Title:
BIOMARKER FOR DIAGNOSIS OF AGING OR AMYOTROPHIA
Document Type and Number:
WIPO Patent Application WO/2015/152413
Kind Code:
A1
Abstract:
Provided is a novel biomarker for the diagnosis of aging or amyotrophia. Also provided are a method for ascertaining the state of aging or amyotrophia, a method for determining the efficacy of therapeutic or preventive effects against aging or amyotrophia, and a screening method for a therapeutic or preventive agent for aging or amyotrophia. The biomarker is an isolated MuSK protein or an mRNA for secretory MuSK.
Inventors:
SHIGEMOTO KAZUHIRO (JP)
Application Number:
PCT/JP2015/060671
Publication Date:
October 08, 2015
Filing Date:
April 03, 2015
Export Citation:
Assignee:
TOKYO METROPOLITAN GERIATRIC HOSPITAL AND INST OF GERONTOLOGY (JP)
International Classes:
G01N33/68; C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12N15/09; C12Q1/68; G01N33/15; G01N33/50
Domestic Patent References:
| WO2013108926A1 | 2013-07-25 | |||
| WO2009101968A1 | 2009-08-20 | |||
| WO2007141971A1 | 2007-12-13 |
Foreign References:
| JP2013100275A | 2013-05-23 | |||
| JP2011173793A | 2011-09-08 | |||
| JP2009189268A | 2009-08-27 | |||
| JP2013503825A | 2013-02-04 | |||
| US20040082010A1 | 2004-04-29 | |||
| JP2000504929A | 2000-04-25 |
Other References:
KAZUHIRO SHIGEMOTO: "Koreisha ni Okeru Kareisei Kinniku Genjaku Gensho (Sarcopenia) ni Kansuru Yobo Taisaku Kakuritsu no Tameno Hokatsuteki Kenkyu Sarcopenia no Biomarker no Kaihatsu to Jitsuyoka", KOREISHA NI OKERU KAREISEI KINNIKU GENJAKU GENSHO (SARCOPENIA) NI KANSURU YOBO TAISAKU KAKURITSU NO TAMENO HOKATSUTEKI KENKYU HEISEI 23 NENDO SOKATSU BUNTAN KENKYU HOKOKUSHO, 2012, pages 63 - 69, XP008182675
VALENZUELA D M ET AL.: "Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury", NEURON, vol. 15, no. 3, 1995, pages 573 - 584, XP 000674260
MASAKATSU MOTOMURA ET AL.: "Men'ekisei Shinkei Shikkan ni Kansuru Chosa Kenkyu Jiko Men'ekisei MuSK Kotai Yosei Jusho Kin Muryokusho Rat Sakusei no Kokoromi", MEN'EKISEI SHINKEI SHIKKAN NI KANSURU CHOSA KENKYU HEISEI 17 NENDO SOKATSU BUNTAN KENKYU HOKOKUSHO, 2006, pages 131 - 132, XP008182676
HIROFUMI MIYATA: "Rat Endplate ni Okeru Synapse Kaku Domain to MuSK Hatsugen no Karei Henka", JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE, vol. 60, no. 6, 2011, pages 605, XP 008182506
KAZUHIRO SHIGEMOTO: "Koreisha ni Okeru Kareisei Kinniku Genjaku Gensho (Sarcopenia) ni Kansuru Yobo Taisaku Kakuritsu no Tameno Hokatsuteki Kenkyu Sarcopenia no Biomarker no Kaihatsu to Jitsuyoka", KOREISHA NI OKERU KAREISEI KINNIKU GENJAKU GENSHO (SARCOPENIA) NI KANSURU YOBO TAISAKU KAKURITSU NO TAMENO HOKATSUTEKI KENKYU HEISEI 24 NENDO SOKATSU BUNTAN KENKYU HOKOKUSHO, 2013, pages 75 - 81, XP008182674
XIE M-H ET AL.: "Direct demonstration of MuSK involvement in acetylcholine receptor clustering through identification of agonist ScFv", NAT BIOTECHNOL, vol. 15, no. 8, 1997, pages 768 - 771, XP 002095742, ISSN: 1087-0156
TSUYOSHI ENDO: "Elucidation of signal transduction mechanism in cell fusion (Foundation for the Promotion Res. on Medical Resources S", RESEARCH REPORT SUPPORTED BY GRANTS FROM THE FOUNDATION FOR PROMOTION RES. ON MEDICAL RESOURCES, vol. 1997, 1996, pages 13 - 15, XP008183369
SHIGEMOTO KAZUHIRO ET AL.: "Induction of myasthenia by immunization against muscle- specific kinase", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 116, no. 4, 2006, pages 1016 - 1024, XP 055229841, ISSN: 0021-9738
See also references of EP 3128326A4
VALENZUELA D M ET AL.: "Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury", NEURON, vol. 15, no. 3, 1995, pages 573 - 584, XP 000674260
MASAKATSU MOTOMURA ET AL.: "Men'ekisei Shinkei Shikkan ni Kansuru Chosa Kenkyu Jiko Men'ekisei MuSK Kotai Yosei Jusho Kin Muryokusho Rat Sakusei no Kokoromi", MEN'EKISEI SHINKEI SHIKKAN NI KANSURU CHOSA KENKYU HEISEI 17 NENDO SOKATSU BUNTAN KENKYU HOKOKUSHO, 2006, pages 131 - 132, XP008182676
HIROFUMI MIYATA: "Rat Endplate ni Okeru Synapse Kaku Domain to MuSK Hatsugen no Karei Henka", JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE, vol. 60, no. 6, 2011, pages 605, XP 008182506
KAZUHIRO SHIGEMOTO: "Koreisha ni Okeru Kareisei Kinniku Genjaku Gensho (Sarcopenia) ni Kansuru Yobo Taisaku Kakuritsu no Tameno Hokatsuteki Kenkyu Sarcopenia no Biomarker no Kaihatsu to Jitsuyoka", KOREISHA NI OKERU KAREISEI KINNIKU GENJAKU GENSHO (SARCOPENIA) NI KANSURU YOBO TAISAKU KAKURITSU NO TAMENO HOKATSUTEKI KENKYU HEISEI 24 NENDO SOKATSU BUNTAN KENKYU HOKOKUSHO, 2013, pages 75 - 81, XP008182674
XIE M-H ET AL.: "Direct demonstration of MuSK involvement in acetylcholine receptor clustering through identification of agonist ScFv", NAT BIOTECHNOL, vol. 15, no. 8, 1997, pages 768 - 771, XP 002095742, ISSN: 1087-0156
TSUYOSHI ENDO: "Elucidation of signal transduction mechanism in cell fusion (Foundation for the Promotion Res. on Medical Resources S", RESEARCH REPORT SUPPORTED BY GRANTS FROM THE FOUNDATION FOR PROMOTION RES. ON MEDICAL RESOURCES, vol. 1997, 1996, pages 13 - 15, XP008183369
SHIGEMOTO KAZUHIRO ET AL.: "Induction of myasthenia by immunization against muscle- specific kinase", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 116, no. 4, 2006, pages 1016 - 1024, XP 055229841, ISSN: 0021-9738
See also references of EP 3128326A4
Attorney, Agent or Firm:
MORITA Kenichi et al. (JP)
Ken-ichi Morita (JP)
Ken-ichi Morita (JP)
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