Title:
BIOMARKERS OF LIVER FUNCTION
Document Type and Number:
WIPO Patent Application WO2003038444
Kind Code:
A3
Abstract:
The present invention provides methods and compositions for screening, diagnosing and prognosing liver reponse, for monitoring the effectiveness of liver response treatment, and for drug development.
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Inventors:
AMACHER DAVID E (US)
FASULO LISA M (US)
HERATH HERATH MUDIYANSELAGE AT (GB)
HOLT GORDON DUANE (GB)
STIGER THOMAS R (US)
FASULO LISA M (US)
HERATH HERATH MUDIYANSELAGE AT (GB)
HOLT GORDON DUANE (GB)
STIGER THOMAS R (US)
Application Number:
PCT/US2002/034847
Publication Date:
April 01, 2004
Filing Date:
October 31, 2002
Export Citation:
Assignee:
PFIZER PROD INC (US)
OXFORD GLYCOSCIENCES UK LTD (GB)
AMACHER DAVID E (US)
FASULO LISA M (US)
HERATH HERATH MUDIYANSELAGE AT (GB)
HOLT GORDON DUANE (GB)
STIGER THOMAS R (US)
OXFORD GLYCOSCIENCES UK LTD (GB)
AMACHER DAVID E (US)
FASULO LISA M (US)
HERATH HERATH MUDIYANSELAGE AT (GB)
HOLT GORDON DUANE (GB)
STIGER THOMAS R (US)
International Classes:
G01N33/576; G01N33/68; (IPC1-7): G01N33/68; C12Q1/52; C12Q1/68; G01N33/50; G01N33/543
Domestic Patent References:
| WO2000062076A1 | 2000-10-19 | |||
| WO1993024140A1 | 1993-12-09 |
Other References:
DATABASE WPI Section Ch Week 199814, Derwent World Patents Index; Class B04, AN 1998-155228, XP002249065
MILKIEWICZ P ET AL: "Wilson's disease with superimposed autoimmune features: report of two cases and review.", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. AUSTRALIA MAY 2000, vol. 15, no. 5, May 2000 (2000-05-01), pages 570 - 574, XP001162711, ISSN: 0815-9319
WU T-W ET AL: "DELTA AND CONJUGATED BILIRUBIN AS COMPLEMENTARY MARKERS OF EARLY REJECTION IN LIVER-TRANSPLANT RECIPIENTS", CLINICAL CHEMISTRY, vol. 36, no. 1, 1990, pages 9 - 14, XP008020105, ISSN: 0009-9147
NAKAMURA KIMIHIDE ET AL: "Efficacy of ursodeoxycholic acid in Japanese patients with type 1 autoimmune hepatitis.", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 13, no. 5, May 1998 (1998-05-01), pages 490 - 495, XP008020094, ISSN: 0815-9319
POL S ET AL: "Nucleotide sequence and tissue distribution of the human mitochondrial aspartate aminotransferase mRNA", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 157, no. 3, 1988, pages 1309 - 1315, XP002155656, ISSN: 0006-291X
MILKIEWICZ P ET AL: "Wilson's disease with superimposed autoimmune features: report of two cases and review.", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. AUSTRALIA MAY 2000, vol. 15, no. 5, May 2000 (2000-05-01), pages 570 - 574, XP001162711, ISSN: 0815-9319
WU T-W ET AL: "DELTA AND CONJUGATED BILIRUBIN AS COMPLEMENTARY MARKERS OF EARLY REJECTION IN LIVER-TRANSPLANT RECIPIENTS", CLINICAL CHEMISTRY, vol. 36, no. 1, 1990, pages 9 - 14, XP008020105, ISSN: 0009-9147
NAKAMURA KIMIHIDE ET AL: "Efficacy of ursodeoxycholic acid in Japanese patients with type 1 autoimmune hepatitis.", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 13, no. 5, May 1998 (1998-05-01), pages 490 - 495, XP008020094, ISSN: 0815-9319
POL S ET AL: "Nucleotide sequence and tissue distribution of the human mitochondrial aspartate aminotransferase mRNA", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 157, no. 3, 1988, pages 1309 - 1315, XP002155656, ISSN: 0006-291X
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