Title:
BIOMARKERS FOR DENGUE
Document Type and Number:
WIPO Patent Application WO/2010/043973
Kind Code:
A3
Abstract:
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying dengue status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with dengue or not infected with dengue. The biomarkers can be detected by SELDI mass spectrometry.
Inventors:
WARD BRIAN (CA)
NDAO MOMAR (CA)
CHAREONSIRISUTHIKUL TAKOL (TH)
UBOL SUKATHIDA (TH)
NDAO MOMAR (CA)
CHAREONSIRISUTHIKUL TAKOL (TH)
UBOL SUKATHIDA (TH)
Application Number:
PCT/IB2009/007358
Publication Date:
June 10, 2010
Filing Date:
October 14, 2009
Export Citation:
Assignee:
UNIV MCGILL (CA)
UNIV MAHIDOL (TH)
WARD BRIAN (CA)
NDAO MOMAR (CA)
CHAREONSIRISUTHIKUL TAKOL (TH)
UBOL SUKATHIDA (TH)
UNIV MAHIDOL (TH)
WARD BRIAN (CA)
NDAO MOMAR (CA)
CHAREONSIRISUTHIKUL TAKOL (TH)
UBOL SUKATHIDA (TH)
International Classes:
C40B40/10; C12Q1/70; C40B30/04; G01N33/569; G01N33/68; G06F19/00
Domestic Patent References:
| WO2008041953A2 | 2008-04-10 |
Other References:
ALBUQUERQUE, L. M. ET AL.: "Two-Dimensional difference gel electrophoresis (DiGE) analysis of plasmas from dengue fever patients.", J. PROTEOME RES., vol. 8, no. 12, December 2009 (2009-12-01), pages 5431 - 5439, XP008146903
VILLAR-CENTENO, L. A. ET AL.: "Biochemical alterations as markers of dengue hemorrhagic fever.", AM. J. TROP. MED. HYG., vol. 78, no. 3, March 2008 (2008-03-01), pages 370 - 374, XP008146904
WIE, Y-J. ET AL.: "Apolipoprotein D as a novel marker in human end-stage heart failure: a preliminary study.", BIOMARKERS., vol. 13, no. 5, August 2008 (2008-08-01), pages 535 - 548, XP008146905
O'BRIEN, M. ET AL.: "Expression of prothrombin and protease activated receptors in human myometrium during pregnancy and labor.", BIOL. REPROD., vol. 78, no. 1, September 2007 (2007-09-01), pages 20 - 26, XP008146902
THAYAN, R. ET AL.: "The use of two-dimension electrophoresis to identify serum biomarkers from patients with dengue haemorrhagic fever.", TRANS. R. SOC. TROP. MED. HYG., vol. 103, no. 4, February 2009 (2009-02-01), pages 413 - 419, XP025966144
See also references of EP 2347039A4
VILLAR-CENTENO, L. A. ET AL.: "Biochemical alterations as markers of dengue hemorrhagic fever.", AM. J. TROP. MED. HYG., vol. 78, no. 3, March 2008 (2008-03-01), pages 370 - 374, XP008146904
WIE, Y-J. ET AL.: "Apolipoprotein D as a novel marker in human end-stage heart failure: a preliminary study.", BIOMARKERS., vol. 13, no. 5, August 2008 (2008-08-01), pages 535 - 548, XP008146905
O'BRIEN, M. ET AL.: "Expression of prothrombin and protease activated receptors in human myometrium during pregnancy and labor.", BIOL. REPROD., vol. 78, no. 1, September 2007 (2007-09-01), pages 20 - 26, XP008146902
THAYAN, R. ET AL.: "The use of two-dimension electrophoresis to identify serum biomarkers from patients with dengue haemorrhagic fever.", TRANS. R. SOC. TROP. MED. HYG., vol. 103, no. 4, February 2009 (2009-02-01), pages 413 - 419, XP025966144
See also references of EP 2347039A4
Attorney, Agent or Firm:
SERAFINI, Andrew, T. (801 California StreetMountain View, CA, US)
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