Title:
BIOMARKERS FOR LIVER FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2014/160275
Kind Code:
A3
Abstract:
Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.
Inventors:
JACOBS JON M (US)
BURNUM-JOHNSON KRISTIN E (US)
BAKER ERIN M (US)
SMITH RICHARD D (US)
GRITSENKO MARINA A (US)
ORTON DANIEL (US)
BURNUM-JOHNSON KRISTIN E (US)
BAKER ERIN M (US)
SMITH RICHARD D (US)
GRITSENKO MARINA A (US)
ORTON DANIEL (US)
Application Number:
PCT/US2014/026208
Publication Date:
November 05, 2015
Filing Date:
March 13, 2014
Export Citation:
Assignee:
BATTELL MEMORIAL INST (US)
International Classes:
A61P1/16
Domestic Patent References:
| WO2007130636A2 | 2007-11-15 |
Other References:
BELL ET AL.: "Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease", HEPATOLOGY, vol. 51, 1 January 2010 (2010-01-01), pages 111 - 120, XP002605132
DIAMOND ET AL.: "HepatoProteomics: applying proteomic technologies to the study of liver function and disease", HEPATOLOGY, vol. 44, 1 August 2006 (2006-08-01), pages 299 - 308, XP055235309
BAKER ET AL.: "Advancing the high throughput identification of liver fibrosis protein signatures using multiplexed ion mobility spectrometry", MOL CELL PROTEOMICS., vol. 13, 8 January 2014 (2014-01-08), pages 1119 - 1127, XP055235311
DIAMOND ET AL.: "HepatoProteomics: applying proteomic technologies to the study of liver function and disease", HEPATOLOGY, vol. 44, 1 August 2006 (2006-08-01), pages 299 - 308, XP055235309
BAKER ET AL.: "Advancing the high throughput identification of liver fibrosis protein signatures using multiplexed ion mobility spectrometry", MOL CELL PROTEOMICS., vol. 13, 8 January 2014 (2014-01-08), pages 1119 - 1127, XP055235311
Attorney, Agent or Firm:
RYBAK, Sheree, Lynn (LLPOne World Trade Center, Suite 1600,121 SW Salmon Stree, Portland OR, US)
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