
CHANG EUN-JU (KR)
LEE EUN-JIN (KR)
LEE EUN-JIN (KR)
Application Number:
PCT/KR2016/008612
Publication Date:
March 02, 2017
Filing Date:
August 04, 2016
Export Citation:
Assignee:
UNIV ULSAN FOUND FOR IND COOP (KR)
International Classes:
G01N33/574; A61K48/00; C12Q1/68; G01N33/50
Foreign References:
| US20090136945A1 | 2009-05-28 | |||
| JP2005170796A | 2005-06-30 |
Other References:
KONG, YEONG YOON: "Studies on Human Disease Using Disease Animal Model-Study on Pathomechanism of Osteoporosis using Gene Targeting Technology", GOVERNMENT TASK FINAL REPORT, 2004, pages 1 - 69
DUAN, W. ET AL.: "Cloning and Characterization of AWP1, a Novel Protein that Associates with Serine/threonine Kinase PRKI in Vivo", GENE, vol. 256, no. 1-2, pages 113 - 121, XP004238397
CHANG, E. J. ET AL.: "AWP1 Binds to Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2) and Is Involved in TRAF2-mediated Nuclear Factor-kappaB Signaling", THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol. 43, no. 11, pages 1612 - 1620, XP028300282
DUAN, W. ET AL.: "Cloning and Characterization of AWP1, a Novel Protein that Associates with Serine/threonine Kinase PRKI in Vivo", GENE, vol. 256, no. 1-2, pages 113 - 121, XP004238397
CHANG, E. J. ET AL.: "AWP1 Binds to Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2) and Is Involved in TRAF2-mediated Nuclear Factor-kappaB Signaling", THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol. 43, no. 11, pages 1612 - 1620, XP028300282
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
Download PDF:
Previous Patent: LASER SOLDERING DEVICE
Next Patent: SAFETY DEVICE AND CRASH PREVENTING DRONE COMPRISING SAME
Next Patent: SAFETY DEVICE AND CRASH PREVENTING DRONE COMPRISING SAME