Title:
BIOMARKERS FOR CARDIOMETABOLIC DISEASES
Document Type and Number:
WIPO Patent Application WO/2017/032815
Kind Code:
A3
Abstract:
The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, or for producing a diagnostically informative value of the amount of one or more protein(s) or mRNA(s) encoding said protein(s) for identifying a predisposition for developing a type 2 diabetes mellitus, said method comprising or consisting of (i) assessing in a sample obtained from said subject the amount of one or more protein(s) and/or mRNA(s) encoding said protein(s), wherein said one or more protein(s) is/are selected from a group of proteins as defined in the following, and (ii) determining parameters of said subject, wherein (a) said parameters are age and sex, and said group consists of AP0C2, AP0C3, APOE, CRP, MASP-1, ADIPOQ, ΙΤΊΗ4, and SHBG; (b) said parameters are age, sex and BMI, and said group consists of AP0C2, AP0C3, APOE, MASP-1, ADIPOQ, ITIH4, PZP and SHBG; or (c) said parameters are age, sex, BMI, smoking status, alcohol intake, physical inactivity, actual hypertension, log 10-transformed triacylglycerol levels and Iog10-transformed total cholesterol/HDL-cholesterol ratio and said group consists of MASP-1, ADIPOQ, ITIH4, ORM1 and PZP; wherein an increase in the amount of APOC2, APOC3, APOE, CRP or MASP-1 or of an mRNA encoding APOC2, APOC3, APOE, CRP or MASP-1 or a decrease in the amount of ADIPOQ, ITIH4, SHBG, PZP or ORM1 or of an mRNA encoding ADIPOQ, ITIH4, SHBG, PZP or ORM1 as compared to the amount of said protein(s) or said mRNA(s), respectively, of a control is indicative of a predisposition to develop type 2 diabetes mellitus.
Inventors:
VON TÖRNE CHRISTINE (DE)
HAUCK STEFANIE M (DE)
HUTH CORNELIA (DE)
THORAND BARBARA (DE)
DE LAS HERAS GALA TONIA (DE)
HAUCK STEFANIE M (DE)
HUTH CORNELIA (DE)
THORAND BARBARA (DE)
DE LAS HERAS GALA TONIA (DE)
Application Number:
PCT/EP2016/070011
Publication Date:
May 04, 2017
Filing Date:
August 24, 2016
Export Citation:
Assignee:
HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH) (DE)
International Classes:
G01N33/68; C12Q1/68
Domestic Patent References:
| WO2009064901A2 | 2009-05-22 |
Other References:
KOLBERG JANICE A ET AL: "Biomarkers in Type 2 diabetes: improving risk stratification with the PreDx (R) Diabetes Risk Score", EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, EXPERT REVIEWS LTD, GB, vol. 11, no. 8, 1 November 2011 (2011-11-01), pages 775 - 792, XP009190929, ISSN: 1744-8352, DOI: 10.1586/ERM.11.63
ALTAN ONAT ET AL: "-482C>T polymorphism, circulating apolipoprotein C-III and smoking: Interrelation and roles in predicting type-2 diabetes and coronary disease", CLINICAL BIOCHEMISTRY, ELSEVIER INC, US, CA, vol. 44, no. 5, 13 December 2010 (2010-12-13), pages 391 - 396, XP028366827, ISSN: 0009-9120, [retrieved on 20101223], DOI: 10.1016/J.CLINBIOCHEM.2010.12.009
VEIKKO SALOMAA ET AL: "Thirty-One Novel Biomarkers as Predictors for Clinically Incident Diabetes", PLOS ONE, vol. 5, no. 4, 9 April 2010 (2010-04-09), pages e10100, XP055106003, DOI: 10.1371/journal.pone.0010100
SABANAYAGAM C ET AL: "Serum C-reactive protein level and prediabetes in two Asian populations", DIABETOLOGIA ; CLINICAL AND EXPERIMENTAL DIABETES AND METABOLISM, SPRINGER, BERLIN, DE, vol. 54, no. 4, 26 January 2011 (2011-01-26), pages 767 - 775, XP019888877, ISSN: 1432-0428, DOI: 10.1007/S00125-011-2052-5
ANNE HIUKKA ET AL: "Alterations of lipids and apolipoprotein CIII in very low density lipoprotein subspecies in type 2 diabetes", DIABETOLOGIA ; CLINICAL AND EXPERIMENTAL DIABETES AND METABOLISM, SPRINGER, BERLIN, DE, vol. 48, no. 6, 1 June 2005 (2005-06-01), pages 1207 - 1215, XP019322561, ISSN: 1432-0428, DOI: 10.1007/S00125-005-1753-Z
S. BÉLIARD ET AL: "Parallel increase of plasma apoproteins C-II and C-III in Type 2 diabetic patients", DIABETIC MEDICINE., vol. 26, no. 7, 1 July 2009 (2009-07-01), GB, pages 736 - 739, XP055322154, ISSN: 0742-3071, DOI: 10.1111/j.1464-5491.2009.02757.x
TOERNE CHRISTINE VON ET AL: "MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study", DIABETOLOGIA, SPRINGER, BERLIN, DE, vol. 59, no. 9, 25 June 2016 (2016-06-25), pages 1882 - 1892, XP036020160, ISSN: 0012-186X, [retrieved on 20160625], DOI: 10.1007/S00125-016-4024-2
V. FRAUENKNECHT ET AL: "Plasma levels of mannan-binding lectin (MBL)-associated serine proteases (MASPs) and MBL-associated protein in cardio- and cerebrovascular diseases", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 173, no. 1, 6 July 2013 (2013-07-06), GB, pages 112 - 120, XP055356242, ISSN: 0009-9104, DOI: 10.1111/cei.12093
L. JENNY ET AL: "Plasma levels of mannan-binding lectin-associated serine proteases MASP-1 and MASP-2 are elevated in type 1 diabetes and correlate with glycaemic control", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 180, no. 2, 14 May 2015 (2015-05-14), GB, pages 227 - 232, XP055356240, ISSN: 0009-9104, DOI: 10.1111/cei.12574
ALTAN ONAT ET AL: "-482C>T polymorphism, circulating apolipoprotein C-III and smoking: Interrelation and roles in predicting type-2 diabetes and coronary disease", CLINICAL BIOCHEMISTRY, ELSEVIER INC, US, CA, vol. 44, no. 5, 13 December 2010 (2010-12-13), pages 391 - 396, XP028366827, ISSN: 0009-9120, [retrieved on 20101223], DOI: 10.1016/J.CLINBIOCHEM.2010.12.009
VEIKKO SALOMAA ET AL: "Thirty-One Novel Biomarkers as Predictors for Clinically Incident Diabetes", PLOS ONE, vol. 5, no. 4, 9 April 2010 (2010-04-09), pages e10100, XP055106003, DOI: 10.1371/journal.pone.0010100
SABANAYAGAM C ET AL: "Serum C-reactive protein level and prediabetes in two Asian populations", DIABETOLOGIA ; CLINICAL AND EXPERIMENTAL DIABETES AND METABOLISM, SPRINGER, BERLIN, DE, vol. 54, no. 4, 26 January 2011 (2011-01-26), pages 767 - 775, XP019888877, ISSN: 1432-0428, DOI: 10.1007/S00125-011-2052-5
ANNE HIUKKA ET AL: "Alterations of lipids and apolipoprotein CIII in very low density lipoprotein subspecies in type 2 diabetes", DIABETOLOGIA ; CLINICAL AND EXPERIMENTAL DIABETES AND METABOLISM, SPRINGER, BERLIN, DE, vol. 48, no. 6, 1 June 2005 (2005-06-01), pages 1207 - 1215, XP019322561, ISSN: 1432-0428, DOI: 10.1007/S00125-005-1753-Z
S. BÉLIARD ET AL: "Parallel increase of plasma apoproteins C-II and C-III in Type 2 diabetic patients", DIABETIC MEDICINE., vol. 26, no. 7, 1 July 2009 (2009-07-01), GB, pages 736 - 739, XP055322154, ISSN: 0742-3071, DOI: 10.1111/j.1464-5491.2009.02757.x
TOERNE CHRISTINE VON ET AL: "MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study", DIABETOLOGIA, SPRINGER, BERLIN, DE, vol. 59, no. 9, 25 June 2016 (2016-06-25), pages 1882 - 1892, XP036020160, ISSN: 0012-186X, [retrieved on 20160625], DOI: 10.1007/S00125-016-4024-2
V. FRAUENKNECHT ET AL: "Plasma levels of mannan-binding lectin (MBL)-associated serine proteases (MASPs) and MBL-associated protein in cardio- and cerebrovascular diseases", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 173, no. 1, 6 July 2013 (2013-07-06), GB, pages 112 - 120, XP055356242, ISSN: 0009-9104, DOI: 10.1111/cei.12093
L. JENNY ET AL: "Plasma levels of mannan-binding lectin-associated serine proteases MASP-1 and MASP-2 are elevated in type 1 diabetes and correlate with glycaemic control", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 180, no. 2, 14 May 2015 (2015-05-14), GB, pages 227 - 232, XP055356240, ISSN: 0009-9104, DOI: 10.1111/cei.12574
Attorney, Agent or Firm:
WEINZIERL, Gerhard (DE)
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