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Title:
BIOMARKER FOR PREDICTING CANCER PROGNOSIS
Document Type and Number:
WIPO Patent Application WO/2018/026190
Kind Code:
A1
Abstract:
The present invention relates to a genetic biomarker for predicting prognosis of cancer, particularly, thyroid cancer or liver cancer, a cancer prognosis predicting composition comprising an agent for measuring an expression level of the genetic biomarker, a cancer prognosis predicting kit comprising the composition, an information providing method for predicting prognosis of cancer by use of the kit, a system for screening a material prophylactic or curative of cancer by use of the genetic biomarker, and a pharmaceutical composition targeting the genetic biomarker to prevent or treat cancer. More particularly, the prognosis of a cancer patient can be predicted by measuring an expression level of the genetic biomarker of the present invention in the cancer patient, and the expression of a corresponding genetic biomarker responsible for poor prognosis can be suppressed, depending on prognosis prediction results, so that cancer patients can be more effectively treated.

Inventors:
LEE, Yeon Su (#1507-204, 26 Daesan-ro 212beon-gil, Ilsanseo-gu,,Goyang-si, Gyeonggi-do, 10370, KR)
KIM, In Hoo (#706-1503, 152 Gangseok-ro, Ilsandong-gu,,Goyang-si, Gyeonggi-do, 10415, KR)
LEE, Yong Sun (5212 Cottonwood Creek Lane, League City, Texas, 77573, US)
LEE, Eun Kyung (#B-901, 79 Gukjegeumyung-ro,,Yeongdeungpo-gu, Seoul, 07340, KR)
Application Number:
KR2017/008336
Publication Date:
February 08, 2018
Filing Date:
August 02, 2017
Export Citation:
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Assignee:
NATIONAL CANCER CENTER (323 Ilsan-ro, Ilsandong-gu,Goyang-si, Gyeonggi-do, 10408, KR)
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (201 West 7th Street, Austin, Texas, 78701, US)
International Classes:
C12Q1/68; A61K31/7088; A61K39/395; G01N33/574
Domestic Patent References:
2014-09-25
Foreign References:
CN104887694A2015-09-09
Other References:
LEE, YONG SUN: "A Novel Type of Non-coding RNA, Nc886, Implicated in Tumor Sensing and Suppression", GENOMICS & INFORMATICS, vol. 13, no. 2, 2015, pages 26 - 30, XP055461430
LEE, KWANG-SOO ET AL.: "Nc886, a Non-coding RNA of Anti-proliferative Role, Is Suppressed by CpG DNA Methylation in Human Gastric Cancer", ONCOTARGET, vol. 5, no. 11, 2014, pages 3944 - 3955, XP055461431
SILVER, MATT J. ET AL.: "Independent Genomewide Screens Identify the Tumor Suppressor VTRNA2-1 as a Human Epiallele Responsive to Periconceptional Environment", GENOME BIOLOGY, vol. 16, no. 118, 2015, pages 1 - 14, XP021224292
LEE, EUN KYUNG ET AL.: "Nc886, a Non-coding RNA and Suppressor of PKR, Exerts an Oncogenic Function in Thyroid Cancer", ONCOTARGET, vol. 7, no. 46, 6 September 2016 (2016-09-06), pages 75000 - 75012, XP055461434
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (3rd Floor, 108 Sapyeong-daero,,Seocho-gu, Seoul, 06575, KR)
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