Title:
BIOMARKER FOR DEPRESSION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/205188
Kind Code:
A1
Abstract:
Provided are a biomarker for depression and the use thereof, comprising at least one selected from the following: Bacteroides thetaiotaomicron and/or an analogue thereof, Butyriyibrio crossotus and/or an analogue thereof, Alistipes shahii and/or an analogue thereof, Clostridium bolteae and/or an analogue thereof, Haemophilus parainfluenzae and/or an analogue thereof, Veillonella dispar and/or an analogue thereof, and Prevotella copri and/or an analogue thereof. Also provided are a kit for detecting the biomarker, and a device for detecting or predicting whether a subject has depression or related diseases.
Inventors:
GUO RUIJIN (CN)
WANG QI (CN)
JIA HUIJUE (CN)
JU YANMEI (CN)
WANG QI (CN)
JIA HUIJUE (CN)
JU YANMEI (CN)
Application Number:
PCT/CN2018/085908
Publication Date:
October 31, 2019
Filing Date:
May 07, 2018
Export Citation:
Assignee:
BGI SHENZHEN (CN)
International Classes:
C12Q1/68; A61K35/74; A61P25/24; C12M1/00; C12N1/20; C12Q1/04; C12R1/01
Foreign References:
| CN107075446A | 2017-08-18 | |||
| CN107002021A | 2017-08-01 | |||
| CN106554998A | 2017-04-05 | |||
| CN106554998A | 2017-04-05 | |||
| CN104546930A | 2015-04-29 | |||
| CN104540962A | 2015-04-22 | |||
| CN107075453A | 2017-08-18 | |||
| CN107075563A | 2017-08-18 | |||
| CN106795480A | 2017-05-31 | |||
| CN106795479A | 2017-05-31 |
Other References:
QIN JLI YCAI Z ET AL.: "A metagenome-wide association study of gut microbiota in type 2 diabetes[J", NATURE, vol. 490, no. 7418, 2012, pages 55 - 60, XP055111695, DOI: 10.1038/nature11450
WANG, JUNHUIJUE JIA: "Metagenome-wide association studies: fine-mining the microbiome", NATURE REVIEWS MICROBIOLOGY, vol. 14, no. 8, 2016, pages 508 - 522, XP055451382, DOI: 10.1038/nrmicro.2016.83
DROGAN DDUNN WBLIN WBUIJSSE BSCHULZE MBLANGENBERG CBROWN MFLOEGEL A.DIETRICH SROLANDSSON O: "Untargeted Metabolic Profiling Identifies Altered Serum Metabolites of Type 2-Diabetes Mellitus in a Prospective, Nested Case Control Study", CLIN CHEM, vol. 61, 2015, pages 487 - 497
MIHALIK SJMICHALISZYN SFDE LAS HERAS JBACHA FLEE SCHACE DHDEJESUS VRVOCKLEY JARSLANIAN SA: "Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation", DIABETES CARE, vol. 35, 2012, pages 605 - 611, XP002690671, DOI: 10.2337/DC11-1577
QIN, J. ET AL.: "A metagenome-wide association study of intestinal microbiota in type 2 diabetes", NATURE, vol. 490, 2012, pages 55 - 60, XP055111695, DOI: 10.1038/nature11450
QIN, J. ET AL.: "A metagenome-wide association study of gut microbiota in type 2 diabetes", NATURE, vol. 490, 2012, pages 55 - 60, XP055111695, DOI: 10.1038/nature11450
ZHENG ZCAI YLI Y: "Oversampling method for imbalanced classification", COMPUTING AND INFORMATICS, vol. 34, no. 5, 2016, pages 1017 - 1037
See also references of EP 3786305A4
WANG, JUNHUIJUE JIA: "Metagenome-wide association studies: fine-mining the microbiome", NATURE REVIEWS MICROBIOLOGY, vol. 14, no. 8, 2016, pages 508 - 522, XP055451382, DOI: 10.1038/nrmicro.2016.83
DROGAN DDUNN WBLIN WBUIJSSE BSCHULZE MBLANGENBERG CBROWN MFLOEGEL A.DIETRICH SROLANDSSON O: "Untargeted Metabolic Profiling Identifies Altered Serum Metabolites of Type 2-Diabetes Mellitus in a Prospective, Nested Case Control Study", CLIN CHEM, vol. 61, 2015, pages 487 - 497
MIHALIK SJMICHALISZYN SFDE LAS HERAS JBACHA FLEE SCHACE DHDEJESUS VRVOCKLEY JARSLANIAN SA: "Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation", DIABETES CARE, vol. 35, 2012, pages 605 - 611, XP002690671, DOI: 10.2337/DC11-1577
QIN, J. ET AL.: "A metagenome-wide association study of intestinal microbiota in type 2 diabetes", NATURE, vol. 490, 2012, pages 55 - 60, XP055111695, DOI: 10.1038/nature11450
QIN, J. ET AL.: "A metagenome-wide association study of gut microbiota in type 2 diabetes", NATURE, vol. 490, 2012, pages 55 - 60, XP055111695, DOI: 10.1038/nature11450
ZHENG ZCAI YLI Y: "Oversampling method for imbalanced classification", COMPUTING AND INFORMATICS, vol. 34, no. 5, 2016, pages 1017 - 1037
See also references of EP 3786305A4
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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