BIOMARKERS FOR PROSPECTIVE DETERMINATION OF RISK FOR DEVELOPMENT OF ACTIVE TUBERCULOSIS

WIPO Patent Application WO/2017/081618

A9

This invention relates to a prognostic method for determining the risk of an asymptomatic human subject with latent tuberculosis (TB) infection or apparent latent TB infection and/or after suspected exposure to TB progressing to active tuberculosis disease comprising the steps of quantifying and computationally analysing relative abundances of a collection of pairs of gene products ("TB biomarkers") derived from a sample obtained from the subject. The invention further relates to a collection of TB biomarkers that generates a transcriptomic signature of risk for prediction of the likelihood of an asymptomatic human subject with latent TB infection and/or after suspected exposure to TB progressing to active tuberculosis disease. Furthermore, a kit comprising gene-specific primers or oligonucleotide probes for the detection of pairs of TB biomarkers that generates a prognostic signature of risk for use with the method of the invention is described. In addition, the invention relates to a method of preventive treatment or prophylaxis for TB infection comprising the use of the prognostic method and/or the kit of the invention to select an appropriate or experimental treatment regime or intervention for the human subject and/or to monitor the response of the human subject to the TB prophylaxis.

PENN-NICHOLSON ADAM GARTH (ZA)
SCRIBA THOMAS JENS (ZA)
ADEREM ALAN ARNOLD (US)
ZAK DANIEL EDWARD (US)
THOMPSON ETHAN GREENE (US)
HANEKOM WILLEM ALBERT (ZA)

PCT/IB2016/056737

July 13, 2017

November 09, 2016

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UNIV CAPE TOWN (ZA)
CENTER FOR INFECTIOUS DISEASE RES (US)

C12Q1/68

EDWARD NATHAN SONNENBERGS INCORPORATED (ZA)

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