Title:
BIOMARKER FOR DIAGNOSING OBESITY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/091237
Kind Code:
A1
Abstract:
Provided are: a composition and a kit for diagnosing obesity by using Ces1b and Cgref1, which are blood biomarkers; and a method for diagnosing obesity by using same. According to the present invention, obesity can be diagnosed at an early stage with high accuracy and sensitivity through a simple method by using blood, and information for preventing obesity-related metabolic diseases can be provided.
Inventors:
CHO JE YOEL (KR)
KIM DONG WOOK (KR)
LEE DA BIN (KR)
KIM DONG WOOK (KR)
LEE DA BIN (KR)
Application Number:
PCT/KR2019/012679
Publication Date:
May 07, 2020
Filing Date:
September 30, 2019
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C12Q1/6883; G01N33/68
Foreign References:
| US20110107439A1 | 2011-05-05 | |||
| KR20150051524A | 2015-05-13 | |||
| US20090186347A1 | 2009-07-23 | |||
| US20090075254A1 | 2009-03-19 |
Other References:
LUNDSGAARD, A. M. ET AL.: "Mechanisms preserving insulin action during high dietary fat intake", CELL METABOLISM, vol. 29, 27 September 2018 (2018-09-27), pages 1 - 14, XP085576372
DE WIT, N. J. W. ET AL.: "The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice", BMC MEDICAL GENOMICS, vol. 1, 6 May 2008 (2008-05-06), pages 1 - 16, XP021040897
LI, C ET AL.: "High-fat diet amplifies renal renin angiotensin system expression, blood pressure elevation, and renal dysfunction caused by C'eacaml null deletion", AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM, vol. 309, 15 September 2015 (2015-09-15), pages E802 - E810, XP055704695, DOI: 10.1152/ajpendo.00158.2015
JONKER, J. W. ET AL.: "A PPAR gamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis", NATURE, vol. 485, 17 May 2012 (2012-05-17), pages 391 - 394, XP055090674
DE WIT, N. J. W. ET AL.: "The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice", BMC MEDICAL GENOMICS, vol. 1, 6 May 2008 (2008-05-06), pages 1 - 16, XP021040897
LI, C ET AL.: "High-fat diet amplifies renal renin angiotensin system expression, blood pressure elevation, and renal dysfunction caused by C'eacaml null deletion", AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM, vol. 309, 15 September 2015 (2015-09-15), pages E802 - E810, XP055704695, DOI: 10.1152/ajpendo.00158.2015
JONKER, J. W. ET AL.: "A PPAR gamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis", NATURE, vol. 485, 17 May 2012 (2012-05-17), pages 391 - 394, XP055090674
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
Download PDF: