Title:
BIOMARKER COMPOSITION FOR DIAGNOSING PANCREATIC NEUROENDOCRINE TUMOR, AND METHOD FOR PROVIDING INFORMATION NECESSARY FOR DIAGNOSING PANCREATIC NEUROENDOCRINE TUMOR USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/265319
Kind Code:
A1
Abstract:
The present invention relates to a biomarker composition for diagnosing a pancreatic neuroendocrine tumor and a method of providing information necessary for diagnosing a pancreatic neuroendocrine tumor using same. The present invention measures an expression level of a protein, such as S100A8, S100A9, CD163, and ACTR3, or a gene encoding same in a biological sample of an individual suspected of having a pancreatic neuroendocrine tumor, and compares the expression level with an expression level of a normal individual to diagnose a pancreatic neuroendocrine tumor. Accordingly, since it is possible to diagnose a pancreatic neuroendocrine tumor early through a convenient and simple method even if clinical symptoms do not appear, the present invention may be effectively used for the diagnosis and treatment of a pancreatic neuroendocrine tumor.
More Like This:
Inventors:
JUN EUN SUNG (KR)
KIM SONG CHEOL (KR)
KIM KYUNG GON (KR)
AHN HEE SEONG (KR)
KO EUN YEONG (KR)
KIM SONG CHEOL (KR)
KIM KYUNG GON (KR)
AHN HEE SEONG (KR)
KO EUN YEONG (KR)
Application Number:
PCT/KR2022/008286
Publication Date:
December 22, 2022
Filing Date:
June 13, 2022
Export Citation:
Assignee:
ASAN FOUND (KR)
UNIV ULSAN FOUND IND COOP (KR)
UNIV ULSAN FOUND IND COOP (KR)
International Classes:
G01N33/574; C12Q1/6886
Domestic Patent References:
| WO2012119013A1 | 2012-09-07 |
Foreign References:
| KR20180037462A | 2018-04-12 |
Other References:
KIM HAERYOUNG, AN SOYEON, LEE KYOUNGBUN, AHN SANGJEONG, PARK DO YOUN, KIM JO-HEON, KANG DONG-WOOK, KIM MIN-JU, CHANG MEE SOO, JUNG: "Pancreatic High-Grade Neuroendocrine Neoplasms in the Korean Population: A Multicenter Study", CANCER RESEARCH AND TREATMENT, KOREAN CANCER ASSOCIATION, KR, vol. 52, no. 1, 1 January 2020 (2020-01-01), KR , pages 263 - 276, XP093015643, ISSN: 1598-2998, DOI: 10.4143/crt.2019.192
LEE OK-JUN Y, YONG MEE CHO; HYANG-IM LEEāDUCK JONG HAN; JAE Y. RO: "Mixed ductal-endocrine carcinoma of the pancreas : a case report. ", JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, 1 January 2004 (2004-01-01), pages 353 - 356, XP093015657, ISSN: 2383-7837
IMAM RAMI, CHANG QING, BLACK MARGARET, YU CAROLINE, CAO WENQING: "CD47 expression and CD163+ macrophages correlated with prognosis of pancreatic neuroendocrine tumor", BMC CANCER, vol. 21, no. 1, 1 December 2021 (2021-12-01), pages 1 - 9, XP093015649, DOI: 10.1186/s12885-021-08045-7
LEE OK-JUN Y, YONG MEE CHO; HYANG-IM LEEāDUCK JONG HAN; JAE Y. RO: "Mixed ductal-endocrine carcinoma of the pancreas : a case report. ", JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, 1 January 2004 (2004-01-01), pages 353 - 356, XP093015657, ISSN: 2383-7837
IMAM RAMI, CHANG QING, BLACK MARGARET, YU CAROLINE, CAO WENQING: "CD47 expression and CD163+ macrophages correlated with prognosis of pancreatic neuroendocrine tumor", BMC CANCER, vol. 21, no. 1, 1 December 2021 (2021-12-01), pages 1 - 9, XP093015649, DOI: 10.1186/s12885-021-08045-7
Attorney, Agent or Firm:
THEWAVE IP LAW FIRM (KR)
Download PDF: