Title:
BIOMARKER FOR EARLY DIAGNOSIS OF DIABETES OR DIABETIC COMPLICATIONS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/150011
Kind Code:
A1
Abstract:
The present invention relates to a biomarker for early diagnosis of diabetes or diabetic complications, and use thereof and, more specifically, to an ADAM2 biomarker for early diagnosis of diabetes or diabetic complications, a composition for early diagnosis of diabetes or diabetic complications using the biomarker, a diagnostic kit, and a method for providing information necessary for early diagnosis of diabetes or diabetic complications. The ADAM2 biomarker for early diagnosis of diabetes or diabetic complications of the present invention was confirmed to have a specifically reduced expression level in the pre-diabetes stage, compared to normal subjects, and a pattern was confirmed in which the expression thereof was further increased in diabetic retinopathy and diabetic nephropathy, which are diabetic complications, as compared to normal or diabetic subjects, and thus the biomarker can be useful for early diagnosis of diabetes or diabetic complications.
Inventors:
CHO HO CHAN (KR)
BAE YUN UI (KR)
PARK JAE HYUNG (KR)
BAE YUN UI (KR)
PARK JAE HYUNG (KR)
Application Number:
PCT/KR2021/000784
Publication Date:
July 29, 2021
Filing Date:
January 20, 2021
Export Citation:
Assignee:
UNIV KEIMYUNG IACF (KR)
International Classes:
G01N33/68; C12Q1/6883; G01N33/53
Foreign References:
| KR20170002318A | 2017-01-06 | |||
| KR20130009205A | 2013-01-23 | |||
| KR20080112817A | 2008-12-26 |
Other References:
CRUJEIRAS A.B.; DIAZ-LAGARES A.; MORENO-NAVARRETE J.M.; SANDOVAL J.; HERVAS D.; GOMEZ A.; RICART W.; CASANUEVA F.F.; ESTELLER M.; : "Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subjects", TRANSLATIONAL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 178, 1 January 1900 (1900-01-01), NL, pages 13, XP029808296, ISSN: 1931-5244, DOI: 10.1016/j.trsl.2016.07.002
ANAN FUTOSHI, TAKAYUKI MASAKI, TAKAHASHI NAOHIKO, NAKAGAWA MIKIKO, ESHIMA NOBUOKI, SAIKAWA TETSUNORI, YOSHIMATSU HIRONOBU: "Diabetic retinopathy is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients", HYPERTENSION RESEARCH. CLINICAL AND EXPERIMENTAL., OSAKA., JP, vol. 32, no. 4, 1 April 2009 (2009-04-01), JP, pages 299 - 305, XP055831587, ISSN: 0916-9636, DOI: 10.1038/hr.2009.8
ANAN FUTOSHI, TAKAYUKI MASAKI, TAKAHASHI NAOHIKO, NAKAGAWA MIKIKO, ESHIMA NOBUOKI, SAIKAWA TETSUNORI, YOSHIMATSU HIRONOBU: "Diabetic retinopathy is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients", HYPERTENSION RESEARCH. CLINICAL AND EXPERIMENTAL., OSAKA., JP, vol. 32, no. 4, 1 April 2009 (2009-04-01), JP, pages 299 - 305, XP055831587, ISSN: 0916-9636, DOI: 10.1038/hr.2009.8
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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