Title:
BIOMARKER FOR PREDICTING EFFECTIVENESS FOR AUTOIMMUNE DISEASE TREATMENT, DIAGNOSTIC KIT, AND USE FOR TREATMENT
Document Type and Number:
WIPO Patent Application WO/2019/240507
Kind Code:
A1
Abstract:
The present invention provides a biomarker for predicting effectiveness for autoimmune disease treatment, a diagnostic kit, and a use for treatment. More particularly, the present invention provides a biomarker for predicting the effectiveness of mesenchymal stem cells (MSC) comprising the chemokine receptor CXCR3 for autoimmune disease treatment; a biomarker comprising the chemokine CXCL10 for predicting the prognosis of autoimmune disease treatment; a diagnostic kit comprising an agent capable of measuring the expression of the biomarker; and a pharmaceutical composition for prevention or treatment of autoimmune disease, which comprises mesenchymal stem cells having an upregulated expression level of the chemokine receptor CXCR3.
Inventors:
KIM KYUNG SUK (KR)
HAN SANG BAE (KR)
HAN SANG BAE (KR)
Application Number:
PCT/KR2019/007121
Publication Date:
December 19, 2019
Filing Date:
June 13, 2019
Export Citation:
Assignee:
CORESTEM CO LTD (KR)
NAT UNIV CHUNGBUK IND ACAD COOP FOUND (KR)
NAT UNIV CHUNGBUK IND ACAD COOP FOUND (KR)
International Classes:
C12Q1/6883; G01N33/68
Foreign References:
| US20090324609A1 | 2009-12-31 | |||
| KR20150016117A | 2015-02-11 | |||
| KR20180069263A | 2018-06-25 | |||
| KR20140097129A | 2014-08-06 |
Other References:
COLLINS, E. ET AL.: "Hematopoetic and mesenchymal stem cell transplantation in the treatment of refractory systemic lupus erythematosus - where are we now?", CLIN. IMMUNOL., pages 328 - 334
LIAO, X.: "Chemokines and Chemokine Receptors in the Development of Lupus Nephritis", MEDIATORS INFLAMM., vol. 6012715, 2016, pages 1 - 15, XP055667847
LEE, J. H.: "CXCR3-deficient mesenchymal stem cells fail to infiltrate into the nephritic kidney and do not ameliorate lupus symptoms in MRL.Faslpr mice", LUPUS, vol. 27, no. 11, 23 August 2018 (2018-08-23), pages 1854 - 1859, XP055767413
YANG DSUN SWANG ZZHU PYANG ZZHANG B: "Stromal cell-derived factor-1 receptor CXCR4-overexpressing bone marrow mesenchymal stem cells accelerate wound healing by migrating into skin injury areas", CELLULAR REPROGRAMMING, vol. 15, 2013, pages 206 - 15
See also references of EP 3808858A4
LIAO, X.: "Chemokines and Chemokine Receptors in the Development of Lupus Nephritis", MEDIATORS INFLAMM., vol. 6012715, 2016, pages 1 - 15, XP055667847
LEE, J. H.: "CXCR3-deficient mesenchymal stem cells fail to infiltrate into the nephritic kidney and do not ameliorate lupus symptoms in MRL.Faslpr mice", LUPUS, vol. 27, no. 11, 23 August 2018 (2018-08-23), pages 1854 - 1859, XP055767413
YANG DSUN SWANG ZZHU PYANG ZZHANG B: "Stromal cell-derived factor-1 receptor CXCR4-overexpressing bone marrow mesenchymal stem cells accelerate wound healing by migrating into skin injury areas", CELLULAR REPROGRAMMING, vol. 15, 2013, pages 206 - 15
See also references of EP 3808858A4
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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