Title:
BIOMARKER FOR PARKINSON'S DISEASE AND USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2015/125702
Kind Code:
A1
Abstract:
This invention provides the following: an antibody that targets the molecule that results when the 65th serine residue in ubiquitin is phosphorylated; a method for early, specific detection of Parkinson's disease that targets the molecule that results when the 65th serine residue in ubiquitin is phosphorylated; a pharmaceutical composition for treating or preventing Parkinson's disease at a fundamental level; and a method for screening for such pharmaceutical compositions.
Inventors:
MATSUDA NORIYUKI (JP)
KOYANO FUMIKA (JP)
OKATSU KEI (JP)
GO ETSU (JP)
KIMURA MAYUMI (JP)
SAEKI YASUSHI (JP)
KOYANO FUMIKA (JP)
OKATSU KEI (JP)
GO ETSU (JP)
KIMURA MAYUMI (JP)
SAEKI YASUSHI (JP)
Application Number:
PCT/JP2015/053930
Publication Date:
August 27, 2015
Filing Date:
February 13, 2015
Export Citation:
Assignee:
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
International Classes:
G01N33/53; A61K39/395; A61P25/16; C07K16/18; C12Q1/02; G01N33/15; G01N33/50; C12P21/08
Domestic Patent References:
| WO2013153386A1 | 2013-10-17 | |||
| WO2010005077A1 | 2010-01-14 |
Foreign References:
| JP2014025764A | 2014-02-06 |
Other References:
TOMOKO KANAO: "The molecular mechanism underlying PINK1-madiated mitochondrial maintenance", GRANTS-IN-AID FOR SCIENTIFIC RESEARCH (KAGAKU KENKYUHI HOJOKIN) KENKYU SEIKA HOKOKUSHO, 27 August 2013 (2013-08-27), XP008184892
NORIYUKI MATSUDA: "The molecular basis for how E3 activity of Parkin is re-established by damaged mitochondria", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 247, no. 10, 2013, pages 1013 - 1018, XP008184610
KOYANO F ET AL.: "Ubiquitin is phosphorylated by PINK1 to activate parkin.", NATURE, vol. 510, no. 7503, pages 162 - 166, XP055221802, ISSN: 0028-0836
NORIYUKI MATSUDA: "Idensei Parkinson-byo Kanren Bunshi PINK1 ni yotte Rinsan-ka sareta Ubiquitin ga Parkin o Kasseika suru", CELL TECHNOLOGY, vol. 33, no. 9, 22 August 2014 (2014-08-22), pages 974 - 976, XP008184596
KAZLAUSKAITE A ET AL.: "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.", BIOCHEM J, vol. 460, no. 1, 15 May 2014 (2014-05-15), pages 127 - 139, XP055357884
KANE LA ET AL.: "PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.", J CELL BIOL, vol. 205, no. 2, 21 April 2014 (2014-04-21), pages 143 - 153, XP055357887
KAZLAUSKAITE A ET AL.: "PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease.", FEBS J, vol. 282, no. 2, January 2015 (2015-01-01), pages 215 - 223, XP055221806, ISSN: 1742-464x
See also references of EP 3109636A4
NORIYUKI MATSUDA: "The molecular basis for how E3 activity of Parkin is re-established by damaged mitochondria", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 247, no. 10, 2013, pages 1013 - 1018, XP008184610
KOYANO F ET AL.: "Ubiquitin is phosphorylated by PINK1 to activate parkin.", NATURE, vol. 510, no. 7503, pages 162 - 166, XP055221802, ISSN: 0028-0836
NORIYUKI MATSUDA: "Idensei Parkinson-byo Kanren Bunshi PINK1 ni yotte Rinsan-ka sareta Ubiquitin ga Parkin o Kasseika suru", CELL TECHNOLOGY, vol. 33, no. 9, 22 August 2014 (2014-08-22), pages 974 - 976, XP008184596
KAZLAUSKAITE A ET AL.: "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.", BIOCHEM J, vol. 460, no. 1, 15 May 2014 (2014-05-15), pages 127 - 139, XP055357884
KANE LA ET AL.: "PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.", J CELL BIOL, vol. 205, no. 2, 21 April 2014 (2014-04-21), pages 143 - 153, XP055357887
KAZLAUSKAITE A ET AL.: "PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease.", FEBS J, vol. 282, no. 2, January 2015 (2015-01-01), pages 215 - 223, XP055221806, ISSN: 1742-464x
See also references of EP 3109636A4
Attorney, Agent or Firm:
OKUYAMA, Shoichi et al. (JP)
Okuyama In addition, it is 1. (JP)
Okuyama In addition, it is 1. (JP)
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