Title:
BIOMARKER FOR CONFIRMING DEGENERATIVE DISEASE TREATMENT OF DROSOPHILA USING LOW-DOSE RADIATION
Document Type and Number:
WIPO Patent Application WO/2019/221502
Kind Code:
A1
Abstract:
The present invention relates to a biomarker, for confirming degenerative disease treatment of Drosophila, comprising immunologically active genes, genes associated with nerve cell regeneration and genes associated with motor function which exhibit sensitivity to low-dose radiation and, more specifically, to classification and selection of genes reacting during treatment of degenerative diseases of Drosophila by means of low-dose radiation. According to the present invention, genes exhibiting changes in expression due to low-dose radiation are classified by functions, and response indicator genes due to low-dose radiation are provided and utilized as basic data for developing a therapeutic marker during low-dose radiation irradiation for degenerative diseases.
Inventors:
NAM SEONYOUNG (KR)
HWANG SOOJIN (KR)
JEONG HAEMIN (KR)
HONG EUNHEE (KR)
HWANG SOOJIN (KR)
JEONG HAEMIN (KR)
HONG EUNHEE (KR)
Application Number:
PCT/KR2019/005816
Publication Date:
November 21, 2019
Filing Date:
May 15, 2019
Export Citation:
Assignee:
KOREA HYDRO & NUCLEAR POWER CO (KR)
International Classes:
A01K67/033; C12Q1/6883
Foreign References:
| KR20120032171A | 2012-04-05 |
Other References:
FAVRIN, G.: "Identification of novel modifiers of Abeta toxicity by transc riptomic analysis in the fruitfly", SCIENTIFIC REPORTS, vol. 3, no. 3512, 16 December 2013 (2013-12-16), pages 1 - 10, XP055654301, DOI: 10.1038/srep03512
LEE, K.-I.: "Role of transient receptor potential ankyrin 1 channels in Alzheimer' s disease", JOURNAL OF NEUROINFLAMMATION, vol. 13, no. 92, 27 April 2016 (2016-04-27), pages 1 - 16, XP055654307, DOI: 10.1186/s12974-016-0557-z
LEE SEON HWA ET AL: "Effects of Low-Dose Radiation on Drosophila Alzheimer's Disease by Anti-Oxidant Enzymesand Sacchammetabolism.", PROCEEDINGS OF THE KOREAN ASSOCIATION FOR RADIATION PROTECTION 2015 SPRING CONFERENCE.), 1 January 2015 (2015-01-01), pages 188 - 189
D. MELANOGASTER, 2014, pages 376 - 377
LEE, K.-I.: "Role of transient receptor potential ankyrin 1 channels in Alzheimer' s disease", JOURNAL OF NEUROINFLAMMATION, vol. 13, no. 92, 27 April 2016 (2016-04-27), pages 1 - 16, XP055654307, DOI: 10.1186/s12974-016-0557-z
LEE SEON HWA ET AL: "Effects of Low-Dose Radiation on Drosophila Alzheimer's Disease by Anti-Oxidant Enzymesand Sacchammetabolism.", PROCEEDINGS OF THE KOREAN ASSOCIATION FOR RADIATION PROTECTION 2015 SPRING CONFERENCE.), 1 January 2015 (2015-01-01), pages 188 - 189
D. MELANOGASTER, 2014, pages 376 - 377
Attorney, Agent or Firm:
LEE, Un Cheol (KR)
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